FI65064C - Foerfarande foer framstaellning av terapeutiskt verkande 2-(2-substituerad metyl)-2'-hydroxi-5,9-dimetyl-6,9-benzomorfaneroch deras syraadditionssalter - Google Patents

Foerfarande foer framstaellning av terapeutiskt verkande 2-(2-substituerad metyl)-2'-hydroxi-5,9-dimetyl-6,9-benzomorfaneroch deras syraadditionssalter Download PDF

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Publication number
FI65064C
FI65064C FI792005A FI792005A FI65064C FI 65064 C FI65064 C FI 65064C FI 792005 A FI792005 A FI 792005A FI 792005 A FI792005 A FI 792005A FI 65064 C FI65064 C FI 65064C
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FI
Finland
Prior art keywords
hydroxy
dimethyl
methyl
benzomorphane
mol
Prior art date
Application number
FI792005A
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English (en)
Finnish (fi)
Other versions
FI792005A (fi
FI65064B (fi
Inventor
Herbert Merz
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
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Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of FI792005A publication Critical patent/FI792005A/fi
Application granted granted Critical
Publication of FI65064B publication Critical patent/FI65064B/fi
Publication of FI65064C publication Critical patent/FI65064C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI792005A 1978-06-26 1979-06-25 Foerfarande foer framstaellning av terapeutiskt verkande 2-(2-substituerad metyl)-2'-hydroxi-5,9-dimetyl-6,9-benzomorfaneroch deras syraadditionssalter FI65064C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2828039 1978-06-26
DE19782828039 DE2828039A1 (de) 1978-06-26 1978-06-26 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung

Publications (3)

Publication Number Publication Date
FI792005A FI792005A (fi) 1979-12-27
FI65064B FI65064B (fi) 1983-11-30
FI65064C true FI65064C (fi) 1984-03-12

Family

ID=6042819

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792005A FI65064C (fi) 1978-06-26 1979-06-25 Foerfarande foer framstaellning av terapeutiskt verkande 2-(2-substituerad metyl)-2'-hydroxi-5,9-dimetyl-6,9-benzomorfaneroch deras syraadditionssalter

Country Status (19)

Country Link
US (1) US4293556A (ko)
EP (1) EP0006449B1 (ko)
JP (1) JPS5513278A (ko)
AT (1) ATE1947T1 (ko)
AU (1) AU518470B2 (ko)
CA (1) CA1107280A (ko)
DE (2) DE2828039A1 (ko)
DK (1) DK156719C (ko)
ES (1) ES481873A1 (ko)
FI (1) FI65064C (ko)
GR (1) GR69233B (ko)
IE (1) IE48430B1 (ko)
IL (1) IL57648A (ko)
MX (1) MX5680E (ko)
NO (1) NO149888C (ko)
NZ (1) NZ190816A (ko)
PH (1) PH15864A (ko)
PT (1) PT69823A (ko)
ZA (1) ZA793150B (ko)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
GB2144639B (en) * 1983-08-11 1986-10-15 Edward Carden Jetting tube for use in micro-laryngeal surgery
JPS61294094A (ja) * 1985-06-24 1986-12-24 東洋ベントナイト株式会社 シ−ルド堀進に於ける裏込補助工法
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
JPH05312414A (ja) * 1992-05-12 1993-11-22 Yukimatsu Fujimoto 集熱器二段の太陽熱温水器
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
DE19740110A1 (de) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
JP5470557B2 (ja) 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
CL2008003407A1 (es) 2007-11-16 2010-01-11 Boehringer Ingelheim Int Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
CA2715290A1 (en) 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8138178B2 (en) 2008-05-01 2012-03-20 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AR071719A1 (es) 2008-05-13 2010-07-07 Boehringer Ingelheim Int Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
UY33001A (es) 2009-11-06 2011-05-31 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
WO2013025664A1 (en) 2011-08-17 2013-02-21 Boehringer Ingelheim International Gmbh Indenopyridine derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3417094A (en) * 1965-05-05 1968-12-17 Geigy Chem Corp Optically active 1,2,3,4,5,6-hexahydro-6-phenyl - 2,6 - methano - 3 - benzazocines an
US3499906A (en) * 1966-05-20 1970-03-10 Merck & Co Inc 5,9-diethyl-2'-hydroxy-2-substituted-6,7-benzomorphans
NL132138C (ko) * 1966-05-20
BR6914879D0 (pt) * 1969-01-23 1973-02-08 Merck & Co Inc Processos quimicos
JPS55383B2 (ko) * 1971-09-13 1980-01-08
US4020164A (en) * 1972-06-30 1977-04-26 Schering Aktiengesellschaft Benzomorphan derivatives
DE2233088A1 (de) * 1972-06-30 1974-01-17 Schering Ag Benzomorphanderivate
DE2411382C3 (de) * 1974-03-09 1979-09-06 C.H. Boehringer Sohn, 6507 Ingelheim 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates

Also Published As

Publication number Publication date
DK156719B (da) 1989-09-25
IE48430B1 (en) 1985-01-23
ES481873A1 (es) 1980-02-16
DK156719C (da) 1990-02-19
NZ190816A (en) 1980-11-28
EP0006449A1 (de) 1980-01-09
JPS5513278A (en) 1980-01-30
AU518470B2 (en) 1981-10-01
NO149888C (no) 1984-07-11
NO149888B (no) 1984-04-02
MX5680E (es) 1983-12-08
JPH0159271B2 (ko) 1989-12-15
FI792005A (fi) 1979-12-27
US4293556A (en) 1981-10-06
FI65064B (fi) 1983-11-30
DE2828039A1 (de) 1980-01-10
NO792119L (no) 1979-12-28
CA1107280A (en) 1981-08-18
IE791189L (en) 1979-12-26
PH15864A (en) 1983-04-13
EP0006449B1 (de) 1982-12-08
PT69823A (de) 1979-07-01
DE2964196D1 (en) 1983-01-13
IL57648A (en) 1984-01-31
IL57648A0 (en) 1979-10-31
AU4832779A (en) 1980-01-03
ZA793150B (en) 1981-03-25
ATE1947T1 (de) 1982-12-15
DK266179A (da) 1979-12-27
GR69233B (ko) 1982-05-10

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Owner name: C.H. BOEHRINGER SOHN