FI853255A7 - Menetelmä 6-kloori-N-metyyli-2,3,4,5 -tetrahydro-1H-3-bentsatsepiinin valmistamiseksi. - Google Patents

Menetelmä 6-kloori-N-metyyli-2,3,4,5 -tetrahydro-1H-3-bentsatsepiinin valmistamiseksi. Download PDF

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Publication number
FI853255A7
FI853255A7 FI853255A FI853255A FI853255A7 FI 853255 A7 FI853255 A7 FI 853255A7 FI 853255 A FI853255 A FI 853255A FI 853255 A FI853255 A FI 853255A FI 853255 A7 FI853255 A7 FI 853255A7
Authority
FI
Finland
Prior art keywords
benzazepine
tetrahydro
chloro
methyl
preparation
Prior art date
Application number
FI853255A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI853255L (fi
FI853255A0 (fi
Inventor
Stanley John Borowski
Thomas Anthony Post
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of FI853255A0 publication Critical patent/FI853255A0/fi
Publication of FI853255L publication Critical patent/FI853255L/fi
Publication of FI853255A7 publication Critical patent/FI853255A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FI853255A 1984-09-05 1985-08-23 Menetelmä 6-kloori-N-metyyli-2,3,4,5 -tetrahydro-1H-3-bentsatsepiinin valmistamiseksi. FI853255A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/647,552 US4541954A (en) 1984-09-05 1984-09-05 Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (3)

Publication Number Publication Date
FI853255A0 FI853255A0 (fi) 1985-08-23
FI853255L FI853255L (fi) 1986-03-06
FI853255A7 true FI853255A7 (fi) 1986-03-06

Family

ID=24597406

Family Applications (1)

Application Number Title Priority Date Filing Date
FI853255A FI853255A7 (fi) 1984-09-05 1985-08-23 Menetelmä 6-kloori-N-metyyli-2,3,4,5 -tetrahydro-1H-3-bentsatsepiinin valmistamiseksi.

Country Status (19)

Country Link
US (1) US4541954A (ref)
EP (1) EP0174118A3 (ref)
JP (1) JPS6168469A (ref)
KR (1) KR860002470A (ref)
AU (1) AU581918B2 (ref)
CA (1) CA1244017A (ref)
DK (1) DK379985A (ref)
EG (1) EG17149A (ref)
ES (1) ES8609266A1 (ref)
FI (1) FI853255A7 (ref)
GR (1) GR852041B (ref)
HU (1) HU194181B (ref)
IL (1) IL76100A0 (ref)
NO (1) NO853255L (ref)
NZ (1) NZ213141A (ref)
PH (1) PH20796A (ref)
PT (1) PT81018B (ref)
ZA (1) ZA856268B (ref)
ZW (1) ZW13385A1 (ref)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
US5401595A (en) * 1991-12-06 1995-03-28 Yuasa Corporation Film type battery and layer-built film type battery
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
ES2571220T3 (es) 2003-06-17 2016-05-24 Arena Pharm Inc Clorhidrato de 8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepina
MXPA05013366A (es) 2003-06-17 2006-04-05 Arena Pharm Inc Derivados de benzazepina utiles para el tratamiento de enfermedades asociadas con el receptor 5ht2c.
EA017894B1 (ru) 2004-12-21 2013-04-30 Арена Фармасьютикалз, Инк. Кристаллические формы гидрохлорида (r)-8-хлор-1-метил-2,3,4,5-тетрагидро-1h-3-бензазепина
NZ555482A (en) 2004-12-23 2011-01-28 Arena Pharm Inc Compositions comprising a 5HT2C receptor modulator and 2-methylamphetamine and methods of use
CA2646044A1 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
US8299241B2 (en) * 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
US8822727B2 (en) * 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
EP2939677A1 (en) 2010-09-01 2015-11-04 Arena Pharmaceuticals, Inc. Administration of lorcaserin to indviduals with renal impairment
WO2012030927A2 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
JP2013536859A (ja) 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストの非吸湿性塩
EP2611782A1 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
UY34436A (es) 2012-10-09 2014-07-31 Arena Pharm Inc Metodo de control del peso

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
US4251660A (en) * 1978-08-10 1981-02-17 Smithkline Corporation Method for preparing tetrahydroisoquinolines
US4200754A (en) * 1979-02-02 1980-04-29 Smithkline Corporation Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
DE3272044D1 (de) * 1981-11-27 1986-08-21 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists
ZA827887B (en) * 1981-11-27 1983-11-30 Smithkline Beckman Corp Pharmaceutical compositions and method of producing alpha2 antagonism
IE53962B1 (en) * 1981-11-27 1989-04-26 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists

Also Published As

Publication number Publication date
FI853255L (fi) 1986-03-06
EG17149A (en) 1989-06-30
EP0174118A2 (en) 1986-03-12
AU581918B2 (en) 1989-03-09
US4541954A (en) 1985-09-17
DK379985A (da) 1986-03-06
HUT38617A (en) 1986-06-30
ZA856268B (en) 1986-07-30
EP0174118A3 (en) 1986-12-30
AU4648185A (en) 1986-03-13
ES8609266A1 (es) 1986-09-01
CA1244017A (en) 1988-11-01
ZW13385A1 (en) 1985-11-20
JPS6168469A (ja) 1986-04-08
FI853255A0 (fi) 1985-08-23
GR852041B (ref) 1985-12-19
IL76100A0 (en) 1985-12-31
NO853255L (no) 1986-03-06
HU194181B (en) 1988-01-28
PT81018A (en) 1985-09-01
PH20796A (en) 1987-04-14
ES546285A0 (es) 1986-09-01
NZ213141A (en) 1988-07-28
DK379985D0 (da) 1985-08-21
KR860002470A (ko) 1986-04-26
PT81018B (en) 1987-06-24

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FD Application lapsed

Owner name: SMITHKLINE BECKMAN CORPORATION