FI80044B - Fosforsyravinylbenzylestrar, deras framstaellning och anvaendning. - Google Patents
Fosforsyravinylbenzylestrar, deras framstaellning och anvaendning. Download PDFInfo
- Publication number
- FI80044B FI80044B FI853623A FI853623A FI80044B FI 80044 B FI80044 B FI 80044B FI 853623 A FI853623 A FI 853623A FI 853623 A FI853623 A FI 853623A FI 80044 B FI80044 B FI 80044B
- Authority
- FI
- Finland
- Prior art keywords
- group
- phosphoric acid
- formula
- tetrahydro
- naphthyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/094—Esters of phosphoric acids with arylalkanols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2429—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of arylalkanols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
Claims (2)
1. Förfarande för framställning av säsom läkemedel användbara fosforsyravinylbensylestrar med formeln I 5 R7 T”9 10. jr 1 r1r2 l R4 väri A är en eventuellt med C1_t-alkylgrupper substituerad me-15 tylen- eller etylengrupp, R1 och R2 betecknar en väteatom eller metylgrupp, R3 är en väteatom eller metyl-, hydroxi- eller Cx_6-alk-oxigrupp, R4 och R5 betecknar en väteatom, C3 _ 4-alkyl- eller metoxi-20 grupp eller halogenatom, R6 är en väteatom, Cx _ 6-alkyl- eller C3 _ 6-cykloalkylgrupp, R7 är en väteatom eller Cx_4-alkylgrupp, och R8 och R9 betecknar en grupp -OR1 0 eller -NR11R12, varvid R1 0 är en väteatom eller Cj.8-alkyl-, fenyl- eller bensyl-25 grupp, R11 och R12 betecknar en väteatom, Cx. 6-alkylgrupp eller tillsammans med kväveatomen, vid vilken de är bundna, en pyrrolidino-, piperidino- eller morfolinogrupp, och varvid i varje enskilt fall tvä av grupperna R10 , R11 30 och/eller R12 kan ocksä tillsammans beteckna en etylen-eller propylengrupp, samt deras fysiologiskt godtagbara salter, känne-t e c k n a t därav, att a) en alkohol med formeln 11 18 80044 R7 K3 R6 yOQj oh r1^V^h5 R R 10 väri A och R1 - R7 betecknar samma som ovan, omsätts med en fosforylationsreagens med formeln III R8 o=p-r9 IIX
15 X väri R8 och R9 betecknar samma som ovan och X är en halo-genatom, en imidazol-, N,N'-dicyklohexylisourea-, triklor-acetimidat-, p-toluensulfonyloxi-, p-nitrofenyloxi- eller 20 mesityloxigrupp eller en grupp -0-P(0)ReR9, eller b) en alkohol med formeln II omsätts under oxide-rande förhällanden med en fosforylationsreagens med formeln V R8 25 1 0=P-R9 V H väri R8 och R9 betecknar samma som ovan, 30 och de s& erhällna föreningarna eventuellt omvand- las till deras fysiologiskt godtagbara salter.
2. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att man framställer föreningar med formeln I säsom definierats i patentkravet 1, i vilka 35 II 19 80044 A är en eventuellt med en metylgrupp substituerad etylen-grupp, R3, R4 och R5 betecknar väteatomer, R6 är en väteatom eller metylgrupp, och 5 R9 är en hydroxi- eller C1_4-alkoxlgrupp.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3434945 | 1984-09-22 | ||
DE3434945 | 1984-09-22 | ||
DE19843438386 DE3438386A1 (de) | 1984-09-22 | 1984-10-19 | Phosphorsaeurevinylbenzylester, ihre herstellung und verwendung |
DE3438386 | 1984-10-19 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI853623A0 FI853623A0 (fi) | 1985-09-20 |
FI853623L FI853623L (fi) | 1986-03-23 |
FI80044B true FI80044B (fi) | 1989-12-29 |
FI80044C FI80044C (sv) | 1990-04-10 |
Family
ID=25825026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI853623A FI80044C (sv) | 1984-09-22 | 1985-09-20 | Förfarande för framställning av fosforsyravinylbensylestrar användbara som läkemedel |
Country Status (9)
Country | Link |
---|---|
US (1) | US4659701A (sv) |
EP (1) | EP0176050B1 (sv) |
AU (1) | AU573389B2 (sv) |
CA (1) | CA1339138C (sv) |
DE (2) | DE3438386A1 (sv) |
FI (1) | FI80044C (sv) |
HU (1) | HU193818B (sv) |
IL (1) | IL76455A (sv) |
NO (1) | NO853697L (sv) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5177241A (en) * | 1987-12-31 | 1993-01-05 | Bronstein Irena Y | Synthesis of 1,2-dioxetanes and intermediates therefor |
EP0303713B2 (en) * | 1987-02-23 | 1997-07-30 | Shiseido Company Limited | Percutaneous absorption promoter and dermatologic preparation for external use |
US5057502A (en) * | 1987-06-02 | 1991-10-15 | Walsh William E | Composition and topical and systemic treatments of conditions caused by heavy, oily or greasy secretions |
DE3726806A1 (de) * | 1987-08-12 | 1989-02-23 | Basf Ag | Arylphosphorderivate, ihre herstellung und verwendung |
US6670344B2 (en) * | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
US20050153939A1 (en) * | 2003-09-10 | 2005-07-14 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts |
WO2017031157A1 (en) | 2015-08-18 | 2017-02-23 | Mateon Therapeutics, Inc. | Use of vdas to enhance immunomodulating therapies against tumors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4326055A (en) * | 1977-12-22 | 1982-04-20 | Hoffmann-La Roche Inc. | Stilbene derivatives |
DK159967C (da) * | 1977-12-22 | 1991-06-03 | Hoffmann La Roche | Analogifremgangsmaade til fremstilling af terapeutisk aktive stilbenderivater |
DE3202118A1 (de) * | 1982-01-23 | 1983-07-28 | Basf Ag, 6700 Ludwigshafen | Substituierte vinylbenzoesaeure-derivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
DE3202100A1 (de) * | 1982-01-23 | 1983-08-04 | Basf Ag, 6700 Ludwigshafen | Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
-
1984
- 1984-10-19 DE DE19843438386 patent/DE3438386A1/de not_active Withdrawn
-
1985
- 1985-09-20 NO NO853697A patent/NO853697L/no unknown
- 1985-09-20 DE DE8585111939T patent/DE3567873D1/de not_active Expired
- 1985-09-20 HU HU853551A patent/HU193818B/hu not_active IP Right Cessation
- 1985-09-20 EP EP85111939A patent/EP0176050B1/de not_active Expired
- 1985-09-20 US US06/778,191 patent/US4659701A/en not_active Expired - Fee Related
- 1985-09-20 FI FI853623A patent/FI80044C/sv not_active IP Right Cessation
- 1985-09-20 CA CA000491251A patent/CA1339138C/en not_active Expired - Fee Related
- 1985-09-22 IL IL76455A patent/IL76455A/xx not_active IP Right Cessation
- 1985-09-24 AU AU47837/85A patent/AU573389B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0176050B1 (de) | 1989-01-25 |
EP0176050A3 (en) | 1986-10-08 |
HUT40449A (en) | 1986-12-28 |
NO853697L (no) | 1986-03-24 |
HU193818B (en) | 1987-12-28 |
AU4783785A (en) | 1986-03-27 |
IL76455A (en) | 1989-01-31 |
DE3567873D1 (en) | 1989-03-02 |
AU573389B2 (en) | 1988-06-09 |
IL76455A0 (en) | 1986-01-31 |
EP0176050A2 (de) | 1986-04-02 |
DE3438386A1 (de) | 1986-04-03 |
CA1339138C (en) | 1997-07-29 |
FI80044C (sv) | 1990-04-10 |
FI853623A0 (fi) | 1985-09-20 |
US4659701A (en) | 1987-04-21 |
FI853623L (fi) | 1986-03-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: BASF AKTIENGESELLSCHAFT |