FI925210L - Kompositioner och foerfaranden foer modulering av rna-molekylens aktivitet genom modifiering av cap-strukturen i rna-molekylens 5'-aenda - Google Patents

Kompositioner och foerfaranden foer modulering av rna-molekylens aktivitet genom modifiering av cap-strukturen i rna-molekylens 5'-aenda Download PDF

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Publication number
FI925210L
FI925210L FI925210A FI925210A FI925210L FI 925210 L FI925210 L FI 925210L FI 925210 A FI925210 A FI 925210A FI 925210 A FI925210 A FI 925210A FI 925210 L FI925210 L FI 925210L
Authority
FI
Finland
Prior art keywords
molekylens
rna
modulering
activitet
modifiering
Prior art date
Application number
FI925210A
Other languages
English (en)
Other versions
FI925210A7 (fi
FI925210A0 (fi
Inventor
Brenda F Baker
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of FI925210A7 publication Critical patent/FI925210A7/fi
Publication of FI925210L publication Critical patent/FI925210L/fi
Publication of FI925210A0 publication Critical patent/FI925210A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI925210A 1990-05-23 1991-05-22 Kompositioner och foerfaranden foer modulering av rna-molekylens aktivitet genom modifiering av cap-strukturen i rna-molekylens 5'-aenda FI925210A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52759990A 1990-05-23 1990-05-23
PCT/US1991/003606 WO1991017755A1 (en) 1990-05-23 1991-05-22 Compositions and methods for modulating rna activity through modification of the 5' cap structure of rna

Publications (3)

Publication Number Publication Date
FI925210A7 FI925210A7 (fi) 1992-11-17
FI925210L true FI925210L (fi) 1992-11-17
FI925210A0 FI925210A0 (fi) 1992-11-17

Family

ID=24102143

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925210A FI925210A0 (fi) 1990-05-23 1991-05-22 Kompositioner och foerfaranden foer modulering av rna-molekylens aktivitet genom modifiering av cap-strukturen i rna-molekylens 5'-aenda

Country Status (15)

Country Link
EP (1) EP0531447B1 (fi)
JP (1) JPH06500075A (fi)
KR (1) KR960004931B1 (fi)
AT (1) ATE186464T1 (fi)
AU (1) AU649458B2 (fi)
BR (1) BR9106486A (fi)
CA (1) CA2083377C (fi)
DE (1) DE69131773T2 (fi)
DK (1) DK0531447T3 (fi)
ES (1) ES2139578T3 (fi)
FI (1) FI925210A0 (fi)
GR (1) GR3032457T3 (fi)
HU (1) HUT63568A (fi)
NO (1) NO924309D0 (fi)
WO (1) WO1991017755A1 (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789573A (en) * 1990-08-14 1998-08-04 Isis Pharmaceuticals, Inc. Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
ATE218372T1 (de) * 1993-04-01 2002-06-15 Isis Pharmaceuticals Inc Antisense oligonnukleotide die mit der mrna cap aktivität interferieren und die translation inhibieren
IL114235A0 (en) * 1994-07-14 1995-10-31 Schering Ag Oligonucleotide conjugates and processes for noninvasive diagnosis utilizing the same
US6380169B1 (en) * 1994-08-31 2002-04-30 Isis Pharmaceuticals, Inc. Metal complex containing oligonucleoside cleavage compounds and therapies
US5962271A (en) * 1996-01-03 1999-10-05 Cloutech Laboratories, Inc. Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end
WO2001062981A1 (en) * 2000-02-25 2001-08-30 Montclair Group Platform for the discovery of the bacterial genes involved in rna modification
US9394333B2 (en) 2008-12-02 2016-07-19 Wave Life Sciences Japan Method for the synthesis of phosphorus atom modified nucleic acids
MX342945B (es) 2009-07-06 2016-10-18 Ontorii Inc * Profármacos de ácido nucleico novedosos y métodos de uso de los mismos.
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
SG11201500243WA (en) 2012-07-13 2015-04-29 Shin Nippon Biomedical Lab Ltd Chiral nucleic acid adjuvant
KR20240148947A (ko) 2012-07-13 2024-10-11 웨이브 라이프 사이언시스 리미티드 키랄 제어
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
EP3095460A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
ES2917473T3 (es) 2014-01-16 2022-07-08 Wave Life Sciences Ltd Diseño quiral

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806463A (en) * 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
AU651569B2 (en) * 1990-01-11 1994-07-28 Isis Pharmaceuticals, Inc. Compositions and methods for detecting and modulating RNA activity and gene expression

Also Published As

Publication number Publication date
EP0531447A4 (en) 1993-08-11
EP0531447A1 (en) 1993-03-17
ES2139578T3 (es) 2000-02-16
DE69131773T2 (de) 2000-03-02
HUT63568A (en) 1993-09-28
KR960004931B1 (ko) 1996-04-18
CA2083377A1 (en) 1991-11-24
FI925210A7 (fi) 1992-11-17
EP0531447B1 (en) 1999-11-10
KR930700118A (ko) 1993-03-13
CA2083377C (en) 2002-11-26
GR3032457T3 (en) 2000-05-31
AU649458B2 (en) 1994-05-26
AU8080291A (en) 1991-12-10
ATE186464T1 (de) 1999-11-15
WO1991017755A1 (en) 1991-11-28
HU9203659D0 (en) 1993-04-28
NO924309L (no) 1992-11-09
DK0531447T3 (da) 2000-03-27
JPH06500075A (ja) 1994-01-06
FI925210A0 (fi) 1992-11-17
BR9106486A (pt) 1993-05-25
NO924309D0 (no) 1992-11-09
DE69131773D1 (de) 1999-12-16

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