FI90871B - Förfarande för framställning av som läkemedel användbara 3a,4,5,6-tetrahydro-(3H)-pyrimidino/4,5,6-k,1/akridiner - Google Patents
Förfarande för framställning av som läkemedel användbara 3a,4,5,6-tetrahydro-(3H)-pyrimidino/4,5,6-k,1/akridiner Download PDFInfo
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- FI90871B FI90871B FI895605A FI895605A FI90871B FI 90871 B FI90871 B FI 90871B FI 895605 A FI895605 A FI 895605A FI 895605 A FI895605 A FI 895605A FI 90871 B FI90871 B FI 90871B
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- Prior art keywords
- formula
- compound
- acridine
- tetrahydro
- compounds
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- 238000002360 preparation method Methods 0.000 title claims abstract description 8
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- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical group 0.000 claims description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Claims (3)
1. Förfarande för framställning av 3a,4,5,6-tetra-hydro-(3H)-pyrlmidino[4,5,6-k,1]akridin som är användbart 5 som läkemedel och som har formeln (I) R A väri
15 R är väte, C^j-alkyl eller fenyl, som kan vara substituerad med halogen, eller ett farmaceutiskt godtagbart sait där-av, kännetecknat därav, att en förening med formeln (V) nh2 OH rrV"i omsätts med en förening med formeln R-C^n, väri R är som 25 ovan definierats.
2. Förfarande enligt patentkrav 1, kännetecknat därav, att man framställer 3a,4,5,6-tetra-hydro-2-metyl-(3H)-pyrimidino[4,5,6-kl]akridin eller ett farmaceutiskt godtagbart syraadditionssalt därav. 30
3. Förfarande enligt patentkrav 1, känne tecknat därav, att man framställer 3a,4,5,6-tetra-hydro-2-fenyl-(3H)-pyrimidino[4,5,6-kl]akridin eller ett farmaceutiskt godtagbart syraadditionssalt därav.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI923845A FI90872C (sv) | 1988-11-25 | 1992-08-27 | Förfarande för framställning av terapeutiskt aktiva 1,2,3a,4,5,6-hexahydro/1,3/oxazino/6,5,4-kl/akridinderivat |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/276,259 US4927820A (en) | 1988-11-25 | 1988-11-25 | Fused heterocyclic derivatives of 1,2,3,4-tetrahydroacridine |
| US27625988 | 1988-11-25 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI895605A0 FI895605A0 (sv) | 1989-11-23 |
| FI90871B true FI90871B (sv) | 1993-12-31 |
| FI90871C FI90871C (sv) | 1994-04-11 |
Family
ID=23055896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI895605A FI90871C (sv) | 1988-11-25 | 1989-11-23 | Förfarande för framställning av som läkemedel användbara 3a,4,5,6-tetrahydro-(3H)-pyrimidino/4,5,6-k,1/akridiner |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4927820A (sv) |
| EP (1) | EP0370449B1 (sv) |
| JP (1) | JPH085881B2 (sv) |
| KR (1) | KR0143235B1 (sv) |
| AT (1) | ATE104298T1 (sv) |
| AU (1) | AU623452B2 (sv) |
| CA (1) | CA2003837C (sv) |
| DE (1) | DE68914600T2 (sv) |
| DK (1) | DK592589A (sv) |
| ES (1) | ES2051965T3 (sv) |
| FI (1) | FI90871C (sv) |
| HU (1) | HU203551B (sv) |
| IE (1) | IE63120B1 (sv) |
| IL (1) | IL92420A (sv) |
| NO (1) | NO173783C (sv) |
| NZ (1) | NZ231494A (sv) |
| PT (1) | PT92389B (sv) |
| ZA (1) | ZA898989B (sv) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4920117A (en) * | 1989-06-09 | 1990-04-24 | Hoechst-Roussel Pharmaceuticals Inc. | 4,5,5a,6-tetrahydro-3H-isoxazolo(5,4,3-kl)acridines, pharmaceutical compositions and use |
| US4994452A (en) * | 1989-11-28 | 1991-02-19 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds |
| US5112829A (en) * | 1989-11-28 | 1992-05-12 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds |
| US5861398A (en) * | 1996-08-26 | 1999-01-19 | Alanex Corporation | Benzoperimidine-carboxylic acids and derivatives thereof |
| CA2711576C (en) | 2008-01-25 | 2016-06-21 | High Point Pharmaceuticals, Llc | Tricyclic compounds as inhibitors of tnf-.alpha. synthesis and as pde4 inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695573A (en) * | 1984-10-25 | 1987-09-22 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
| EP0179383B1 (en) * | 1984-10-25 | 1991-05-29 | Hoechst-Roussel Pharmaceuticals Incorporated | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments |
| MX13270A (es) * | 1987-10-05 | 1993-06-01 | Pfizer | Procedimiento para la preparacion de derivados de 4-aminopiridina |
| US4920117A (en) * | 1989-06-09 | 1990-04-24 | Hoechst-Roussel Pharmaceuticals Inc. | 4,5,5a,6-tetrahydro-3H-isoxazolo(5,4,3-kl)acridines, pharmaceutical compositions and use |
-
1988
- 1988-11-25 US US07/276,259 patent/US4927820A/en not_active Expired - Fee Related
-
1989
- 1989-11-21 ES ES89121488T patent/ES2051965T3/es not_active Expired - Lifetime
- 1989-11-21 AT AT89121488T patent/ATE104298T1/de not_active IP Right Cessation
- 1989-11-21 DE DE68914600T patent/DE68914600T2/de not_active Expired - Fee Related
- 1989-11-21 EP EP89121488A patent/EP0370449B1/en not_active Expired - Lifetime
- 1989-11-23 FI FI895605A patent/FI90871C/sv not_active IP Right Cessation
- 1989-11-23 KR KR1019890017024A patent/KR0143235B1/ko not_active IP Right Cessation
- 1989-11-23 PT PT92389A patent/PT92389B/pt not_active IP Right Cessation
- 1989-11-23 IL IL9242089A patent/IL92420A/en not_active IP Right Cessation
- 1989-11-23 NZ NZ231494A patent/NZ231494A/en unknown
- 1989-11-24 HU HU896174A patent/HU203551B/hu not_active IP Right Cessation
- 1989-11-24 ZA ZA898989A patent/ZA898989B/xx unknown
- 1989-11-24 NO NO894698A patent/NO173783C/no not_active IP Right Cessation
- 1989-11-24 AU AU45480/89A patent/AU623452B2/en not_active Ceased
- 1989-11-24 DK DK592589A patent/DK592589A/da not_active Application Discontinuation
- 1989-11-24 CA CA002003837A patent/CA2003837C/en not_active Expired - Fee Related
- 1989-11-24 IE IE375889A patent/IE63120B1/en not_active IP Right Cessation
- 1989-11-24 JP JP1303465A patent/JPH085881B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2051965T3 (es) | 1994-07-01 |
| DK592589A (da) | 1990-05-26 |
| CA2003837A1 (en) | 1990-05-25 |
| NZ231494A (en) | 1992-04-28 |
| EP0370449A1 (en) | 1990-05-30 |
| FI90871C (sv) | 1994-04-11 |
| EP0370449B1 (en) | 1994-04-13 |
| PT92389B (pt) | 1995-07-18 |
| NO173783C (no) | 1994-02-02 |
| KR0143235B1 (ko) | 1998-07-15 |
| JPH02193996A (ja) | 1990-07-31 |
| PT92389A (pt) | 1990-05-31 |
| IE63120B1 (en) | 1995-03-22 |
| HU896174D0 (en) | 1990-02-28 |
| DE68914600D1 (de) | 1994-05-19 |
| FI895605A0 (sv) | 1989-11-23 |
| IE893758L (en) | 1990-05-25 |
| HU203551B (en) | 1991-08-28 |
| ZA898989B (en) | 1990-08-29 |
| AU623452B2 (en) | 1992-05-14 |
| JPH085881B2 (ja) | 1996-01-24 |
| IL92420A (en) | 1994-02-27 |
| DE68914600T2 (de) | 1994-09-15 |
| NO894698L (no) | 1990-05-28 |
| AU4548089A (en) | 1990-05-31 |
| CA2003837C (en) | 2000-01-18 |
| ATE104298T1 (de) | 1994-04-15 |
| NO173783B (no) | 1993-10-25 |
| KR900007848A (ko) | 1990-06-02 |
| DK592589D0 (da) | 1989-11-24 |
| HUT53107A (en) | 1990-09-28 |
| IL92420A0 (en) | 1990-07-26 |
| US4927820A (en) | 1990-05-22 |
| NO894698D0 (no) | 1989-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| PC | Transfer of assignment of patent |
Owner name: HOECHST MARION ROUSSEL, INC. |
|
| MM | Patent lapsed |
Owner name: HOECHST MARION ROUSSEL INC., INC. |