FI77643C - Magnesiumhalogenidkomplex av alfa-brompropionsyra och dess framställni ngsförfarande. - Google Patents
Magnesiumhalogenidkomplex av alfa-brompropionsyra och dess framställni ngsförfarande. Download PDFInfo
- Publication number
- FI77643C FI77643C FI831197A FI831197A FI77643C FI 77643 C FI77643 C FI 77643C FI 831197 A FI831197 A FI 831197A FI 831197 A FI831197 A FI 831197A FI 77643 C FI77643 C FI 77643C
- Authority
- FI
- Finland
- Prior art keywords
- magnesium
- halogenidkomplex
- brompropionsyra
- alfa
- alpha
- Prior art date
Links
- 239000011777 magnesium Substances 0.000 title description 11
- 229910052749 magnesium Inorganic materials 0.000 title description 9
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 16
- MONMFXREYOKQTI-UHFFFAOYSA-N 2-bromopropanoic acid Chemical compound CC(Br)C(O)=O MONMFXREYOKQTI-UHFFFAOYSA-N 0.000 description 12
- 150000004795 grignard reagents Chemical class 0.000 description 11
- -1 Magnesium halide Chemical class 0.000 description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 8
- 239000007818 Grignard reagent Substances 0.000 description 7
- NXPHGHWWQRMDIA-UHFFFAOYSA-M magnesium;carbanide;bromide Chemical compound [CH3-].[Mg+2].[Br-] NXPHGHWWQRMDIA-UHFFFAOYSA-M 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- CCERQOYLJJULMD-UHFFFAOYSA-M magnesium;carbanide;chloride Chemical compound [CH3-].[Mg+2].[Cl-] CCERQOYLJJULMD-UHFFFAOYSA-M 0.000 description 5
- IUYHWZFSGMZEOG-UHFFFAOYSA-M magnesium;propane;chloride Chemical compound [Mg+2].[Cl-].C[CH-]C IUYHWZFSGMZEOG-UHFFFAOYSA-M 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 239000000010 aprotic solvent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- IWCVDCOJSPWGRW-UHFFFAOYSA-M magnesium;benzene;chloride Chemical compound [Mg+2].[Cl-].C1=CC=[C-]C=C1 IWCVDCOJSPWGRW-UHFFFAOYSA-M 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 238000010626 work up procedure Methods 0.000 description 2
- SEZHLKZEWYFCRB-UHFFFAOYSA-N 1,2-dimethoxyethane;oxolane Chemical compound C1CCOC1.COCCOC SEZHLKZEWYFCRB-UHFFFAOYSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- YBPFQOFSPMWGKA-UHFFFAOYSA-M [Cl-].CC1=CC=C([Mg+])C=C1 Chemical compound [Cl-].CC1=CC=C([Mg+])C=C1 YBPFQOFSPMWGKA-UHFFFAOYSA-M 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 description 1
- 229910001623 magnesium bromide Inorganic materials 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- YCCXQARVHOPWFJ-UHFFFAOYSA-M magnesium;ethane;chloride Chemical compound [Mg+2].[Cl-].[CH2-]C YCCXQARVHOPWFJ-UHFFFAOYSA-M 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76907077A | 1977-02-16 | 1977-02-16 | |
| US76907077 | 1977-02-16 | ||
| US05/863,290 US4144397A (en) | 1977-02-16 | 1977-12-19 | Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex |
| US86329077 | 1977-12-19 | ||
| FI780417 | 1978-02-09 | ||
| FI780417A FI64571C (fi) | 1977-02-16 | 1978-02-09 | Foerfarande foer framstaellning av 2-aryl-propionsyra |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI831197A0 FI831197A0 (fi) | 1983-04-11 |
| FI831197L FI831197L (fi) | 1983-04-11 |
| FI77643B FI77643B (fi) | 1988-12-30 |
| FI77643C true FI77643C (sv) | 1989-04-10 |
Family
ID=27241004
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI831198A FI82442C (sv) | 1977-02-16 | 1983-04-11 | Förfarande för framställning av 2-arylpropionsyra-magnesiumhalogenidko mplex och dess användning vid framställning av 2-arylpropionsyra |
| FI831197A FI77643C (sv) | 1977-02-16 | 1983-04-11 | Magnesiumhalogenidkomplex av alfa-brompropionsyra och dess framställni ngsförfarande. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI831198A FI82442C (sv) | 1977-02-16 | 1983-04-11 | Förfarande för framställning av 2-arylpropionsyra-magnesiumhalogenidko mplex och dess användning vid framställning av 2-arylpropionsyra |
Country Status (1)
| Country | Link |
|---|---|
| FI (2) | FI82442C (sv) |
-
1983
- 1983-04-11 FI FI831198A patent/FI82442C/sv not_active IP Right Cessation
- 1983-04-11 FI FI831197A patent/FI77643C/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI831197A0 (fi) | 1983-04-11 |
| FI77643B (fi) | 1988-12-30 |
| FI831197L (fi) | 1983-04-11 |
| FI831198A0 (fi) | 1983-04-11 |
| FI82442C (sv) | 1991-03-11 |
| FI831198L (fi) | 1983-04-11 |
| FI82442B (fi) | 1990-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |
Owner name: SYNTEX PHARMACEUTICALS INTERNATIONAL |