FI56823C - Foerfarande foer framstaellning av fenylaminoetanolderivat - Google Patents

Foerfarande foer framstaellning av fenylaminoetanolderivat Download PDF

Info

Publication number
FI56823C
FI56823C FI1389/71A FI138971A FI56823C FI 56823 C FI56823 C FI 56823C FI 1389/71 A FI1389/71 A FI 1389/71A FI 138971 A FI138971 A FI 138971A FI 56823 C FI56823 C FI 56823C
Authority
FI
Finland
Prior art keywords
formaldehyde
benzyl
process according
preparation
borate
Prior art date
Application number
FI1389/71A
Other languages
English (en)
Finnish (fi)
Other versions
FI56823B (fi
Inventor
Michael Atkinson
David Hartley
Original Assignee
Allen & Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen & Hanburys Ltd filed Critical Allen & Hanburys Ltd
Application granted granted Critical
Publication of FI56823B publication Critical patent/FI56823B/fi
Publication of FI56823C publication Critical patent/FI56823C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (7)

1. Förfarande for framställning av fenylaminoetanolderivat, vilkas allmänna formel är I HOCHg w ^Rl HO -(f H?- CH-CHp-N (I) iH r2 där R betecknar en väteatom eller en benzylgrupp och R,, betecknar en väteatom eller en rakkedj ad eller förgrenad alkylradikal, som innehäller 1-6 kolatomer, eller en ary läikylradikal, kännetecknat därav, att en förening, vars allmänna formel är II f/ \ (k) HO -( V- CH-CHp-N ^ » 2 där R^ och Rg betecknar detsamma som ovan definierades, behandlas med formaldehyd eller med en förening, fr&n vilken bildas formaldehyd, i närvaro av en stark bas och alkalimetallborat, varvid produktet när s& önskas debenzyleras p& i och för sig känt sätt när R är i formeln I benzyl eller om över Rg betecknar benzyl ocksä denna converseras tili väte.
2. Förfarande enligt patentkravet 1,kännetecknat därav, att det ansändes en vattenlösning av formaldehyd.
3. Förfarande enligt patentkravet 1 eller 2,kännetecknat därav, att starka basen är en aikaiimetallhydroxid. U. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att alkalimetallboratet är natriumborat.
5. Förfarande enligt n&got av patentkraven 1-4, kännetecknat därav, att det genomför8 i vattenlösning vid omgivningene temperatur.
6. Förfarande för framställning av e^-(benzyl-tert.-butylaminometyl)-4-hydroxi- m-xylen- , oC^-diol, kännetecknat därav, att (benzyl-tert .-butyl- aminometyl)-4-hydroxi-benzylalkohol omsättes med formaldehyd i närvaro av natriumborat och natriumhydroxid.
FI1389/71A 1970-06-02 1971-05-21 Foerfarande foer framstaellning av fenylaminoetanolderivat FI56823C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB26523/70A GB1298284A (en) 1970-06-02 1970-06-02 Preparation of phenylaminoethanols
GB2652370 1970-06-02

Publications (2)

Publication Number Publication Date
FI56823B FI56823B (fi) 1979-12-31
FI56823C true FI56823C (fi) 1980-04-10

Family

ID=10244972

Family Applications (1)

Application Number Title Priority Date Filing Date
FI1389/71A FI56823C (fi) 1970-06-02 1971-05-21 Foerfarande foer framstaellning av fenylaminoetanolderivat

Country Status (14)

Country Link
JP (1) JPS5216102B1 (sv)
AT (1) AT308724B (sv)
CA (1) CA989418A (sv)
CH (1) CH558329A (sv)
DE (1) DE2127177C3 (sv)
DK (1) DK125388B (sv)
ES (1) ES391800A1 (sv)
FI (1) FI56823C (sv)
GB (1) GB1298284A (sv)
IL (1) IL36836A (sv)
NL (1) NL174040C (sv)
NO (1) NO130312B (sv)
SE (1) SE376764B (sv)
YU (1) YU34979B (sv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118737A (en) * 1975-04-10 1976-10-18 Shionogi & Co Ltd Novel process for preparation of monosubstituted aminobenzylalcohols a t o-n position
US4952729A (en) * 1986-09-05 1990-08-28 Schering-Plough Corp. Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino) methyl)-4-hydroxy-1,3-benzenedimethanol
EP0259159A3 (en) * 1986-09-05 1989-08-09 Schering Corporation Method for the preparation of alpha1- [[(1,1-Dimethylethyl) amino] methyl]-4-hydroxy-1,3-benzenedimethanol, and intermediates used in its preparation

Also Published As

Publication number Publication date
FI56823B (fi) 1979-12-31
YU34979B (en) 1980-06-30
YU127171A (en) 1979-12-31
NL174040C (nl) 1984-04-16
DE2127177C3 (de) 1981-01-29
DK125388B (da) 1973-02-12
CH558329A (de) 1975-01-31
SE376764B (sv) 1975-06-09
NO130312B (sv) 1974-08-12
AT308724B (de) 1973-07-25
NL7107588A (sv) 1971-12-06
GB1298284A (en) 1972-11-29
CA989418A (en) 1976-05-18
JPS5216102B1 (sv) 1977-05-06
NL174040B (nl) 1983-11-16
DE2127177A1 (de) 1971-12-09
DE2127177B2 (de) 1980-05-22
ES391800A1 (es) 1974-11-01
IL36836A (en) 1973-07-30
IL36836A0 (en) 1971-07-28

Similar Documents

Publication Publication Date Title
KR850001229A (ko) 4'-탈메틸-4-에피포도필로톡신 유도체의 제조방법
HU186760B (en) Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
NZ197041A (en) Substituted phenyl ethers and pharmaceutical compositions containing them
KR850008166A (ko) 인돌린 및 2-인돌리논 유도체의 제조방법
FI56823C (fi) Foerfarande foer framstaellning av fenylaminoetanolderivat
GB1059256A (en) Fluorescent, practically colourless, benzimidazole and benzoxazole derivatives
GB1418287A (en) 1-ethyl-trizoles process for their preparation and their use as fungicides
US4294972A (en) 1,2-Disubstituted oxo triazolidine
GB1399235A (en) N-sulphenylated n-methylcarbamidoximes process for their preparation and their use as insecticides acaricides or fungicides
US2695290A (en) Derivatives of indole and method for the production thereof
IL39672A (en) Pyrimidine derivatives and their preparation
GB1320031A (en) Process for the manufacture of imidazole derivatives
ATE102211T1 (de) Verfahren zur herstellung von nphosphonomethylglycin.
US3867455A (en) Preparation of phenylaminoethanols
ES2029830T3 (es) Un procedimiento para preparar un derivado de 6-cetoprostaglandina e1.
US3290332A (en) 6, 7-dihydroindoles and derivatives thereof
GB1398066A (en) Quinoline derivatives
US3725437A (en) Process for the preparation of {60 -hydroxy-{62 -phenypropionic acid derivatives and alkalimetal-or ammonium salts thereof
GB1589883A (en) 7-aminocephalosporin derivatives
US1866956A (en) Phenyl-indol-sulphonic acids
SU466683A3 (ru) Способ получени производных 5-аминометил-(оксазино-(5,6,-е)индолов)
US2573607A (en) Hydroxyalkyl fluorenyl amines
SU117044A1 (ru) Способ получени 1-фенил-2, 3 диметил-4-диметиламинопиразолона-5 (пирамидона)
GB1478203A (en) Derivatives of pyrazolidine method for their manufacture and medicaments containing these derivatives
US3808204A (en) 1-((5-nitrofurfurylidene)amino)hexahydrobenzimidazol-2(3h)-one