GB201906052D0 - Proteins with cardioprotective activity - Google Patents

Proteins with cardioprotective activity

Info

Publication number
GB201906052D0
GB201906052D0 GBGB1906052.4A GB201906052A GB201906052D0 GB 201906052 D0 GB201906052 D0 GB 201906052D0 GB 201906052 A GB201906052 A GB 201906052A GB 201906052 D0 GB201906052 D0 GB 201906052D0
Authority
GB
United Kingdom
Prior art keywords
proteins
cardioprotective activity
cardioprotective
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1906052.4A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Int Centre For Genetic Engineering And Biotechnology
International Centre for Genetic Engineering and Biotechnology
Original Assignee
Int Centre For Genetic Engineering And Biotechnology
International Centre for Genetic Engineering and Biotechnology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Int Centre For Genetic Engineering And Biotechnology, International Centre for Genetic Engineering and Biotechnology filed Critical Int Centre For Genetic Engineering And Biotechnology
Priority to GBGB1906052.4A priority Critical patent/GB201906052D0/en
Publication of GB201906052D0 publication Critical patent/GB201906052D0/en
Priority to KR1020217038850A priority patent/KR20220027829A/ko
Priority to PT207216375T priority patent/PT3962534T/pt
Priority to HUE20721637A priority patent/HUE066324T2/hu
Priority to HRP20240441TT priority patent/HRP20240441T1/hr
Priority to PL20721637.5T priority patent/PL3962534T3/pl
Priority to SI202030402T priority patent/SI3962534T1/sl
Priority to RS20240413A priority patent/RS65469B1/sr
Priority to FIEP20721637.5T priority patent/FI3962534T3/fi
Priority to SG11202111267WA priority patent/SG11202111267WA/en
Priority to SM20240151T priority patent/SMT202400151T1/it
Priority to BR112021021626A priority patent/BR112021021626A2/pt
Priority to DK20721637.5T priority patent/DK3962534T3/da
Priority to EP24157959.8A priority patent/EP4389211A3/en
Priority to EP20721637.5A priority patent/EP3962534B1/en
Priority to MX2021013298A priority patent/MX2021013298A/es
Priority to PCT/EP2020/062156 priority patent/WO2020221906A1/en
Priority to ES20721637T priority patent/ES2975422T3/es
Priority to CN202510498600.3A priority patent/CN120518738A/zh
Priority to CA3137662A priority patent/CA3137662A1/en
Priority to LTEPPCT/EP2020/062156T priority patent/LT3962534T/lt
Priority to AU2020267029A priority patent/AU2020267029A1/en
Priority to JP2021564417A priority patent/JP7707075B2/ja
Priority to CN202080032910.1A priority patent/CN113795504B/zh
Priority to US17/606,080 priority patent/US12569574B2/en
Priority to ZA2021/07778A priority patent/ZA202107778B/en
Priority to IL287525A priority patent/IL287525A/en
Priority to MX2026002607A priority patent/MX2026002607A/es
Priority to US17/820,243 priority patent/US12121594B2/en
Priority to ZA2023/09540A priority patent/ZA202309540B/en
Priority to US18/827,357 priority patent/US20250057982A1/en
Priority to JP2025029903A priority patent/JP2025107171A/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
GBGB1906052.4A 2019-04-30 2019-04-30 Proteins with cardioprotective activity Ceased GB201906052D0 (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
GBGB1906052.4A GB201906052D0 (en) 2019-04-30 2019-04-30 Proteins with cardioprotective activity
US17/606,080 US12569574B2 (en) 2019-04-30 2020-04-30 Proteins with cardioprotective activity
EP20721637.5A EP3962534B1 (en) 2019-04-30 2020-04-30 Proteins with cardioprotective activity
MX2021013298A MX2021013298A (es) 2019-04-30 2020-04-30 Proteinas con actividad cardioprotectora.
HUE20721637A HUE066324T2 (hu) 2019-04-30 2020-04-30 Fehérjék kardioprotektív aktivitással
HRP20240441TT HRP20240441T1 (hr) 2019-04-30 2020-04-30 Proteini s kardioprotektivnim djelovanjem
PL20721637.5T PL3962534T3 (pl) 2019-04-30 2020-04-30 Białka o działaniu kardioprotekcyjnym
SI202030402T SI3962534T1 (sl) 2019-04-30 2020-04-30 Proteini s kardioprotektivnim delovanjem
RS20240413A RS65469B1 (sr) 2019-04-30 2020-04-30 Proteini sa kardioprotektivnim dejstvom
FIEP20721637.5T FI3962534T3 (fi) 2019-04-30 2020-04-30 Proteiineja, joilla on kardioprotektiivinen vaikutus
ES20721637T ES2975422T3 (es) 2019-04-30 2020-04-30 Proteínas con actividad cardioprotectora
SM20240151T SMT202400151T1 (it) 2019-04-30 2020-04-30 Proteine con attività cardioprotettiva
BR112021021626A BR112021021626A2 (pt) 2019-04-30 2020-04-30 Proteína selecionada a partir do grupo que consiste em chrdll, fam3c, fam3b e fragmentos da mesma ou um polinucleotídeo que codifica a mesma, proteína ou polinucleotídeo para uso, vetor para uso no tratamento ou redução do risco de doença cardíaca, e, composição farmacêutica
DK20721637.5T DK3962534T3 (da) 2019-04-30 2020-04-30 Proteiner med kardioprotektiv aktivitet
EP24157959.8A EP4389211A3 (en) 2019-04-30 2020-04-30 Proteins with cardioprotective activity
KR1020217038850A KR20220027829A (ko) 2019-04-30 2020-04-30 심장보호 활성 갖는 단백질
PCT/EP2020/062156 WO2020221906A1 (en) 2019-04-30 2020-04-30 Proteins with cardioprotective activity
CN202510498600.3A CN120518738A (zh) 2019-04-30 2020-04-30 具有心脏保护活性的蛋白质
SG11202111267WA SG11202111267WA (en) 2019-04-30 2020-04-30 Proteins with cardioprotective activity
PT207216375T PT3962534T (pt) 2019-04-30 2020-04-30 Proteínas com atividade cardioprotetora
CA3137662A CA3137662A1 (en) 2019-04-30 2020-04-30 Proteins with cardioprotective activity
LTEPPCT/EP2020/062156T LT3962534T (lt) 2019-04-30 2020-04-30 Kardioapsauginiu poveikiu pasižymintys baltymai
AU2020267029A AU2020267029A1 (en) 2019-04-30 2020-04-30 Proteins with cardioprotective activity
JP2021564417A JP7707075B2 (ja) 2019-04-30 2020-04-30 心臓保護的活性のあるタンパク質
CN202080032910.1A CN113795504B (zh) 2019-04-30 2020-04-30 具有心脏保护活性的蛋白质
ZA2021/07778A ZA202107778B (en) 2019-04-30 2021-10-13 Proteins with cardioprotective activity
IL287525A IL287525A (en) 2019-04-30 2021-10-24 Proteins with cardioprotective activity
MX2026002607A MX2026002607A (es) 2019-04-30 2021-10-29 Proteinas con actividad cardioprotectora
US17/820,243 US12121594B2 (en) 2019-04-30 2022-08-16 Proteins with cardioprotective activity
ZA2023/09540A ZA202309540B (en) 2019-04-30 2023-10-12 Proteins with cardioprotective activity
US18/827,357 US20250057982A1 (en) 2019-04-30 2024-09-06 Proteins with cardioprotective activity
JP2025029903A JP2025107171A (ja) 2019-04-30 2025-02-27 心臓保護的活性のあるタンパク質

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1906052.4A GB201906052D0 (en) 2019-04-30 2019-04-30 Proteins with cardioprotective activity

Publications (1)

Publication Number Publication Date
GB201906052D0 true GB201906052D0 (en) 2019-06-12

Family

ID=66589570

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1906052.4A Ceased GB201906052D0 (en) 2019-04-30 2019-04-30 Proteins with cardioprotective activity

Country Status (25)

Country Link
US (3) US12569574B2 (https=)
EP (2) EP4389211A3 (https=)
JP (2) JP7707075B2 (https=)
KR (1) KR20220027829A (https=)
CN (2) CN113795504B (https=)
AU (1) AU2020267029A1 (https=)
BR (1) BR112021021626A2 (https=)
CA (1) CA3137662A1 (https=)
DK (1) DK3962534T3 (https=)
ES (1) ES2975422T3 (https=)
FI (1) FI3962534T3 (https=)
GB (1) GB201906052D0 (https=)
HR (1) HRP20240441T1 (https=)
HU (1) HUE066324T2 (https=)
IL (1) IL287525A (https=)
LT (1) LT3962534T (https=)
MX (2) MX2021013298A (https=)
PL (1) PL3962534T3 (https=)
PT (1) PT3962534T (https=)
RS (1) RS65469B1 (https=)
SG (1) SG11202111267WA (https=)
SI (1) SI3962534T1 (https=)
SM (1) SMT202400151T1 (https=)
WO (1) WO2020221906A1 (https=)
ZA (2) ZA202107778B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201906052D0 (en) 2019-04-30 2019-06-12 Int Centre For Genetic Engineering And Biotechnology Proteins with cardioprotective activity
WO2025253097A1 (en) * 2024-06-03 2025-12-11 Forcefield Therapeutics Limited Proteins with cardiopreservation activity

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WO2013093870A1 (en) 2011-12-23 2013-06-27 International Centre For Genetic Engineering And Biotechnology - Icgeb microRNAs FOR CARDIAC REGENERATION THROUGH INDUCTION OF CARDIAC MYOCYTE PROLIFERATION

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WO2008124724A1 (en) 2007-04-09 2008-10-16 University Of Florida Research Foundation, Inc. Raav vector compositions having tyrosine-modified capsid proteins and methods for use
WO2013093870A1 (en) 2011-12-23 2013-06-27 International Centre For Genetic Engineering And Biotechnology - Icgeb microRNAs FOR CARDIAC REGENERATION THROUGH INDUCTION OF CARDIAC MYOCYTE PROLIFERATION

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BORTOLOTTI, F. ET AL.: "In Vivo Functional Selection Identifies Cardiotrophin-1 as a Cardiac Engraftment Factor for Mesenchymal Stromal Cells", CIRCULATION, vol. 136, 2017, pages 1509 - 1524
BUJAK, M.FRANGOGIANNIS, N.G.: "The role of TGF-beta signaling in myocardial infarction and cardiac remodeling", CARDIOVASC RES, vol. 74, 2007, pages 184 - 195, XP022033845, DOI: doi:10.1016/j.cardiores.2006.10.002
CAI, Y. ET AL., ELIFE, vol. 3, 2014, pages e01911
CHANDRA, A. ET AL.: "Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells", BIOCHEM BIOPHYS RES COMMUN, vol. 344, 2006, pages 786 - 791, XP024924962, DOI: doi:10.1016/j.bbrc.2006.03.195
CHEN, Z. ET AL.: "FAM3C activates HSF1 to suppress hepatic gluconeogenesis and attenuate hyperglycemia of type 1 diabetic mice", ONCOTARGET, vol. 8, 2017, pages 106038 - 106049
CHEN, Z. ET AL.: "Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice", DIABETES, vol. 66, 2017, pages 1185 - 1197
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COFFINIER, C.TRAN, U.LARRAIN, J.DE ROBERTIS, E.M.: "Neuralin-1 is a novel Chordin-related molecule expressed in the mouse neural plate", MECH DEV, vol. 100, 2001, pages 119 - 122, XP002966349, DOI: doi:10.1016/S0925-4773(00)00507-4
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