FI4010082T3 - Multispesifisiä vaihtelevan tcr-deltaketjun 1 vastaisia vasta-aineita - Google Patents
Multispesifisiä vaihtelevan tcr-deltaketjun 1 vastaisia vasta-aineita Download PDFInfo
- Publication number
- FI4010082T3 FI4010082T3 FIEP21756070.5T FI21756070T FI4010082T3 FI 4010082 T3 FI4010082 T3 FI 4010082T3 FI 21756070 T FI21756070 T FI 21756070T FI 4010082 T3 FI4010082 T3 FI 4010082T3
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- Finland
- Prior art keywords
- fragment
- multispecific antibody
- epitope
- antibody
- multispecific
- Prior art date
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- 239000012634 fragment Substances 0.000 claims 20
- 108091008874 T cell receptors Proteins 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 3
- 230000000422 nocturnal effect Effects 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 1
- -1 FAPa Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101001023379 Homo sapiens Lysosome-associated membrane glycoprotein 1 Proteins 0.000 claims 1
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 claims 1
- 102000003735 Mesothelin Human genes 0.000 claims 1
- 108090000015 Mesothelin Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 108700041286 delta Proteins 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000003828 downregulation Effects 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 230000009258 tissue cross reactivity Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Claims (15)
1. Multispesifinen vasta-aine tai sen fragmentti, joka sitoutuu spesifisesti a. ensimmäiseen kohde-epitooppiin, jolloin ensimmäinen kohde-epitooppi on yö- T-solureseptorin (TCR) vaihtelevan delta 1 (V81) -ketjun epitooppi; ja b. toiseen kohde-epitooppiin, jolloin toinen epitooppi valitaan ryhmästä, jonka muodostavat CD19:n, Her2:n (CD340), EGFR:n, FAPa:n, mesoteliinin, PD-1:n, 4- 1 BB:n, OX40:n ja TIGIT:n epitooppi.
2. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen fragmentti, jossa ensimmäinen kohde-epitooppi on epitooppi, joka käsittää yhden tai useamman aminohappotähteen aminohappoalueilla (i) 3-20 sekvenssissä SEQ ID NO: 1 ja/tai (ii) 37—77 sekvenssissä SEQ ID NO: 1.
3. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen fragmentti, jossa ensimmäinen kohde-epitooppi on yö-T-solun aktivoiva epitooppi.
4. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen antigeeniä sitova fragmentti, jossa aktivoivan epitoopin sitoutuminen (i) alasajaa yö- TCR:ää; (ii) aktivoi yö-T-solun degranulaation ja/tai (iii) edistää yö-T-soluvälitteistä tappamista.
5. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen fragmentti, jossa ensimmäinen kohde-epitooppi on epitooppi, joka ylösajaa CD107a:n, CD25:n, CD69:n ja/tai Ki67:n ilmentymistä.
6. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen — fragmentti, jolloin multispesifinen vasta-aine tai sen fragmentti sitoo ensimmäistä epitooppia sitoutumisaffiniteetilla (KD), joka on pintaplasmoniresonanssilla mitattuna alle 1,5 x 107 M, alle 1,3 x 1077 M, alle 1,0 x 107 M tai alle 5,0 x 10-8 M.
7. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen fragmentti, jolloin vasta-aine on bispesifinen vasta-aine.
8. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen fragmentti, jolloin multispesifinen vasta-aine tai sen fragmentti on ihmisen vasta-aine tai sen antigeeniä sitova fragmentti.
9. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen fragmentti, jolloin multispesifinen vasta-aine tai sen antigeeniä sitova fragmentti on — multispesifinen 1gG-vasta-aine, jolloin mahdollisesti multispesifinen vasta-aine tai sen antigeeniä sitova fragmentti on multispesifinen 1gG1-vasta-aine.
10. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen fragmentti, jolloin multispesifinen vasta-aine on Fc:tä ilmentävä.
11. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen fragmentti, jolloin multispesifinen vasta-aine on tunnettu siitä, että a. se aiheuttaa TCR:ien alasajon V51-T-soluissa b. sillä ei ilmene CDC:tä tai ADCC:tä ja c. se ei tuhoa Vd1-T-soluja.
12. Jonkin edellisen patenttivaatimuksen mukainen multispesifinen vasta-aine tai sen fragmentti, jolloin multispesifinen vasta-aine aiheuttaa alle noin 30 %:n tai alle noin 20 %:n tai alle noin 10 %:n elävien Vö1-T+-solujen populaatiosta tuhoutumisen ADCC:n jaltai CDC:n kautta.
13. Lääkekoostumus, joka käsittää jonkin patenttivaatimuksen 1—12 mukaista multispesifistä vasta-ainetta tai sen fragmenttia ja farmaseuttisesti hyväksyttävää laimennusainetta tai kantoainetta.
14. Jonkin patenttivaatimuksen 1-12 mukainen multispesifinen vasta-aine tai sen fragmentti tai patenttivaatimuksen 13 mukainen lääkekoostumus käytettäväksi menetelmässä, jolla hoidetaan hoidettavan sairautta tai häiriötä.
15. Patenttivaatimuksen 14 mukaisesti käytettävä multispesifinen vasta-aine tai sen fragmentti, jolloin sairaus tai häiriö on syöpä, tartuntatauti tai tulehdussairaus.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2020/051959 WO2021032963A1 (en) | 2019-08-16 | 2020-08-14 | Therapeutic uses of anti-tcr delta variable 1 antibodies |
GBGB2102224.9A GB202102224D0 (en) | 2021-02-17 | 2021-02-17 | Anti-TRC delta variable 1 antibodies |
GBGB2102222.3A GB202102222D0 (en) | 2021-02-17 | 2021-02-17 | Multispecific anti-TCR delta variable 1 antibodies |
PCT/IB2021/057509 WO2022034562A1 (en) | 2020-08-14 | 2021-08-14 | Multispecific anti-tcr delta variable 1 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
FI4010082T3 true FI4010082T3 (fi) | 2023-04-04 |
Family
ID=80247426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FIEP21756070.5T FI4010082T3 (fi) | 2020-08-14 | 2021-08-14 | Multispesifisiä vaihtelevan tcr-deltaketjun 1 vastaisia vasta-aineita |
Country Status (18)
Country | Link |
---|---|
EP (7) | EP4218932A3 (fi) |
JP (1) | JP2023537534A (fi) |
KR (1) | KR20230083267A (fi) |
CN (1) | CN116209456A (fi) |
AU (1) | AU2021323512A1 (fi) |
BR (1) | BR112023002741A2 (fi) |
CA (1) | CA3188682A1 (fi) |
CO (1) | CO2023003009A2 (fi) |
DK (1) | DK4010082T3 (fi) |
ES (1) | ES2943063T3 (fi) |
FI (1) | FI4010082T3 (fi) |
IL (1) | IL300517A (fi) |
LT (1) | LT4010082T (fi) |
MX (1) | MX2023001728A (fi) |
PL (1) | PL4010082T3 (fi) |
PT (1) | PT4010082T (fi) |
SI (1) | SI4010082T1 (fi) |
WO (1) | WO2022034562A1 (fi) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116209456A (zh) | 2020-08-14 | 2023-06-02 | 伽马三角洲疗法有限公司 | 多特异性抗TCRδ可变1抗体 |
WO2023250485A1 (en) * | 2022-06-23 | 2023-12-28 | LAVA Therapeutics N.V. | Assay for t cell dependent multispecific compounds |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2546268A1 (en) | 2011-07-13 | 2013-01-16 | F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. | Internalising immunoglobulin |
WO2015063069A1 (en) * | 2013-10-28 | 2015-05-07 | Benjamin Felder | Chimeric antigen receptors with antigen binding domains derived from gamma delta t cell receptors |
GB201506423D0 (en) * | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
EP3307875B1 (en) | 2015-06-09 | 2021-12-15 | Lymphact - Lymphocyte Activation Technologies, S.A. | Methods for the production of tcr gamma delta+ t cells |
MY198084A (en) | 2015-10-30 | 2023-07-31 | Cancer Research Tech Ltd | Expansion of non-haematopoietic tissue-resident ()()t cells and uses of these cells |
KR102519861B1 (ko) | 2016-05-12 | 2023-04-10 | 아디셋 바이오, 인크. | γδ T-세포 집단의 선택적 확장을 위한 방법 및 그의 조성물 |
GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
EP3490675A4 (en) | 2016-07-29 | 2020-07-29 | New York University | T GAMMA DELTA LYMPHOCYTES USED AS A TARGET FOR THE TREATMENT OF SOLID TUMORS |
US10546518B2 (en) | 2017-05-15 | 2020-01-28 | Google Llc | Near-eye display with extended effective eyebox via eye tracking |
JP7356970B2 (ja) | 2017-06-25 | 2023-10-05 | システィミューン, インク. | 多重特異性抗体とその作製及び使用方法 |
EP3743081A4 (en) | 2018-01-23 | 2021-12-01 | New York University | SPECIFIC ANTIBODIES OF THE DELTA 1 CHAIN OF THE T-LYMPHOCYTE RECEPTOR |
US20210371525A1 (en) * | 2018-09-19 | 2021-12-02 | Lava Therapeutics B.V. | Novel bispecific antibodies for use in the treatment of hematological malignancies |
GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
WO2020159368A1 (en) | 2019-02-01 | 2020-08-06 | Lava Therapeutics B.V. | Novel cd40-binding antibodies |
JP2022525435A (ja) | 2019-04-08 | 2022-05-13 | メモリアル スローン ケタリング キャンサー センター | Cd19抗体およびこれを使用する方法 |
CA3145523A1 (en) * | 2019-08-16 | 2021-02-25 | GammaDelta Therapeutics Limited | Therapeutic uses of anti-tcr delta variable 1 antibodies |
US20220290101A1 (en) | 2019-08-16 | 2022-09-15 | GammaDelta Therapeutics Limited | Ex vivo gamma delta t cell populations |
CN116209456A (zh) | 2020-08-14 | 2023-06-02 | 伽马三角洲疗法有限公司 | 多特异性抗TCRδ可变1抗体 |
WO2022175414A1 (en) | 2021-02-17 | 2022-08-25 | Adaptate Biotherapeutics Ltd. | Multispecific anti-tcr delta variable 1 antibodies |
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2021
- 2021-08-14 CN CN202180069269.3A patent/CN116209456A/zh active Pending
- 2021-08-14 EP EP23153152.6A patent/EP4218932A3/en active Pending
- 2021-08-14 SI SI202130032T patent/SI4010082T1/sl unknown
- 2021-08-14 EP EP21756070.5A patent/EP4010082B1/en active Active
- 2021-08-14 EP EP23187270.6A patent/EP4265642B1/en active Active
- 2021-08-14 CA CA3188682A patent/CA3188682A1/en active Pending
- 2021-08-14 IL IL300517A patent/IL300517A/en unknown
- 2021-08-14 EP EP23187272.2A patent/EP4269445B1/en active Active
- 2021-08-14 AU AU2021323512A patent/AU2021323512A1/en active Pending
- 2021-08-14 JP JP2023510439A patent/JP2023537534A/ja active Pending
- 2021-08-14 ES ES21756070T patent/ES2943063T3/es active Active
- 2021-08-14 LT LTEPPCT/IB2021/057509T patent/LT4010082T/lt unknown
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- 2021-08-14 EP EP23187269.8A patent/EP4269444B1/en active Active
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