FI3821891T3 - FK506:n käyttö pulmonaarisen valtimohypertension hoidossa - Google Patents

FK506:n käyttö pulmonaarisen valtimohypertension hoidossa Download PDF

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Publication number
FI3821891T3
FI3821891T3 FIEP20211109.2T FI20211109T FI3821891T3 FI 3821891 T3 FI3821891 T3 FI 3821891T3 FI 20211109 T FI20211109 T FI 20211109T FI 3821891 T3 FI3821891 T3 FI 3821891T3
Authority
FI
Finland
Prior art keywords
compound
arterial hypertension
subject
pulmonary arterial
use according
Prior art date
Application number
FIEP20211109.2T
Other languages
English (en)
Finnish (fi)
Inventor
Edda Spiekerkoetter
Marlene Rabinovitch
Philip Beachy
David Solow-Cordero
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of FI3821891T3 publication Critical patent/FI3821891T3/fi

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FIEP20211109.2T 2011-05-02 2012-04-30 FK506:n käyttö pulmonaarisen valtimohypertension hoidossa FI3821891T3 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161481317P 2011-05-02 2011-05-02

Publications (1)

Publication Number Publication Date
FI3821891T3 true FI3821891T3 (fi) 2023-08-24

Family

ID=47108011

Family Applications (1)

Application Number Title Priority Date Filing Date
FIEP20211109.2T FI3821891T3 (fi) 2011-05-02 2012-04-30 FK506:n käyttö pulmonaarisen valtimohypertension hoidossa

Country Status (19)

Country Link
US (6) US9474745B2 (enExample)
EP (3) EP3821891B1 (enExample)
JP (1) JP6177765B2 (enExample)
AU (2) AU2012250974B9 (enExample)
CA (1) CA2834368C (enExample)
CY (1) CY1123900T1 (enExample)
DK (2) DK3821891T3 (enExample)
ES (2) ES2954905T3 (enExample)
FI (1) FI3821891T3 (enExample)
HR (1) HRP20210245T1 (enExample)
HU (1) HUE053229T2 (enExample)
LT (1) LT2704711T (enExample)
PL (1) PL2704711T3 (enExample)
PT (2) PT2704711T (enExample)
RS (1) RS61480B1 (enExample)
SI (1) SI2704711T1 (enExample)
SM (1) SMT202100085T1 (enExample)
WO (1) WO2012151153A1 (enExample)
ZA (1) ZA201307905B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20210245T1 (hr) 2011-05-02 2021-04-02 The Board Of Trustees Of The Leland Stanford Junior University Primjena fk506 za liječenje plućne arterijske hipertenzije
CN107427698A (zh) * 2015-01-13 2017-12-01 维瓦斯公司 肺高血压的组合疗法
AU2016262391A1 (en) * 2015-05-08 2017-11-23 Vivus, Inc. Compositions and methods for the treatment or prevention of pulmonary hypertension
CN105062976B (zh) * 2015-08-05 2018-05-11 中国医学科学院基础医学研究所 肺动脉高压治疗药物的干细胞筛选模型及应用
ES2683921B1 (es) * 2017-03-28 2019-04-22 Univ Vigo Método para la determinación del pronóstico en sujetos diagnosticados con hipertensión arterial pulmonar
CA3064275A1 (en) * 2017-05-19 2018-11-22 The Board Of Trustees Of The Leland Stanford Junior University Enzastaurin and fragile histidine triad (fhit)-increasing agents for the treatment of pulmonary hypertension
US12440479B2 (en) 2018-03-28 2025-10-14 Georg-August-Universitaet Goettingen, Stiftung Oeffentlichen Rechts, Universitaetsmedizin Prevention or treatment of chronic organ injury

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489335B2 (en) * 2000-02-18 2002-12-03 Gholam A. Peyman Treatment of ocular disease
US20050119330A1 (en) * 2003-03-17 2005-06-02 Kao Peter N. Use of antiproliferative agents in the treatment and prevention of pulmonary proliferative vascular diseases
US8222271B2 (en) 2006-03-23 2012-07-17 Santen Pharmaceutical Co., Ltd. Formulations and methods for vascular permeability-related diseases or conditions
FR2936060B1 (fr) * 2008-09-17 2010-11-19 Assist Publ Hopitaux De Paris Procede de diagnostic d'une sclerodermie systemique ou d'une hypertension arterielle pulmonaire.
MX2011004284A (es) * 2008-10-22 2011-06-21 Sam Amer & Co Inc Metodo para tratar la hipertension arterial pulmonar.
HRP20210245T1 (hr) 2011-05-02 2021-04-02 The Board Of Trustees Of The Leland Stanford Junior University Primjena fk506 za liječenje plućne arterijske hipertenzije

Also Published As

Publication number Publication date
PL2704711T3 (pl) 2021-07-05
AU2017210583B2 (en) 2019-02-07
US20180185340A1 (en) 2018-07-05
US20220184042A1 (en) 2022-06-16
EP2704711A4 (en) 2014-11-19
CA2834368C (en) 2020-02-18
EP2704711A1 (en) 2014-03-12
EP4279130A3 (en) 2024-02-21
ZA201307905B (en) 2015-05-27
DK2704711T3 (da) 2021-02-22
ES2856173T3 (es) 2021-09-27
US20170007585A1 (en) 2017-01-12
JP2014513121A (ja) 2014-05-29
WO2012151153A1 (en) 2012-11-08
ES2954905T3 (es) 2023-11-27
AU2017210583A1 (en) 2017-08-24
US9474745B2 (en) 2016-10-25
DK3821891T3 (da) 2023-09-04
HRP20210245T1 (hr) 2021-04-02
CY1123900T1 (el) 2022-05-27
SMT202100085T1 (it) 2021-05-07
EP3821891B1 (en) 2023-06-07
US20190091208A1 (en) 2019-03-28
HUE053229T2 (hu) 2021-06-28
US12521379B2 (en) 2026-01-13
SI2704711T1 (sl) 2021-04-30
US20140135358A1 (en) 2014-05-15
PT2704711T (pt) 2021-03-02
AU2012250974B9 (en) 2017-05-18
JP6177765B2 (ja) 2017-08-09
CA2834368A1 (en) 2012-11-08
EP4279130A2 (en) 2023-11-22
PT3821891T (pt) 2023-08-31
EP2704711B1 (en) 2020-12-02
US20230404982A1 (en) 2023-12-21
RS61480B1 (sr) 2021-03-31
EP3821891A1 (en) 2021-05-19
AU2012250974A1 (en) 2013-11-14
LT2704711T (lt) 2021-04-26
AU2012250974B2 (en) 2017-05-04

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