FI79699B - Foerfarande foer framstaellning av indol och en mellanprodukt. - Google Patents

Foerfarande foer framstaellning av indol och en mellanprodukt. Download PDF

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Publication number
FI79699B
FI79699B FI844788A FI844788A FI79699B FI 79699 B FI79699 B FI 79699B FI 844788 A FI844788 A FI 844788A FI 844788 A FI844788 A FI 844788A FI 79699 B FI79699 B FI 79699B
Authority
FI
Finland
Prior art keywords
group
general formula
compound
hydrogen atom
alkyl
Prior art date
Application number
FI844788A
Other languages
English (en)
Finnish (fi)
Other versions
FI844788A0 (fi
FI844788L (fi
FI79699C (sv
Inventor
Darko Butina
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FI844788A0 publication Critical patent/FI844788A0/fi
Publication of FI844788L publication Critical patent/FI844788L/fi
Application granted granted Critical
Publication of FI79699B publication Critical patent/FI79699B/fi
Publication of FI79699C publication Critical patent/FI79699C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (2)

1. Förfarande för framställning av indol med den allmänna formeln (I) R]R2NS02CHR3 AlkNR4R5 XX/ H där Rl är en väteatom eller Ci_g alkyl eller ¢3.5 alkenylgrupp; R2 är en väteatom eller Ci_3 alkyl-, fenyl- eller fen(Ci_4)-alkylgrupp; R3 är en väteatom, R4 och R5, vilka kan vara likadana eller olika, är var och en väteatom eller Ci_3 alkyl- eller propenylgrupp eller R4 och R5 tillsammans bildar en bensylidengrupp; och Alk är en alkylenkedja med 2 eller 3 kolatomer, eller deras fysiologiskt godtagbara sait eller soivat, kännetecknat därav, att (A) en indol med den allmänna formeln (II) XS02CHR3 AlkNR4R5 XXX H där X är en grupp ORg, där Rg är en hydrokarbylgrupp och R3, R4, R5 och Alk avser samma som i den allmänna formeln (I), bringas att reagera med en förening med den allmänna formeln (III) i9 79699 RK NH (III) *2^ (där R^ och R2 avser samma som i den allmänna formeln (I)); och vid behov och/eller om sa önskas, underkastas den erhallna föreningen en eller flera av följande reaktioner, där (B) (i) en förening med den allmänna formeln (I) eller dess salt eller skyddade derivat omvandlas till en annan förening med den allmänna formeln (I); (ii) avlägsnas en eventuell skyddsgrupp eller -grupper; (iii) omvandlas en förening med den allmänna formeln (I) eller dess salt till sitt fysiologiskt lämpliga salt eller soivat.
2. En förening med den allmänna formeln (II) XSO2CHR3 AlkNR4R5 —Z (II) XXj H där R3 är en väteatom; R4 och R5, vilka kan vara likadana eller olika, är vardera en väteatom eller Ci_3 alkylgrupp; Alk är en alkylenkedja med 2 eller 3 kolatomer, och X är fenoxi, och deras salter.
FI844788A 1983-12-06 1984-12-05 Förfarande för framställning av indol och en mellanprodukt FI79699C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838332434A GB8332434D0 (en) 1983-12-06 1983-12-06 Production of chemical compounds
GB8332434 1983-12-06

Publications (4)

Publication Number Publication Date
FI844788A0 FI844788A0 (fi) 1984-12-05
FI844788L FI844788L (fi) 1985-06-07
FI79699B true FI79699B (fi) 1989-10-31
FI79699C FI79699C (sv) 1990-02-12

Family

ID=10552844

Family Applications (1)

Application Number Title Priority Date Filing Date
FI844788A FI79699C (sv) 1983-12-06 1984-12-05 Förfarande för framställning av indol och en mellanprodukt

Country Status (7)

Country Link
EP (1) EP0145459A3 (sv)
JP (1) JPS60139669A (sv)
KR (1) KR920000895B1 (sv)
CA (1) CA1230602A (sv)
ES (1) ES538335A0 (sv)
FI (1) FI79699C (sv)
GB (1) GB8332434D0 (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
DE3678805D1 (de) * 1985-11-08 1991-05-23 Glaxo Group Ltd Indolderivate.
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
ES2033578B1 (es) * 1991-06-06 1995-01-16 Quimica Sint S A Con El 50 Procedimiento para la obtencion de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida.
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
KR920000895B1 (ko) 1992-01-30
EP0145459A3 (en) 1985-07-10
KR850004460A (ko) 1985-07-15
ES8603822A1 (es) 1986-01-01
FI844788A0 (fi) 1984-12-05
CA1230602A (en) 1987-12-22
GB8332434D0 (en) 1984-01-11
ES538335A0 (es) 1986-01-01
FI844788L (fi) 1985-06-07
FI79699C (sv) 1990-02-12
JPS60139669A (ja) 1985-07-24
EP0145459A2 (en) 1985-06-19

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Owner name: GLAXO GROUP LIMITED