FI3962534T3 - Proteiineja, joilla on kardioprotektiivinen vaikutus - Google Patents
Proteiineja, joilla on kardioprotektiivinen vaikutus Download PDFInfo
- Publication number
- FI3962534T3 FI3962534T3 FIEP20721637.5T FI20721637T FI3962534T3 FI 3962534 T3 FI3962534 T3 FI 3962534T3 FI 20721637 T FI20721637 T FI 20721637T FI 3962534 T3 FI3962534 T3 FI 3962534T3
- Authority
- FI
- Finland
- Prior art keywords
- fam3c
- polynucleotide
- vector
- use according
- heart disease
- Prior art date
Links
- 230000003293 cardioprotective effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 101150086776 FAM3C gene Proteins 0.000 claims 14
- 239000002157 polynucleotide Substances 0.000 claims 12
- 102000040430 polynucleotide Human genes 0.000 claims 12
- 108091033319 polynucleotide Proteins 0.000 claims 12
- 239000013598 vector Substances 0.000 claims 8
- 208000019622 heart disease Diseases 0.000 claims 6
- 208000010125 myocardial infarction Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000013603 viral vector Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000004413 cardiac myocyte Anatomy 0.000 claims 2
- 238000013146 percutaneous coronary intervention Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 108091006020 Fc-tagged proteins Proteins 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 208000009525 Myocarditis Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000004217 heart function Effects 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Marine Sciences & Fisheries (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1906052.4A GB201906052D0 (en) | 2019-04-30 | 2019-04-30 | Proteins with cardioprotective activity |
| PCT/EP2020/062156 WO2020221906A1 (en) | 2019-04-30 | 2020-04-30 | Proteins with cardioprotective activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3962534T3 true FI3962534T3 (fi) | 2024-04-17 |
Family
ID=66589570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP20721637.5T FI3962534T3 (fi) | 2019-04-30 | 2020-04-30 | Proteiineja, joilla on kardioprotektiivinen vaikutus |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US12569574B2 (https=) |
| EP (2) | EP4389211A3 (https=) |
| JP (2) | JP7707075B2 (https=) |
| KR (1) | KR20220027829A (https=) |
| CN (2) | CN113795504B (https=) |
| AU (1) | AU2020267029A1 (https=) |
| BR (1) | BR112021021626A2 (https=) |
| CA (1) | CA3137662A1 (https=) |
| DK (1) | DK3962534T3 (https=) |
| ES (1) | ES2975422T3 (https=) |
| FI (1) | FI3962534T3 (https=) |
| GB (1) | GB201906052D0 (https=) |
| HR (1) | HRP20240441T1 (https=) |
| HU (1) | HUE066324T2 (https=) |
| IL (1) | IL287525A (https=) |
| LT (1) | LT3962534T (https=) |
| MX (2) | MX2021013298A (https=) |
| PL (1) | PL3962534T3 (https=) |
| PT (1) | PT3962534T (https=) |
| RS (1) | RS65469B1 (https=) |
| SG (1) | SG11202111267WA (https=) |
| SI (1) | SI3962534T1 (https=) |
| SM (1) | SMT202400151T1 (https=) |
| WO (1) | WO2020221906A1 (https=) |
| ZA (2) | ZA202107778B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201906052D0 (en) | 2019-04-30 | 2019-06-12 | Int Centre For Genetic Engineering And Biotechnology | Proteins with cardioprotective activity |
| WO2025253097A1 (en) * | 2024-06-03 | 2025-12-11 | Forcefield Therapeutics Limited | Proteins with cardiopreservation activity |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002008284A2 (en) * | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| WO2004084800A2 (en) | 2002-08-29 | 2004-10-07 | Pfizer Products Inc. | A3 receptor-mediated cardioprotective proteins and therapeutic and diagnostic methods of use |
| US7312079B1 (en) * | 2005-10-06 | 2007-12-25 | Lexicon Pharmaceuticals, Inc. | Variants of FAM3C |
| ES2714007T3 (es) | 2007-04-09 | 2019-05-24 | Univ Florida | Composiciones de vectores rAAV que tienen proteínas de la cápside modificadas en tirosina y métodos para su uso |
| WO2011094137A1 (en) * | 2010-01-26 | 2011-08-04 | Ngm Biopharmaceuticals, Inc. | Methods of treating glucose metabolism disorders |
| US8609612B2 (en) | 2010-02-12 | 2013-12-17 | Ngm Biopharmaceuticals, Inc. | Methods of treating glucose metabolism disorders |
| ES2777002T3 (es) | 2011-09-30 | 2020-08-03 | Somalogic Inc | Predicción de eventos de riesgo cardiovascular y usos de la misma |
| ITRM20110685A1 (it) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci |
| EP2981334A4 (en) | 2013-04-03 | 2016-11-23 | Univ California | COMPOSITIONS AND METHODS FOR INHIBITING VIRAL ACTIVITY |
| US20170209621A1 (en) | 2016-01-21 | 2017-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Use of chordin-like 1 or collagen vi with mesenchymal stem cells |
| KR102022021B1 (ko) | 2018-01-10 | 2019-09-18 | 한국과학기술연구원 | 심혈관 질환의 진단을 위한 바이오마커 및 이의 용도 |
| GB201906052D0 (en) | 2019-04-30 | 2019-06-12 | Int Centre For Genetic Engineering And Biotechnology | Proteins with cardioprotective activity |
-
2019
- 2019-04-30 GB GBGB1906052.4A patent/GB201906052D0/en not_active Ceased
-
2020
- 2020-04-30 MX MX2021013298A patent/MX2021013298A/es unknown
- 2020-04-30 AU AU2020267029A patent/AU2020267029A1/en active Pending
- 2020-04-30 SI SI202030402T patent/SI3962534T1/sl unknown
- 2020-04-30 PT PT207216375T patent/PT3962534T/pt unknown
- 2020-04-30 HR HRP20240441TT patent/HRP20240441T1/hr unknown
- 2020-04-30 JP JP2021564417A patent/JP7707075B2/ja active Active
- 2020-04-30 ES ES20721637T patent/ES2975422T3/es active Active
- 2020-04-30 SM SM20240151T patent/SMT202400151T1/it unknown
- 2020-04-30 EP EP24157959.8A patent/EP4389211A3/en active Pending
- 2020-04-30 CN CN202080032910.1A patent/CN113795504B/zh active Active
- 2020-04-30 FI FIEP20721637.5T patent/FI3962534T3/fi active
- 2020-04-30 US US17/606,080 patent/US12569574B2/en active Active
- 2020-04-30 WO PCT/EP2020/062156 patent/WO2020221906A1/en not_active Ceased
- 2020-04-30 RS RS20240413A patent/RS65469B1/sr unknown
- 2020-04-30 HU HUE20721637A patent/HUE066324T2/hu unknown
- 2020-04-30 SG SG11202111267WA patent/SG11202111267WA/en unknown
- 2020-04-30 CN CN202510498600.3A patent/CN120518738A/zh active Pending
- 2020-04-30 BR BR112021021626A patent/BR112021021626A2/pt unknown
- 2020-04-30 KR KR1020217038850A patent/KR20220027829A/ko not_active Ceased
- 2020-04-30 DK DK20721637.5T patent/DK3962534T3/da active
- 2020-04-30 PL PL20721637.5T patent/PL3962534T3/pl unknown
- 2020-04-30 CA CA3137662A patent/CA3137662A1/en active Pending
- 2020-04-30 EP EP20721637.5A patent/EP3962534B1/en active Active
- 2020-04-30 LT LTEPPCT/EP2020/062156T patent/LT3962534T/lt unknown
-
2021
- 2021-10-13 ZA ZA2021/07778A patent/ZA202107778B/en unknown
- 2021-10-24 IL IL287525A patent/IL287525A/en unknown
- 2021-10-29 MX MX2026002607A patent/MX2026002607A/es unknown
-
2022
- 2022-08-16 US US17/820,243 patent/US12121594B2/en active Active
-
2023
- 2023-10-12 ZA ZA2023/09540A patent/ZA202309540B/en unknown
-
2024
- 2024-09-06 US US18/827,357 patent/US20250057982A1/en active Pending
-
2025
- 2025-02-27 JP JP2025029903A patent/JP2025107171A/ja active Pending
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