FI90995C - Förfarande för framställning av kirala ämnen som rena optiska isomerer - Google Patents

Förfarande för framställning av kirala ämnen som rena optiska isomerer Download PDF

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Publication number
FI90995C
FI90995C FI912377A FI912377A FI90995C FI 90995 C FI90995 C FI 90995C FI 912377 A FI912377 A FI 912377A FI 912377 A FI912377 A FI 912377A FI 90995 C FI90995 C FI 90995C
Authority
FI
Finland
Prior art keywords
carbon dioxide
chiral
supercritical carbon
ibuprofen
racemic
Prior art date
Application number
FI912377A
Other languages
English (en)
Finnish (fi)
Other versions
FI912377A (sv
FI90995B (sv
FI912377A0 (sv
Inventor
Olli Aaltonen
Markku Rantakylae
Original Assignee
Valtion Teknillinen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valtion Teknillinen filed Critical Valtion Teknillinen
Priority to FI912377A priority Critical patent/FI90995C/sv
Publication of FI912377A0 publication Critical patent/FI912377A0/sv
Priority to PCT/FI1992/000151 priority patent/WO1992020812A1/en
Priority to EP92909747A priority patent/EP0588809A1/en
Publication of FI912377A publication Critical patent/FI912377A/sv
Application granted granted Critical
Publication of FI90995B publication Critical patent/FI90995B/sv
Publication of FI90995C publication Critical patent/FI90995C/sv

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (3)

1. Forfarande for framstållning av kirala åmnen som optiska isomerer, kånnetecknat dårav, att a) en forening, som hor till gruppen av karboksylsyror eller estrar och en alkohol, som reagerar med denna, varvid den ena reagerande foreningen år kiral och den andra icke-kiral, upploses i overkritisk koldioxid, b) den erhållna losningen av den kirala och den icke-kirala foreningen i overkritisk koldioxid fores i kontakt med ett enzym, som tillhor lipasgruppen (EC 3.1.1.3) och som alstras av jåsten Mucormiehei vid temperaturen 35-70 C och trycket 80-250 bar, varvid det i den overkritiska koldioxiden finns 0.4-1.5 ml vatten per koldioxidliter, sålunda att huvudsakligen bara en stereoisomer form av den kirala foreningen reagerar med den icke-kirala foreningen.
2. Ffirfarande i enlighet med patentkrav 1 kånnetecknat dårav, att den i overkritisk koldioxid upplosta kirala foreningen bildar en rasemisk blandning.
3. Forfarande enligt patentkrav 1 kånnetecknat dårav, att den i overkritisk koldioxid upplosta kirala fdreningen år rasemisk ibuprofen.
FI912377A 1991-05-16 1991-05-16 Förfarande för framställning av kirala ämnen som rena optiska isomerer FI90995C (sv)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI912377A FI90995C (sv) 1991-05-16 1991-05-16 Förfarande för framställning av kirala ämnen som rena optiska isomerer
PCT/FI1992/000151 WO1992020812A1 (en) 1991-05-16 1992-05-14 Process for producing chiral compounds as pure optical isomers
EP92909747A EP0588809A1 (en) 1991-05-16 1992-05-14 Process for producing chiral compounds as pure optical isomers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI912377A FI90995C (sv) 1991-05-16 1991-05-16 Förfarande för framställning av kirala ämnen som rena optiska isomerer
FI912377 1991-05-16

Publications (4)

Publication Number Publication Date
FI912377A0 FI912377A0 (sv) 1991-05-16
FI912377A FI912377A (sv) 1992-11-17
FI90995B FI90995B (sv) 1994-01-14
FI90995C true FI90995C (sv) 1994-04-25

Family

ID=8532533

Family Applications (1)

Application Number Title Priority Date Filing Date
FI912377A FI90995C (sv) 1991-05-16 1991-05-16 Förfarande för framställning av kirala ämnen som rena optiska isomerer

Country Status (3)

Country Link
EP (1) EP0588809A1 (sv)
FI (1) FI90995C (sv)
WO (1) WO1992020812A1 (sv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI93833C (sv) * 1992-05-14 1995-06-12 Orion Yhtymae Oy Förfarande för framställning av propionsyraderivat
JP3289058B2 (ja) * 1992-09-11 2002-06-04 工業技術院長 酵素を用いたエステル製造方法
US6486355B1 (en) 2000-02-23 2002-11-26 Brookhaven Science Associates Llc Application of chiral critical clusters to assymetric synthesis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925790A (en) * 1985-08-30 1990-05-15 The Regents Of The University Of California Method of producing products by enzyme-catalyzed reactions in supercritical fluids
DE3919029A1 (de) * 1989-06-10 1990-12-13 Hoechst Ag Verfahren zur enzymatischen spaltung von 2-arylpropionsaeure-vinylester
CA2039857A1 (en) * 1990-04-26 1991-10-27 Wilfred Po-Sum Shum Process for producing epoxyalcohols of high optical purity

Also Published As

Publication number Publication date
EP0588809A1 (en) 1994-03-30
FI912377A (sv) 1992-11-17
WO1992020812A1 (en) 1992-11-26
FI90995B (sv) 1994-01-14
FI912377A0 (sv) 1991-05-16

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Owner name: VALTION TEKNILLINEN TUTKIMUSKESKUS

BB Publication of examined application