FI853255L - Foerfarande foer framstaellning av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-bensazepin. - Google Patents

Foerfarande foer framstaellning av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-bensazepin.

Info

Publication number
FI853255L
FI853255L FI853255A FI853255A FI853255L FI 853255 L FI853255 L FI 853255L FI 853255 A FI853255 A FI 853255A FI 853255 A FI853255 A FI 853255A FI 853255 L FI853255 L FI 853255L
Authority
FI
Finland
Prior art keywords
bensazepine
framstaellning
tetrahydro
chloro
methyl
Prior art date
Application number
FI853255A
Other languages
English (en)
Finnish (fi)
Other versions
FI853255A7 (fi
FI853255A0 (fi
Inventor
Stanley John Borowski
Thomas Anthony Post
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of FI853255A0 publication Critical patent/FI853255A0/fi
Publication of FI853255A7 publication Critical patent/FI853255A7/fi
Publication of FI853255L publication Critical patent/FI853255L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FI853255A 1984-09-05 1985-08-23 Foerfarande foer framstaellning av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-bensazepin. FI853255L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/647,552 US4541954A (en) 1984-09-05 1984-09-05 Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (3)

Publication Number Publication Date
FI853255A0 FI853255A0 (fi) 1985-08-23
FI853255A7 FI853255A7 (fi) 1986-03-06
FI853255L true FI853255L (fi) 1986-03-06

Family

ID=24597406

Family Applications (1)

Application Number Title Priority Date Filing Date
FI853255A FI853255L (fi) 1984-09-05 1985-08-23 Foerfarande foer framstaellning av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-bensazepin.

Country Status (19)

Country Link
US (1) US4541954A (show.php)
EP (1) EP0174118A3 (show.php)
JP (1) JPS6168469A (show.php)
KR (1) KR860002470A (show.php)
AU (1) AU581918B2 (show.php)
CA (1) CA1244017A (show.php)
DK (1) DK379985A (show.php)
EG (1) EG17149A (show.php)
ES (1) ES8609266A1 (show.php)
FI (1) FI853255L (show.php)
GR (1) GR852041B (show.php)
HU (1) HU194181B (show.php)
IL (1) IL76100A0 (show.php)
NO (1) NO853255L (show.php)
NZ (1) NZ213141A (show.php)
PH (1) PH20796A (show.php)
PT (1) PT81018B (show.php)
ZA (1) ZA856268B (show.php)
ZW (1) ZW13385A1 (show.php)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
WO1993011572A1 (en) * 1991-12-06 1993-06-10 Yuasa Corporation Thin battery and monolithic thin battery
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EP2332919A3 (en) * 2003-06-17 2011-10-19 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
US7704993B2 (en) 2003-06-17 2010-04-27 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
CN102321023A (zh) 2004-12-21 2012-01-18 艾尼纳制药公司 (r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓盐酸盐的晶型
AU2005322183B2 (en) 2004-12-23 2012-03-29 Arena Pharmaceuticals, Inc. 5HT2C receptor modulator compositions and methods of use
EP2001852A2 (en) 2006-04-03 2008-12-17 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
US8299241B2 (en) * 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
WO2009111004A1 (en) * 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
AU2011296014A1 (en) 2010-09-01 2013-04-04 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
NZ608266A (en) 2010-09-01 2015-09-25 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
US9365521B2 (en) 2010-09-01 2016-06-14 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-HT2C agonists
JP2015534563A (ja) 2012-10-09 2015-12-03 アリーナ ファーマシューティカルズ， インコーポレイテッド 体重管理の方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
US4251660A (en) * 1978-08-10 1981-02-17 Smithkline Corporation Method for preparing tetrahydroisoquinolines
US4200754A (en) * 1979-02-02 1980-04-29 Smithkline Corporation Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
IE53962B1 (en) * 1981-11-27 1989-04-26 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists
ZA827887B (en) * 1981-11-27 1983-11-30 Smithkline Beckman Corp Pharmaceutical compositions and method of producing alpha2 antagonism
EP0080779B1 (en) * 1981-11-27 1986-07-16 Smithkline Beckman Corporation 3-benzazepines as alpha-2 antagonists

Also Published As

Publication number Publication date
ZW13385A1 (en) 1985-11-20
EP0174118A3 (en) 1986-12-30
ZA856268B (en) 1986-07-30
EG17149A (en) 1989-06-30
DK379985A (da) 1986-03-06
PT81018A (en) 1985-09-01
KR860002470A (ko) 1986-04-26
EP0174118A2 (en) 1986-03-12
NZ213141A (en) 1988-07-28
HU194181B (en) 1988-01-28
GR852041B (show.php) 1985-12-19
DK379985D0 (da) 1985-08-21
AU4648185A (en) 1986-03-13
IL76100A0 (en) 1985-12-31
FI853255A7 (fi) 1986-03-06
AU581918B2 (en) 1989-03-09
NO853255L (no) 1986-03-06
FI853255A0 (fi) 1985-08-23
US4541954A (en) 1985-09-17
JPS6168469A (ja) 1986-04-08
HUT38617A (en) 1986-06-30
ES546285A0 (es) 1986-09-01
CA1244017A (en) 1988-11-01
PT81018B (en) 1987-06-24
ES8609266A1 (es) 1986-09-01
PH20796A (en) 1987-04-14

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: SMITHKLINE BECKMAN CORPORATION