FI20105806A0 - Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia - Google Patents

Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia

Info

Publication number
FI20105806A0
FI20105806A0 FI20105806A FI20105806A FI20105806A0 FI 20105806 A0 FI20105806 A0 FI 20105806A0 FI 20105806 A FI20105806 A FI 20105806A FI 20105806 A FI20105806 A FI 20105806A FI 20105806 A0 FI20105806 A0 FI 20105806A0
Authority
FI
Finland
Prior art keywords
arylamide derivatives
antiandrogenic properties
new
new arylamide
antiandrogenic
Prior art date
Application number
FI20105806A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Inventor
Jari Ratilainen
Original Assignee
Medeia Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medeia Therapeutics Ltd filed Critical Medeia Therapeutics Ltd
Priority to FI20105806A priority Critical patent/FI20105806A0/fi
Publication of FI20105806A0 publication Critical patent/FI20105806A0/fi
Priority to NZ605636A priority patent/NZ605636A/en
Priority to JP2013519121A priority patent/JP5990833B2/ja
Priority to MX2013000474A priority patent/MX2013000474A/es
Priority to ARP110102539A priority patent/AR082218A1/es
Priority to AU2011278201A priority patent/AU2011278201B2/en
Priority to BR112013000783-4A priority patent/BR112013000783B1/pt
Priority to EA201390008A priority patent/EA022619B1/ru
Priority to US13/809,787 priority patent/US8816119B2/en
Priority to KR1020137000843A priority patent/KR101928375B1/ko
Priority to PCT/FI2011/050655 priority patent/WO2012007644A1/en
Priority to CA2804765A priority patent/CA2804765C/en
Priority to SG2013002555A priority patent/SG187049A1/en
Priority to EP11770471.8A priority patent/EP2593424B1/en
Priority to ES11770471T priority patent/ES2750309T3/es
Priority to CN201180034245.0A priority patent/CN102985403B/zh
Priority to TW100124935A priority patent/TWI542343B/zh
Priority to ZA2013/00300A priority patent/ZA201300300B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI20105806A 2010-07-15 2010-07-15 Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia FI20105806A0 (fi)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FI20105806A FI20105806A0 (fi) 2010-07-15 2010-07-15 Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia
TW100124935A TWI542343B (zh) 2010-07-15 2011-07-14 具抗雄性素性質新芳醯胺衍生物
US13/809,787 US8816119B2 (en) 2010-07-15 2011-07-14 Arylamide derivatives having antiandrogenic properties
PCT/FI2011/050655 WO2012007644A1 (en) 2010-07-15 2011-07-14 Novel arylamide derivatives having antiandrogenic properties
MX2013000474A MX2013000474A (es) 2010-07-15 2011-07-14 Derivados de arilamida novedosos que tienen propiedades antiandrogenicas.
ARP110102539A AR082218A1 (es) 2010-07-15 2011-07-14 Derivados de arilamida que tienen propiedades antiandrogenicas y proceso de preparacion
AU2011278201A AU2011278201B2 (en) 2010-07-15 2011-07-14 Novel arylamide derivatives having antiandrogenic properties
BR112013000783-4A BR112013000783B1 (pt) 2010-07-15 2011-07-14 Derivados arilamídicos apresentando propriedades antiandrogênicas, seu processo de preparação, e composição farmacêutica
EA201390008A EA022619B1 (ru) 2010-07-15 2011-07-14 Ариламидные производные, обладающие антиандрогенными свойствами
NZ605636A NZ605636A (en) 2010-07-15 2011-07-14 Novel arylamide derivatives having antiandrogenic properties
KR1020137000843A KR101928375B1 (ko) 2010-07-15 2011-07-14 항안드로겐 특성을 지니는 신규한 아릴아미드 유도체
JP2013519121A JP5990833B2 (ja) 2010-07-15 2011-07-14 抗アンドロゲン特性を有する新規なアリールアミド誘導体
CA2804765A CA2804765C (en) 2010-07-15 2011-07-14 Novel arylamide derivatives having antiandrogenic properties
SG2013002555A SG187049A1 (en) 2010-07-15 2011-07-14 Novel arylamide derivatives having antiandrogenic properties
EP11770471.8A EP2593424B1 (en) 2010-07-15 2011-07-14 Novel arylamide derivatives having antiandrogenic properties
ES11770471T ES2750309T3 (es) 2010-07-15 2011-07-14 Nuevos derivados de arilamida que tienen propiedades antiandrogénicas
CN201180034245.0A CN102985403B (zh) 2010-07-15 2011-07-14 具有抗雄激素性质的新型芳基酰胺衍生物
ZA2013/00300A ZA201300300B (en) 2010-07-15 2013-01-11 Novel arylamide derivatives having antiandrogenic properties

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20105806A FI20105806A0 (fi) 2010-07-15 2010-07-15 Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia

Publications (1)

Publication Number Publication Date
FI20105806A0 true FI20105806A0 (fi) 2010-07-15

Family

ID=42555499

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20105806A FI20105806A0 (fi) 2010-07-15 2010-07-15 Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia

Country Status (18)

Country Link
US (1) US8816119B2 (ru)
EP (1) EP2593424B1 (ru)
JP (1) JP5990833B2 (ru)
KR (1) KR101928375B1 (ru)
CN (1) CN102985403B (ru)
AR (1) AR082218A1 (ru)
AU (1) AU2011278201B2 (ru)
BR (1) BR112013000783B1 (ru)
CA (1) CA2804765C (ru)
EA (1) EA022619B1 (ru)
ES (1) ES2750309T3 (ru)
FI (1) FI20105806A0 (ru)
MX (1) MX2013000474A (ru)
NZ (1) NZ605636A (ru)
SG (1) SG187049A1 (ru)
TW (1) TWI542343B (ru)
WO (1) WO2012007644A1 (ru)
ZA (1) ZA201300300B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013104831A1 (en) * 2012-01-13 2013-07-18 Medeia Therapeutics Ltd Arylamide derivatives having antiandrogenic properties
WO2016079521A1 (en) * 2014-11-20 2016-05-26 University College Cardiff Consultants Limited Androgen receptor modulators and their use as anti-cancer agents
US10806720B2 (en) 2015-04-21 2020-10-20 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10035763B2 (en) 2015-04-21 2018-07-31 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
MX2017013565A (es) 2015-04-21 2018-02-19 Gtx Inc Ligandos degradadores selectivos del receptor androgénico (sard) y sus métodos uso.
US10654809B2 (en) 2016-06-10 2020-05-19 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10017471B2 (en) 2015-04-21 2018-07-10 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10441570B2 (en) 2015-04-21 2019-10-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) Ligands and methods of use thereof
KR20170140291A (ko) 2015-04-21 2017-12-20 지티엑스, 인코포레이티드 선택적 안드로겐 수용체 분해제(sard) 리간드 및 이의 사용 방법
US10865184B2 (en) 2015-04-21 2020-12-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10093613B2 (en) 2015-04-21 2018-10-09 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US9834507B2 (en) 2015-04-21 2017-12-05 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US11230523B2 (en) 2016-06-10 2022-01-25 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA831466B (en) * 1982-03-23 1984-10-31 Ici Plc Heterocyclic compounds
EP0099165A1 (en) * 1982-03-23 1984-01-25 Imperial Chemical Industries Plc Triazole and imidazole compounds, process for their preparation and their use as fungicides and plant growth regulators, and intermediates for their synthesis
DE3372965D1 (en) 1982-07-23 1987-09-17 Ici Plc Amide derivatives
US6160011A (en) * 1997-05-30 2000-12-12 The University Of Tennessee Research Corporation Non-steroidal agonist compounds and their use in male hormone therapy
US7741371B2 (en) * 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
CA2642598C (en) * 2006-03-03 2014-05-27 Orion Corporation Selective androgen receptor modulators
TW200812962A (en) 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
BRPI0713200A2 (pt) 2006-07-19 2012-04-10 Osurf Ohio State University Res Foundation moduladores seletivos de receptores de androgênio, seus análogos e derivados, e seus usos
CN101516835A (zh) * 2006-07-19 2009-08-26 俄亥俄州立大学研究基金会 选择性雄激素受体调节剂、它们的类似物和衍生物以及它们的用途
US20090275515A1 (en) * 2006-10-18 2009-11-05 Yuntae Kim 2-hydroxy-2-phenylthiophenylpropionamides as androgen receptor modulators
DE102006061913A1 (de) * 2006-12-21 2008-06-26 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
EP2260028B1 (en) * 2008-02-22 2014-05-07 Radius Health, Inc. Selective androgen receptor modulators
EP2424853B1 (en) * 2009-04-10 2018-09-19 Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori (I.R.S.T.) S.R.L. Non-steroidal compounds for androgen receptor modulation, processes for the preparation and uses thereof

Also Published As

Publication number Publication date
EP2593424B1 (en) 2019-08-28
ES2750309T3 (es) 2020-03-25
AR082218A1 (es) 2012-11-21
US20130109750A1 (en) 2013-05-02
AU2011278201A1 (en) 2013-01-31
EP2593424A1 (en) 2013-05-22
SG187049A1 (en) 2013-02-28
BR112013000783A2 (pt) 2020-11-03
CA2804765C (en) 2018-08-07
CA2804765A1 (en) 2012-01-19
CN102985403B (zh) 2016-03-23
TWI542343B (zh) 2016-07-21
NZ605636A (en) 2014-05-30
BR112013000783B1 (pt) 2022-01-25
WO2012007644A1 (en) 2012-01-19
JP5990833B2 (ja) 2016-09-14
ZA201300300B (en) 2013-09-25
MX2013000474A (es) 2013-05-17
US8816119B2 (en) 2014-08-26
CN102985403A (zh) 2013-03-20
EA022619B1 (ru) 2016-02-29
TW201208669A (en) 2012-03-01
JP2013532178A (ja) 2013-08-15
KR101928375B1 (ko) 2018-12-12
KR20130079479A (ko) 2013-07-10
AU2011278201B2 (en) 2014-08-21
EA201390008A1 (ru) 2013-05-30

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