FI68622C - Foerfarande foer framstaellning av indolaettiksyraderivat - Google Patents
Foerfarande foer framstaellning av indolaettiksyraderivat Download PDFInfo
- Publication number
- FI68622C FI68622C FI812418A FI812418A FI68622C FI 68622 C FI68622 C FI 68622C FI 812418 A FI812418 A FI 812418A FI 812418 A FI812418 A FI 812418A FI 68622 C FI68622 C FI 68622C
- Authority
- FI
- Finland
- Prior art keywords
- methyl
- chlorobenzoyl
- methoxy
- acetic acid
- indole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (9)
1. Förfarande för framställning av derivat för bl.a. behandling av reumatiska sjukdomar med den allmänna formeln I 0 CH3Q^\________^CH2-c-S-(CH2)n-^ 4- X J \ X I CH3 OO Λ Ύ där c^ X är H, F, Cl eller en C.j ^-alkylgrupp n är ett heltal mellan 0 och 3, och dess farmakologiskt godtagbara salter, kännetecknat av att a) 1-(p-klorbenzoyl)-5-metoxi-2-metyl-indol-3-ättiksyraklorid omsättes med ett alkalisalt av en förening med den allmänna formeln II X _l/ -Λ- (CH ) -SH II .Tl 2 n där X och n betyder detsamma som i formel I, i ett organiskt inert lösningsmedel, eller b) 1-(p-klorbenzoyl)-5-metoxi-2-metyl-indol-3-ättiksyra omsättes med en förening av den ovan angivna allmänna formeln II i närvaro av en karbodiimid eller i närvaro av Ν,Ν-dimetylfos-foramiddiklorid tillsammans med en svag bas i ett organiskt inert lösningsmedel eller c) 1-(p-klorbenzoyl)-5-metoxi-3-metyl-indol-3-ättiksyra-C1 4~ alkylester omsättes med den förening av den ovan angivna formeln i3 68622 II i närvaro av trimetylaluminium i ett organiskt inert lösningsmedel.
2. Förfarande enligt patentkravet 1, kännetecknat av att det framställs 1-(p-klorbenzoyl)-5-metoxi-2-metyl-3-indol-ättiksyra-2-pyridylmetyltioester och dess farmakologiskt godtagbara salter.
3. Förfarande enligt patentkravet 1, kännetecknat av att det framställs 1-(p-klorbenzoyl)-5-metoxi-2-metyl-3-indol-ättiksyra-3-pyridylmetyltioester och dess farmakologiskt godtagbara salter.
4. Förfarande enligt patentkravet 1, kännetecknat av att det framställs 1-(p-klorbenzoyl)-5-metoxi-2-metyl-3-indol-ättiksyra-2-(3-pyridyl)-etyltioester och dess farmakologiskt godtagbara salter.
5. Förfarande enligt patentkravet 1,kännetecknat av att det framställs 1-(p-klorbenzoyl)-5-metoxi-2-metyl-3» indol-ättiksyra-3-(3-pyridyl)propyltioester och dess farmakologiskt godtagbara salter.
6. Förfarande enligt patentkravet 1 , kännetecknat av att det framställs 1-(p-klorbenzoyl)-5-metoxi-2-metyl-3-indol-ättiksyra-4-pyridylmetyltioester och dess farmakologiskt godtagbara salter.
7. Förfarande enligt patentkravet 1, kännetecknat av att det framställs 1-(p-klorbenzoyl)-5-metoxi-2-metyl-3-indol-ättikrya-(6-metyl-3-pyridyl)-metyltioester och dess farmakologiskt godtagbara salter.
8. Förfarande enligt patentkravet 1, kännetecknat! av att det framställs 1-(p-klorbenzoyl)-5-metoxi-2-metyl-3-indol-ättiksyra-2-pyridyltioester och dess farmakologiskt godtagbara salter.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3034005A DE3034005C2 (de) | 1980-09-10 | 1980-09-10 | Indolessigsäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen |
| DE3034005 | 1980-09-10 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI812418L FI812418L (fi) | 1982-03-11 |
| FI68622B FI68622B (fi) | 1985-06-28 |
| FI68622C true FI68622C (fi) | 1985-10-10 |
Family
ID=6111558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI812418A FI68622C (fi) | 1980-09-10 | 1981-08-04 | Foerfarande foer framstaellning av indolaettiksyraderivat |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0047358B1 (sv) |
| JP (1) | JPS5750988A (sv) |
| AR (1) | AR229470A1 (sv) |
| AT (1) | ATE9470T1 (sv) |
| AU (1) | AU539442B2 (sv) |
| CA (1) | CA1164862A (sv) |
| DE (1) | DE3034005C2 (sv) |
| DK (1) | DK236781A (sv) |
| ES (1) | ES8300747A1 (sv) |
| FI (1) | FI68622C (sv) |
| HU (1) | HU187338B (sv) |
| IE (1) | IE51776B1 (sv) |
| PT (1) | PT73435B (sv) |
| YU (1) | YU135081A (sv) |
| ZA (1) | ZA813637B (sv) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3236243A1 (de) * | 1982-09-30 | 1984-04-05 | Merck Patent Gmbh, 6100 Darmstadt | Schwefelhaltige indolderivate |
| WO2004048371A1 (en) | 2002-11-25 | 2004-06-10 | F.Hoffmann-La Roche Ag | Indolyl derivatives |
| CN104876848B (zh) * | 2015-05-15 | 2017-05-17 | 南开大学 | 一种1‑酰基‑3‑吲哚硫酯化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD70880A (sv) * | ||||
| US3966956A (en) * | 1972-07-14 | 1976-06-29 | Troponwerke Dinklage & Company | [1-(P-Chlorobenzoyl)-5-methoxy-2-methyl-3-indole]acetoxyacetic acid and salts in treating inflammation |
| US4119638A (en) * | 1976-11-29 | 1978-10-10 | G. D. Searle & Co. | Thio-ester of 1 (p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid |
| DE2735537A1 (de) * | 1977-08-06 | 1979-02-22 | Troponwerke Gmbh & Co Kg | Indolacetoxyacetylaminosaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
-
1980
- 1980-09-10 DE DE3034005A patent/DE3034005C2/de not_active Expired
-
1981
- 1981-05-26 EP EP81104024A patent/EP0047358B1/en not_active Expired
- 1981-05-26 YU YU01350/81A patent/YU135081A/xx unknown
- 1981-05-26 AT AT81104024T patent/ATE9470T1/de not_active IP Right Cessation
- 1981-05-29 ZA ZA00813637A patent/ZA813637B/xx unknown
- 1981-05-29 CA CA000378654A patent/CA1164862A/en not_active Expired
- 1981-05-29 DK DK236781A patent/DK236781A/da not_active Application Discontinuation
- 1981-05-29 JP JP56081284A patent/JPS5750988A/ja active Pending
- 1981-05-29 IE IE1209/81A patent/IE51776B1/en unknown
- 1981-06-08 ES ES502848A patent/ES8300747A1/es not_active Expired
- 1981-06-12 AR AR285704A patent/AR229470A1/es active
- 1981-07-08 AU AU72650/81A patent/AU539442B2/en not_active Ceased
- 1981-07-15 HU HU812076A patent/HU187338B/hu unknown
- 1981-07-27 PT PT73435A patent/PT73435B/pt unknown
- 1981-08-04 FI FI812418A patent/FI68622C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3034005A1 (de) | 1982-05-06 |
| ZA813637B (en) | 1982-06-30 |
| FI812418L (fi) | 1982-03-11 |
| PT73435B (en) | 1982-10-08 |
| ES502848A0 (es) | 1982-11-01 |
| EP0047358A1 (en) | 1982-03-17 |
| CA1164862A (en) | 1984-04-03 |
| DE3034005C2 (de) | 1982-12-09 |
| AU7265081A (en) | 1982-03-18 |
| YU135081A (en) | 1984-02-29 |
| PT73435A (en) | 1981-08-01 |
| EP0047358B1 (en) | 1984-09-19 |
| IE811209L (en) | 1982-03-10 |
| AU539442B2 (en) | 1984-09-27 |
| HU187338B (en) | 1985-12-28 |
| FI68622B (fi) | 1985-06-28 |
| AR229470A1 (es) | 1983-08-31 |
| ATE9470T1 (de) | 1984-10-15 |
| JPS5750988A (en) | 1982-03-25 |
| IE51776B1 (en) | 1987-04-01 |
| ES8300747A1 (es) | 1982-11-01 |
| DK236781A (da) | 1982-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: A. NATTERMANN & CIE. G.M.B.H |