FI80599B - Foerfarande foer rening av maenniskoleukocytinterferon. - Google Patents
Foerfarande foer rening av maenniskoleukocytinterferon. Download PDFInfo
- Publication number
- FI80599B FI80599B FI862737A FI862737A FI80599B FI 80599 B FI80599 B FI 80599B FI 862737 A FI862737 A FI 862737A FI 862737 A FI862737 A FI 862737A FI 80599 B FI80599 B FI 80599B
- Authority
- FI
- Finland
- Prior art keywords
- protein
- column
- interferon
- added
- volume
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (3)
1. Förfarande för rening av människoleukocytinterferon, genom utfällning av nativa proteiner med ammonium- 5 sulfat, separering av proteinfällningen, upplösning av den separerade fällningen och gelfiltrering av den önskade slutprodukten, kännetecknat därav, att fällningen upplöses i en buffertlösning med ett pH-värde av 2,5 - 9, och innehällande ett aggregationförhindrande me- 10 del, och att innan gelfiltreringen päbörjas sättes tili kolonnen samma buffertlösning i en mängd av 3-5 % beräknat pä kolonnens volym.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att säsom aggregationförhindrande 15 medel i buffertlösningen användes karbamid i en hait av 2-8 mol/1.
3. Förfarande enligt patentkravet 1, kännetecknat därav, att säsom aggregationförhindrande medel i buffertlösningen användes guanidinklorid i en hait 20 av 1-6 mol/1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SU1984/000052 WO1986001723A1 (en) | 1984-09-21 | 1984-09-21 | Method of rectification of human leukocytic interferon |
SU8400052 | 1984-09-21 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI862737A0 FI862737A0 (fi) | 1986-06-26 |
FI862737A FI862737A (fi) | 1986-06-26 |
FI80599B true FI80599B (fi) | 1990-03-30 |
FI80599C FI80599C (sv) | 1990-07-10 |
Family
ID=21616868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI862737A FI80599C (sv) | 1984-09-21 | 1986-06-26 | Förfarande för rening av människoleukocytinterferon |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0195084B1 (sv) |
JP (1) | JPS62500237A (sv) |
DE (1) | DE3482307D1 (sv) |
FI (1) | FI80599C (sv) |
HU (2) | HU193472B (sv) |
WO (1) | WO1986001723A1 (sv) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7404589A (nl) * | 1974-04-03 | 1975-10-07 | Stichting Rega V Z W | Werkwijze voor het stabiliseren van interferon. |
NL7404590A (nl) * | 1974-04-03 | 1975-10-07 | Stichting Rega V Z W | Werkwijze voor het reactiveren van interferon. |
FR2351665A1 (fr) * | 1976-05-21 | 1977-12-16 | Elf Aquitaine | Procede de purification de preparations possedant notamment une activite interferon, preparations purifiees ainsi obtenues et leur application en tant que medicament |
-
1984
- 1984-09-21 JP JP59504219A patent/JPS62500237A/ja active Granted
- 1984-09-21 DE DE8484904229T patent/DE3482307D1/de not_active Expired - Fee Related
- 1984-09-21 WO PCT/SU1984/000052 patent/WO1986001723A1/ru active IP Right Grant
- 1984-09-21 HU HU85185A patent/HU193472B/hu not_active IP Right Cessation
- 1984-09-21 EP EP84904229A patent/EP0195084B1/de not_active Expired - Lifetime
- 1984-09-21 HU HU85186D patent/HU193078B/hu not_active IP Right Cessation
-
1986
- 1986-06-26 FI FI862737A patent/FI80599C/sv not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU193472B (en) | 1987-10-28 |
DE3482307D1 (de) | 1990-06-28 |
JPH0521120B2 (sv) | 1993-03-23 |
JPS62500237A (ja) | 1987-01-29 |
EP0195084A1 (de) | 1986-09-24 |
WO1986001723A1 (en) | 1986-03-27 |
FI80599C (sv) | 1990-07-10 |
HUT40575A (en) | 1987-01-28 |
FI862737A0 (fi) | 1986-06-26 |
HU193078B (en) | 1987-08-28 |
EP0195084B1 (de) | 1990-05-23 |
FI862737A (fi) | 1986-06-26 |
EP0195084A4 (de) | 1988-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: VSESOJUZNY NAUCHNO-ISSLEDOVATELSKY |