FI113367B - Menetelmä terapeuttisesti käyttökelpoisten 3,4,5-substituoitujen bentsoyyliguanidiinien valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten 3,4,5-substituoitujen bentsoyyliguanidiinien valmistamiseksi Download PDFInfo
- Publication number
- FI113367B FI113367B FI932998A FI932998A FI113367B FI 113367 B FI113367 B FI 113367B FI 932998 A FI932998 A FI 932998A FI 932998 A FI932998 A FI 932998A FI 113367 B FI113367 B FI 113367B
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- hydrogen
- substituted
- phenyl
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4221594 | 1992-07-01 | ||
DE4221594 | 1992-07-01 | ||
DE4224107 | 1992-07-22 | ||
DE4224107 | 1992-07-22 | ||
DE4244319 | 1992-12-28 | ||
DE4244319 | 1992-12-28 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI932998A0 FI932998A0 (fi) | 1993-06-29 |
FI932998A FI932998A (fi) | 1994-01-02 |
FI113367B true FI113367B (fi) | 2004-04-15 |
Family
ID=27203913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI932998A FI113367B (fi) | 1992-07-01 | 1993-06-29 | Menetelmä terapeuttisesti käyttökelpoisten 3,4,5-substituoitujen bentsoyyliguanidiinien valmistamiseksi |
Country Status (15)
Country | Link |
---|---|
US (1) | US5693672A (sh) |
EP (1) | EP0577024B1 (sh) |
JP (1) | JP3490739B2 (sh) |
AT (1) | ATE144248T1 (sh) |
AU (1) | AU658309B2 (sh) |
CA (1) | CA2099445A1 (sh) |
DE (1) | DE59304166D1 (sh) |
DK (1) | DK0577024T3 (sh) |
ES (1) | ES2092729T3 (sh) |
FI (1) | FI113367B (sh) |
GR (1) | GR3021397T3 (sh) |
IL (1) | IL106157A (sh) |
NO (1) | NO179673C (sh) |
NZ (1) | NZ248013A (sh) |
TW (1) | TW328536B (sh) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4325822A1 (de) * | 1993-07-31 | 1995-02-02 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4417004A1 (de) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
IL114670A0 (en) * | 1994-08-05 | 1995-11-27 | Fujisawa Pharmaceutical Co | Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4430213A1 (de) * | 1994-08-28 | 1996-02-29 | Merck Patent Gmbh | Arylbenzoylguanidine |
DE4430212A1 (de) * | 1994-08-28 | 1996-02-29 | Merck Patent Gmbh | Ortho-substituierte Benzoesäure-Derivate |
DE4430916A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Alkyl-benzoylguanidin-Derivate |
DE4432101A1 (de) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Aminosäure-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
AU670224B3 (en) * | 1994-09-28 | 1996-07-04 | Chain Reaction Sales Promotion Pty Ltd | Signage apparatus |
TW372967B (en) * | 1994-12-27 | 1999-11-01 | Kanebo Ltd | 1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof |
DE19531138A1 (de) * | 1995-08-24 | 1997-02-27 | Merck Patent Gmbh | Alkenyl-benzoylguanidin-Derivate |
DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19542306A1 (de) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
EP0972767A4 (en) * | 1997-03-06 | 2000-05-24 | Toa Eiyo Ltd | CYCLOALCA [b] PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVES, THEIR PRODUCTION PROCESS AND MEDICAMENTS CONTAINING THEM |
US6410563B1 (en) | 1999-12-22 | 2002-06-25 | Merck Frosst Canada & Co. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
US6639077B2 (en) | 2000-03-23 | 2003-10-28 | Merck Frosst Canada & Co. | Tri-aryl-substituted-ethane PDE4 inhibitors |
MY123585A (en) | 2000-03-23 | 2006-05-31 | Merck Canada Inc | Tri-aryl-substituted-ethane pde4 inhibitors. |
JP2003534328A (ja) | 2000-05-25 | 2003-11-18 | メルク フロスト カナダ アンド カンパニー | フルオロアルコキシ置換ベンズアミドジクロロピリジニルn−オキシドpde4阻害剤 |
US6740666B2 (en) | 2000-12-20 | 2004-05-25 | Merck & Co., Inc. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
ATE303384T1 (de) | 2001-05-24 | 2005-09-15 | Merck Frosst Canada Inc | 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren |
JO2311B1 (en) | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
ATE486600T1 (de) | 2002-03-12 | 2010-11-15 | Merck Sharp & Dohme | Di-aryl-substituierte tetrazol-modulatoren des metabotropen glutamat-rezeptors-5 |
DE60329030D1 (de) * | 2002-12-04 | 2009-10-08 | Ore Pharmaceuticals Inc | Melanocortin-rezeptormodulatoren |
US7504401B2 (en) | 2003-08-29 | 2009-03-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents and uses thereof |
JP4667384B2 (ja) * | 2003-10-07 | 2011-04-13 | レノビス, インコーポレイテッド | イオンチャネルリガンドとしてのアミド誘導体および薬学的組成物、ならびにこれらを使用する方法 |
MX2007009381A (es) * | 2005-02-28 | 2007-09-25 | Renovis Inc | Derivados de amida como ligandos de canales ionicos y composiciones farmaceuticas y metodos para usar los mismos. |
KR20070119655A (ko) * | 2005-02-28 | 2007-12-20 | 레노비스, 인크. | 이온-채널 리간드로서의 아미드 유도체, 및 이를 사용한제약 조성물 및 방법 |
US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
SI3649109T1 (sl) * | 2017-07-04 | 2021-11-30 | Sanofi | Etinilne spojine, njihova priprava in njihova terapevtska uporaba za zdravljenje malarije |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3420874A (en) * | 1962-09-28 | 1969-01-07 | Standard Oil Co | Amine addition salts of nitro-carboxyalkali metal phenolates |
US3247035A (en) * | 1962-09-28 | 1966-04-19 | Standard Oil Co | Ammonium nitrate propellants containing a nitro-aminocarboxy-alkali metal phenolate combustion catalyst |
US3780027A (en) * | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
US3728332A (en) * | 1971-09-03 | 1973-04-17 | Nat Starch Chem Corp | Preparation of starch esters |
US4178387A (en) * | 1976-03-30 | 1979-12-11 | William H. Rorer, Inc. | Method for the treatment of arrhythmia |
US4251545A (en) * | 1979-09-19 | 1981-02-17 | Gaf Corporation | Fungicidal process using 1-(alkoxyaroyl)guanidines |
DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
US5093194A (en) * | 1989-11-01 | 1992-03-03 | Mobil Oil Corporation | Oriented multilayer heat sealable packaging film |
ATE139526T1 (de) * | 1992-02-15 | 1996-07-15 | Hoechst Ag | 3,5-substituierte benzoylguanidine, mit antiarrythmischer wirkung und inhibierender wirkung auf die proliferationen von zellen |
-
1993
- 1993-06-25 ES ES93110195T patent/ES2092729T3/es not_active Expired - Lifetime
- 1993-06-25 EP EP93110195A patent/EP0577024B1/de not_active Expired - Lifetime
- 1993-06-25 DE DE59304166T patent/DE59304166D1/de not_active Expired - Lifetime
- 1993-06-25 DK DK93110195.0T patent/DK0577024T3/da active
- 1993-06-25 AT AT93110195T patent/ATE144248T1/de not_active IP Right Cessation
- 1993-06-28 IL IL10615793A patent/IL106157A/en not_active IP Right Cessation
- 1993-06-29 NZ NZ248013A patent/NZ248013A/en unknown
- 1993-06-29 FI FI932998A patent/FI113367B/fi not_active IP Right Cessation
- 1993-06-30 NO NO932392A patent/NO179673C/no unknown
- 1993-06-30 AU AU41635/93A patent/AU658309B2/en not_active Ceased
- 1993-06-30 JP JP15988693A patent/JP3490739B2/ja not_active Expired - Fee Related
- 1993-06-30 CA CA002099445A patent/CA2099445A1/en not_active Abandoned
- 1993-08-23 TW TW082106777A patent/TW328536B/zh active
-
1995
- 1995-05-26 US US08/451,309 patent/US5693672A/en not_active Expired - Lifetime
-
1996
- 1996-10-17 GR GR960402615T patent/GR3021397T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0577024B1 (de) | 1996-10-16 |
JP3490739B2 (ja) | 2004-01-26 |
DK0577024T3 (sh) | 1997-02-24 |
NO179673B (no) | 1996-08-19 |
FI932998A0 (fi) | 1993-06-29 |
JPH06116230A (ja) | 1994-04-26 |
DE59304166D1 (de) | 1996-11-21 |
NO932392D0 (no) | 1993-06-30 |
ES2092729T3 (es) | 1996-12-01 |
AU658309B2 (en) | 1995-04-06 |
IL106157A0 (en) | 1993-10-20 |
TW328536B (en) | 1998-03-21 |
ATE144248T1 (de) | 1996-11-15 |
IL106157A (en) | 1999-11-30 |
NO179673C (no) | 1996-11-27 |
GR3021397T3 (en) | 1997-01-31 |
NO932392L (no) | 1994-01-03 |
AU4163593A (en) | 1994-01-06 |
US5693672A (en) | 1997-12-02 |
NZ248013A (en) | 1995-12-21 |
CA2099445A1 (en) | 1994-01-02 |
EP0577024A1 (de) | 1994-01-05 |
FI932998A (fi) | 1994-01-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |