FI914826A7 - Kinatsoliinijohdokset ja niiden valmistus - Google Patents
Kinatsoliinijohdokset ja niiden valmistus Download PDFInfo
- Publication number
- FI914826A7 FI914826A7 FI914826A FI914826A FI914826A7 FI 914826 A7 FI914826 A7 FI 914826A7 FI 914826 A FI914826 A FI 914826A FI 914826 A FI914826 A FI 914826A FI 914826 A7 FI914826 A7 FI 914826A7
- Authority
- FI
- Finland
- Prior art keywords
- preparation
- quinazoline derivatives
- quinazoline
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909022306A GB9022306D0 (en) | 1990-10-15 | 1990-10-15 | Quinazoline derivatives and their preparation |
| GB919118337A GB9118337D0 (en) | 1991-08-27 | 1991-08-27 | Quinazoline derivatives and their preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI914826A0 FI914826A0 (fi) | 1991-10-14 |
| FI914826L FI914826L (fi) | 1992-04-16 |
| FI914826A7 true FI914826A7 (fi) | 1992-04-16 |
Family
ID=26297803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI914826A FI914826A7 (fi) | 1990-10-15 | 1991-10-14 | Kinatsoliinijohdokset ja niiden valmistus |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5304560A (https=) |
| EP (1) | EP0481342A1 (https=) |
| JP (1) | JP3164119B2 (https=) |
| KR (1) | KR920008031A (https=) |
| CN (1) | CN1060841A (https=) |
| AU (1) | AU648110B2 (https=) |
| CA (1) | CA2053475A1 (https=) |
| FI (1) | FI914826A7 (https=) |
| HU (1) | HUT59390A (https=) |
| IE (1) | IE913473A1 (https=) |
| NO (1) | NO914036L (https=) |
| PT (1) | PT99227B (https=) |
| TW (1) | TW201308B (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE126796T1 (de) * | 1990-01-02 | 1995-09-15 | Fujisawa Pharmaceutical Co | Quinazolinderivate und ihre herstellung. |
| US5994542A (en) * | 1995-11-14 | 1999-11-30 | Sumitomo Chemical Company, Limited | Process for producing 1-substituted tetrahydroquinazolines |
| US6413724B1 (en) | 1996-10-28 | 2002-07-02 | Versicor, Inc. | Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones |
| US6025371A (en) * | 1996-10-28 | 2000-02-15 | Versicor, Inc. | Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones |
| US6133275A (en) * | 1998-05-06 | 2000-10-17 | Abbott Laboratories | 3-phenylpyrrolidine alpha-1 adrenergic compounds |
| CA2341370A1 (en) * | 1998-08-20 | 2000-03-02 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
| ES2259476T3 (es) | 1998-08-21 | 2006-10-01 | Daiichi Asubio Pharma Co., Ltd. | Derivados de quinazolina y sus aplicaciones farmaceuticas. |
| US6521630B1 (en) | 1999-08-31 | 2003-02-18 | Pfizer Inc. | Tetrahydroquinazoline-2,4-diones and therapeutic uses thereof |
| EP1233950B1 (en) | 1999-11-23 | 2005-10-05 | Smithkline Beecham Corporation | 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/P39 kINASE INHIBITORS |
| JP2003514900A (ja) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物 |
| ATE281439T1 (de) | 1999-11-23 | 2004-11-15 | Smithkline Beecham Corp | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren |
| US6759410B1 (en) * | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| AU1626001A (en) * | 1999-11-23 | 2001-06-04 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)-quinazolin-2-ones and their use as csbp/p38 kinase inhibitors |
| CN1245979C (zh) * | 2000-02-22 | 2006-03-22 | 第一阿斯比奥制药株式会社 | 含有胃促胰酶抑制剂作为有效成分的预防和治疗皮炎的药物 |
| US7235551B2 (en) * | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| CN100525768C (zh) * | 2000-10-23 | 2009-08-12 | 史密丝克莱恩比彻姆公司 | 新化合物 |
| KR20040103972A (ko) * | 2002-04-19 | 2004-12-09 | 스미스클라인 비참 코포레이션 | 신규 화합물 |
| WO2005026153A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinazoline-2, 4-diones as antibacterial agents |
| CA2546002C (en) * | 2003-11-20 | 2012-09-18 | Janssen Pharmaceutica N.V. | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| BRPI0416206A (pt) | 2003-11-20 | 2006-12-26 | Janssen Pharmaceutica Nv | 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose) |
| SG151249A1 (en) * | 2003-12-05 | 2009-04-30 | Janssen Pharmaceutica Nv | 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| ATE540936T1 (de) * | 2004-06-30 | 2012-01-15 | Janssen Pharmaceutica Nv | Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer |
| EA011552B1 (ru) | 2004-06-30 | 2009-04-28 | Янссен Фармацевтика Н.В. | Производные хиназолиндиона в качестве ингибиторов parp |
| SG154433A1 (en) * | 2004-06-30 | 2009-08-28 | Janssen Pharmaceutica Nv | Phthalazine derivatives as parp inhibitors |
| PE20061193A1 (es) * | 2005-03-25 | 2006-12-02 | Glaxo Group Ltd | DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38 |
| US20080096905A1 (en) * | 2005-03-25 | 2008-04-24 | Glaxo Group Limited | Process For Preparing Pyrido[2,3-D]Pyrimidin-7-One And 3,4-Dihydropyrimido{4,5-D}Pyrimidin-2(1H)-One Derivatives |
| MY145343A (en) * | 2005-03-25 | 2012-01-31 | Glaxo Group Ltd | Novel compounds |
| US7423042B2 (en) * | 2005-03-25 | 2008-09-09 | Glaxo Group Limited | Compounds |
| GB0507298D0 (en) * | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| US8299256B2 (en) * | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
| US8404713B2 (en) * | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
| ES2367760T3 (es) * | 2008-03-27 | 2011-11-08 | Janssen Pharmaceutica, N.V. | Derivados de quinazolinona como inhibidores de la polimerización de la tubulina. |
| CN101981013B (zh) | 2008-03-27 | 2013-05-29 | 詹森药业有限公司 | 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮 |
| CN102786483B (zh) * | 2011-05-19 | 2016-03-30 | 复旦大学 | 4-（4-苯基哌嗪基）喹唑啉类衍生物的药用用途 |
| EP3332645A1 (de) | 2016-12-12 | 2018-06-13 | Bayer Cropscience AG | Verwendung substituierter pyrimidindione oder jeweils deren salze als wirkstoffe gegen abiotischen pflanzenstress |
| EP4141009A1 (de) * | 2021-08-30 | 2023-03-01 | Saltigo GmbH | Verfahren zur herstellung von mischungen enthaltend 2 (2 hydroxyethyl)-piperidinyl-carbamidsäure-sek.-butylester |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274194A (en) * | 1963-03-29 | 1966-09-20 | Miles Lab | Quinazolinedione derivatives |
| US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
| US4522945A (en) * | 1979-10-12 | 1985-06-11 | Janssen Pharmaceutica N.V. | (Piperidinylalkyl) quinazoline derivatives |
| JPS5948777B2 (ja) * | 1980-07-07 | 1984-11-28 | 株式会社クボタ | 厚形瓦の製造方法 |
| JPS608274A (ja) * | 1983-06-27 | 1985-01-17 | Fujisawa Pharmaceut Co Ltd | 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤 |
| US4716161A (en) * | 1984-04-17 | 1987-12-29 | Mitsubishi Chemical Industries Limited | Phenylpiperazine derivatives and their acid addition salts |
| US4711883A (en) * | 1985-09-30 | 1987-12-08 | Ortho Pharmaceutical Corporation | Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use |
-
1991
- 1991-10-02 IE IE347391A patent/IE913473A1/en not_active Application Discontinuation
- 1991-10-09 EP EP91117203A patent/EP0481342A1/en not_active Ceased
- 1991-10-11 AU AU85800/91A patent/AU648110B2/en not_active Ceased
- 1991-10-12 TW TW080108057A patent/TW201308B/zh active
- 1991-10-14 NO NO91914036A patent/NO914036L/no unknown
- 1991-10-14 FI FI914826A patent/FI914826A7/fi not_active Application Discontinuation
- 1991-10-14 KR KR1019910018015A patent/KR920008031A/ko not_active Withdrawn
- 1991-10-14 HU HU913243A patent/HUT59390A/hu unknown
- 1991-10-14 CN CN91109920A patent/CN1060841A/zh active Pending
- 1991-10-14 PT PT99227A patent/PT99227B/pt not_active IP Right Cessation
- 1991-10-15 JP JP33299691A patent/JP3164119B2/ja not_active Expired - Fee Related
- 1991-10-15 CA CA002053475A patent/CA2053475A1/en not_active Abandoned
-
1993
- 1993-08-09 US US08/103,315 patent/US5304560A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI914826L (fi) | 1992-04-16 |
| EP0481342A1 (en) | 1992-04-22 |
| NO914036D0 (no) | 1991-10-14 |
| HU913243D0 (en) | 1992-01-28 |
| KR920008031A (ko) | 1992-05-27 |
| JP3164119B2 (ja) | 2001-05-08 |
| AU8580091A (en) | 1992-04-16 |
| FI914826A0 (fi) | 1991-10-14 |
| HUT59390A (en) | 1992-05-28 |
| CN1060841A (zh) | 1992-05-06 |
| TW201308B (https=) | 1993-03-01 |
| CA2053475A1 (en) | 1992-04-16 |
| US5304560A (en) | 1994-04-19 |
| AU648110B2 (en) | 1994-04-14 |
| PT99227B (pt) | 1999-04-30 |
| PT99227A (pt) | 1992-09-30 |
| JPH04261170A (ja) | 1992-09-17 |
| IE913473A1 (en) | 1992-04-22 |
| NO914036L (no) | 1992-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |