FI90995C - Förfarande för framställning av kirala ämnen som rena optiska isomerer - Google Patents
Förfarande för framställning av kirala ämnen som rena optiska isomerer Download PDFInfo
- Publication number
- FI90995C FI90995C FI912377A FI912377A FI90995C FI 90995 C FI90995 C FI 90995C FI 912377 A FI912377 A FI 912377A FI 912377 A FI912377 A FI 912377A FI 90995 C FI90995 C FI 90995C
- Authority
- FI
- Finland
- Prior art keywords
- carbon dioxide
- chiral
- supercritical carbon
- ibuprofen
- racemic
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0203—Solvent extraction of solids with a supercritical fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (3)
1. Forfarande for framstållning av kirala åmnen som optiska isomerer, kånnetecknat dårav, att a) en forening, som hor till gruppen av karboksylsyror eller estrar och en alkohol, som reagerar med denna, varvid den ena reagerande foreningen år kiral och den andra icke-kiral, upploses i overkritisk koldioxid, b) den erhållna losningen av den kirala och den icke-kirala foreningen i overkritisk koldioxid fores i kontakt med ett enzym, som tillhor lipasgruppen (EC 3.1.1.3) och som alstras av jåsten Mucormiehei vid temperaturen 35-70 C och trycket 80-250 bar, varvid det i den overkritiska koldioxiden finns 0.4-1.5 ml vatten per koldioxidliter, sålunda att huvudsakligen bara en stereoisomer form av den kirala foreningen reagerar med den icke-kirala foreningen.
2. Ffirfarande i enlighet med patentkrav 1 kånnetecknat dårav, att den i overkritisk koldioxid upplosta kirala foreningen bildar en rasemisk blandning.
3. Forfarande enligt patentkrav 1 kånnetecknat dårav, att den i overkritisk koldioxid upplosta kirala fdreningen år rasemisk ibuprofen.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI912377A FI90995C (sv) | 1991-05-16 | 1991-05-16 | Förfarande för framställning av kirala ämnen som rena optiska isomerer |
PCT/FI1992/000151 WO1992020812A1 (en) | 1991-05-16 | 1992-05-14 | Process for producing chiral compounds as pure optical isomers |
EP92909747A EP0588809A1 (en) | 1991-05-16 | 1992-05-14 | Process for producing chiral compounds as pure optical isomers |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI912377A FI90995C (sv) | 1991-05-16 | 1991-05-16 | Förfarande för framställning av kirala ämnen som rena optiska isomerer |
FI912377 | 1991-05-16 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI912377A0 FI912377A0 (sv) | 1991-05-16 |
FI912377A FI912377A (sv) | 1992-11-17 |
FI90995B FI90995B (sv) | 1994-01-14 |
FI90995C true FI90995C (sv) | 1994-04-25 |
Family
ID=8532533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI912377A FI90995C (sv) | 1991-05-16 | 1991-05-16 | Förfarande för framställning av kirala ämnen som rena optiska isomerer |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0588809A1 (sv) |
FI (1) | FI90995C (sv) |
WO (1) | WO1992020812A1 (sv) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI93833C (sv) * | 1992-05-14 | 1995-06-12 | Orion Yhtymae Oy | Förfarande för framställning av propionsyraderivat |
JP3289058B2 (ja) * | 1992-09-11 | 2002-06-04 | 工業技術院長 | 酵素を用いたエステル製造方法 |
US6486355B1 (en) | 2000-02-23 | 2002-11-26 | Brookhaven Science Associates Llc | Application of chiral critical clusters to assymetric synthesis |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4925790A (en) * | 1985-08-30 | 1990-05-15 | The Regents Of The University Of California | Method of producing products by enzyme-catalyzed reactions in supercritical fluids |
DE3919029A1 (de) * | 1989-06-10 | 1990-12-13 | Hoechst Ag | Verfahren zur enzymatischen spaltung von 2-arylpropionsaeure-vinylester |
CA2039857A1 (en) * | 1990-04-26 | 1991-10-27 | Wilfred Po-Sum Shum | Process for producing epoxyalcohols of high optical purity |
-
1991
- 1991-05-16 FI FI912377A patent/FI90995C/sv active IP Right Grant
-
1992
- 1992-05-14 WO PCT/FI1992/000151 patent/WO1992020812A1/en not_active Application Discontinuation
- 1992-05-14 EP EP92909747A patent/EP0588809A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP0588809A1 (en) | 1994-03-30 |
FI912377A (sv) | 1992-11-17 |
WO1992020812A1 (en) | 1992-11-26 |
FI90995B (sv) | 1994-01-14 |
FI912377A0 (sv) | 1991-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Owner name: VALTION TEKNILLINEN TUTKIMUSKESKUS |
|
BB | Publication of examined application |