FI71058C - Foerfarande foer framstaellning av en magsyraneutraliserande suspension - Google Patents
Foerfarande foer framstaellning av en magsyraneutraliserande suspension Download PDFInfo
- Publication number
- FI71058C FI71058C FI802139A FI802139A FI71058C FI 71058 C FI71058 C FI 71058C FI 802139 A FI802139 A FI 802139A FI 802139 A FI802139 A FI 802139A FI 71058 C FI71058 C FI 71058C
- Authority
- FI
- Finland
- Prior art keywords
- suspension
- magnesium
- acid
- aluminum hydroxide
- sorbitol
- Prior art date
Links
- 239000000725 suspension Substances 0.000 title claims description 96
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 47
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 43
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 34
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 34
- 239000000600 sorbitol Substances 0.000 claims description 34
- 235000010356 sorbitol Nutrition 0.000 claims description 34
- 239000001095 magnesium carbonate Substances 0.000 claims description 24
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 24
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 24
- 239000000347 magnesium hydroxide Substances 0.000 claims description 23
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 23
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 21
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 18
- 239000000395 magnesium oxide Substances 0.000 claims description 15
- 230000003472 neutralizing effect Effects 0.000 claims description 13
- 210000004211 gastric acid Anatomy 0.000 claims description 11
- 150000005846 sugar alcohols Chemical class 0.000 claims description 11
- 239000000159 acid neutralizing agent Substances 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 9
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 9
- 229910018072 Al 2 O 3 Inorganic materials 0.000 claims description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 8
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 8
- 239000008103 glucose Substances 0.000 claims description 8
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 8
- 239000000594 mannitol Substances 0.000 claims description 8
- 235000010355 mannitol Nutrition 0.000 claims description 8
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 8
- 239000000811 xylitol Substances 0.000 claims description 8
- 235000010447 xylitol Nutrition 0.000 claims description 8
- 229960002675 xylitol Drugs 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 150000002482 oligosaccharides Polymers 0.000 claims description 5
- 229920001282 polysaccharide Polymers 0.000 claims description 5
- 239000005017 polysaccharide Substances 0.000 claims description 5
- 230000000087 stabilizing effect Effects 0.000 claims description 5
- 239000005715 Fructose Substances 0.000 claims description 4
- 229930091371 Fructose Natural products 0.000 claims description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000007900 aqueous suspension Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000000375 suspending agent Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 description 50
- 239000000047 product Substances 0.000 description 47
- 239000000203 mixture Substances 0.000 description 38
- 235000010449 maltitol Nutrition 0.000 description 37
- 229940024545 aluminum hydroxide Drugs 0.000 description 35
- 239000000499 gel Substances 0.000 description 33
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 32
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 26
- 235000012254 magnesium hydroxide Nutrition 0.000 description 25
- 238000002360 preparation method Methods 0.000 description 20
- 229910052782 aluminium Inorganic materials 0.000 description 19
- 229940069428 antacid Drugs 0.000 description 19
- 239000003159 antacid agent Substances 0.000 description 19
- 230000000694 effects Effects 0.000 description 19
- 235000010216 calcium carbonate Nutrition 0.000 description 17
- 235000014380 magnesium carbonate Nutrition 0.000 description 17
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 16
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 16
- 229960002216 methylparaben Drugs 0.000 description 16
- 235000012245 magnesium oxide Nutrition 0.000 description 15
- ADKOXSOCTOWDOP-UHFFFAOYSA-L magnesium;aluminum;dihydroxide;trihydrate Chemical compound O.O.O.[OH-].[OH-].[Mg+2].[Al] ADKOXSOCTOWDOP-UHFFFAOYSA-L 0.000 description 15
- 239000011777 magnesium Substances 0.000 description 14
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 13
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 13
- 244000246386 Mentha pulegium Species 0.000 description 12
- 235000016257 Mentha pulegium Nutrition 0.000 description 12
- 235000004357 Mentha x piperita Nutrition 0.000 description 12
- 235000001050 hortel pimenta Nutrition 0.000 description 12
- WKHMXCIUCCIPOU-UHFFFAOYSA-N perfluoro-1-methyladamantane Chemical compound FC1(F)C(C2(F)F)(F)C(F)(F)C3(F)C(F)(F)C2(F)C(F)(F)C1(C(F)(F)F)C3(F)F WKHMXCIUCCIPOU-UHFFFAOYSA-N 0.000 description 12
- 235000013599 spices Nutrition 0.000 description 12
- 230000001458 anti-acid effect Effects 0.000 description 10
- 239000000470 constituent Substances 0.000 description 10
- 229910052749 magnesium Inorganic materials 0.000 description 10
- 239000004615 ingredient Substances 0.000 description 9
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 8
- LHPJBAIYHPWIOT-UHFFFAOYSA-K aluminum;magnesium;carbonate;hydroxide Chemical compound [OH-].[Mg+2].[Al+3].[O-]C([O-])=O LHPJBAIYHPWIOT-UHFFFAOYSA-K 0.000 description 8
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 8
- 235000000346 sugar Nutrition 0.000 description 8
- 239000011230 binding agent Substances 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 235000017557 sodium bicarbonate Nutrition 0.000 description 7
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 7
- 229920002472 Starch Polymers 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- PWZFXELTLAQOKC-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide;tetrahydrate Chemical compound O.O.O.O.[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O PWZFXELTLAQOKC-UHFFFAOYSA-A 0.000 description 6
- 150000002681 magnesium compounds Chemical class 0.000 description 6
- 239000008107 starch Substances 0.000 description 6
- 235000019698 starch Nutrition 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 5
- 150000001298 alcohols Chemical class 0.000 description 5
- 150000002303 glucose derivatives Chemical class 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 150000008163 sugars Chemical class 0.000 description 5
- 235000020357 syrup Nutrition 0.000 description 5
- 239000006188 syrup Substances 0.000 description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
- 235000005979 Citrus limon Nutrition 0.000 description 4
- 244000131522 Citrus pyriformis Species 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000006096 absorbing agent Substances 0.000 description 4
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 4
- LCWAOCHOPBSGMU-UHFFFAOYSA-J aluminum;magnesium;sodium;hydrogen carbonate;oxygen(2-);silicon;trihydroxide Chemical compound [OH-].[OH-].[OH-].[O-2].[Na+].[Mg+2].[Al+3].[Si].OC([O-])=O LCWAOCHOPBSGMU-UHFFFAOYSA-J 0.000 description 4
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
- 229940045140 gaviscon Drugs 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 235000011160 magnesium carbonates Nutrition 0.000 description 4
- 150000004804 polysaccharides Chemical class 0.000 description 4
- 230000003389 potentiating effect Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 4
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 4
- 229960003415 propylparaben Drugs 0.000 description 4
- -1 salt salts Chemical class 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- 239000005913 Maltodextrin Substances 0.000 description 3
- RYXPMWYHEBGTRV-UHFFFAOYSA-N Omeprazole sodium Chemical compound [Na+].N=1C2=CC(OC)=CC=C2[N-]C=1S(=O)CC1=NC=C(C)C(OC)=C1C RYXPMWYHEBGTRV-UHFFFAOYSA-N 0.000 description 3
- 208000007107 Stomach Ulcer Diseases 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
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- 239000003755 preservative agent Substances 0.000 description 3
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- 239000002516 radical scavenger Substances 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 229910018134 Al-Mg Inorganic materials 0.000 description 2
- 229910017119 AlPO Inorganic materials 0.000 description 2
- 229910018467 Al—Mg Inorganic materials 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- 239000001828 Gelatine Substances 0.000 description 2
- 208000037147 Hypercalcaemia Diseases 0.000 description 2
- 229920002774 Maltodextrin Polymers 0.000 description 2
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- KFVBMBOOLFSJHV-DEDIIKBZSA-K [Na+].[Al+2]O.[O-]C([O-])=O.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO Chemical compound [Na+].[Al+2]O.[O-]C([O-])=O.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO KFVBMBOOLFSJHV-DEDIIKBZSA-K 0.000 description 2
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 2
- 229940024546 aluminum hydroxide gel Drugs 0.000 description 2
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
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- 235000011132 calcium sulphate Nutrition 0.000 description 2
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- 238000012512 characterization method Methods 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- PPQREHKVAOVYBT-UHFFFAOYSA-H dialuminum;tricarbonate Chemical compound [Al+3].[Al+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O PPQREHKVAOVYBT-UHFFFAOYSA-H 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
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- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- 230000000148 hypercalcaemia Effects 0.000 description 2
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- XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 description 1
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- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
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- HBYOLNPZXLHVQA-UHFFFAOYSA-J dicalcium dicarbonate Chemical compound [Ca+2].[Ca+2].[O-]C([O-])=O.[O-]C([O-])=O HBYOLNPZXLHVQA-UHFFFAOYSA-J 0.000 description 1
- WUEJAKIJDOEDJD-UHFFFAOYSA-K dimagnesium;carbonate;hydroxide Chemical compound [OH-].[Mg+2].[Mg+2].[O-]C([O-])=O WUEJAKIJDOEDJD-UHFFFAOYSA-K 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- JGBUYEVOKHLFID-UHFFFAOYSA-N gelred Chemical compound [I-].[I-].C=1C(N)=CC=C(C2=CC=C(N)C=C2[N+]=2CCCCCC(=O)NCCCOCCOCCOCCCNC(=O)CCCCC[N+]=3C4=CC(N)=CC=C4C4=CC=C(N)C=C4C=3C=3C=CC=CC=3)C=1C=2C1=CC=CC=C1 JGBUYEVOKHLFID-UHFFFAOYSA-N 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 235000013324 preserved food Nutrition 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000001739 rebound effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7905972A SE7905972L (sv) | 1979-07-09 | 1979-07-09 | Forfarande for framstellning av magsyraneutraliserande medel, magsyraneutraliserande medel, samt metod for behandling av hyperaciditet och dermed relaterande sjukdomstillstand |
| SE7905972 | 1979-07-09 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI802139A FI802139A (fi) | 1981-01-10 |
| FI71058B FI71058B (fi) | 1986-08-14 |
| FI71058C true FI71058C (fi) | 1986-11-24 |
Family
ID=20338481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI802139A FI71058C (fi) | 1979-07-09 | 1980-07-03 | Foerfarande foer framstaellning av en magsyraneutraliserande suspension |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4465667A (no) |
| EP (1) | EP0022429B1 (no) |
| JP (1) | JPS5618922A (no) |
| AR (1) | AR228854A1 (no) |
| AT (1) | ATE1968T1 (no) |
| AU (1) | AU535403B2 (no) |
| CA (1) | CA1146860A (no) |
| DE (1) | DE3061333D1 (no) |
| DK (1) | DK154265C (no) |
| ES (1) | ES493187A0 (no) |
| FI (1) | FI71058C (no) |
| GR (1) | GR69623B (no) |
| HK (1) | HK43484A (no) |
| IE (1) | IE50141B1 (no) |
| MY (1) | MY8500445A (no) |
| NO (1) | NO152892C (no) |
| NZ (1) | NZ194165A (no) |
| PH (2) | PH16372A (no) |
| PT (1) | PT71503B (no) |
| SE (1) | SE7905972L (no) |
| SG (1) | SG9384G (no) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0642001B2 (ja) * | 1983-10-20 | 1994-06-01 | セイコーエプソン株式会社 | 合成樹脂製レンズ |
| JPS6486101A (en) * | 1987-06-18 | 1989-03-30 | Toray Industries | Production of antireflecting article |
| JPH0696536B2 (ja) * | 1988-02-26 | 1994-11-30 | 佐藤製薬株式会社 | 制酸剤含有内用懸濁液 |
| US5158770A (en) * | 1989-12-29 | 1992-10-27 | Freund Industrial Co., Ltd. | Aqueous solution containing ginkgo leaf extract |
| AU657882B2 (en) * | 1993-03-26 | 1995-03-23 | Wallace Victor Wind | Improvements in or relating to the treatment of diarrhoea |
| US5360793A (en) * | 1993-05-24 | 1994-11-01 | Sterling Winthrop Inc. | Rafting antacid formulation |
| SE509300C2 (sv) * | 1995-02-02 | 1999-01-11 | Sueddeutsche Kalkstickstoff | Katjoniskt dispergerade aluminiumhydroxiduppslamningar |
| US5569466A (en) * | 1995-05-17 | 1996-10-29 | R. P. Scherer Corporation | Fill compositions for soft elastic gel capsules |
| US6187317B1 (en) | 1999-07-14 | 2001-02-13 | Judith Taylor | Natural anti-diarrheal composition and method |
| ES2278115T3 (es) * | 2003-10-13 | 2007-08-01 | Zoser B. Nat.Rer.Dr. Salama | Composicion farmaceutica que comprende oxoplatino y sus sales. |
| US20060073202A1 (en) * | 2004-10-05 | 2006-04-06 | Rocca Jose G | Dual component medicament delivery system |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2211745A (en) * | 1940-04-18 | 1940-08-13 | Alba Pharmaceutical Company In | Compound of aluminum hydroxide and process of making the same |
| US2999790A (en) * | 1959-08-24 | 1961-09-12 | Sterling Drug Inc | Stable aluminum hydroxide suspension |
| US3239416A (en) * | 1963-05-29 | 1966-03-08 | Armour Pharma | Aluminum hydroxide-metal hydroxide antacid and process of making the same |
| US3272704A (en) * | 1963-06-06 | 1966-09-13 | Armour Pharma | Stable aluminum hydroxide-magnesium compound codried gel antacids and process of making the same |
| US3499963A (en) * | 1964-04-15 | 1970-03-10 | Armour Pharma | Codried aluminum hydroxide-aluminum chelate antacid |
| US3350266A (en) * | 1964-06-04 | 1967-10-31 | Bristol Myers Co | Antacid composition comprising aluminum hydroxide, magnesium hydroxide and magnesium gluconate |
| IL32020A (en) * | 1968-04-18 | 1972-11-28 | Brown G | Antacid compositions |
| US3599150A (en) * | 1969-08-01 | 1971-08-10 | Miles Lab | Stabilized aluminum hydroxide suspensions |
| GB1414121A (en) * | 1971-09-15 | 1975-11-19 | Smith W J | Antacid composition and its preparation |
| US3873694A (en) * | 1973-09-27 | 1975-03-25 | Cpc International Inc | Direct compression tabletting composition and pharmaceutical tablets produced therefrom |
-
1979
- 1979-07-09 SE SE7905972A patent/SE7905972L/ not_active Application Discontinuation
-
1980
- 1980-06-06 EP EP80850081A patent/EP0022429B1/en not_active Expired
- 1980-06-06 AT AT80850081T patent/ATE1968T1/de not_active IP Right Cessation
- 1980-06-06 DE DE8080850081T patent/DE3061333D1/de not_active Expired
- 1980-06-18 PH PH24163A patent/PH16372A/en unknown
- 1980-06-27 NZ NZ194165A patent/NZ194165A/en unknown
- 1980-06-27 AU AU59734/80A patent/AU535403B2/en not_active Expired
- 1980-07-03 FI FI802139A patent/FI71058C/fi not_active IP Right Cessation
- 1980-07-04 NO NO802030A patent/NO152892C/no unknown
- 1980-07-04 DK DK290080A patent/DK154265C/da not_active IP Right Cessation
- 1980-07-07 IE IE1402/80A patent/IE50141B1/en unknown
- 1980-07-07 GR GR62397A patent/GR69623B/el unknown
- 1980-07-07 PT PT71503A patent/PT71503B/pt unknown
- 1980-07-08 CA CA000355688A patent/CA1146860A/en not_active Expired
- 1980-07-08 ES ES493187A patent/ES493187A0/es active Granted
- 1980-07-09 JP JP9281580A patent/JPS5618922A/ja active Granted
-
1981
- 1981-11-27 PH PH26541A patent/PH16705A/en unknown
-
1982
- 1982-01-11 US US06/338,302 patent/US4465667A/en not_active Expired - Lifetime
-
1983
- 1983-01-01 AR AR22885483D patent/AR228854A1/es active
-
1984
- 1984-02-04 SG SG93/84A patent/SG9384G/en unknown
- 1984-05-17 HK HK434/84A patent/HK43484A/xx not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY445/85A patent/MY8500445A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT71503B (en) | 1981-12-11 |
| SE7905972L (sv) | 1981-01-10 |
| DK154265B (da) | 1988-10-31 |
| JPS5618922A (en) | 1981-02-23 |
| US4465667A (en) | 1984-08-14 |
| HK43484A (en) | 1984-05-25 |
| ES8106835A1 (es) | 1981-09-01 |
| NZ194165A (en) | 1984-07-06 |
| IE801402L (en) | 1981-01-09 |
| NO152892B (no) | 1985-09-02 |
| AU5973480A (en) | 1981-01-15 |
| ATE1968T1 (de) | 1982-12-15 |
| EP0022429B1 (en) | 1982-12-15 |
| IE50141B1 (en) | 1986-02-19 |
| EP0022429A1 (en) | 1981-01-14 |
| NO802030L (no) | 1981-01-12 |
| AU535403B2 (en) | 1984-03-22 |
| FI802139A (fi) | 1981-01-10 |
| CA1146860A (en) | 1983-05-24 |
| NO152892C (no) | 1985-12-11 |
| PH16372A (en) | 1983-09-14 |
| PT71503A (en) | 1980-08-01 |
| MY8500445A (en) | 1985-12-31 |
| FI71058B (fi) | 1986-08-14 |
| SG9384G (en) | 1985-02-15 |
| AR228854A1 (es) | 1983-04-29 |
| GR69623B (no) | 1982-07-06 |
| DE3061333D1 (en) | 1983-01-20 |
| PH16705A (en) | 1984-01-20 |
| DK154265C (da) | 1989-03-28 |
| ES493187A0 (es) | 1981-09-01 |
| DK290080A (da) | 1981-01-10 |
| JPS6411008B2 (no) | 1989-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |
Owner name: AKTIEBOLAGET HAESSLE |