FI61702C - Foerfarande foer framstaellning av 12-(1-metyl-4-piperidyliden)-12h-benso(a)xanten med antipsykotisk verkan - Google Patents
Foerfarande foer framstaellning av 12-(1-metyl-4-piperidyliden)-12h-benso(a)xanten med antipsykotisk verkan Download PDFInfo
- Publication number
- FI61702C FI61702C FI772960A FI772960A FI61702C FI 61702 C FI61702 C FI 61702C FI 772960 A FI772960 A FI 772960A FI 772960 A FI772960 A FI 772960A FI 61702 C FI61702 C FI 61702C
- Authority
- FI
- Finland
- Prior art keywords
- benzo
- acid
- piperidylidene
- methyl
- formula
- Prior art date
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- -1 1-METHYL-4-PIPERIDYLIDENE Chemical class 0.000 title claims description 15
- 238000000034 method Methods 0.000 title claims description 9
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- 238000002360 preparation method Methods 0.000 claims description 4
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- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- 210000001009 nucleus accumben Anatomy 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- DIVDFFZHCJEHGG-UHFFFAOYSA-N oxidopamine Chemical compound NCCC1=CC(O)=C(O)C=C1O DIVDFFZHCJEHGG-UHFFFAOYSA-N 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical class C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 230000001144 postural effect Effects 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000003340 retarding agent Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229960002324 trifluoperazine Drugs 0.000 description 1
- ZEWQUBUPAILYHI-UHFFFAOYSA-N trifluoperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 ZEWQUBUPAILYHI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/731,254 US4073912A (en) | 1976-10-12 | 1976-10-12 | Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof |
| US73125476 | 1976-10-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI772960A FI772960A (fi) | 1978-04-13 |
| FI61702B FI61702B (fi) | 1982-05-31 |
| FI61702C true FI61702C (fi) | 1982-09-10 |
Family
ID=24938741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI772960A FI61702C (fi) | 1976-10-12 | 1977-10-07 | Foerfarande foer framstaellning av 12-(1-metyl-4-piperidyliden)-12h-benso(a)xanten med antipsykotisk verkan |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4073912A (no) |
| JP (1) | JPS5346982A (no) |
| AR (1) | AR218465A1 (no) |
| AT (1) | AT358583B (no) |
| AU (1) | AU515264B2 (no) |
| BE (1) | BE859567A (no) |
| CA (1) | CA1102807A (no) |
| CH (1) | CH637132A5 (no) |
| DE (1) | DE2745742A1 (no) |
| DK (1) | DK445877A (no) |
| ES (1) | ES462975A1 (no) |
| FI (1) | FI61702C (no) |
| FR (1) | FR2367761A1 (no) |
| GB (1) | GB1588337A (no) |
| HU (1) | HU175304B (no) |
| IE (1) | IE45884B1 (no) |
| IL (1) | IL53065A (no) |
| IT (1) | IT1088097B (no) |
| LU (1) | LU78283A1 (no) |
| MX (1) | MX4640E (no) |
| NL (1) | NL7711144A (no) |
| NO (1) | NO147523C (no) |
| PH (1) | PH13896A (no) |
| SE (1) | SE430691B (no) |
| ZA (1) | ZA775614B (no) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4285956A (en) * | 1978-05-12 | 1981-08-25 | Kefalas A/S | Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith |
| US5250681A (en) * | 1988-06-02 | 1993-10-05 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| US5393890A (en) * | 1988-06-02 | 1995-02-28 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| CA2004211A1 (en) * | 1988-11-30 | 1990-05-31 | Masataka Syoji | Piperidine derivatives and hyportensives containing the same |
| US4937371A (en) * | 1989-02-21 | 1990-06-26 | Hoffmann-La Roche Inc. | Dihydroxynaphthalene derivatives |
| AU1742492A (en) * | 1991-04-05 | 1992-11-02 | Smithkline Beecham Corporation | Disubstituted naphthalenes |
| ATE236151T1 (de) * | 1995-11-08 | 2003-04-15 | Smithkline Beecham Corp | Ein verfahren zur herstellung von 3-phenyl-1- methylendioxyphenyl-indan-2-carbonsäurederivate |
| IL122072A (en) * | 1996-11-14 | 2001-03-19 | Akzo Nobel Nv | Piperidine derivatives their preparation and pharmaceutical compositions containing them |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL283292A (no) * | 1961-09-29 | |||
| NL6805112A (no) * | 1967-04-27 | 1968-10-28 | ||
| ZA756550B (en) * | 1974-11-06 | 1976-09-29 | Smithkline Corp | Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms |
-
1976
- 1976-10-12 US US05/731,254 patent/US4073912A/en not_active Expired - Lifetime
-
1977
- 1977-09-20 ZA ZA00775614A patent/ZA775614B/xx unknown
- 1977-09-30 GB GB40652/77A patent/GB1588337A/en not_active Expired
- 1977-10-02 MX MX776475U patent/MX4640E/es unknown
- 1977-10-05 JP JP12044077A patent/JPS5346982A/ja active Pending
- 1977-10-05 CA CA288,167A patent/CA1102807A/en not_active Expired
- 1977-10-06 ES ES462975A patent/ES462975A1/es not_active Expired
- 1977-10-06 IL IL53065A patent/IL53065A/xx unknown
- 1977-10-07 FR FR7730215A patent/FR2367761A1/fr active Granted
- 1977-10-07 FI FI772960A patent/FI61702C/fi not_active IP Right Cessation
- 1977-10-07 HU HU77SI1599A patent/HU175304B/hu unknown
- 1977-10-07 IE IE2058/77A patent/IE45884B1/en unknown
- 1977-10-07 DK DK445877A patent/DK445877A/da not_active Application Discontinuation
- 1977-10-07 PH PH20312A patent/PH13896A/en unknown
- 1977-10-10 IT IT28436/77A patent/IT1088097B/it active
- 1977-10-10 AT AT720677A patent/AT358583B/de active
- 1977-10-10 LU LU78283A patent/LU78283A1/xx unknown
- 1977-10-10 SE SE7711383A patent/SE430691B/xx unknown
- 1977-10-11 DE DE19772745742 patent/DE2745742A1/de not_active Withdrawn
- 1977-10-11 AR AR269542A patent/AR218465A1/es active
- 1977-10-11 CH CH1239377A patent/CH637132A5/de not_active IP Right Cessation
- 1977-10-11 BE BE181607A patent/BE859567A/xx not_active IP Right Cessation
- 1977-10-11 AU AU29573/77A patent/AU515264B2/en not_active Expired
- 1977-10-11 NO NO773472A patent/NO147523C/no unknown
- 1977-10-11 NL NL7711144A patent/NL7711144A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES462975A1 (es) | 1978-12-16 |
| MX4640E (es) | 1982-07-14 |
| HU175304B (hu) | 1980-06-28 |
| JPS5346982A (en) | 1978-04-27 |
| PH13896A (en) | 1980-10-27 |
| BE859567A (fr) | 1978-04-11 |
| NO147523B (no) | 1983-01-17 |
| AR218465A1 (es) | 1980-06-13 |
| FR2367761A1 (fr) | 1978-05-12 |
| AU515264B2 (en) | 1981-03-26 |
| IT1088097B (it) | 1985-06-04 |
| ZA775614B (en) | 1978-08-30 |
| ATA720677A (de) | 1980-02-15 |
| DK445877A (da) | 1978-04-13 |
| FI61702B (fi) | 1982-05-31 |
| NO773472L (no) | 1978-04-13 |
| SE430691B (sv) | 1983-12-05 |
| IL53065A (en) | 1982-03-31 |
| IE45884L (en) | 1978-04-12 |
| NL7711144A (nl) | 1978-04-14 |
| DE2745742A1 (de) | 1978-04-13 |
| IE45884B1 (en) | 1982-12-29 |
| IL53065A0 (en) | 1977-12-30 |
| GB1588337A (en) | 1981-04-23 |
| FI772960A (fi) | 1978-04-13 |
| US4073912A (en) | 1978-02-14 |
| AT358583B (de) | 1980-09-25 |
| LU78283A1 (no) | 1978-01-23 |
| CA1102807A (en) | 1981-06-09 |
| NO147523C (no) | 1983-04-27 |
| FR2367761B1 (no) | 1980-06-20 |
| AU2957377A (en) | 1979-04-26 |
| CH637132A5 (de) | 1983-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: SMITHKLINE CORPORATION |