DE69027569D1 - Verfahren zur Herstellung von Enynderivaten - Google Patents

Verfahren zur Herstellung von Enynderivaten

Info

Publication number
DE69027569D1
DE69027569D1 DE69027569T DE69027569T DE69027569D1 DE 69027569 D1 DE69027569 D1 DE 69027569D1 DE 69027569 T DE69027569 T DE 69027569T DE 69027569 T DE69027569 T DE 69027569T DE 69027569 D1 DE69027569 D1 DE 69027569D1
Authority
DE
Germany
Prior art keywords
preparation
enzyme derivatives
enzyme
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69027569T
Other languages
English (en)
Other versions
DE69027569T2 (de
Inventor
Susumu Nakagawa
Akira Asai
Satoru Kuroyanagi
Makoto Ishihara
Yoshiharu Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17304583&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69027569(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of DE69027569D1 publication Critical patent/DE69027569D1/de
Application granted granted Critical
Publication of DE69027569T2 publication Critical patent/DE69027569T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/24—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69027569T 1989-10-02 1990-09-28 Verfahren zur Herstellung von Enynderivaten Expired - Lifetime DE69027569T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP25731089 1989-10-02

Publications (2)

Publication Number Publication Date
DE69027569D1 true DE69027569D1 (de) 1996-08-01
DE69027569T2 DE69027569T2 (de) 1996-12-19

Family

ID=17304583

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69027569T Expired - Lifetime DE69027569T2 (de) 1989-10-02 1990-09-28 Verfahren zur Herstellung von Enynderivaten
DE69032859T Expired - Lifetime DE69032859T2 (de) 1989-10-02 1990-09-28 Zwischenverbindungen für ein Verfahren zur Herstellung von Enynderivaten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69032859T Expired - Lifetime DE69032859T2 (de) 1989-10-02 1990-09-28 Zwischenverbindungen für ein Verfahren zur Herstellung von Enynderivaten

Country Status (5)

Country Link
US (5) US5231183A (de)
EP (2) EP0645369B1 (de)
JP (2) JP3116364B2 (de)
CA (2) CA2351999C (de)
DE (2) DE69027569T2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3116364B2 (ja) * 1989-10-02 2000-12-11 萬有製薬株式会社 エンイン誘導体の製造法
FR2719047B1 (fr) * 1994-04-21 1996-07-12 Pf Medicament Nouveaux dérivés de benzylamines, leur procédé de fabrication et les compositions pharmaceutiques les renfermant.
DE69837628T2 (de) * 1997-08-05 2008-01-03 Pola Chemical Industries, Inc. Aminderivate und Verfahren zu ihrer Herstellung
SK5202000A3 (en) * 2000-04-07 2001-12-03 Slovakofarma As Method for the preparation of (e)-n-(6,6-dimethyl-2-hepten-4- inyl)-n-methyl-1-naphthalenemethylamine (terbinaphin)
AU2000255769A1 (en) * 2000-07-01 2002-01-14 Chemtech Research Incorporation Process for preparation of terbinafine and its hydrochloride as an antifungal agent
KR100459275B1 (ko) 2001-12-28 2004-12-03 주식회사유한양행 터비나핀 또는 그의 염산염의 제조방법
ITMI20022534A1 (it) 2002-11-29 2004-05-30 Dinamite Dipharma S P A Procedimento per la preparazione di terbinafina mediante l'uso di platino come catalizzatore.
GB0320312D0 (en) * 2003-08-29 2003-10-01 Novartis Ag Purification process
GB0503942D0 (en) * 2005-02-25 2005-04-06 Novartis Ag Purification process
US20050197512A1 (en) * 2003-08-29 2005-09-08 Ulrich Beutler Purification process
US20060078580A1 (en) 2004-10-08 2006-04-13 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US7740875B2 (en) * 2004-10-08 2010-06-22 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
CN102898314B (zh) * 2012-11-13 2014-09-03 山东铂源药业有限公司 一种盐酸特比萘芬的制备方法
CN104725240B (zh) * 2015-02-12 2017-05-24 吉林修正药业新药开发有限公司 一种盐酸特比萘芬z型异构体的制备方法
KR101994919B1 (ko) * 2017-12-18 2019-07-03 안채연 단열기능을 구비한 전기밥솥 커버
CN111606811B (zh) * 2020-06-04 2022-09-06 山东安弘制药有限公司 一种盐酸特比萘芬的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19375084I2 (de) * 1979-08-22 2000-11-16 Novartis Ag Propenylamine Verfahren zu ihrer Herstellung sie enthaltende pharmazeutische Zusammensetzungen und ihre Verwendung als Arzneimittel
CH648030A5 (de) * 1980-12-15 1985-02-28 Sandoz Ag Benzopyran-allylaminderivate, verfahren zu ihrer herstellung und ihre verwendung.
GB2110689A (en) * 1981-12-03 1983-06-22 Sandoz Ltd Herbicidal heterocyclic aminosulfonyl ureas and isoureas
FR2526423B1 (fr) * 1982-05-07 1987-07-10 Sandoz Sa Nouvelles amines insaturees, leur preparation et leur utilisation comme medicaments
HU197881B (en) * 1982-08-06 1989-06-28 Banyu Pharma Co Ltd Process for producing new carbamoyl-oxy-alkyl-carboxy-lic acid derivatives
US4855086A (en) * 1982-10-15 1989-08-08 Burroughs Wellcome Co. Novel pesticides, preparation and use
EP0254677A1 (de) * 1986-07-08 1988-01-27 Sandoz Ag Antimykotische 6-Phenyl-2-hexen-4-ynamine
US4689242A (en) * 1986-07-21 1987-08-25 United Technologies Corporation Method for adhesion of grit to blade tips
JP3116364B2 (ja) * 1989-10-02 2000-12-11 萬有製薬株式会社 エンイン誘導体の製造法

Also Published As

Publication number Publication date
CA2351999A1 (en) 1991-04-03
JPH03209348A (ja) 1991-09-12
JP3173602B2 (ja) 2001-06-04
EP0645369A3 (de) 1995-06-28
US5440049A (en) 1995-08-08
US5436354A (en) 1995-07-25
EP0645369B1 (de) 1998-12-23
CA2026599C (en) 2002-02-26
CA2351999C (en) 2002-02-12
JP3116364B2 (ja) 2000-12-11
DE69032859D1 (de) 1999-02-04
EP0421302A2 (de) 1991-04-10
CA2026599A1 (en) 1991-04-03
EP0645369A2 (de) 1995-03-29
DE69027569T2 (de) 1996-12-19
DE69032859T2 (de) 1999-05-12
US5296612A (en) 1994-03-22
EP0421302A3 (en) 1992-03-04
JP2000063334A (ja) 2000-02-29
US5359091A (en) 1994-10-25
EP0421302B1 (de) 1996-06-26
US5231183A (en) 1993-07-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH