YU48311B - Postupak za dobijanje racemskih ili optički aktivnih perhidro-1h-pirido /1,2-a/pirazina - Google Patents
Postupak za dobijanje racemskih ili optički aktivnih perhidro-1h-pirido /1,2-a/pirazinaInfo
- Publication number
- YU48311B YU48311B YU19892A YU19892A YU48311B YU 48311 B YU48311 B YU 48311B YU 19892 A YU19892 A YU 19892A YU 19892 A YU19892 A YU 19892A YU 48311 B YU48311 B YU 48311B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- pirido
- pyrazine
- procedure
- optically active
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
POSTUPAK ZA DOBIJANJE RACEMSKIH ILI OPTICKI AKTIVNIH PERHIDRO-1H-PIRIDO /1,2-A/PIRAZINA formule u kojoj: L i X kada su uzeti odvojeno, X je H ili Cl alkil sa C2 i L je R(CH2)mCO, ili L i X uzeti zajedno predstavljaju R je C1 do C8 alkil, C3 do C7 cikloalkil, fenil, naftil, furil, benzofuranil, tienil, benzotienil, pirolil, indolil, izoindolil, norbornilmetil, ili jedna od pomenutih grupa supstituisana u aromaticnom ili heteroaromaticnom prstenu sa F, C1, C1 do C2 alkil ili C1 do C2 alkoksi grupom; R1, R2 i R3 su svaki nezavisno H ili metil; R4 je fenil ili fenil supstituisan sa F, C1, C1 do C2 alkil ili C1 do C" alkoksi grupom; X1 je CH ili N; Y je O ili S; Y1 je CH2, S, O ili NH; Y2 i Y3 su uzeti odvojeno i predstavljaju nezavisno H ili metil ili Y2 i Y3 kada su uzeti zajedno predstavljaju (CH2)q; Z je H ili C1; m je O, 1, 2 ili 3; n je 1, 2, 3 ili 4; p je 1 ili 2; q je 2, 3, 4 ili 5; r je O ili 1; s je O ili 1; i predstavlja vezu ili nije veza, naznacen time, sto obuhvata (a) kada su L i X uzeti odvojeno, acilovanje jedinjenja formule u kojoj X, Y i n su kao sto je gore definisano, reakciju sa aktiviranim oblikom jedinjenja formule R (CH2)mCOOH, gde R i m su kao sto je gore definisano; (b) kada L i X su uzeti zajedno, reakciju jedinjenja formule u kojoj Y i n su kao sto je gore definisano, a D je nukleofilna grupa koja se moze zameniti, u reakciono inertnom rastvaracu, sa (i) kada L i X zajedno obrazuju imid ili ciklicni sulfonamid, njegov anjonski derivat, ili (ii) kada L i X zajedno obrazuju prost piperidinski derivat, njegov oblik slobodnog amina; ili (c) reakciju, pod uslovima nukleofilnog premestanja, jedinjenja formule u kojoj L, X i n su kao sto je gore definisano, sa jedinjenjem formule u kojoj Y i Z su kao sto je gore definisano. Prijava sadrzi jos 18 zavisnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/661,791 US5157034A (en) | 1991-02-27 | 1991-02-27 | Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU19892A YU19892A (sh) | 1994-11-15 |
| YU48311B true YU48311B (sh) | 1998-05-15 |
Family
ID=24655130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU19892A YU48311B (sh) | 1991-02-27 | 1992-02-26 | Postupak za dobijanje racemskih ili optički aktivnih perhidro-1h-pirido /1,2-a/pirazina |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5157034A (sh) |
| EP (1) | EP0573467B1 (sh) |
| JP (1) | JP2546770B2 (sh) |
| KR (1) | KR0163413B1 (sh) |
| AT (1) | ATE123284T1 (sh) |
| AU (1) | AU652422B2 (sh) |
| CA (2) | CA2101518C (sh) |
| DE (2) | DE9190206U1 (sh) |
| DK (1) | DK0573467T3 (sh) |
| ES (1) | ES2073914T3 (sh) |
| FI (3) | FI105030B (sh) |
| HU (1) | HU216637B (sh) |
| IE (1) | IE67190B1 (sh) |
| IL (2) | IL101021A (sh) |
| MX (1) | MX9200803A (sh) |
| MY (1) | MY108185A (sh) |
| NO (1) | NO300847B1 (sh) |
| NZ (1) | NZ241739A (sh) |
| PT (1) | PT100160B (sh) |
| RU (1) | RU2090565C1 (sh) |
| TW (1) | TW207540B (sh) |
| WO (1) | WO1992015580A1 (sh) |
| YU (1) | YU48311B (sh) |
| ZA (1) | ZA921405B (sh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2101252C (en) * | 1991-02-27 | 1998-02-17 | Frank J. Urban | Process for preparing trans-piperidine-2,5- dicarboxylates |
| JP2753146B2 (ja) * | 1992-06-16 | 1998-05-18 | ファイザー・インコーポレーテッド | ビス−アザー二環式抗不安薬の製法および中間体 |
| JP3287574B2 (ja) * | 1994-09-30 | 2002-06-04 | ファイザー・インク | ２，７−置換オクタヒドロ−１ｈ−ピリド［１，２−ａ］ピラジン誘導体 |
| US6231833B1 (en) | 1999-08-05 | 2001-05-15 | Pfizer Inc | 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors |
| WO1996010570A1 (en) * | 1994-09-30 | 1996-04-11 | Pfizer Inc. | NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES |
| PA8469101A1 (es) * | 1998-04-09 | 2000-09-29 | Pfizer Prod Inc | Ligandos azabiciclicos de receptores 5ht1 |
| UA62015C2 (en) * | 1998-12-28 | 2003-12-15 | Pfizer Prod Inc | Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants) |
| PL378749A1 (pl) * | 2003-03-12 | 2006-05-15 | Pfizer Products Inc. | Azabicykliczne pochodne pirydyloksymetylowe i benzoizoksazolowe |
| PL1622569T3 (pl) | 2003-04-24 | 2016-06-30 | Incyte Holdings Corp | Pochodne aza spiro alkanów jako inhibitory metaloproteaz |
| US7910108B2 (en) * | 2006-06-05 | 2011-03-22 | Incyte Corporation | Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases |
| EP2919788A4 (en) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681938A (en) * | 1984-08-27 | 1987-07-21 | Ciba-Geigy Corporation | Novel polycyclic hydrazones of rifamycins, their manufacture, and their pharmaceutical compositions for treating tuberculosis |
| US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
| US4957916A (en) * | 1988-08-05 | 1990-09-18 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
| MX19222A (es) * | 1989-01-23 | 1993-12-01 | Pfizer | Agentes ansioliticos bis-aza-biciclicos |
-
1991
- 1991-02-27 US US07/661,791 patent/US5157034A/en not_active Expired - Lifetime
- 1991-11-18 DK DK92904861.9T patent/DK0573467T3/da active
- 1991-11-18 RU RU9193045711A patent/RU2090565C1/ru not_active IP Right Cessation
- 1991-11-18 AU AU12599/92A patent/AU652422B2/en not_active Ceased
- 1991-11-18 DE DE9190206U patent/DE9190206U1/de not_active Expired - Lifetime
- 1991-11-18 EP EP92904861A patent/EP0573467B1/en not_active Expired - Lifetime
- 1991-11-18 WO PCT/US1991/008378 patent/WO1992015580A1/en active IP Right Grant
- 1991-11-18 JP JP4505183A patent/JP2546770B2/ja not_active Expired - Fee Related
- 1991-11-18 HU HU9302427A patent/HU216637B/hu unknown
- 1991-11-18 AT AT92904861T patent/ATE123284T1/de not_active IP Right Cessation
- 1991-11-18 CA CA002101518A patent/CA2101518C/en not_active Expired - Fee Related
- 1991-11-18 CA CA002163274A patent/CA2163274C/en not_active Expired - Fee Related
- 1991-11-18 DE DE69110135T patent/DE69110135T2/de not_active Expired - Fee Related
- 1991-11-18 ES ES92904861T patent/ES2073914T3/es not_active Expired - Lifetime
- 1991-11-18 KR KR1019930702554A patent/KR0163413B1/ko not_active IP Right Cessation
-
1992
- 1992-01-21 TW TW081100420A patent/TW207540B/zh active
- 1992-02-20 IL IL10102192A patent/IL101021A/en not_active IP Right Cessation
- 1992-02-20 IL IL11232595A patent/IL112325A/xx not_active IP Right Cessation
- 1992-02-25 PT PT100160A patent/PT100160B/pt not_active IP Right Cessation
- 1992-02-25 MX MX9200803A patent/MX9200803A/es not_active IP Right Cessation
- 1992-02-26 MY MYPI92000318A patent/MY108185A/en unknown
- 1992-02-26 NZ NZ24173992A patent/NZ241739A/en not_active IP Right Cessation
- 1992-02-26 YU YU19892A patent/YU48311B/sh unknown
- 1992-02-26 IE IE920601A patent/IE67190B1/en not_active IP Right Cessation
- 1992-02-26 ZA ZA921405A patent/ZA921405B/xx unknown
-
1993
- 1993-08-26 NO NO933049A patent/NO300847B1/no unknown
- 1993-08-26 FI FI933753A patent/FI105030B/fi not_active IP Right Cessation
-
2000
- 2000-02-17 FI FI20000354A patent/FI112865B/fi not_active IP Right Cessation
-
2003
- 2003-03-11 FI FI20030361A patent/FI114214B/fi not_active IP Right Cessation
Also Published As
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