FI67663C - Foerfarande foer framstaellning av inhalerbara mjuka dinatriumkromoglykatgranulater - Google Patents
Foerfarande foer framstaellning av inhalerbara mjuka dinatriumkromoglykatgranulater Download PDFInfo
- Publication number
- FI67663C FI67663C FI770070A FI770070A FI67663C FI 67663 C FI67663 C FI 67663C FI 770070 A FI770070 A FI 770070A FI 770070 A FI770070 A FI 770070A FI 67663 C FI67663 C FI 67663C
- Authority
- FI
- Finland
- Prior art keywords
- granules
- spheres
- soft
- drug
- water
- Prior art date
Links
- 239000008187 granular material Substances 0.000 claims description 79
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- 239000002245 particle Substances 0.000 claims description 25
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims description 20
- 229960000265 cromoglicic acid Drugs 0.000 claims description 18
- 230000009467 reduction Effects 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 230000004044 response Effects 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 4
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229940047135 glycate Drugs 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 description 40
- 229940079593 drug Drugs 0.000 description 38
- 239000002775 capsule Substances 0.000 description 18
- 239000000843 powder Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 14
- 239000004615 ingredient Substances 0.000 description 10
- 239000000126 substance Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 239000002002 slurry Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 5
- 238000007664 blowing Methods 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000005054 agglomeration Methods 0.000 description 4
- 230000002776 aggregation Effects 0.000 description 4
- 239000007903 gelatin capsule Substances 0.000 description 4
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000001694 spray drying Methods 0.000 description 3
- 239000000969 carrier Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 238000005243 fluidization Methods 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 208000035126 Facies Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- -1 e.g. Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB260676 | 1976-01-23 | ||
| GB260676A GB1569611A (en) | 1976-01-23 | 1976-01-23 | Pelletised or granular medicament formulation |
| GB260876 | 1976-01-23 | ||
| GB260876 | 1976-01-23 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI770070A7 FI770070A7 (enrdf_load_stackoverflow) | 1977-07-24 |
| FI67663B FI67663B (fi) | 1985-01-31 |
| FI67663C true FI67663C (fi) | 1985-05-10 |
Family
ID=26237614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI770070A FI67663C (fi) | 1976-01-23 | 1977-01-11 | Foerfarande foer framstaellning av inhalerbara mjuka dinatriumkromoglykatgranulater |
Country Status (12)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0072046B1 (en) * | 1981-07-24 | 1986-01-15 | FISONS plc | Inhalation drugs, methods for their production and pharmaceutical formulations containing them |
| US6102036A (en) * | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
| NZ752946A (en) | 2016-12-08 | 2025-03-28 | Scherer Technologies Llc R P | A method to relieve stress in capsule shells to reduce propensity to break |
-
1977
- 1977-01-05 IE IE14/77A patent/IE45260B1/en not_active IP Right Cessation
- 1977-01-11 FI FI770070A patent/FI67663C/fi not_active IP Right Cessation
- 1977-01-20 ZA ZA770327A patent/ZA77327B/xx unknown
- 1977-01-20 FR FR7701501A patent/FR2361104A2/fr active Granted
- 1977-01-21 LU LU76618A patent/LU76618A1/xx unknown
- 1977-01-21 NO NO770198A patent/NO148542C/no unknown
- 1977-01-21 CA CA000270236A patent/CA1116516A/en not_active Expired
- 1977-01-21 SE SE7700665A patent/SE442950B/xx not_active IP Right Cessation
- 1977-01-21 DK DK27177A patent/DK27177A/da not_active Application Discontinuation
- 1977-01-22 ES ES455273A patent/ES455273A1/es not_active Expired
- 1977-01-24 AU AU21589/77A patent/AU506878B2/en not_active Ceased
- 1977-01-24 JP JP597877A patent/JPS5294413A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ZA77327B (en) | 1977-12-28 |
| ES455273A1 (es) | 1978-04-01 |
| DK27177A (da) | 1977-07-24 |
| NO148542B (no) | 1983-07-25 |
| FI770070A7 (enrdf_load_stackoverflow) | 1977-07-24 |
| IE45260L (en) | 1977-07-23 |
| NO770198L (no) | 1977-07-26 |
| AU506878B2 (en) | 1980-01-24 |
| SE7700665L (sv) | 1977-07-24 |
| AU2158977A (en) | 1978-08-03 |
| CA1116516A (en) | 1982-01-19 |
| FI67663B (fi) | 1985-01-31 |
| LU76618A1 (enrdf_load_stackoverflow) | 1977-08-12 |
| FR2361104B2 (enrdf_load_stackoverflow) | 1982-09-17 |
| NO148542C (no) | 1983-11-02 |
| SE442950B (sv) | 1986-02-10 |
| IE45260B1 (en) | 1982-07-28 |
| FR2361104A2 (fr) | 1978-03-10 |
| JPS5294413A (en) | 1977-08-09 |
| JPS6228124B2 (enrdf_load_stackoverflow) | 1987-06-18 |
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| FI67663C (fi) | Foerfarande foer framstaellning av inhalerbara mjuka dinatriumkromoglykatgranulater | |
| EP1014955B1 (en) | New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising terbutaline sulphate, a process for preparing the formulation and the use thereof | |
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| DE2702504A1 (de) | Arzneimittel in weicher tabletten- oder koernerform | |
| JPH0142950B2 (enrdf_load_stackoverflow) | ||
| GB1569612A (en) | Disodium cromoglycate pellets or granules | |
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| GB1569613A (en) | Disodium cromoglycate in a form |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired | ||
| MA | Patent expired |
Owner name: FISONS LIMITED |