LT2199B - THE 2-TRIZOLIDINONE'S BODY RECEIVING - Google Patents
THE 2-TRIZOLIDINONE'S BODY RECEIVINGInfo
- Publication number
- LT2199B LT2199B LTRP854A LTRP854A LT2199B LT 2199 B LT2199 B LT 2199B LT RP854 A LTRP854 A LT RP854A LT RP854 A LTRP854 A LT RP854A LT 2199 B LT2199 B LT 2199B
- Authority
- LT
- Lithuania
- Prior art keywords
- general formula
- trizolidinone
- body receiving
- gastric
- 4alkoxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- SLYRGJDSFOCAAI-UHFFFAOYSA-N 1,3-thiazolidin-2-one Chemical class O=C1NCCS1 SLYRGJDSFOCAAI-UHFFFAOYSA-N 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 230000001120 cytoprotective effect Effects 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
Abstract
The present invention relates to novel 2-thiazolidinone derivatives of the general formula (I), <CHEM> wherein A stands for hydrogen, halogen or a C1-4alkyl, C1-4alkoxy or nitro group; and n is 0 or 1. The compounds according to the invention show a cytoprotective and gastric acid secretion-inhibiting effect and thus, may be used in the therapy of gastric and duodenal ulcers. The invention includes preparation methods for the above compounds with the general formula (I) and pharmaceutical compositions containing them.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU875632A HU198915B (en) | 1987-12-14 | 1987-12-14 | Process for producing new 2-thiazolidinone derivatives and pharmaceutical compositions containing them |
| SU884613151A SU1657062A3 (en) | 1987-12-14 | 1988-12-14 | Method for preparation of 2-thiazolidinone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2199B true LT2199B (en) | 1993-10-15 |
Family
ID=10970509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTRP854A LT2199B (en) | 1987-12-14 | 1993-08-13 | THE 2-TRIZOLIDINONE'S BODY RECEIVING |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4937252A (en) |
| EP (1) | EP0320910B1 (en) |
| JP (1) | JPH02279A (en) |
| KR (1) | KR920010179B1 (en) |
| CN (1) | CN1019196B (en) |
| AT (1) | ATE98235T1 (en) |
| CA (1) | CA1332419C (en) |
| DE (1) | DE3886185T2 (en) |
| ES (1) | ES2049243T3 (en) |
| HU (1) | HU198915B (en) |
| LT (1) | LT2199B (en) |
| LV (1) | LV5491A3 (en) |
| SU (1) | SU1657062A3 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU205092B (en) * | 1989-11-24 | 1992-03-30 | Richter Gedeon Vegyeszet | Process for producing new thiazolidinone derivatives and pharmaceutical compositions comprising same |
| HU210789B (en) * | 1992-12-23 | 1995-07-28 | Richter Gedeon Vegyeszet | Process for preparing new thiazolidinone derivatives and pharmaceutical preparations containing them |
| CN103351358B (en) * | 2013-07-03 | 2015-05-27 | 北京化工大学 | Method for preparing 5-substituted-2-thiazolidinone |
| RU2643669C1 (en) * | 2017-04-03 | 2018-02-05 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | 3-[3-(morpholine-4-yl)propyl]-2-[(2,2,3-trimethylcyclopent-3-ene-1-yl)methyl-1,3-thiazolidine-4-one with anti-ulcer and anti-inflammatory activity |
| CN115093378B (en) * | 2022-07-21 | 2024-01-26 | 三门峡奥科科技有限公司 | Preparation method of 2-thiazolidinone |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3066919A (en) * | 1958-11-12 | 1962-12-04 | Waimer Eberhard | Concrete mixer |
| JPS53127466A (en) * | 1977-04-13 | 1978-11-07 | Asahi Chem Ind Co Ltd | Thiocarbamate type heterocyclic compounds and its preparation |
| US4664694A (en) * | 1985-04-24 | 1987-05-12 | Uniroyal Chemical Company, Inc. | Substituted thiazolidinones useful as plant growth regulators |
-
1987
- 1987-12-14 HU HU875632A patent/HU198915B/en not_active IP Right Cessation
-
1988
- 1988-12-07 CA CA000585257A patent/CA1332419C/en not_active Expired - Fee Related
- 1988-12-13 JP JP63314813A patent/JPH02279A/en active Pending
- 1988-12-13 US US07/283,809 patent/US4937252A/en not_active Expired - Fee Related
- 1988-12-13 CN CN88108626A patent/CN1019196B/en not_active Expired
- 1988-12-14 EP EP88120908A patent/EP0320910B1/en not_active Expired - Lifetime
- 1988-12-14 AT AT88120908T patent/ATE98235T1/en not_active IP Right Cessation
- 1988-12-14 KR KR1019880016674A patent/KR920010179B1/en not_active IP Right Cessation
- 1988-12-14 ES ES88120908T patent/ES2049243T3/en not_active Expired - Lifetime
- 1988-12-14 SU SU884613151A patent/SU1657062A3/en active
- 1988-12-14 DE DE88120908T patent/DE3886185T2/en not_active Expired - Fee Related
-
1993
- 1993-06-28 LV LV930678A patent/LV5491A3/en unknown
- 1993-08-13 LT LTRP854A patent/LT2199B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE98235T1 (en) | 1993-12-15 |
| ES2049243T3 (en) | 1994-04-16 |
| KR890009897A (en) | 1989-08-04 |
| EP0320910A1 (en) | 1989-06-21 |
| CN1019196B (en) | 1992-11-25 |
| HU198915B (en) | 1989-12-28 |
| LV5491A3 (en) | 1994-03-10 |
| EP0320910B1 (en) | 1993-12-08 |
| CN1033625A (en) | 1989-07-05 |
| US4937252A (en) | 1990-06-26 |
| DE3886185D1 (en) | 1994-01-20 |
| KR920010179B1 (en) | 1992-11-19 |
| DE3886185T2 (en) | 1994-05-05 |
| SU1657062A3 (en) | 1991-06-15 |
| CA1332419C (en) | 1994-10-11 |
| JPH02279A (en) | 1990-01-05 |
| HUT49125A (en) | 1989-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE882929L (en) | "immunomodulatory azaspiranes" | |
| GR3018387T3 (en) | Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them. | |
| DK0430045T3 (en) | Ascorbic acid ethocopheryl phosphate diesters to inhibit Maillard's reaction | |
| CS782686A2 (en) | Method of benzimidazole derivatives production | |
| PL268455A1 (en) | The method of manufacture of new derivatives of benzimidazole | |
| IL88810A (en) | 1, 2, 3, 4, 6, 7, 8, 12b-octahydro 7-(mercaptomethyl)- 6-oxopyrido (2,1-a) (2)- benzazepine-4-carboxylic acid, esters thereof and pharmaceutical compositions containing same | |
| HUT45984A (en) | Process for production of quinoline-derivatives and of their medically acceptable acid-additioned salts | |
| DK0393494T3 (en) | Bile acid derivatives, processes for their preparation and pharmaceutical agents containing them | |
| EP0314098A3 (en) | Imide derivatives, their production and use | |
| ATE26273T1 (en) | 3-INDOLCARBOXAMIDE COMPOUNDS. | |
| LT2199B (en) | THE 2-TRIZOLIDINONE'S BODY RECEIVING | |
| IL75987A (en) | Tri-and tetrasubstituted-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them | |
| EP0399626A3 (en) | Substituted tetrahydroisoquinoline compounds, their production, and pharmaceutical compositions containing them | |
| AU1586588A (en) | Fungicidal derivatives of propenoic acid and processes for their preparation | |
| ES8801270A1 (en) | Benzo[C]-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments. | |
| HUT47897A (en) | Process for producing salicilates and pharmaceutical compositions containing them | |
| EP0301466A3 (en) | Uricosuric composition | |
| EP0408107A3 (en) | Novel acrylic acid salts, a process for their preparation, pharmaceutical compositions containing them and their use in the medicine | |
| DE3379224D1 (en) | 3-methoxy-n-methylmorphinane : theophyllinacetic acid (1:2) complex, process for preparing the same and said complex for therapeutical use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 19950813 |