FI89503B - Kaern-skal-dispersionspolymerer, foerfarande foer deras framstaellning och deras anvaendning - Google Patents
Kaern-skal-dispersionspolymerer, foerfarande foer deras framstaellning och deras anvaendning Download PDFInfo
- Publication number
- FI89503B FI89503B FI871664A FI871664A FI89503B FI 89503 B FI89503 B FI 89503B FI 871664 A FI871664 A FI 871664A FI 871664 A FI871664 A FI 871664A FI 89503 B FI89503 B FI 89503B
- Authority
- FI
- Finland
- Prior art keywords
- monomers
- dispersion polymers
- polymer
- weight
- dispersion
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F257/00—Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00
- C08F257/02—Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00 on to polymers of styrene or alkyl-substituted styrenes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polymerisation Methods In General (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Graft Or Block Polymers (AREA)
- Colloid Chemistry (AREA)
Claims (10)
1. Kärn-skal-dispersionspolymerer för användning vid diagnostiska förfaranden, varvid förändringar av par-5 tikelstorleken mätes, vilka innehäller latexpartiklar pä vars yta finnes kopolymerat som är tillverkat av en mono-merblandning innehällande ätminstone en förening innehäl-lande acetalgrupper, med formeln
10. OR~ Il 2 CH=C-C-N-(CH0) -CH ^ (I) il 1 2 n H R1 H 0R3 väri n = 1 - 6,
15 R3 = H, CH3 och R2 och R3 är likadana eller olika grupper, varvid R2, R3 = - (CH2 )m - CH3, väri m = 0 - 7, eller X /
20 -C—Y, väri X, Y och Z = (CH9) CH.,, \ /pj Z väri p = 1 - 3, varvid X, Y och Z är likadana eller olika, eller R2, R3 = akrylrest, och eventuellt innehäller 25 krotonsyra och/eller akrylsyra och/eller metakrylsyra och/eller karbocykliska, aromatiska monovinylidenmonome-rer, kännetecknade därav, att restmonomer-halten hos kärnlatexpartiklarna före polymering av ska-let, utgör 5-50 vikt-% av latexpartiklarna.
2. Dispersionspolymerer enligt patentkravet 1, kännetecknade därav, att fröpolymeren utgörs av polystyrenlatex.
3. Dispersionspolymerer enligt patentkravet 1, kännetecknade därav, att fröpolymeren uppvi-35 sar en restmonomerhalt pä 10 - 40 vikt-% beräknar pä po-lymeren. 18 '*9503
4. Dispersionspolymerer enligt patentkravet 1, kännetecknade därav, att som monomerer med formeln I användes akryl- eller metakrylamidoalkylalde-hyd-di-alkylacetaler, vilkas alkylgrupper innehäller 2 - 5. kolatomer.
5. Dispersionspolymerer enligt patentkravet 1, kännetecknade därav, att som monomerer med formeln I användes metakrylamidoalkylaldehyd-di-n-pentyl-acetal. 10
6. Förfarande för framställning av dispersionspo lymerer, kännetecknat därav, att först fram-ställes fröpolymerer med en restmonomerhalt pä 5 - 50 vikt-%, genom att utföra polymerisationen sälunda, att endast 30 - 90 % av de närvarande monomererna polymerise-15 ras, varefter de tili polymeren ej bundna monomererna av-skiljes och därefter polymeriseras i närvaro av den sälunda erhällna fröpolymeren en monomerblandning, som innehäller ätminstone en förening med formeln I och dess-utom 0-30 vikt-% av blandningen, akryl-, metakryl-20 och/eller krotonsyra och/eller 0-30 vikt-%, även sä av blandningens totalmängd, karbocykliska, aromatiska viny-1idenmonomerer.
7. Biologiskt aktiva dispersionspolymerer kännetecknade därav, att de bestär av dispersions- 25 polymerer enligt patentkravet 1 och tili dessa bundna an-tikroppar, antigener eller haptener.
8. Användning av en biologiskt aktiv dispersions-polymer enligt patentkravet 7 för att diagnostiskt pävisa antikroppar, antigener eller haptener.
9. Användning av en biologiskt aktiv dispersions- polymer enligt patentkravet 7 i ett nefelometriskt och ett turbidimetriskt förfarande, samt i ett partikelräk-ningsförfarande.
10. Diagnostiskt medel, kännetecknat 35 därav, att det innehäller biologiskt aktiva dispersions-polymer, vilka bestär av dispersionspolymerer enligt patentkravet 1 och tili dessa bundna antikroppar, antigener eller haptener.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3613111 | 1986-04-18 | ||
| DE19863613111 DE3613111A1 (de) | 1986-04-18 | 1986-04-18 | Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI871664A0 FI871664A0 (fi) | 1987-04-15 |
| FI871664A FI871664A (fi) | 1987-10-19 |
| FI89503B true FI89503B (fi) | 1993-06-30 |
| FI89503C FI89503C (sv) | 1993-10-11 |
Family
ID=6298985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI871664A FI89503C (sv) | 1986-04-18 | 1987-04-15 | Kärn-skal-dispersionspolymerer, förfarande för deras framställning och deras användning |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4962046A (sv) |
| EP (1) | EP0246446B1 (sv) |
| JP (2) | JP2714571B2 (sv) |
| AT (1) | ATE59194T1 (sv) |
| AU (1) | AU608753B2 (sv) |
| CA (1) | CA1292683C (sv) |
| DE (2) | DE3613111A1 (sv) |
| DK (1) | DK172505B1 (sv) |
| ES (1) | ES2020220B3 (sv) |
| FI (1) | FI89503C (sv) |
| NO (1) | NO168308C (sv) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3545595A1 (de) * | 1985-12-21 | 1987-06-25 | Behringwerke Ag | Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung |
| US5183766A (en) * | 1986-04-18 | 1993-02-02 | Behringwerke Aktiengesellschaft | Dispersion polymers, processes for their preparation and their use |
| US4968742A (en) * | 1987-11-09 | 1990-11-06 | Miles Inc. | Preparation of ligand-polymer conjugate having a controlled number of introduced ligands |
| ATE395364T1 (de) | 1999-12-22 | 2008-05-15 | Dade Behring Marburg Gmbh | Gegen procalcitonin gerichtete antikörper, ihre herstellung und verwendung |
| ES2280170T3 (es) | 1999-12-22 | 2007-09-16 | Dade Behring Marburg Gmbh | Soluciones de procalcitonina humana. |
| DE10064827A1 (de) | 2000-12-22 | 2002-06-27 | Dade Behring Marburg Gmbh | Nachweisverfahren |
| DE20213920U1 (de) | 2002-07-03 | 2003-01-16 | Böhm, Martina, 60439 Frankfurt | Diagnostikum zum Nachweis der den von Willebrand-Faktorspaltenden Aktivität von ADAMTS13 |
| WO2005062048A1 (de) | 2003-12-01 | 2005-07-07 | Dade Behring Marburg Gmbh | Homogenes nachweisverfahren |
| US20050118727A1 (en) * | 2003-12-01 | 2005-06-02 | Carsten Schelp | Conjugates and their use in detection methods |
| DE102005026163A1 (de) | 2004-08-24 | 2006-03-02 | Dade Behring Marburg Gmbh | Gegen den Marburg I Polymorphismus der Faktor VII aktivierenden Protease (FSAP) gerichtete Antikörper, ihre Herstellung und Verwendung |
| DE102005022047A1 (de) | 2005-05-09 | 2006-11-30 | Dade Behring Marburg Gmbh | Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung |
| DE102008049601A1 (de) | 2008-09-30 | 2010-04-01 | Siemens Healthcare Diagnostics Products Gmbh | Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay |
| US20110306148A1 (en) * | 2010-06-14 | 2011-12-15 | Siemens Healthcare Diagnostics Inc. | Composition for use as an assay reagent |
| US8945827B2 (en) | 2013-03-13 | 2015-02-03 | Awareness Technology, Inc. | Serological methods and diagnostic tests for syphilis antibodies |
| EP2829878A1 (de) | 2013-07-23 | 2015-01-28 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur Bestimmung der GPIb-Rezeptor-abhängigen Plättchenfunktion |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1469358A (en) * | 1975-06-12 | 1977-04-06 | Nestle Sa | Enzyme product |
| DE3145082A1 (de) * | 1981-11-13 | 1983-05-19 | Behringwerke Ag, 3550 Marburg | "ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung" |
| US4693912A (en) * | 1985-02-28 | 1987-09-15 | Technicon Instruments Corporation | Lyophilization of reagent-coated particles |
| US4735907A (en) * | 1985-03-18 | 1988-04-05 | Eastman Kodak Company | Stabilized fluorescent rare earth labels and labeled physiologically reactive species |
| US4738932A (en) * | 1985-12-03 | 1988-04-19 | Advanced Polymer Systems, Inc. | Reaginic test for syphilis |
| DE3545595A1 (de) * | 1985-12-21 | 1987-06-25 | Behringwerke Ag | Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung |
| DE3622993A1 (de) * | 1986-07-09 | 1988-01-21 | Behringwerke Ag | Dispersionspolymere, biologisch aktive dispersionspolymere, verfahren zu ihrer herstellung und verwendung als diagnostisches mittel |
| DE3730515A1 (de) * | 1987-09-11 | 1989-03-23 | Behringwerke Ag | Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung |
-
1986
- 1986-04-18 DE DE19863613111 patent/DE3613111A1/de not_active Withdrawn
-
1987
- 1987-04-14 DE DE8787105536T patent/DE3766751D1/de not_active Expired - Lifetime
- 1987-04-14 EP EP87105536A patent/EP0246446B1/de not_active Expired - Lifetime
- 1987-04-14 AT AT87105536T patent/ATE59194T1/de not_active IP Right Cessation
- 1987-04-14 ES ES87105536T patent/ES2020220B3/es not_active Expired - Lifetime
- 1987-04-15 DK DK198701990A patent/DK172505B1/da not_active IP Right Cessation
- 1987-04-15 FI FI871664A patent/FI89503C/sv not_active IP Right Cessation
- 1987-04-15 NO NO871601A patent/NO168308C/no unknown
- 1987-04-16 AU AU71744/87A patent/AU608753B2/en not_active Ceased
- 1987-04-16 US US07/039,107 patent/US4962046A/en not_active Expired - Lifetime
- 1987-04-16 CA CA000535002A patent/CA1292683C/en not_active Expired - Lifetime
- 1987-04-17 JP JP62093446A patent/JP2714571B2/ja not_active Expired - Lifetime
-
1996
- 1996-08-21 JP JP8219605A patent/JP2892990B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK199087A (da) | 1987-10-19 |
| NO168308B (no) | 1991-10-28 |
| EP0246446B1 (de) | 1990-12-19 |
| DK199087D0 (da) | 1987-04-15 |
| US4962046A (en) | 1990-10-09 |
| ES2020220B3 (es) | 1991-08-01 |
| FI871664A0 (fi) | 1987-04-15 |
| JPS62252410A (ja) | 1987-11-04 |
| NO871601D0 (no) | 1987-04-15 |
| CA1292683C (en) | 1991-12-03 |
| JPH09241320A (ja) | 1997-09-16 |
| JP2892990B2 (ja) | 1999-05-17 |
| DE3613111A1 (de) | 1987-10-22 |
| ATE59194T1 (de) | 1991-01-15 |
| AU7174487A (en) | 1987-10-22 |
| NO871601L (no) | 1987-10-19 |
| EP0246446A3 (en) | 1988-05-04 |
| EP0246446A2 (de) | 1987-11-25 |
| FI871664A (fi) | 1987-10-19 |
| NO168308C (no) | 1992-02-05 |
| DE3766751D1 (de) | 1991-01-31 |
| FI89503C (sv) | 1993-10-11 |
| AU608753B2 (en) | 1991-04-18 |
| DK172505B1 (da) | 1998-10-26 |
| JP2714571B2 (ja) | 1998-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| PC | Transfer of assignment of patent |
Owner name: DADE BEHRING MARBURG GMBH |
|
| FG | Patent granted |
Owner name: DADE BEHRING MARBURG GMBH |
|
| MA | Patent expired |