FI883745A0 - NYA KONDENSERADE DIAZEPINONER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEEEMEDEL. - Google Patents

NYA KONDENSERADE DIAZEPINONER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEEEMEDEL.

Info

Publication number
FI883745A0
FI883745A0 FI883745A FI883745A FI883745A0 FI 883745 A0 FI883745 A0 FI 883745A0 FI 883745 A FI883745 A FI 883745A FI 883745 A FI883745 A FI 883745A FI 883745 A0 FI883745 A0 FI 883745A0
Authority
FI
Finland
Prior art keywords
atom
group
hydrogen
image
lower alkyl
Prior art date
Application number
FI883745A
Other languages
Finnish (fi)
Other versions
FI883745A (en
Inventor
Wolfhard Engel
Guenter Trummlitz
Wolfgang Eberlein
Gerhard Mihm
Norbert Mayer
Jonge Adriaan De
Klaus Rudolf
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI883745A0 publication Critical patent/FI883745A0/en
Publication of FI883745A publication Critical patent/FI883745A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Condensed diazepinones of the general formula I <IMAGE> in which <IMAGE> represents one of the divalent radicals <IMAGE> and X<1>, X<2>, A, R<1> to R<1><0> and Z have the following meanings: X<1> and X<2> represent a = CH-group or, if <IMAGE> assumes the meanings of the abovementioned divalent radicals (S), (U) or (W), both or only X<1> or only X<2> can also represent a nitrogen atom; A is an alkylene radical having two to seven carbon atoms; which can also be interrupted by an oxygen or sulphur atom or by the methylimino or ethylimino group; Z is a single bond, an oxygen or sulphur atom, the methylene or 1,2-ethylene group; R<1> is a lower alkyl radical or the benzyl group; R<2> is an alkyl radical having 1 to 7 carbon atoms, which can optionally be further substituted by a hydroxyl group on its 2nd to 7th carbon atom, a cycloalkyl or a cycloalkylmethyl radical, where the cycloalkyl ring can optionally be further substituted by a hydroxyl group; R<1> and R<2>, however, together with the nitrogen atom lying in between, can also form a 4- to 7-membered saturated, monocyclic heterocyclic ring which can optionally be interrupted by an oxygen atom or by the N-CH3 group; R<2> can, however, also be linked to A via an alkylene bridge such that, together with the group NR<1>, a saturated, 5 to 7-membered heterocyclic ring system is formed; R<3> is a lower alkyl group, a chlorine atom or a hydrogen atom; R<4> is a hydrogen atom or a methyl group; R<5> and R<6> each denote a hydrogen atom, a fluorine, chlorine or bromine atom or a lower alkyl group; R<7> is a hydrogen or chlorine atom or a methyl group; R<8> is a hydrogen atom or a lower alkyl radical; R<9> is a hydrogen or halogen atom or a lower alkyl group and R<1><0> is a hydrogen atom or a methyl group, where in the case in which <IMAGE> represents the divalent radical (T) and R<7> is hydrogen, R<3> cannot be chlorine and Z cannot be sulphur. Processes for their preparation and medicaments which contain these compounds are also described. In view of the lack of gastric acid secretion-inhibiting, salivation-inhibiting and mydriatic influences, the novel diazepinones are suitable as vagal pacemakers for the treatment of bradycardias and bradyarrhythmias in human and veterinary medicine.
FI883745A 1987-08-13 1988-08-12 NYA KONDENSERADE DIAZEPINONER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEEEMEDEL. FI883745A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873726908 DE3726908A1 (en) 1987-08-13 1987-08-13 NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS

Publications (2)

Publication Number Publication Date
FI883745A0 true FI883745A0 (en) 1988-08-12
FI883745A FI883745A (en) 1989-02-14

Family

ID=6333620

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883745A FI883745A (en) 1987-08-13 1988-08-12 NYA KONDENSERADE DIAZEPINONER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEEEMEDEL.

Country Status (16)

Country Link
EP (1) EP0306698B1 (en)
JP (1) JPS6466186A (en)
KR (1) KR890003763A (en)
AT (1) ATE74133T1 (en)
AU (1) AU608641B2 (en)
DD (1) DD282226A5 (en)
DE (2) DE3726908A1 (en)
DK (1) DK451688A (en)
FI (1) FI883745A (en)
HU (1) HU201924B (en)
IL (1) IL87433A (en)
NO (1) NO167145C (en)
NZ (1) NZ225790A (en)
PH (1) PH25578A (en)
PT (1) PT88262A (en)
ZA (1) ZA885955B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3819444A1 (en) * 1988-06-08 1989-12-14 Thomae Gmbh Dr K NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS
DE3820345A1 (en) * 1988-06-15 1989-12-21 Thomae Gmbh Dr K CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS
CA2019812C (en) * 1989-06-28 2000-11-21 Gunther Schmidt (Deceased) Novel 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-ones and their use in the prevention or treatment of aids
DE3930266A1 (en) * 1989-09-11 1991-03-14 Thomae Gmbh Dr K CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS
DE3930262A1 (en) * 1989-09-11 1991-03-21 Thomae Gmbh Dr K CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
IE912239A1 (en) * 1990-07-24 1992-01-29 Akzo Nv Tetrahydropyridinyldibenzazepine derivatives
US8278313B2 (en) 2008-03-11 2012-10-02 Abbott Laboratories Macrocyclic spiro pyrimidine derivatives
US8436005B2 (en) 2008-04-03 2013-05-07 Abbott Laboratories Macrocyclic pyrimidine derivatives

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795183B1 (en) * 1968-08-20 1972-07-20 Thomae Gmbh Dr K 5,11-dihydro-6H-pyrido [2,3-b] [1,4] benzodiazepin-6-one derivatives and drugs
DE2724478C2 (en) * 1977-05-31 1986-05-22 Dr. Karl Thomae Gmbh, 7950 Biberach 5,11-Dihydro-6H-pyrido [2,3-b] [1,4] benzodiazepin-6-one derivatives, processes for their preparation and pharmaceuticals containing these compounds
DE2724434A1 (en) * 1977-05-31 1979-02-22 Thomae Gmbh Dr K NEW, 11-POSITION SUBSTITUTED 5,11-DIHYDRO-6H-PYRIDO SQUARE CLAMP ON 2.3-B SQUARE CLAMP ON SQUARE CLAMP ON 1.4 SQUARED CLAMP ON BENZODIAZEPIN-6-ONE, METHOD FOR THEIR PRODUCTION AND THESE CONNECTIONS DRUG
CA1154762A (en) * 1979-08-03 1983-10-04 Georg Rainer Substituted tetraazatricyclic compounds, a process for their preparation, their use and medicaments containing them
IL62792A (en) * 1980-05-07 1985-02-28 Byk Gulden Lomberg Chem Fab Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them
DE3204157A1 (en) * 1982-02-06 1983-08-11 Dr. Karl Thomae Gmbh, 7950 Biberach SUBSTITUTED DIBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT
DE3204153A1 (en) * 1982-02-06 1983-08-11 Dr. Karl Thomae Gmbh, 7950 Biberach SUBSTITUTED THIENOBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT
DE3204403A1 (en) * 1982-02-09 1983-08-11 Dr. Karl Thomae Gmbh, 7950 Biberach NEW PYRIDOBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
IT1212742B (en) * 1983-05-17 1989-11-30 Dompe Farmaceutici Spa DIBENZO DERIVATIVES [1,4] PYRID DIAZEPINONIC [1,4] BENZODIAZEPINONIC, PYRID [1,5] BENZODIAZEPINONIC AND THEIR PHARMACOLOGICAL ACTIVITY
DD236731B3 (en) * 1983-10-19 1992-12-10 Dresden Arzneimittel PROCESS FOR PREPARING NEW 5-POSITION SUBSTITUTED 5,10-DIHYDRO-11H-DIBENZO | B, E¨ | 1,4¨DIAZEPINE-11-ONEN
DE3409237A1 (en) * 1984-03-14 1985-09-19 Dr. Karl Thomae Gmbh, 7950 Biberach CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3529372A1 (en) * 1985-08-16 1987-02-19 Dompe Farmaceutici Spa AMINOACYL DERIVATIVE OF 4,9-DIHYDRO-10H-PYRIDO (3,2-B) -THIENO (3,2-E) (1,4) -DIAZEPINONE AND OF 4,9-DIHYDRO-10H-PYRIDO (3, 2-B) THIENO (3,4-E) (1,4) DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
DE3626095A1 (en) * 1986-07-31 1988-02-11 Thomae Gmbh Dr K NEW SUBSTITUTED PYRIDO (2,3-B) (1,4) BENZODIAZEPIN-6-ONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
IT8721978A0 (en) * 1987-09-21 1987-09-21 Angeli Inst Spa NEW TRICYCLIC AMIDE DERIVATIVES.
DE3802334A1 (en) * 1988-01-27 1989-08-10 Thomae Gmbh Dr K NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS
DE3818299A1 (en) * 1988-05-30 1989-12-07 Thomae Gmbh Dr K NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS

Also Published As

Publication number Publication date
NO883585L (en) 1989-02-14
HU201924B (en) 1991-01-28
KR890003763A (en) 1989-04-17
NO167145C (en) 1991-10-09
DK451688A (en) 1989-02-14
EP0306698B1 (en) 1992-03-25
IL87433A (en) 1991-12-12
DE3726908A1 (en) 1989-02-23
HUT50793A (en) 1990-03-28
ZA885955B (en) 1990-04-25
DD282226A5 (en) 1990-09-05
NZ225790A (en) 1991-01-29
NO883585D0 (en) 1988-08-12
JPS6466186A (en) 1989-03-13
AU608641B2 (en) 1991-04-11
PH25578A (en) 1991-08-08
AU2091288A (en) 1989-02-16
EP0306698A1 (en) 1989-03-15
PT88262A (en) 1989-06-30
DK451688D0 (en) 1988-08-12
NO167145B (en) 1991-07-01
ATE74133T1 (en) 1992-04-15
DE3869523D1 (en) 1992-04-30
FI883745A (en) 1989-02-14
IL87433A0 (en) 1989-01-31

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: DR. KARL THOMAE GESELLSCHAFT MIT BESCHRAE