FI780044A - Foerfarande foer framstaellning av amiderivat av 3 4 5-trim etoxibensen - Google Patents

Foerfarande foer framstaellning av amiderivat av 3 4 5-trim etoxibensen

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Publication number
FI780044A
FI780044A FI780044A FI780044A FI780044A FI 780044 A FI780044 A FI 780044A FI 780044 A FI780044 A FI 780044A FI 780044 A FI780044 A FI 780044A FI 780044 A FI780044 A FI 780044A
Authority
FI
Finland
Prior art keywords
amideria
etoxy
trim
frequency refrigeration
refrigeration
Prior art date
Application number
FI780044A
Other languages
English (en)
Finnish (fi)
Inventor
Maurice Joullie
Gabriel Maillard
Lucien Lakah
Christian Jean Marie Warolin
Original Assignee
Metabio Joullie Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabio Joullie Sa filed Critical Metabio Joullie Sa
Publication of FI780044A publication Critical patent/FI780044A/fi

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
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    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
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    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
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    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI780044A 1977-01-14 1978-01-06 Foerfarande foer framstaellning av amiderivat av 3 4 5-trim etoxibensen FI780044A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1605/77A GB1574019A (en) 1977-01-14 1977-01-14 Therapeutically useful 3,4,5-trimethoxybenzene derivatives

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FI780044A true FI780044A (fi) 1978-07-15

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FI780044A FI780044A (fi) 1977-01-14 1978-01-06 Foerfarande foer framstaellning av amiderivat av 3 4 5-trim etoxibensen

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US (1) US4252804A (da)
JP (1) JPS53135945A (da)
AU (1) AU3233878A (da)
BE (1) BE868162A (da)
CA (1) CA1104132A (da)
DE (1) DE2801187A1 (da)
ES (1) ES465938A1 (da)
FI (1) FI780044A (da)
FR (1) FR2377377A1 (da)
GB (1) GB1574019A (da)
IT (1) IT1206608B (da)
LU (1) LU79926A1 (da)
NZ (1) NZ186197A (da)
SE (1) SE7806467L (da)
ZA (1) ZA78143B (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3062981D1 (en) * 1979-11-09 1983-06-09 Bayer Ag Alkyl-urea derivatives for the treatment of lipometabolic diseases; process for their preparation, their use in medicaments for the treatment of lipometabolic disorders, medicaments containing them, process for the preparation of the medicaments, and some alkyl-urea derivatives
CH653019A5 (de) * 1981-03-20 1985-12-13 Sandoz Ag N-beta-aminoaethylpiperidinverbindungen.
US4473694A (en) * 1981-04-03 1984-09-25 The B. F. Goodrich Company Process for the preparation of polysubstituted α-aminoacetamides
US4500529A (en) * 1981-05-20 1985-02-19 A. H. Robins Company, Incorporated Method of treating cardiac disorders with N-(aryloxyalkyl)-N'-(aminoalkyl)ureas
US4624953A (en) * 1981-12-02 1986-11-25 Bjoerk Anders K 1-piperazinocarboxylates and pharmaceutical compositions containing them
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides
EP0144853B1 (en) * 1983-11-21 1990-09-26 Fujisawa Pharmaceutical Co., Ltd. Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
FR2568878B1 (fr) * 1984-08-07 1986-11-21 Cortial Nouveaux derives de (phenylpiperazinylethylamine ethoxy)-4 phenol, leur methode de preparation et leur application therapeutique
JPS61215381A (ja) * 1985-03-22 1986-09-25 Ube Ind Ltd ベンゾオキサジン誘導体および除草剤
FR2579461B1 (fr) * 1985-03-28 1988-08-26 Strasbourg Universite L Pasteu Amides de l'acide para-methoxycinnamique et de l'acide urocanique utilises comme filtres solaires; procedes d'obtention, compositions dermo-pharmaceutiques et cosmetiques les contenant et applications
US4855497A (en) * 1985-04-02 1989-08-08 Chugai Seiyaku Kabushiki Kaisha Novel diamine derivatives
FR2582514B1 (fr) * 1985-05-30 1988-02-19 Rhone Poulenc Sante Medicaments a base d'amides, nouveaux amides et leur preparation
IL85700A0 (en) * 1987-03-24 1988-08-31 Takeda Chemical Industries Ltd 1,4-disubstituted piperazine compounds,their production and use
US4895840A (en) * 1987-06-10 1990-01-23 A. H. Robins Company, Incorporated N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines
JP2712222B2 (ja) * 1988-01-29 1998-02-10 三菱化学株式会社 抗不安薬
US5182284A (en) * 1990-01-26 1993-01-26 Taiho Pharmaceutical Co., Ltd. Piperazine compounds, processes for preparation thereof and medical uses thereof
DE69124392T2 (de) * 1990-10-25 1997-06-26 Yamanouchi Pharma Co Ltd Tri(c1-c6 alkoxy)benzolderivat
US5514690A (en) * 1992-11-17 1996-05-07 E. R. Squibb & Sons, Inc. Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline
US5602119A (en) * 1993-10-29 1997-02-11 Vazquez; Michael L. Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
WO1997041846A1 (en) * 1996-05-06 1997-11-13 Eli Lilly And Company Anti-viral compounds
DE69704180T2 (de) 1996-05-06 2001-08-30 Eli Lilly And Co., Indianapolis Antivirusverbindungen
AU2752297A (en) * 1996-05-06 1997-11-26 Eli Lilly And Company Anti-viral compounds
US6127422A (en) * 1996-05-06 2000-10-03 Eli Lilly And Company Anti-viral method
AU2752597A (en) * 1996-05-06 1997-11-26 Eli Lilly And Company Anti-viral compounds
US6156924A (en) * 1996-05-06 2000-12-05 Eli Lilly And Company Anti-viral compounds
US6103923A (en) * 1996-05-06 2000-08-15 Eli Lilly And Company Anti-viral compounds
EP0968200A1 (en) 1997-02-24 2000-01-05 ZymoGenetics, Inc. Calcitonin mimetics
US6096917A (en) * 1997-05-02 2000-08-01 Eli Lilly And Company Anti-viral compounds
GB9720052D0 (en) * 1997-09-19 1997-11-19 Smithkline Beecham Plc Novel compounds
US6268367B1 (en) * 1998-02-23 2001-07-31 Zymogenetics, Inc. Piperazine derivatives for treating bone deficit conditions
US6462034B1 (en) 1998-04-03 2002-10-08 Theravance, Inc. Local anesthetic compounds and uses
CO5040088A1 (es) * 1998-04-03 2001-05-29 Advanced Medicine Inc Nuevos compuestos y usos anestesicos locales
EP1095022A1 (en) 1998-07-08 2001-05-02 G.D. Searle & Co. Retroviral protease inhibitors
US6175034B1 (en) 2000-04-10 2001-01-16 Eli Lilly And Company Anti-viral compounds
AU2002351731A1 (en) 2001-12-14 2003-06-30 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
WO2004002531A1 (ja) * 2002-06-26 2004-01-08 Ono Pharmaceutical Co., Ltd. 血管の収縮または拡張による疾患治療剤
BRPI0404222A (pt) * 2004-06-07 2006-02-07 Fundacao Oswaldo Cruz Compostos derivados da lidocaìna, composições farmacêuticas contendo os mesmos, uso das respectivas composições farmacêuticas no tratamento, prevenção ou inibição de doenças bem como o método de tratamento, prevenção ou inibição de doenças com as ditas composições farmacêuticas
JPWO2006028161A1 (ja) * 2004-09-09 2008-05-08 財団法人乙卯研究所 セロトニン５−ｈｔ３受容体作動薬
CA2579227A1 (en) * 2004-11-04 2006-05-18 Neurogen Corporation Arylalkyl ureas as cb1 antagonists
KR101691954B1 (ko) * 2016-04-26 2017-01-02 고려대학교 산학협력단 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물
CN116239551B (zh) * 2022-12-05 2024-07-26 湖北大学 具有杀螺活性的呋喃脲类化合物及其制备和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870145A (en) * 1955-09-09 1959-01-20 Bristol Lab Inc Therapeutic agents
US2870146A (en) * 1958-02-10 1959-01-20 Bristol Lab Inc Therapeutic agents
US2882273A (en) * 1958-02-07 1959-04-14 Bristol Lab Inc Therapeutic agents
GB872350A (en) * 1959-01-23 1961-07-05 Egyt Gyogyszervegyeszeti Gyar Methoxybenzoic acid amides and their preparation
GB912788A (en) 1959-11-16 1962-12-12 Miles Lab Phenylpiperazinylacyl anilines
FR1382907A (fr) * 1962-05-21 1964-12-24 Miles Lab Production de carbamates de phénylpipérazinylalkyle
US3234276A (en) * 1963-04-12 1966-02-08 Rexall Drug Chemical N-acyl-n-(trialkoxyphenylalkylene)-alkylenediamines
DE1445969A1 (de) * 1963-07-24 1969-11-20 Krewel Werke Gmbh Verfahren zur Herstellung von basischen 3,4,5-Trimethoxybenzoesaeureestern
FR2043489B1 (da) * 1969-05-29 1973-07-13 Orsymonde
IT1043955B (it) * 1970-07-31 1980-02-29 Isf Spa Tioamidi dell acido siringo 4 sostituito e loro preparazione
DE2116293A1 (de) 1971-04-02 1972-10-19 Cassella Farbwerke Mainkur Ag, 6000 Frankfurt Ketonderivate und Verfahren zu ihrer Herstellung
US3953448A (en) * 1972-12-07 1976-04-27 Delmar Chemicals Limited Piperazino-anilido compounds

Also Published As

Publication number Publication date
BE868162A (fr) 1978-12-15
IT1206608B (it) 1989-04-27
GB1574019A (en) 1980-09-03
ZA78143B (en) 1978-12-27
SE7806467L (sv) 1979-06-22
NZ186197A (en) 1980-11-28
FR2377377B1 (da) 1981-12-04
US4252804A (en) 1981-02-24
ES465938A1 (es) 1978-09-16
LU79926A1 (fr) 1979-04-09
FR2377377A1 (fr) 1978-08-11
IT7823948A0 (it) 1978-05-29
JPS53135945A (en) 1978-11-28
CA1104132A (en) 1981-06-30
AU3233878A (en) 1979-07-19
DE2801187A1 (de) 1978-07-20

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