FI117668B - Förfarande för framställning av en komposition som innehåller gangliosid-KLH-konjugat och QS-21-substans - Google Patents
Förfarande för framställning av en komposition som innehåller gangliosid-KLH-konjugat och QS-21-substans Download PDFInfo
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- FI117668B FI117668B FI953529A FI953529A FI117668B FI 117668 B FI117668 B FI 117668B FI 953529 A FI953529 A FI 953529A FI 953529 A FI953529 A FI 953529A FI 117668 B FI117668 B FI 117668B
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- patients
- ganglioside
- klh
- conjugate
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- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
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Landscapes
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- Pharmacology & Pharmacy (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Claims (21)
1. Förfarande för framställning av en komposition, kännetecknat av att a) ett konjugat av ett ganglio- 5 sidderivat (i) bildas, som omfattar en oförändrad oligo-sackariddel och en förändrad ceramiddel, tili en immunogen proteinbaserad bärare (ii); b) saponin, som erhälls frän barken av ett Quillaja saponaria Molina-träd, tillsätts; och c) en farmaceutiskt godtagbar bärare tillsätts; väri 10 de relativa mängderna av konjugatet och saponinet är ef-fektiva för att stimulera eller förstärka antikroppspro-duktion i en patient, väri den immunogena proteinbaserade bäraren har erhällits frän ett protein, som valts frän ma-laria-T-cellsepitop, yttermembranprotein frän Neisseria 15 meningitides, katjoniserat bovint serumalbumin, hemocyanin frän nyckelhälssnäcka eller derivat därav, eller polyly-sin; väri gangliosidderivatets konjugat är konjugerat tili den immunogena proteinbaserade bäraren genom ett koi med ceramidursprung i gangliosidderivatet tili den immunogena 20 proteinbaserade bäraren. ΐ
2. Förfarande enligt patentkrav 1, känneteck-nat av att ceramiddelen innefattar en sfingosinbas, och * ,·, : väri gangliosidderivatet i konjugatet är konjugerat tili • M : j*t/ den immunogena proteinbaserade bäraren genom ett C-4-kol i * * * XV 25 sfingosinbasen i ceramiddelen av gangliosidderivatet tili t • · * • · ; * den immununogena proteinbaserade bäraren. i · ·
3. Förfarande enligt patentkrav 1, känneteck- • · · *.* * nat av att den immunogena proteinbaserade bäraren inne fattar en ε-aminolysylgrupp, och väri i konjugatet gangli-ί,·.* 30 osidderivatet är konjugerat tili den immunogena proteinba- serade bäraren genom ε-aminolysylgruppen i den immunogena proteinbaserade bäraren. t
· ***, 4. Förfarande enligt patentkrav 1, känneteck- ,* nat av att ceramidddelen innefattar en sfingosinbas, och ·· · • *#! 35 den immunogena proteinbaserade bäraren innefattar en ε- aminolysylgrupp, och väri gangliosidderivatet i konjugatet 117668 är konjugerat till den immunogena proteinbaserade bäraren genom ett C-4-kol i sfingosinbasen i ceramiddelen av gang-liosidderivatet tili ε-aminolysylgruppen i den immunogena proteinbaserade bäraren.
5 5. Förfarande enligt vilket som heist av patent- kraven 1 - 4, kännetecknat av att saponinen erhäll-bar frän barken av ett Quillaja saponaria Molina-träd är QS-21.
6. Förfarande för framställning av en komposition, 10 kännetecknat av att a) ett konjugat av (i) en gang- liosids oligosackariddel och (ii) hemocyanin frän nyckel-älssnäcka bildas; b) saponin, som erhälls frän barken av ett Quillaja saponaria Molina-träd, tillsätts; och c) en ;; farmaceutiskt godtagbar bärare tillsätts; väri de relativa 15 mängderna av konjugatet och saponinet är effektiva för att stimulera eller förstärka antikroppsproduktion i en patient.
7. Förfarande enligt patentkrav 6, kännetecknat av att saponinen erhällbar frän barken av ett Quil- 20 laja saponaria Molina-träd är QS-21.
8. Förfarande enligt vilket som heist av patent- ;1·2. kraven 1 - 5, kännetecknat av att gangliosidderiva- : tet är konjugerat tili hemocyanin frän nyckelälssnäcka. • · · • 1
• ,·, 9. Förfarande enligt vilket som heist av patent- » i · JIV 25 kraven 1-5 och 8, kännetecknat av att gangliosid- * · ; ; derivatet är ett derivat av en gangliosid utvald frän • · · gruppen bestäende av GM2, GM3, GD2, GD3, GD3-lakton, 0- *·2 1 acetyl-GD3, samt GT3.
10. Förfarande enligt patentkrav 9, känneteck- ·.·.· 30 n a t av att gangliosidderivatet är ett derivat av GM2 el- :3: ler GD2.
♦ ·· ,··· 11. Förfarande enligt patentkrav 10, känne- • ♦ tecknat av att gangliosidderivatet är ett derivat av GM2. ·· · ··· • · · • · · 2 • ·♦ 3 * · 117668
12. Förfarande enligt patentkrav 10, känne- tecknat av att gangliosidderivatet är ett derivat av GD2.
13. Förfarande enligt vilket som heist av patent-5 kraven 1 - 12, kännetecknat av att mängden konjugat är en mängd mellan 1 pg och 200 pg.
14. Förfarande enligt patentkrav 13, känne tecknat av att mängden konjugat är en mängd mellan 50 pg och 90 pg. 10
15. Förfarande enligt patentkrav 14, känne tecknat av att mängden konjugat är 70 pg.
16. Förfarande enligt patentkrav 13, känne tecknat av att mängden konjugat är en mängd mellan 1 pg och 10 pg. 15
17. Förfarande enligt patentkrav 16, kännetecknat av att mängden konjugat är 7 pg. ·
18. Förfarande enligt vilket som heist av patent-kraven 1-17, kännetecknat av att mängden saponin är en mängd mellan 10 pg och 200 pg. 20
19. Förfarande enligt patentkrav 18, känne tecknat av att mängden saponin är 100 pg.
20. Förfarande enligt patentkrav 18, kanne- : tecknat av att mängden saponin är 200 pg. • «· j
21. Förfarande enligt patentkrav 2, känneteck- • f 1 JIV 25 nat av att i konjugatet är gangliosidderivatet konjuge- • 1 I ; rat tili den immunogena proteinbaserade bäraren med en • 1 · •;|4: stabil aminbindning, som är mellan sfingosinbasens C-4-kol * 1 · *·1 1 i gangliosidderivatets ceramiddel och den immunogena pro teinbaserade bärarens ε-aminolysylgrupp. • · · • 1 · • 1 1 • · t • · • · • · · > · * · ·«· IM·» • 1 ·· · * · · • · • 1 · ··· • · • ·
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US926893 | 1992-08-07 | ||
| US926893A | 1993-01-22 | 1993-01-22 | |
| US9400757 | 1994-01-21 | ||
| PCT/US1994/000757 WO1994016731A1 (en) | 1993-01-22 | 1994-01-21 | Ganglioside-klh conjugate vaccines with qs-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI953529A0 FI953529A0 (sv) | 1995-07-21 |
| FI953529A FI953529A (sv) | 1995-09-15 |
| FI117668B true FI117668B (sv) | 2007-01-15 |
Family
ID=21736616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI953529A FI117668B (sv) | 1993-01-22 | 1995-07-21 | Förfarande för framställning av en komposition som innehåller gangliosid-KLH-konjugat och QS-21-substans |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US7014856B1 (sv) |
| EP (2) | EP0680338B1 (sv) |
| JP (1) | JP3852945B2 (sv) |
| KR (1) | KR100307289B1 (sv) |
| AT (2) | ATE237357T1 (sv) |
| AU (1) | AU685776B2 (sv) |
| CA (1) | CA2154488C (sv) |
| DE (2) | DE69432513T2 (sv) |
| DK (1) | DK0680338T3 (sv) |
| ES (1) | ES2196024T3 (sv) |
| FI (1) | FI117668B (sv) |
| HK (1) | HK1014659A1 (sv) |
| HU (1) | HU221420B1 (sv) |
| NO (1) | NO318920B1 (sv) |
| NZ (2) | NZ314058A (sv) |
| WO (1) | WO1994016731A1 (sv) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE237357T1 (de) * | 1993-01-22 | 2003-05-15 | Sloan Kettering Inst Cancer | Gangliosid-klh-konjugatimastoffe mit qs-21 |
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