FI906045A - KVAEVEHALTIGA SPIROCYKLISKA FOERENINGAR. - Google Patents

KVAEVEHALTIGA SPIROCYKLISKA FOERENINGAR. Download PDF

Info

Publication number
FI906045A
FI906045A FI906045A FI906045A FI906045A FI 906045 A FI906045 A FI 906045A FI 906045 A FI906045 A FI 906045A FI 906045 A FI906045 A FI 906045A FI 906045 A FI906045 A FI 906045A
Authority
FI
Finland
Prior art keywords
spirocykliska
kvaevehaltiga
foereningar
spirocycles
chem
Prior art date
Application number
FI906045A
Other languages
Finnish (fi)
Other versions
FI906045A0 (en
Inventor
John J Baldwin
David A Claremon
Jason M Elliott
Gerald S Ponticello
David C Remy
Harold G Selnick
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI906045A0 publication Critical patent/FI906045A0/en
Publication of FI906045A publication Critical patent/FI906045A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Abstract

Spirocycles of general structural formula <CHEM> are Class III antiarrhythmic agents.
FI906045A 1989-12-08 1990-12-07 KVAEVEHALTIGA SPIROCYKLISKA FOERENINGAR. FI906045A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44795089A 1989-12-08 1989-12-08
US61209190A 1990-11-16 1990-11-16

Publications (2)

Publication Number Publication Date
FI906045A0 FI906045A0 (en) 1990-12-07
FI906045A true FI906045A (en) 1991-06-09

Family

ID=27035165

Family Applications (1)

Application Number Title Priority Date Filing Date
FI906045A FI906045A (en) 1989-12-08 1990-12-07 KVAEVEHALTIGA SPIROCYKLISKA FOERENINGAR.

Country Status (17)

Country Link
EP (1) EP0431943B1 (en)
JP (1) JPH0747576B2 (en)
KR (1) KR910011859A (en)
CN (2) CN1053613A (en)
AT (1) ATE168377T1 (en)
AU (2) AU6787390A (en)
CA (1) CA2031633A1 (en)
DE (1) DE69032480T2 (en)
ES (1) ES2118715T3 (en)
FI (1) FI906045A (en)
HU (1) HU908122D0 (en)
IE (1) IE904430A1 (en)
IL (1) IL96507A0 (en)
NO (1) NO905306L (en)
NZ (1) NZ236315A (en)
PT (1) PT96126A (en)
YU (1) YU231790A (en)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0445974A3 (en) * 1990-03-05 1992-04-29 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents
IE911192A1 (en) * 1990-04-12 1991-10-23 Merck & Co Inc Substituted aromatic sulfonamides as antiglaucoma agents
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK78692D0 (en) * 1992-06-12 1992-06-12 Lundbeck & Co As H DIMER PIPERIDINE AND PIPERAZINE DERIVATIVES
PL176993B1 (en) * 1992-12-11 1999-08-31 Merck & Co Inc Spiropiperidines and their homologues stimulating growth hormone release
US5578593A (en) * 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
DE69412067T2 (en) * 1993-01-28 1999-03-25 Merck & Co Inc SUBSTITUTED SPIRO AZARINGES AS TACHYKININE RECEPTOR ANTAGONISTS
JPH08511522A (en) * 1993-06-07 1996-12-03 メルク エンド カンパニー インコーポレーテッド Spiro-Substituted Aza Rings as Neurokinin Antagonists
US5484923A (en) * 1993-06-10 1996-01-16 Merck & Co., Inc. Process of making spirocycles and analogs thereof
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
US5464788A (en) * 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
AU2223495A (en) * 1994-04-15 1995-11-10 Yamanouchi Pharmaceutical Co., Ltd. Spiro compound and medicinal composition thereof
US5434158A (en) * 1994-04-26 1995-07-18 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin-3 antagonists
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
HUP9600928A3 (en) * 1996-04-10 1999-03-29 Richter Gedeon Vegyeszet Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation
US6156783A (en) * 1996-04-30 2000-12-05 Smithkline Beecham P.L.C. Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use
US6110935A (en) 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
TW403740B (en) 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
US6013652A (en) * 1997-12-04 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
MXPA01012694A (en) * 1999-06-07 2003-10-15 Warner Lambert Co Tricyclic analgesics.
US6774132B1 (en) * 1999-07-21 2004-08-10 Astrazeneca Ab Spirooxindole derivatives that act as analgesics
BR0013717A (en) * 1999-09-03 2002-07-02 Asahi Chemical Ind Process for the preparation of a compound, for the preparation of any of the optical isomers of a halohydrin, optical isomer, compound, and, process for the preparation of an alpha-chlorophenone derivative
AU2003235912A1 (en) * 2002-05-10 2003-11-11 Taisho Pharmaceutical Co., Ltd. Spiro-ring compound
RS20050208A (en) 2002-09-09 2007-08-03 Janssen Pharmaceutica N.V., Hydroxy alkyl substituted 1,3,8- triazaspiro/4,5/decan-4- one derivatives useful for the treatment of orl-1 receptor mediated disorders
JP3856815B2 (en) 2003-04-04 2006-12-13 メルク エンド カムパニー インコーポレーテッド Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists
WO2004092179A1 (en) * 2003-04-14 2004-10-28 Nippon Soda Co. Ltd. Spiro derivative, production process, and antioxidant
US20060079566A1 (en) 2003-10-03 2006-04-13 Ching-Shih Chen PDK-1/Akt signaling inhibitors
CA2561488A1 (en) 2004-03-29 2005-10-06 Pfizer Inc. Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonists
SE0401539D0 (en) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
RU2417987C2 (en) 2004-08-27 2011-05-10 Лабораторьос Дель Др.Эстеве, С.А. Sigma-receptor inhibitors
JP5139061B2 (en) 2004-08-27 2013-02-06 ラボラトリオス デル ドクトール エステベ エセ．ア． Sigma receptor inhibitor
BRPI0514736A (en) 2004-08-27 2008-06-24 Esteve Labor Dr sigma receptor inhibitors
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
EP2522669B1 (en) * 2005-06-02 2016-12-28 Janssen Pharmaceutica NV 3-Spirocyclic indolyl derivatives useful as ORL-1 receptor modulators
AU2006270145B2 (en) * 2005-07-19 2011-04-14 Msd K.K. Spirochromanone derivatives as acetyl coenzyme a carboxylase (ACC) inhibitors
AR057570A1 (en) 2005-11-14 2007-12-05 Solvay Pharm Gmbh DERIVATIVES OF N-SULFAMOIL-N'-BENZOPIRANOPIPERIDINAS ESPIROCONDENSADAS, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, A PROCEDURE FOR THEIR PREPARATION AND ITS USE IN THE PREPARATION OF MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY ISOIDAS IIB
WO2007063385A2 (en) * 2005-12-01 2007-06-07 Pfizer Products Inc. Spirocyclic amine histamine-3 receptor antagonists
EP1829875A1 (en) 2006-03-01 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Pyrazole derivatives as sigma receptor inhibitors
EP1829866A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
EP1829867A1 (en) 2006-03-03 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Imidazole compounds having pharmaceutical activity towards the sigma receptor
EP2097420B1 (en) * 2006-11-29 2012-04-04 Pfizer Products Inc. Spiroketone inhibitors of acetyl-coa carboxylase
EP2120569B1 (en) 2007-01-12 2013-08-14 Merck Sharp & Dohme Corp. Spirochromanon derivatives
PE20081559A1 (en) 2007-01-12 2008-11-20 Merck & Co Inc SPIROCHROMANONE DERIVATIVES SUBSTITUTED AS ACETYL COA CARBOXYLASE INHIBITORS
WO2008124209A1 (en) 2007-04-09 2008-10-16 Janssen Pharmaceutica, N.V. 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
US8309544B2 (en) * 2007-05-16 2012-11-13 Merck Sharp & Dohme Corp. Spiroindalones
US8039502B2 (en) 2007-07-24 2011-10-18 The Ohio State University Research Foundation Anti-infective agents against intracellular pathogens
WO2009108905A2 (en) * 2008-02-28 2009-09-03 Life Technologies Corporation Fluorescence polarization herg assay
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
US10412788B2 (en) 2008-06-13 2019-09-10 Lg Chem, Ltd. Heating element and manufacturing method thereof
US20120108823A1 (en) 2009-04-22 2012-05-03 The Ohio State University Research Foundation Anti-francisella agents
UA107943C2 (en) 2009-11-16 2015-03-10 Lilly Co Eli Compounds of spiropiperidines as antagonists of the orl-1 receptors
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2353598A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for use in the prevention and/or treatment of postoperative pain
HUE028983T2 (en) 2010-05-06 2017-01-30 Vertex Pharma Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2395003A1 (en) 2010-05-27 2011-12-14 Laboratorios Del. Dr. Esteve, S.A. Pyrazole compounds as sigma receptor inhibitors
TW201643169A (en) * 2010-07-09 2016-12-16 艾伯維股份有限公司 Spiro-piperidine derivatives as S1P modulators
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
TWI520964B (en) 2011-02-02 2016-02-11 維泰克斯製藥公司 Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
AU2012217616B2 (en) 2011-02-18 2017-03-02 Vertex Pharmaceuticals Incorporated Chroman - spirocyclic piperidine amides as modulators of ion channels
WO2012125613A1 (en) 2011-03-14 2012-09-20 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
EP2524694A1 (en) 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
EP2951179B1 (en) * 2013-02-04 2020-03-11 Merck Patent GmbH Spiro-quinazolinone derivatives useful for the treatment of neurological diseases and conditions
BR112016013754A2 (en) 2013-12-17 2017-08-08 Esteve Labor Dr SEROTONIN-NOREPINEPHRINE REUPtake INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGAND COMBINATIONS
WO2018108627A1 (en) 2016-12-12 2018-06-21 Bayer Cropscience Aktiengesellschaft Use of substituted indolinylmethyl sulfonamides, or the salts thereof for increasing the stress tolerance of plants
CN108752360B (en) * 2018-04-12 2019-10-29 牡丹江医学院 A kind of compound and preparation method thereof for treating baby diarrhea
CN112334192A (en) * 2018-07-12 2021-02-05 Ucb生物制药有限责任公司 Spirocyclic indane analogs as IL-17 modulators
JP2022553802A (en) 2019-10-31 2022-12-26 エスケープ・バイオ・インコーポレイテッド Solid Forms of S1P Receptor Modulators

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3301857A (en) 1963-08-26 1967-01-31 Hoffmann La Roche Spiro
US3649635A (en) * 1969-10-24 1972-03-14 Warner Lambert Co Spiropyranopyridines
US3686186A (en) * 1970-10-05 1972-08-22 William J Houlihan Substituted isochroman or phthalan piperidenes
JPS4867287A (en) * 1971-12-20 1973-09-13
JPS5224748B2 (en) * 1972-07-04 1977-07-02
JPS5343513B2 (en) * 1972-09-20 1978-11-20
IL45823A (en) * 1973-10-20 1977-10-31 Hoechst Ag Substituted 1-phenyl-4-alkyl(dialkyl or cyclic) aminoalkyl-1,4-dihydro-2h-isoquinoline-3-one derivatives
DE2353702C3 (en) 1973-10-26 1979-03-29 Guenter 7000 Stuttgart Haag Burglary protection for areas
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
US3962259A (en) * 1973-12-12 1976-06-08 American Hoechst Corporation 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof
JPS5089377A (en) * 1973-12-19 1975-07-17
JPS50111082A (en) * 1974-02-18 1975-09-01
DE2611910A1 (en) 1976-03-20 1977-09-22 Bayer Ag Substd. chroman (4) ones prodn. - by reacting (2)-hydroxy-acetophenones and ketootkk ketones in presence of sec. amines
DE2535338A1 (en) 1975-08-07 1977-02-17 Bayer Ag Substd. chroman (4) ones prodn. - by reacting (2)-hydroxy-acetophenones and ketootkk ketones in presence of sec. amines
JPS5368784A (en) * 1976-11-30 1978-06-19 Sumitomo Chem Co Ltd Novel spiroamine derivatives and their preparation
DE2816380A1 (en) * 1977-04-21 1978-12-07 Hoechst Ag SPIRO SQUARE CLAMP ON INDOLIN-3,4'-PIPERIDINE SQUARE CLAMP AND RELATED CONNECTIONS
US4209625A (en) 1977-04-21 1980-06-24 American Hoechst Corporation Spiro[indoline-3,4'-piperidine]s
DE2745306A1 (en) 1977-10-07 1979-04-19 Bayer Ag INSECTICIDAL AGENTS
JPS54109983A (en) * 1978-02-13 1979-08-29 Sumitomo Chem Co Ltd Novel spiroamine derivative and its preparation
DE2814983A1 (en) 1978-04-07 1979-10-18 Bayer Ag NEW CHROMANON DERIVATIVES
US4166119A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4166120A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4307235A (en) 1978-08-23 1981-12-22 American Hoechst Corporation Spiro[indoline-3,4'-piperidine]s
JPS55139333A (en) * 1979-04-13 1980-10-31 Dai Ichi Seiyaku Co Ltd Spiro compound
JPS55139381A (en) * 1979-04-13 1980-10-31 Dai Ichi Seiyaku Co Ltd Spiroisochroman
JPS55143980A (en) * 1979-04-27 1980-11-10 Dai Ichi Seiyaku Co Ltd Anti-allergic preparation
FR2498603A1 (en) * 1981-01-29 1982-07-30 Delalande Sa Spiro iso:benzofuran and iso:benzothiophene derivs. - with anticonvulsant and analgesic activities
US4349549A (en) * 1981-05-18 1982-09-14 Syntex (U.S.A.) Inc. Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s
JPS5815979A (en) * 1981-07-11 1983-01-29 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and its preparation
US4353900A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
JPS5959685A (en) * 1982-09-28 1984-04-05 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and its preparation
US4420485A (en) * 1982-09-29 1983-12-13 Hoechst-Roussel Pharmaceuticals Inc. 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
US4558049A (en) * 1982-11-24 1985-12-10 Farmitalia Carlo Erba S.P.A. Antipsycotic benzoxazines
DE3308554A1 (en) * 1983-03-10 1984-09-13 Hoechst Ag, 6230 Frankfurt 1- / 1,3-DIOXOLAN-2-YLMETHYL) -AZOLE, THEIR SALTS, METHOD FOR THE PRODUCTION AND THEIR USE
DK139684A (en) * 1983-04-11 1984-10-12 Janssen Pharmaceutica Nv N-aryl-alpha-amino carboxamides
US4452802A (en) 1983-08-25 1984-06-05 Hoechst-Roussel Pharmaceuticals Incorporated Antihypertensive spiro[benzofuran-azalkanes]
JPS60158190A (en) * 1984-01-30 1985-08-19 Eisai Co Ltd Hydantoin derivative, its preparation, and drug containing it

Also Published As

Publication number Publication date
CA2031633A1 (en) 1991-06-09
AU6787390A (en) 1991-06-13
IE904430A1 (en) 1991-06-19
EP0431943B1 (en) 1998-07-15
AU6329794A (en) 1994-07-21
HU908122D0 (en) 1991-06-28
JPH04217960A (en) 1992-08-07
FI906045A0 (en) 1990-12-07
EP0431943A3 (en) 1992-03-25
JPH0747576B2 (en) 1995-05-24
DE69032480T2 (en) 1999-05-06
ATE168377T1 (en) 1998-08-15
NO905306L (en) 1991-06-10
PT96126A (en) 1991-09-30
YU231790A (en) 1993-05-28
IL96507A0 (en) 1991-08-16
DE69032480D1 (en) 1998-08-20
ES2118715T3 (en) 1998-10-01
NZ236315A (en) 1994-09-27
KR910011859A (en) 1991-08-07
CN1053613A (en) 1991-08-07
EP0431943A2 (en) 1991-06-12
NO905306D0 (en) 1990-12-07
CN1110685A (en) 1995-10-25

Similar Documents

Publication Publication Date Title
FI906045A0 (en) KVAEVEHALTIGA SPIROCYKLISKA FOERENINGAR.
ES2066991T3 (en) HIPOGLUCEMIANT AGENTS OF OXAZOLIDINADIONA.
FI852974L (en) NYA N-HYDROXYLGRUPPEN SKYDDANDE GRUPPER OCH FRAMSTAELLNINGSFOERFARANDE FOER 3-ACYLAMINO-1-HYDROXI-2-AZETIDINONER.
FI932104A0 (en) 4-arylpiperazine and 4-arylpiperidine
ES2107998T3 (en) DERIVATIZED ALCANOLAMINES AS CARDIOVASCULAR AGENTS.
ES2062374T3 (en) HETEROARILPIPERAZINAS, ANTIPSYCHOTIC AGENTS.
DE69511424T2 (en) ANTIFUNGAL SORDARID DERIVATIVES
SE9100920D0 (en) NEW ACTIVE COMPOUNDS
ITMI931012A1 (en) SPIRAL-PYRANIC COMPOUNDS EQUIPPED WITH PHOTOCROMATIC CHARACTERISTICS
GR1000887B (en) Spirofurane new derivatives
FI901277A0 (en) 2,5,6,7-TETRANOR-4,8-INTER-M-PHENYL PG1Z-DERIVATIVE.
FI932691A (en) NYA BENZYL- OCH BENZHYDRYLALKOHOLER
DK439286D0 (en) PROPANOL DERIVATIVES

Legal Events

Date Code Title Description
FA Application withdrawn

Owner name: MERCK & CO INC.