FI925875A7 - Menetelmä uusien proteolyyttisten entsyymien inhibiittoreina käyttökelpoisten 2-sakkarinyylimetyyli- ja 4,5,6,7-tetrahydro-2-sakkarinyylimetyylifosfaattien, -fosfonaattien ja -fosfinaattien valmistamiseksi - Google Patents
Menetelmä uusien proteolyyttisten entsyymien inhibiittoreina käyttökelpoisten 2-sakkarinyylimetyyli- ja 4,5,6,7-tetrahydro-2-sakkarinyylimetyylifosfaattien, -fosfonaattien ja -fosfinaattien valmistamiseksi Download PDFInfo
- Publication number
- FI925875A7 FI925875A7 FI925875A FI925875A FI925875A7 FI 925875 A7 FI925875 A7 FI 925875A7 FI 925875 A FI925875 A FI 925875A FI 925875 A FI925875 A FI 925875A FI 925875 A7 FI925875 A7 FI 925875A7
- Authority
- FI
- Finland
- Prior art keywords
- saccharinylmethyl
- phosphonates
- tetrahydro
- inhibitors
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/814,741 US5187173A (en) | 1991-12-27 | 1991-12-27 | 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI925875A0 FI925875A0 (fi) | 1992-12-23 |
| FI925875L FI925875L (fi) | 1993-06-28 |
| FI925875A7 true FI925875A7 (fi) | 1993-06-28 |
Family
ID=25215883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI925875A FI925875A7 (fi) | 1991-12-27 | 1992-12-23 | Menetelmä uusien proteolyyttisten entsyymien inhibiittoreina käyttökelpoisten 2-sakkarinyylimetyyli- ja 4,5,6,7-tetrahydro-2-sakkarinyylimetyylifosfaattien, -fosfonaattien ja -fosfinaattien valmistamiseksi |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5187173A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0549073B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH05271262A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE150755T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU648938B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2085427A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ371692A3 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69218568T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0549073T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2100274T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI925875A7 (cg-RX-API-DMAC7.html) |
| GR (1) | GR3023632T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUT63630A (cg-RX-API-DMAC7.html) |
| IL (3) | IL116601A (cg-RX-API-DMAC7.html) |
| MX (1) | MX9207542A (cg-RX-API-DMAC7.html) |
| MY (1) | MY106897A (cg-RX-API-DMAC7.html) |
| NO (1) | NO303639B1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ245585A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2091377C1 (cg-RX-API-DMAC7.html) |
| SG (1) | SG48310A1 (cg-RX-API-DMAC7.html) |
| SK (1) | SK371692A3 (cg-RX-API-DMAC7.html) |
| TW (1) | TW225538B (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5296496A (en) * | 1991-12-27 | 1994-03-22 | Sterling Winthrop Inc. | 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| AU653279B2 (en) * | 1991-12-30 | 1994-09-22 | Sanofi | Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5541168A (en) * | 1994-12-02 | 1996-07-30 | Sterling Winthrop Inc. | Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof |
| DE60321141D1 (en) * | 2002-03-05 | 2008-07-03 | Axys Pharm Inc | Cathepsin-cystein-protease-hemmer |
| MXPA04008999A (es) * | 2002-03-20 | 2004-12-07 | Squibb Bristol Myers Co | Profarmacos de fosfato de fluorooxindoles. |
| US7488848B2 (en) * | 2005-03-21 | 2009-02-10 | Virobay, Inc. | Alpha ketoamide compounds as cysteine protease inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3002884A (en) * | 1959-04-15 | 1961-10-03 | Rohm & Haas | Horticultural process with n-halomethyl-1,2-benzisothiazolin - 3 - one-1,1-dioxides for controlling fungus diseases |
| US3314960A (en) * | 1964-08-25 | 1967-04-18 | American Home Prod | Benzisothiazol glutarimides |
| FR1451417A (fr) * | 1965-07-15 | 1966-01-07 | Roussel Uclaf | Nouveaux esters d'acides cycliques et leur procédé de préparation |
| US4195023A (en) * | 1975-08-20 | 1980-03-25 | Merck & Co., Inc. | 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin |
| US4276298A (en) * | 1978-03-24 | 1981-06-30 | Merck & Co., Inc. | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
| US4263393A (en) * | 1979-09-06 | 1981-04-21 | Eastman Kodak Company | Novel electron donor precursors and photographic element containing them |
| US4350752A (en) * | 1980-12-29 | 1982-09-21 | Eastman Kodak Company | Photographic elements and film units containing imidomethyl blocked photographic reagents |
| US4363865A (en) * | 1981-03-04 | 1982-12-14 | Eastman Kodak Company | Imido methyl blocked photographic dyes and dye releasing compounds |
| US4410618A (en) * | 1982-06-11 | 1983-10-18 | Eastman Kodak Company | Blocked photographic reagents |
| US4547371A (en) * | 1983-04-18 | 1985-10-15 | Merck & Co., Inc. | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents |
| US4623645A (en) * | 1983-04-18 | 1986-11-18 | Merck & Co., Inc. | Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents |
| US4659855A (en) * | 1983-05-09 | 1987-04-21 | Georgia Tech Research Corporation | Aryl sulfonyl fluoride compounds |
| JPH026496A (ja) * | 1988-06-27 | 1990-01-10 | Ishihara Sangyo Kaisha Ltd | 有機リン酸アミド系化合物、それらの製造方法及びそれらを含有する有害動物防除剤 |
| US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| NZ233521A (en) * | 1989-05-04 | 1992-05-26 | Sterling Drug Inc | 2-substituted saccharin derivatives, preparation and pharmaceutical compositions thereof |
| AU642537B2 (en) * | 1990-11-01 | 1993-10-21 | Sanofi | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
-
1991
- 1991-12-27 US US07/814,741 patent/US5187173A/en not_active Expired - Fee Related
-
1992
- 1992-11-12 AU AU28294/92A patent/AU648938B2/en not_active Ceased
- 1992-11-18 TW TW081109246A patent/TW225538B/zh active
- 1992-12-15 CA CA002085427A patent/CA2085427A1/en not_active Abandoned
- 1992-12-17 CZ CS923716A patent/CZ371692A3/cs unknown
- 1992-12-17 SK SK3716-92A patent/SK371692A3/sk unknown
- 1992-12-19 DK DK92204032.4T patent/DK0549073T3/da active
- 1992-12-19 ES ES92204032T patent/ES2100274T3/es not_active Expired - Lifetime
- 1992-12-19 AT AT92204032T patent/ATE150755T1/de not_active IP Right Cessation
- 1992-12-19 EP EP92204032A patent/EP0549073B1/en not_active Expired - Lifetime
- 1992-12-19 SG SG1996008831A patent/SG48310A1/en unknown
- 1992-12-19 DE DE69218568T patent/DE69218568T2/de not_active Expired - Fee Related
- 1992-12-23 NZ NZ245585A patent/NZ245585A/en unknown
- 1992-12-23 FI FI925875A patent/FI925875A7/fi unknown
- 1992-12-23 HU HU9204123A patent/HUT63630A/hu unknown
- 1992-12-23 NO NO924991A patent/NO303639B1/no unknown
- 1992-12-23 MX MX9207542A patent/MX9207542A/es not_active IP Right Cessation
- 1992-12-24 MY MYPI92002386A patent/MY106897A/en unknown
- 1992-12-25 RU RU9292016280A patent/RU2091377C1/ru active
- 1992-12-25 IL IL116601A patent/IL116601A/xx not_active IP Right Cessation
- 1992-12-25 IL IL10422992A patent/IL104229A/xx not_active IP Right Cessation
- 1992-12-28 JP JP4348373A patent/JPH05271262A/ja not_active Withdrawn
-
1995
- 1995-12-28 IL IL11660195A patent/IL116601A0/xx unknown
-
1997
- 1997-05-30 GR GR970401278T patent/GR3023632T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI925875L (fi) | 1993-06-28 |
| IL104229A (en) | 1997-02-18 |
| IL116601A (en) | 1997-04-15 |
| NO924991D0 (no) | 1992-12-23 |
| CA2085427A1 (en) | 1993-06-28 |
| DE69218568D1 (de) | 1997-04-30 |
| JPH05271262A (ja) | 1993-10-19 |
| IL116601A0 (en) | 1996-03-31 |
| ES2100274T3 (es) | 1997-06-16 |
| US5187173A (en) | 1993-02-16 |
| ATE150755T1 (de) | 1997-04-15 |
| FI925875A0 (fi) | 1992-12-23 |
| EP0549073A1 (en) | 1993-06-30 |
| IL104229A0 (en) | 1993-05-13 |
| NO924991L (no) | 1993-06-28 |
| MY106897A (en) | 1995-08-30 |
| AU2829492A (en) | 1993-07-01 |
| SK371692A3 (en) | 1995-05-10 |
| AU648938B2 (en) | 1994-05-05 |
| NZ245585A (en) | 1995-05-26 |
| MX9207542A (es) | 1993-06-01 |
| NO303639B1 (no) | 1998-08-10 |
| SG48310A1 (en) | 1998-04-17 |
| DK0549073T3 (da) | 1997-10-06 |
| HUT63630A (en) | 1993-09-28 |
| RU2091377C1 (ru) | 1997-09-27 |
| EP0549073B1 (en) | 1997-03-26 |
| DE69218568T2 (de) | 1997-11-13 |
| HU9204123D0 (en) | 1993-04-28 |
| CZ371692A3 (en) | 1994-04-13 |
| TW225538B (cg-RX-API-DMAC7.html) | 1994-06-21 |
| GR3023632T3 (en) | 1997-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: SANOFI |