FI886048A - Foerfarande och anordning foer beroeringsfri akustisk testning av elasticiteten hos mjuk biologisk vaevnad. - Google Patents

Foerfarande och anordning foer beroeringsfri akustisk testning av elasticiteten hos mjuk biologisk vaevnad. Download PDF

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Publication number
FI886048A
FI886048A FI886048A FI886048A FI886048A FI 886048 A FI886048 A FI 886048A FI 886048 A FI886048 A FI 886048A FI 886048 A FI886048 A FI 886048A FI 886048 A FI886048 A FI 886048A
Authority
FI
Finland
Prior art keywords
vaevnad
testning
mjuk
elasticiteten
biologisk
Prior art date
Application number
FI886048A
Other languages
English (en)
Finnish (fi)
Inventor
P Armen Sarvazyan
Viktor Ponomarjev
Dusan Vucelic
Goran Popovic
Akiva Veksler
Original Assignee
Inst Of General And Physical C
Inst Biolog Physics Of The Uss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Of General And Physical C, Inst Biolog Physics Of The Uss filed Critical Inst Of General And Physical C
Publication of FI886048A publication Critical patent/FI886048A/fi

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0051Detecting, measuring or recording by applying mechanical forces or stimuli by applying vibrations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0053Detecting, measuring or recording by applying mechanical forces or stimuli by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0057Detecting, measuring or recording by applying mechanical forces or stimuli by applying motion other than vibrations, e.g. rolling, rubbing, applying a torque, tribometry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/44Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/442Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48Diagnostic techniques
    • A61B8/485Diagnostic techniques involving measuring strain or elastic properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/04Analysing solids
    • G01N29/07Analysing solids by measuring propagation velocity or propagation time of acoustic waves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/45For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4519Muscles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/028Material parameters
    • G01N2291/02827Elastic parameters, strength or force
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/04Wave modes and trajectories
    • G01N2291/044Internal reflections (echoes), e.g. on walls or defects

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
FI886048A 1988-02-19 1988-12-30 Foerfarande och anordning foer beroeringsfri akustisk testning av elasticiteten hos mjuk biologisk vaevnad. FI886048A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU32588A YU47190B (sh) 1988-02-19 1988-02-19 Uredjaj za neinvazivno akustičko ispitivanje elastičnosti mekih bioloških materijala

Publications (1)

Publication Number Publication Date
FI886048A true FI886048A (fi) 1989-08-20

Family

ID=25549387

Family Applications (1)

Application Number Title Priority Date Filing Date
FI886048A FI886048A (fi) 1988-02-19 1988-12-30 Foerfarande och anordning foer beroeringsfri akustisk testning av elasticiteten hos mjuk biologisk vaevnad.

Country Status (26)

Country Link
US (1) US4947851A (pt)
EP (1) EP0329817B1 (pt)
JP (1) JPH0221840A (pt)
KR (1) KR920006032B1 (pt)
CN (1) CN1023442C (pt)
AR (1) AR242898A1 (pt)
AT (1) ATE79473T1 (pt)
AU (1) AU621341B2 (pt)
BR (1) BR8900698A (pt)
CA (1) CA1318018C (pt)
DD (1) DD283560A5 (pt)
DE (1) DE3873742T2 (pt)
DK (1) DK75389A (pt)
ES (1) ES2035156T3 (pt)
FI (1) FI886048A (pt)
GR (1) GR3006246T3 (pt)
HU (1) HU202650B (pt)
IE (1) IE890137L (pt)
IL (1) IL88691A (pt)
IS (1) IS1488B (pt)
NO (1) NO890496L (pt)
NZ (1) NZ227893A (pt)
PL (1) PL277821A1 (pt)
PT (1) PT89735B (pt)
TR (1) TR24539A (pt)
YU (1) YU47190B (pt)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5115808A (en) * 1988-02-19 1992-05-26 Institute Of General And Physical Chemistry Method and device for noninvasive acoustic testing of elasticity of soft biological tissues
DE3832690C1 (pt) * 1988-09-26 1990-04-12 Courage + Khazaka Electronic Gmbh, 5000 Koeln, De
US5107837A (en) * 1989-11-17 1992-04-28 Board Of Regents, University Of Texas Method and apparatus for measurement and imaging of tissue compressibility or compliance
US5293870A (en) * 1989-11-17 1994-03-15 Board Of Regents The University Of Texas System Method and apparatus for elastographic measurement and imaging
US5426979A (en) * 1990-06-04 1995-06-27 Medicano Systems Ltd. Frequency spectrum apparatus for determining mechanical properties
CA2102785A1 (en) * 1991-05-10 1992-11-26 Jonathan Ophir Method and apparatus for elastographic measurement and imaging
US5524636A (en) * 1992-12-21 1996-06-11 Artann Corporation Dba Artann Laboratories Method and apparatus for elasticity imaging
US5785663A (en) * 1992-12-21 1998-07-28 Artann Corporation Method and device for mechanical imaging of prostate
US5265612A (en) * 1992-12-21 1993-11-30 Medical Biophysics International Intracavity ultrasonic device for elasticity imaging
US5922018A (en) * 1992-12-21 1999-07-13 Artann Corporation Method for using a transrectal probe to mechanically image the prostate gland
US5860934A (en) * 1992-12-21 1999-01-19 Artann Corporation Method and device for mechanical imaging of breast
US6142959A (en) * 1992-12-21 2000-11-07 Armed L.L.C. Device for palpation and mechanical imaging of the prostate
US5836876A (en) * 1993-03-03 1998-11-17 Washington University Method and apparatus for determining bone density and diagnosing osteoporosis
JPH08201490A (ja) * 1995-01-31 1996-08-09 Mitsumi Electric Co Ltd センサic
JPH11513280A (ja) * 1995-09-27 1999-11-16 アータン・ラボラトリーズ 組織の異方性の機械的特性の測定
US5606971A (en) * 1995-11-13 1997-03-04 Artann Corporation, A Nj Corp. Method and device for shear wave elasticity imaging
US5810731A (en) * 1995-11-13 1998-09-22 Artann Laboratories Method and apparatus for elasticity imaging using remotely induced shear wave
IL116784A (en) * 1996-01-16 2000-01-31 Hadasit Med Res Service Device for examining viscoelasticity of a living or artificial tissue
US5911694A (en) * 1996-08-22 1999-06-15 Olympus Optical Co., Ltd. Endoceliac physical quantity measuring apparatus having excellent measuring resolution
CA2279199C (en) * 1996-12-06 2006-04-11 Jocelyn W. Cowie Method and apparatus for locating and assessing soft tissue lesions
ZA985834B (en) * 1997-07-21 1999-01-14 Henkel Corp Method for reinforcing structural members
US6364849B1 (en) 1999-05-03 2002-04-02 Access Wellness And Physical Therapy Soft tissue diagnostic apparatus and method
CN1383374A (zh) * 2000-04-26 2002-12-04 皇家菲利浦电子有限公司 用于切变波参数估算的超声波方法和系统
DE50010517D1 (de) 2000-06-21 2005-07-14 Courage Brewing Ltd Messgerät zur Messung der elastischen Eigenschaften einer Oberflächenstruktur
WO2002016925A1 (fr) * 2000-08-23 2002-02-28 Mitsubishi Denki Kabushiki Kaisha Dispositif non destructif d'inspection
CA2333224A1 (en) 2001-01-31 2002-07-31 University Technologies International Inc. Non-invasive diagnostic method and apparatus for musculoskeletal systems
US6569108B2 (en) 2001-03-28 2003-05-27 Profile, Llc Real time mechanical imaging of the prostate
US6923065B2 (en) * 2001-09-17 2005-08-02 Thyssen Elevator Capital Corp. Apparatus for testing aramid fiber elevator cables
US6662660B2 (en) * 2001-09-17 2003-12-16 Thyssen Elevator Capital Corp. Apparatus for testing aramid fiber elevator cables
ITMI20030568A1 (it) * 2003-03-21 2004-09-22 Derming S R L Strumento di misura delle proprieta' meccaniche della pelle e metodo di valutazione dell'efficacia di trattamenti estetici e/o prodotti cosmetici e farmaceutici sulla pelle
JP4443957B2 (ja) * 2003-04-28 2010-03-31 株式会社根本杏林堂 漏出検出装置および方法
US7611465B2 (en) * 2003-07-15 2009-11-03 Board Of Regents, The University Of Texas System Rapid and accurate detection of bone quality using ultrasound critical angle reflectometry
WO2005023093A2 (en) * 2003-09-05 2005-03-17 William Marsh Rice University Noninvasive tissue assessment
US20060052719A1 (en) * 2004-09-09 2006-03-09 Eduardo Ruvolo Method of measuring of skin anisotropy
JP4762147B2 (ja) 2004-09-14 2011-08-31 株式会社根本杏林堂 漏出検出装置
CN1873406B (zh) * 2006-06-30 2011-02-16 王岩松 声学材料性能综合测试仪
US20080125653A1 (en) * 2006-11-27 2008-05-29 Board Of Regents, The University Of Texas System Density and porosity measurements by ultrasound
US8175689B2 (en) * 2007-03-19 2012-05-08 Nicholas Hunter-Jones Skin elasticity measurement
KR101411210B1 (ko) * 2007-05-16 2014-06-23 수퍼 소닉 이매진 관심 영역의 점탄성의 평균 값을 측정하기 위한 방법 및 장치
US9044192B2 (en) * 2008-04-07 2015-06-02 Mayo Foundation For Medical Education And Research System and method for non-invasively measuring tissue viscoelasticity using surface waves
WO2010048160A2 (en) 2008-10-20 2010-04-29 The Johns Hopkins University Environment property estimation and graphical display
US8147410B2 (en) * 2009-03-23 2012-04-03 The Hong Kong Polytechnic University Method and apparatus for ultrasound imaging and elasticity measurement
US8052622B2 (en) * 2009-09-02 2011-11-08 Artann Laboratories Inc Methods for characterizing vaginal tissue elasticity
US8187208B2 (en) * 2009-09-02 2012-05-29 Artann Laboratories Inc. Methods for assessment of pelvic organ conditions affecting the vagina
CN102548496B (zh) 2009-09-15 2015-04-29 皇家飞利浦电子股份有限公司 具有力探测的医学超声设备
NO336532B1 (no) * 2011-01-12 2015-09-21 Mecsense As Sensor for måling av densiteten av et kroppsfluid og/eller motstanden til en membran
WO2013105987A2 (en) 2011-02-15 2013-07-18 Hemosonics, Llc Characterization of blood hemostasis and oxygen transport parameters
JP5491671B2 (ja) * 2013-11-22 2014-05-14 スーパー ソニック イマジン 関心領域の粘弾性の平均値を測定するための方法
AT514566B1 (de) 2013-12-04 2015-02-15 Mkw Electronics Gmbh Verfahren und Vorrichtung für die Untersuchung von Tierhufen bzw. Tierklauen
FR3016791B1 (fr) * 2014-01-30 2019-09-20 Centre National De La Recherche Scientifique - Cnrs Procede et dispositif de caracterisation de la peau
US9726647B2 (en) 2015-03-17 2017-08-08 Hemosonics, Llc Determining mechanical properties via ultrasound-induced resonance
TWI580960B (zh) * 2015-05-08 2017-05-01 國立臺灣大學 彈性分布影像生成系統
CN105300812B (zh) * 2015-10-26 2017-11-28 苏州大学 生物软组织力学特性测试仪及生物软组织的力学测试方法
CN106264605B (zh) * 2016-08-04 2020-10-09 无锡海斯凯尔医学技术有限公司 超声装置及产生机械振动的装置
CN106680369B (zh) * 2017-02-23 2024-02-09 天健创新(北京)监测仪表股份有限公司 一种超声波泥水界面测量装置及方法
AR113330A1 (es) 2017-10-31 2020-04-08 Univ La Republica Equipo y método para determinar la elasticidad de sólidos blandos
CN113229841B (zh) * 2021-04-26 2022-08-02 中南大学湘雅三医院 一种医用声音、振动采集分析系统与方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3783679A (en) * 1971-02-22 1974-01-08 Walter A Gunkel Time base measurement circuit
US4175546A (en) * 1977-09-06 1979-11-27 Ahron P. Leichtman Device for measuring sensitivity to vibration
DE2741338A1 (de) * 1977-09-14 1979-03-22 Industrie Automation Gmbh & Co Einrichtung zur bestimmung der mechanischen eigenfrequenz von blutgefaessen, sehnen, knochen oder aehnlichen organen in einem koerper
IL54277A0 (en) * 1978-03-14 1978-06-15 Yissum Res Dev Co Measurement of elasticity
US4250894A (en) * 1978-11-14 1981-02-17 Yeda Research & Development Co., Ltd. Instrument for viscoelastic measurement
DE3242284A1 (de) * 1982-11-16 1984-05-17 Philips Patentverwaltung Gmbh, 2000 Hamburg Verfahren und anordnung zur laufzeitbestimmung eines ultraschallimpulses
US4522071A (en) * 1983-07-28 1985-06-11 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for measuring stress
JPS60181606A (ja) * 1984-02-28 1985-09-17 Yoshio Takemori 脂肪厚測定装置
EP0181131A3 (en) * 1984-11-01 1987-05-20 Kent Scientific and Industrial Projects Limited Apparatus for detecting the resonant frequency of a bone
US4777599A (en) * 1985-02-26 1988-10-11 Gillette Company Viscoelastometry of skin using shear wave propagation
SU1357827A1 (ru) * 1985-10-23 1987-12-07 Куйбышевский политехнический институт им.В.В.Куйбышева Способ измерени скорости и затухани продольных упругих волн
CA1264196A (en) * 1986-07-18 1990-01-02 Canadian Patents And Development Limited/Societe Canadienne Des Brevets Et D'exploitation Limitee Method of, and an apparatus for, evaluating forming capabilities of solid plate
US4768379A (en) * 1986-07-25 1988-09-06 Grumman Aerospace Corporation Method and apparatus for determining flow resistance of fully assembled acoustic liners

Also Published As

Publication number Publication date
BR8900698A (pt) 1989-10-17
GR3006246T3 (pt) 1993-06-21
DK75389A (da) 1989-08-20
JPH0221840A (ja) 1990-01-24
AU621341B2 (en) 1992-03-12
YU47190B (sh) 1995-01-31
NO890496L (no) 1989-08-21
PL277821A1 (en) 1989-11-13
IE890137L (en) 1989-08-19
AR242898A1 (es) 1993-06-30
US4947851A (en) 1990-08-14
DE3873742T2 (de) 1993-01-28
EP0329817B1 (en) 1992-08-12
KR920006032B1 (en) 1992-07-27
AU3000089A (en) 1989-08-24
TR24539A (tr) 1991-11-20
DE3873742D1 (de) 1992-09-17
YU32588A (en) 1989-10-31
HUT52623A (en) 1990-07-28
IS3423A7 (is) 1989-08-20
EP0329817A3 (en) 1990-04-25
NZ227893A (en) 1992-09-25
IL88691A (en) 1993-05-13
EP0329817A2 (en) 1989-08-30
IS1488B (is) 1992-06-30
NO890496D0 (no) 1989-02-07
DK75389D0 (da) 1989-02-17
PT89735B (pt) 1991-10-31
CN1023442C (zh) 1994-01-12
KR890013479A (ko) 1989-09-23
PT89735A (pt) 1989-03-01
IL88691A0 (en) 1989-07-31
DD283560A5 (de) 1990-10-17
CN1036505A (zh) 1989-10-25
CA1318018C (en) 1993-05-18
ATE79473T1 (de) 1992-08-15
ES2035156T3 (es) 1993-04-16
HU202650B (en) 1991-03-28

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