FI86690B - Foerfarande foer framstaellning av oxazafosforinloesningar. - Google Patents

Foerfarande foer framstaellning av oxazafosforinloesningar. Download PDF

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Publication number
FI86690B
FI86690B FI873064A FI873064A FI86690B FI 86690 B FI86690 B FI 86690B FI 873064 A FI873064 A FI 873064A FI 873064 A FI873064 A FI 873064A FI 86690 B FI86690 B FI 86690B
Authority
FI
Finland
Prior art keywords
solutions
ethanol
cyclophosphamide
oxazaphosphorines
solution
Prior art date
Application number
FI873064A
Other languages
English (en)
Finnish (fi)
Other versions
FI86690C (sv
FI873064A0 (fi
FI873064A (fi
Inventor
Otto Isaac
Dieter Sauerbier
Klaus Molge
Werner Weigert
Original Assignee
Asta Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Pharma Ag filed Critical Asta Pharma Ag
Publication of FI873064A0 publication Critical patent/FI873064A0/fi
Publication of FI873064A publication Critical patent/FI873064A/fi
Application granted granted Critical
Publication of FI86690B publication Critical patent/FI86690B/fi
Publication of FI86690C publication Critical patent/FI86690C/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Paper (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)

Claims (2)

1. Förfarande för framställning av lösningar av oxazafosforiner med den allmänna formeln 5 Ri R. \ I .N .N-CH„ 10 \ 3 4 R? /P 2 ^ CH0 1 /\. / O x0- CH2 15 vilken Rx, R2 och R3 är lika eller olika och anger väte, 20 metyl, etyl, 2-kloretyl eller 2-metansulfonyloxietyl, i 80 - 100 -%:ig (vol/vol) etanol, varvid oxazafosforin-koncentrationen är 10 - 70 % (vikt/volym), känne-t e c k n a t därav, att oxazafosforinerna med formeln I löses vid en temperatur av 15 - 40 °C i 80 - 100 -%:ig 25 (vol/vol) vattenhaltig etanol, eventuellt under omröring eller genom att röra lösningsmedlet, varvid man per 100 ml lösningsmedel använder 10 - 150 g oxazafosforin.
2. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att oxazafosforinet utgörs av cyklo- 30 fosfamid och/eller ifosfamid.
FI873064A 1986-07-11 1987-07-10 Förfarande för framställning av oxazafosforinlösningar FI86690C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3623369 1986-07-11
DE3623369 1986-07-11

Publications (4)

Publication Number Publication Date
FI873064A0 FI873064A0 (fi) 1987-07-10
FI873064A FI873064A (fi) 1988-01-12
FI86690B true FI86690B (fi) 1992-06-30
FI86690C FI86690C (sv) 1992-10-12

Family

ID=6304930

Family Applications (1)

Application Number Title Priority Date Filing Date
FI873064A FI86690C (sv) 1986-07-11 1987-07-10 Förfarande för framställning av oxazafosforinlösningar

Country Status (16)

Country Link
US (1) US4952575A (sv)
EP (1) EP0254902B1 (sv)
JP (1) JPS6323888A (sv)
KR (1) KR880001282A (sv)
AT (1) ATE66609T1 (sv)
AU (1) AU598282B2 (sv)
CA (1) CA1289886C (sv)
DE (2) DE3772482D1 (sv)
DK (1) DK168322B1 (sv)
ES (1) ES2038623T3 (sv)
FI (1) FI86690C (sv)
GR (1) GR3002618T3 (sv)
IE (1) IE59897B1 (sv)
IL (1) IL83141A (sv)
PT (1) PT85293B (sv)
ZA (1) ZA875059B (sv)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051257A (en) * 1989-05-09 1991-09-24 Pietronigro Dennis D Antineoplastic solution and method for treating neoplasms
RO113611B1 (ro) * 1990-08-03 1998-09-30 Asta Pharma Ag Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
WO1999018973A2 (de) * 1997-10-13 1999-04-22 Stada Arzneimittel Ag Flüssige darreichungsformen oxazaphosphorinhaltiger pharmazeutischer produkte
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
AUPQ849900A0 (en) * 2000-06-30 2000-07-27 Dbl Australia Pty Ltd. Injectable composition
US6613927B1 (en) 2002-02-08 2003-09-02 American Pharmaceutical Partners, Inc. Sterile lyophilized ifosfamide and associated methods
US20050272698A1 (en) * 2002-09-05 2005-12-08 Daftary Gautam V Liquid stable composition of oxazaphosphorine with mesna
US7199111B2 (en) * 2002-12-02 2007-04-03 Bharat Serums & Vaccines Ltd. Aqueous ifosfamide compositions for parenteral administration and a process for their preparations
EA200700440A1 (ru) * 2004-09-13 2008-02-28 Бхарат Сирумс Энд Вэксинс Лтд. Композиции стабильных эмульсий для внутривенного введения, имеющие защитную эффективность
EP3623364A1 (en) 2014-02-13 2020-03-18 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
BR112016026140A2 (pt) * 2014-05-09 2018-08-07 AuroMedics Pharma LLC formulações de concentrado líquido de ciclofosfamida.
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
WO2016005962A2 (en) 2014-07-11 2016-01-14 Dr. Reddy’S Laboratories Limited Stable liquid formulations of cyclophosphamide and processes
US10849916B2 (en) 2014-07-11 2020-12-01 Dr. Reddys Laboratories Limited Stable liquid formulations of cyclophosphamide and its impurities
US10993952B2 (en) * 2015-02-16 2021-05-04 Leiutis Pharmaceuticals Pvt. Ltd. Stable ready to use cyclophosphamide liquid formulations
JP2021509907A (ja) 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド アセタール化合物およびその治療的使用
WO2022038072A1 (en) * 2020-08-17 2022-02-24 Sandoz Ag Parenteral pharmaceutical composition comprising cyclophosphamide and a mixture of liquids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3530147A1 (de) * 1985-08-23 1987-02-26 Bayer Ag Verwendung von diazaphosphorinen zur bekaempfung von endoparasiten

Also Published As

Publication number Publication date
IL83141A (en) 1992-11-15
IE871867L (en) 1988-01-11
DE3722043A1 (de) 1988-01-14
US4952575A (en) 1990-08-28
AU7554987A (en) 1988-01-14
DK168322B1 (da) 1994-03-14
CA1289886C (en) 1991-10-01
EP0254902B1 (de) 1991-08-28
DE3772482D1 (de) 1991-10-02
EP0254902A2 (de) 1988-02-03
GR3002618T3 (en) 1993-01-25
ATE66609T1 (de) 1991-09-15
EP0254902A3 (en) 1988-08-03
AU598282B2 (en) 1990-06-21
FI86690C (sv) 1992-10-12
IE59897B1 (en) 1994-04-20
ZA875059B (en) 1988-02-24
DK359387D0 (da) 1987-07-10
IL83141A0 (en) 1987-12-31
FI873064A0 (fi) 1987-07-10
PT85293B (pt) 1990-03-30
KR880001282A (ko) 1988-04-22
ES2038623T3 (es) 1993-08-01
JPS6323888A (ja) 1988-02-01
JPH0543711B2 (sv) 1993-07-02
FI873064A (fi) 1988-01-12
PT85293A (de) 1987-08-01
DK359387A (da) 1988-01-12

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Owner name: ASTA MEDICA AKTIENGESELLSCHAFT

MA Patent expired