FI112485B - Uusia 1,4-dihydro-4-okso-1,8-naftyridiinijohdannaisia, menetelmä niiden valmistamiseksi ja kasvaintenvastaisia aineita - Google Patents

Uusia 1,4-dihydro-4-okso-1,8-naftyridiinijohdannaisia, menetelmä niiden valmistamiseksi ja kasvaintenvastaisia aineita

Info

Publication number
FI112485B
FI112485B FI965020A FI965020A FI112485B FI 112485 B FI112485 B FI 112485B FI 965020 A FI965020 A FI 965020A FI 965020 A FI965020 A FI 965020A FI 112485 B FI112485 B FI 112485B
Authority
FI
Finland
Prior art keywords
hydrogen atom
preparation
dihydro
oxo
novel
Prior art date
Application number
FI965020A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI965020A7 (fi
FI965020A0 (fi
Inventor
Kyoji Tomita
Katsumi Chiba
Shigeki Kashimoto
Koh-Ichiro Shibamori
Yasunori Tsuzuki
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Publication of FI965020A0 publication Critical patent/FI965020A0/fi
Publication of FI965020A7 publication Critical patent/FI965020A7/fi
Application granted granted Critical
Publication of FI112485B publication Critical patent/FI112485B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI965020A 1994-06-14 1996-12-13 Uusia 1,4-dihydro-4-okso-1,8-naftyridiinijohdannaisia, menetelmä niiden valmistamiseksi ja kasvaintenvastaisia aineita FI112485B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP15657894 1994-06-14
JP19792194 1994-07-28
JP30691494 1994-11-15
JP33995694 1994-12-28
JP8170595 1995-03-13
PCT/JP1995/001110 WO1995034559A1 (en) 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent

Publications (3)

Publication Number Publication Date
FI965020A0 FI965020A0 (fi) 1996-12-13
FI965020A7 FI965020A7 (fi) 1996-12-16
FI112485B true FI112485B (fi) 2003-12-15

Family

ID=27524935

Family Applications (1)

Application Number Title Priority Date Filing Date
FI965020A FI112485B (fi) 1994-06-14 1996-12-13 Uusia 1,4-dihydro-4-okso-1,8-naftyridiinijohdannaisia, menetelmä niiden valmistamiseksi ja kasvaintenvastaisia aineita

Country Status (27)

Country Link
US (1) US5817669A (en:Method)
EP (1) EP0787726B1 (en:Method)
JP (1) JP3391796B2 (en:Method)
KR (1) KR100350921B1 (en:Method)
CN (1) CN1053668C (en:Method)
AT (1) ATE209645T1 (en:Method)
AU (1) AU679859B2 (en:Method)
BR (1) BR9508037A (en:Method)
CA (1) CA2192824C (en:Method)
CZ (1) CZ292631B6 (en:Method)
DE (1) DE69524251T2 (en:Method)
DK (1) DK0787726T3 (en:Method)
ES (1) ES2163512T3 (en:Method)
FI (1) FI112485B (en:Method)
HK (1) HK1000495A1 (en:Method)
HU (1) HU220072B (en:Method)
MX (1) MX9606331A (en:Method)
NO (1) NO307255B1 (en:Method)
NZ (1) NZ287139A (en:Method)
PL (1) PL181867B1 (en:Method)
PT (1) PT787726E (en:Method)
RO (1) RO117793B1 (en:Method)
RU (1) RU2151770C1 (en:Method)
SI (1) SI0787726T1 (en:Method)
SK (1) SK281341B6 (en:Method)
TW (1) TW319769B (en:Method)
WO (1) WO1995034559A1 (en:Method)

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WO2004091627A2 (en) * 2003-04-07 2004-10-28 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs
SI1666477T1 (sl) * 2003-09-10 2013-10-30 Kyorin Pharmaceutical Co., Ltd. Derivati 7-(4-substituiran 3-ciklopropilaminometil-1-pirolidinil) kinolonkarboksilne kisline
DE10352979A1 (de) * 2003-11-13 2005-06-09 Merck Patent Gmbh Pyridopyrimidinone
ES2358267T3 (es) 2004-03-15 2011-05-09 Sunesis Pharmaceuticals, Inc. Composición farmacéutica que comprende sns-595 y sus usos.
AU2013201203C1 (en) * 2004-03-15 2015-04-23 Sumitomo Dainippon Pharma Co., Ltd. Sns-595 and methods of using the same
BRPI0518164A (pt) * 2004-10-14 2008-11-04 Hoffmann La Roche quinazolinilmetilenotiazolinonas como inibidores de cdk1
EP1805174A1 (en) * 2004-10-14 2007-07-11 F.Hoffmann-La Roche Ag 1,5-naphthyridine azolidinones having cdk1 antiproliferative activity
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
EP1926372A2 (en) * 2005-08-19 2008-06-04 Cylene Pharmaceuticals, Inc. HUMAN RIBOSOMAL DNA(rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF
CN104873502A (zh) * 2005-09-02 2015-09-02 逊尼希思制药公司 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法
CA2620915C (en) * 2005-09-02 2014-03-25 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
RU2428983C2 (ru) * 2005-09-02 2011-09-20 Санесис Фармасьютикалз, Инк. Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака
EP1931339B1 (en) * 2005-09-02 2018-05-16 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
AU2013219242C1 (en) * 2005-09-02 2016-09-22 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
JP2009507924A (ja) * 2005-09-14 2009-02-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ｃ−ｆｍｓキナーゼ阻害剤としての５−オキソ−５，８−ジヒドロ−ピリド−ピリミジン
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
CN104027333B (zh) 2006-06-12 2017-05-17 逊尼希思制药公司 治疗癌症的化合物和组合物
US20100048609A1 (en) * 2006-08-01 2010-02-25 Jacobs Jeffrey W Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
MX344865B (es) 2006-08-02 2016-12-19 Sunesis Pharmaceuticals Inc Metodos para usar acido (+)-1,4-dihidro-7-[(3s,4s)-3-metoxi-4-(met ilamino)-1-pirrolidinil]-4-oxo-1(2-tiazolil)-1,8-naftiridina-3-ca rboxilico para el tratamiento de ciertos padecimientos hematologicos.
EP3141250A1 (en) * 2007-10-22 2017-03-15 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy
EP2649997B1 (en) * 2007-12-10 2019-01-23 Sunesis Pharmaceuticals, Inc. (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for use in the treatment of myelodyspastic syndrome
JP6129471B2 (ja) 2008-12-31 2017-05-17 サネシス ファーマシューティカルズ， インコーポレイテッド （＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の製造方法
SG10201400258SA (en) 2009-02-27 2014-05-29 Sunesis Pharmaceuticals Inc Methods Of Using SNS-595 For Treatment Of Cancer Subjects With Reduced BRCA2 Activity
UA110465C2 (en) * 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
WO2011056566A2 (en) * 2009-10-26 2011-05-12 Sunesis Pharmaceuticals, Inc. Compounds and methods for treatment of cancer
PT2712358T (pt) 2011-05-13 2017-02-20 Array Biopharma Inc Compostos de pirrolidinil ureia, pirrolidinil tioureia e pirrolidinil guanida como inibidores de trka quinase
CN103497186B (zh) * 2013-09-24 2015-02-25 浙江司太立制药股份有限公司 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法
CN110520422B (zh) * 2017-03-24 2023-09-05 涌永制药株式会社 新型吡啶酮羧酸衍生物或其盐

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US4384001A (en) * 1978-12-21 1983-05-17 Gosalvez Mario Treatment of tumors with thiazolidine-4-carboxylic acid
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
DE3577089D1 (de) * 1984-01-26 1990-05-17 Abbott Lab Antibakterielle chinolinderivate.
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
JPS61152682A (ja) * 1984-12-27 1986-07-11 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体、そのエステルおよびその塩
JPS61251667A (ja) * 1985-04-30 1986-11-08 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
IL79110A0 (en) * 1985-06-13 1986-09-30 Schering Corp Polycyclic quinoline,naphthyridine and pyrazinopyridine derivatives
EP0226624A1 (en) * 1985-06-14 1987-07-01 The Upjohn Company Cyclopentapyrazole and tetrahydroindazole compounds
JPS6233176A (ja) * 1985-08-05 1987-02-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
JP2704428B2 (ja) * 1988-06-15 1998-01-26 富山化学工業株式会社 キノロンカルボン酸誘導体またはその塩
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
JPH06233176A (ja) * 1993-01-29 1994-08-19 Sony Corp ビデオカメラ

Also Published As

Publication number Publication date
EP0787726A1 (en) 1997-08-06
WO1995034559A1 (en) 1995-12-21
CZ364396A3 (en) 1997-06-11
CZ292631B6 (cs) 2003-11-12
HU220072B (hu) 2001-10-28
FI965020A7 (fi) 1996-12-16
PT787726E (pt) 2002-04-29
DE69524251D1 (de) 2002-01-10
SK157496A3 (en) 1997-08-06
ATE209645T1 (de) 2001-12-15
EP0787726A4 (en:Method) 1997-08-06
PL317726A1 (en) 1997-04-28
HU9603455D0 (en) 1997-02-28
BR9508037A (pt) 1997-09-16
US5817669A (en) 1998-10-06
AU679859B2 (en) 1997-07-10
NO307255B1 (no) 2000-03-06
NO965305L (no) 1997-02-04
RO117793B1 (ro) 2002-07-30
JP3391796B2 (ja) 2003-03-31
FI965020A0 (fi) 1996-12-13
CN1158614A (zh) 1997-09-03
TW319769B (en:Method) 1997-11-11
RU2151770C1 (ru) 2000-06-27
NO965305D0 (no) 1996-12-11
SK281341B6 (sk) 2001-02-12
CN1053668C (zh) 2000-06-21
ES2163512T3 (es) 2002-02-01
EP0787726B1 (en) 2001-11-28
HK1000495A1 (en) 2002-07-19
NZ287139A (en) 1997-07-27
KR100350921B1 (ko) 2002-11-18
HUT75777A (en) 1997-05-28
PL181867B1 (pl) 2001-09-28
DK0787726T3 (da) 2002-02-11
AU2576795A (en) 1996-01-05
SI0787726T1 (en) 2002-04-30
CA2192824A1 (en) 1995-12-21
CA2192824C (en) 2006-11-07
MX9606331A (es) 1997-03-29
DE69524251T2 (de) 2002-07-11

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Legal Events

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PC Transfer of assignment of patent

Owner name: DAINIPPON SUMITOMO PHARMA CO., LTD.

Free format text: DAINIPPON SUMITOMO PHARMA CO., LTD.

MA Patent expired