FI114214B - Perhydro-1H-pyrido[1,2-a]pyrazinderivat - Google Patents

Perhydro-1H-pyrido[1,2-a]pyrazinderivat Download PDF

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Publication number
FI114214B
FI114214B FI20030361A FI20030361A FI114214B FI 114214 B FI114214 B FI 114214B FI 20030361 A FI20030361 A FI 20030361A FI 20030361 A FI20030361 A FI 20030361A FI 114214 B FI114214 B FI 114214B
Authority
FI
Finland
Prior art keywords
mmol
eller
methylene chloride
title
product
Prior art date
Application number
FI20030361A
Other languages
English (en)
Finnish (fi)
Other versions
FI20030361A (sv
Inventor
Gene Michael Bright
Kishor Amratlal Desai
Thomas Francis Seeger
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI20030361A publication Critical patent/FI20030361A/sv
Application granted granted Critical
Publication of FI114214B publication Critical patent/FI114214B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI20030361A 1991-02-27 2003-03-11 Perhydro-1H-pyrido[1,2-a]pyrazinderivat FI114214B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66179191 1991-02-27
US07/661,791 US5157034A (en) 1991-02-27 1991-02-27 Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US9108378 1991-11-18
PCT/US1991/008378 WO1992015580A1 (en) 1991-02-27 1991-11-18 NEUROLEPTIC PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES

Publications (2)

Publication Number Publication Date
FI20030361A FI20030361A (sv) 2003-03-11
FI114214B true FI114214B (sv) 2004-09-15

Family

ID=24655130

Family Applications (3)

Application Number Title Priority Date Filing Date
FI933753A FI105030B (sv) 1991-02-27 1993-08-26 Förfarande för framställning av terapeutiskt användbara racemiska eller optiskt aktiva 2-(bentso[d]isoxazol-och-isotiazol-3-yl)-perhydro-1H-pyrido[1,2-a]-pyrazinderivat
FI20000354A FI112865B (sv) 1991-02-27 2000-02-17 Perhydro-1H-pyrido[1,2-a]pyrazinderivat
FI20030361A FI114214B (sv) 1991-02-27 2003-03-11 Perhydro-1H-pyrido[1,2-a]pyrazinderivat

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FI933753A FI105030B (sv) 1991-02-27 1993-08-26 Förfarande för framställning av terapeutiskt användbara racemiska eller optiskt aktiva 2-(bentso[d]isoxazol-och-isotiazol-3-yl)-perhydro-1H-pyrido[1,2-a]-pyrazinderivat
FI20000354A FI112865B (sv) 1991-02-27 2000-02-17 Perhydro-1H-pyrido[1,2-a]pyrazinderivat

Country Status (24)

Country Link
US (1) US5157034A (sv)
EP (1) EP0573467B1 (sv)
JP (1) JP2546770B2 (sv)
KR (1) KR0163413B1 (sv)
AT (1) ATE123284T1 (sv)
AU (1) AU652422B2 (sv)
CA (2) CA2101518C (sv)
DE (2) DE9190206U1 (sv)
DK (1) DK0573467T3 (sv)
ES (1) ES2073914T3 (sv)
FI (3) FI105030B (sv)
HU (1) HU216637B (sv)
IE (1) IE67190B1 (sv)
IL (2) IL101021A (sv)
MX (1) MX9200803A (sv)
MY (1) MY108185A (sv)
NO (1) NO300847B1 (sv)
NZ (1) NZ241739A (sv)
PT (1) PT100160B (sv)
RU (1) RU2090565C1 (sv)
TW (1) TW207540B (sv)
WO (1) WO1992015580A1 (sv)
YU (1) YU48311B (sv)
ZA (1) ZA921405B (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2101252C (en) * 1991-02-27 1998-02-17 Frank J. Urban Process for preparing trans-piperidine-2,5- dicarboxylates
JP2753146B2 (ja) * 1992-06-16 1998-05-18 ファイザー・インコーポレーテッド ビス−アザー二環式抗不安薬の製法および中間体
JP3287574B2 (ja) * 1994-09-30 2002-06-04 ファイザー・インク ２，７−置換オクタヒドロ−１ｈ−ピリド［１，２−ａ］ピラジン誘導体
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
WO1996010570A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
UA62015C2 (en) * 1998-12-28 2003-12-15 Pfizer Prod Inc Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants)
PL378749A1 (pl) * 2003-03-12 2006-05-15 Pfizer Products Inc. Azabicykliczne pochodne pirydyloksymetylowe i benzoizoksazolowe
PL1622569T3 (pl) 2003-04-24 2016-06-30 Incyte Holdings Corp Pochodne aza spiro alkanów jako inhibitory metaloproteaz
US7910108B2 (en) * 2006-06-05 2011-03-22 Incyte Corporation Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681938A (en) * 1984-08-27 1987-07-21 Ciba-Geigy Corporation Novel polycyclic hydrazones of rifamycins, their manufacture, and their pharmaceutical compositions for treating tuberculosis
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos

Also Published As

Publication number Publication date
HU9302427D0 (en) 1993-11-29
FI933753A0 (fi) 1993-08-26
CA2101518C (en) 1997-11-25
US5157034A (en) 1992-10-20
FI933753A (fi) 1993-08-26
ZA921405B (en) 1993-08-26
ES2073914T3 (es) 1995-08-16
FI20000354A (sv) 2000-02-17
IL101021A (en) 1996-03-31
JPH06500120A (ja) 1994-01-06
ATE123284T1 (de) 1995-06-15
MY108185A (en) 1996-08-30
FI20030361A (sv) 2003-03-11
HU216637B (hu) 1999-07-28
IE67190B1 (en) 1996-03-06
JP2546770B2 (ja) 1996-10-23
MX9200803A (es) 1992-08-31
PT100160A (pt) 1993-05-31
YU19892A (sh) 1994-11-15
CA2163274C (en) 1999-02-09
RU2090565C1 (ru) 1997-09-20
DE69110135T2 (de) 1995-10-19
HUT66965A (en) 1995-01-30
DE9190206U1 (de) 1993-10-14
DK0573467T3 (da) 1995-10-09
NZ241739A (en) 1994-07-26
NO300847B1 (no) 1997-08-04
IL112325A0 (en) 1995-03-30
KR930703315A (ko) 1993-11-29
YU48311B (sh) 1998-05-15
WO1992015580A1 (en) 1992-09-17
EP0573467A1 (en) 1993-12-15
CA2101518A1 (en) 1992-08-28
FI105030B (sv) 2000-05-31
AU652422B2 (en) 1994-08-25
EP0573467B1 (en) 1995-05-31
FI112865B (sv) 2004-01-30
IE920601A1 (en) 1992-09-09
KR0163413B1 (ko) 1998-12-01
NO933049L (no) 1993-08-26
PT100160B (pt) 1999-09-30
NO933049D0 (no) 1993-08-26
DE69110135D1 (de) 1995-07-06
TW207540B (sv) 1993-06-11
CA2163274A1 (en) 1992-08-28
AU1259992A (en) 1992-10-06
IL112325A (en) 1997-08-14

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