FI83525B - Foerfarande foer att framstaella en farmakologiskt vaerdefull 1-metyl-4,5-dihydro-orotylhistidyl-prolinamid. - Google Patents

Foerfarande foer att framstaella en farmakologiskt vaerdefull 1-metyl-4,5-dihydro-orotylhistidyl-prolinamid. Download PDF

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Publication number
FI83525B
FI83525B FI852533A FI852533A FI83525B FI 83525 B FI83525 B FI 83525B FI 852533 A FI852533 A FI 852533A FI 852533 A FI852533 A FI 852533A FI 83525 B FI83525 B FI 83525B
Authority
FI
Finland
Prior art keywords
methyl
compound
mixture
dihydro
acid
Prior art date
Application number
FI852533A
Other languages
English (en)
Finnish (fi)
Other versions
FI83525C (sv
FI852533L (fi
FI852533A0 (fi
Inventor
Hiroshi Sugano
Ryuichi Ishida
Michio Yamamura
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB08417541A external-priority patent/GB2161486A/en
Priority claimed from GB858509929A external-priority patent/GB8509929D0/en
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of FI852533A0 publication Critical patent/FI852533A0/fi
Publication of FI852533L publication Critical patent/FI852533L/fi
Application granted granted Critical
Publication of FI83525B publication Critical patent/FI83525B/fi
Publication of FI83525C publication Critical patent/FI83525C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp

Claims (4)

1. Förfarande för att framställa en farmakologiskt värdefull 1-metyl-4,5-dihydroorotylhistidyl-prolinamid, vars formel (I) är 0 11 CH
3. I L J-CO-NHCHCO-N-CONH. (I) | 2 H CH r> 1!— H eller dess farmaceutiskt godtagbara syraadditionssalt, kännetecknat därav, att (A) l-metyl-4,5-dihydroorotinsyra enligt formeln (II) O 'ch3-n^N i\ iJ-COOH (II) O x där X1 är en iminogrupp eller en skyddad iminogrupp eller dess reaktiva derivat kondenseras med histidylprolinamid enligt formeln (III) o NH2CHCO-N-L-CONH2 (III) ,;H2 IL> 35 83525 där X2 är en iminogrupp eller en skyddad iminogrupp eller dess sait, (B) 1-metyl-4,5-dihydrooroty1histidin enligt formeln (IV) O CH L· , >CO-NHCHCOOH (IV)
0 X | CH2 -N\ _X2-^ där X1 och X2 avser samma som ovan, eller dess sait eller dess reaktiva derivat kondenseras med prolinamid enligt formeln (V) HN—]_C0NH2 (V) eller dess sait, eller (C) 1-metyl-4,5-dihydroorotyl-histidylprolin enligt formeln (VD “3-Λ O L ^*-CO-NHCHCO-N-LCOOH (VI)
0 X | CH2 ΓνΝ l_x2/ 36 83525 där X1 och X2 avser samma som ovan, eller dess salt eller dess reaktiva derivat omvandlas till sin motsvarande amid, (D) dä X1 och/eller X2 i den i reaktionssteget (A), (B) eller (C) erhällna produkten är skyddad (skyddade) iminogrupp eller -grupper, avlägsnas skyddsgruppen eller -grupperna, och (E) vid behov omvandlas även produkten till sitt farmaceutiskt godtagbara syraaddtionssalt.
FI852533A 1984-07-10 1985-06-27 Förfarande för att framställa en farmakologiskt värdefull 1-metyl-4,5- dihydro-orotylhistidyl-prolinamid FI83525C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8417541 1984-07-10
GB08417541A GB2161486A (en) 1984-07-10 1984-07-10 Novel 1-methyl-4,5-dihydroorotic acid derivative and processes for preparing the same
GB8509929 1985-04-18
GB858509929A GB8509929D0 (en) 1985-04-18 1985-04-18 Pharmaceutical composition

Publications (4)

Publication Number Publication Date
FI852533A0 FI852533A0 (fi) 1985-06-27
FI852533L FI852533L (fi) 1986-01-11
FI83525B true FI83525B (fi) 1991-04-15
FI83525C FI83525C (sv) 1991-07-25

Family

ID=26287968

Family Applications (1)

Application Number Title Priority Date Filing Date
FI852533A FI83525C (sv) 1984-07-10 1985-06-27 Förfarande för att framställa en farmakologiskt värdefull 1-metyl-4,5- dihydro-orotylhistidyl-prolinamid

Country Status (14)

Country Link
US (1) US4665056A (sv)
EP (1) EP0168042B1 (sv)
KR (1) KR890002085B1 (sv)
AU (1) AU580311B2 (sv)
CA (1) CA1248698A (sv)
DE (1) DE3577443D1 (sv)
DK (1) DK171354B1 (sv)
ES (3) ES8705463A1 (sv)
FI (1) FI83525C (sv)
HK (1) HK86292A (sv)
HU (1) HU199876B (sv)
IL (1) IL75641A (sv)
MY (1) MY101747A (sv)
SG (1) SG59992G (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69025272T2 (de) * 1989-11-17 1996-06-27 Takeda Chemical Industries Ltd Therapeutisches Mittel für Erkrankungen des Zentralnervensystems
EP0862429A4 (en) * 1995-10-24 2003-05-28 Gruenenthal Gmbh METHOD FOR ADJUSTING THE CIRCADIAN RHYTHM OF A MAMMAL
EP1321151A4 (en) * 2000-08-31 2009-07-15 Shionogi & Co MEANS FOR THE TREATMENT OF PARKINSON
KR101137503B1 (ko) * 2009-07-14 2012-04-20 웰이앤씨 주식회사 고분자 고체 지지체를 이용한 히스티딜-프롤린아미드 유도체의 제조 방법
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
KR101589910B1 (ko) 2013-12-31 2016-02-01 한밭대학교 산학협력단 결정형 α 탈티레린의 제조방법 및 결정형의 변환방법
GB201907591D0 (en) * 2019-05-29 2019-07-10 Eolas Res Limited Composition and use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3757003A (en) * 1969-12-18 1973-09-04 K Folkers Process for preparing l pyroglutamyl l histidyl l prolinamide
US3753969A (en) * 1969-12-22 1973-08-21 K Folkers Method for synthesizing pyroglutamylhistidyl-prolinamide
SE408300B (sv) * 1974-10-16 1979-06-05 Gruenenthal Chemie Sett att framstella nya dipeptidderivat
JPS5944308B2 (ja) * 1976-03-23 1984-10-29 武田薬品工業株式会社 ペプタイド
HU180926B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for preparing trh analogues,tripeptide amides infectives on the central nerve sysrhem
US4260601A (en) * 1979-10-23 1981-04-07 Nyegaard & Co. A/S Chemical compounds
GB2171101A (en) * 1985-02-20 1986-08-20 Tanabe Seiyaku Co Peptide and processes for preparation of the same

Also Published As

Publication number Publication date
CA1248698A (en) 1989-01-10
SG59992G (en) 1992-09-04
AU580311B2 (en) 1989-01-12
US4665056A (en) 1987-05-12
DK313785A (da) 1986-01-11
ES545053A0 (es) 1987-05-01
HU199876B (en) 1990-03-28
KR890002085B1 (ko) 1989-06-16
DE3577443D1 (de) 1990-06-07
EP0168042B1 (en) 1990-05-02
KR860001102A (ko) 1986-02-22
IL75641A (en) 1990-11-05
FI83525C (sv) 1991-07-25
MY101747A (en) 1992-01-17
ES8800208A1 (es) 1987-10-16
FI852533L (fi) 1986-01-11
AU4442185A (en) 1986-01-16
DK171354B1 (da) 1996-09-16
ES557144A0 (es) 1987-08-16
ES8707738A1 (es) 1987-08-16
ES8705463A1 (es) 1987-05-01
IL75641A0 (en) 1985-10-31
DK313785D0 (da) 1985-07-09
ES552699A0 (es) 1987-10-16
FI852533A0 (fi) 1985-06-27
EP0168042A2 (en) 1986-01-15
HK86292A (en) 1992-11-13
HUT38369A (en) 1986-05-28
EP0168042A3 (en) 1987-09-30

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FG Patent granted

Owner name: TANABE SEIYAKU CO.,_. LTD.

MA Patent expired