FI112482B - 6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isokinolin- och 1,6,7,8-tetrahydrobentso[2,1-b;3,4-c]-2,3-dion-oximderivat, förfarande för framställning därav, och deras användning - Google Patents

6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isokinolin- och 1,6,7,8-tetrahydrobentso[2,1-b;3,4-c]-2,3-dion-oximderivat, förfarande för framställning därav, och deras användning

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Publication number
FI112482B
FI112482B FI970750A FI970750A FI112482B FI 112482 B FI112482 B FI 112482B FI 970750 A FI970750 A FI 970750A FI 970750 A FI970750 A FI 970750A FI 112482 B FI112482 B FI 112482B
Authority
FI
Finland
Prior art keywords
pct
tetrahydrobenzo
pyrrolo
isoquinoline
dione
Prior art date
Application number
FI970750A
Other languages
English (en)
Finnish (fi)
Other versions
FI970750A0 (sv
FI970750A (sv
Inventor
Peter Moldt
Frank Waetjen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of FI970750A0 publication Critical patent/FI970750A0/sv
Publication of FI970750A publication Critical patent/FI970750A/sv
Application granted granted Critical
Publication of FI112482B publication Critical patent/FI112482B/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI970750A 1994-09-14 1997-02-21 6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isokinolin- och 1,6,7,8-tetrahydrobentso[2,1-b;3,4-c]-2,3-dion-oximderivat, förfarande för framställning därav, och deras användning FI112482B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK105394 1994-09-14
PCT/EP1995/003593 WO1996008494A1 (en) 1994-09-14 1995-09-12 Indole-2,3-dione-3-oxime derivatives, their preparation and use

Publications (3)

Publication Number Publication Date
FI970750A0 FI970750A0 (sv) 1997-02-21
FI970750A FI970750A (sv) 1997-03-13
FI112482B true FI112482B (sv) 2003-12-15

Family

ID=8100455

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970750A FI112482B (sv) 1994-09-14 1997-02-21 6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]isokinolin- och 1,6,7,8-tetrahydrobentso[2,1-b;3,4-c]-2,3-dion-oximderivat, förfarande för framställning därav, och deras användning

Country Status (12)

Country Link
US (1) US5917053A (sv)
EP (1) EP0781284B1 (sv)
JP (1) JP3164371B2 (sv)
AT (1) ATE188700T1 (sv)
AU (1) AU687255B2 (sv)
CA (1) CA2199613C (sv)
DE (1) DE69514532T2 (sv)
EE (1) EE03355B1 (sv)
FI (1) FI112482B (sv)
NO (1) NO308852B1 (sv)
NZ (1) NZ293265A (sv)
WO (1) WO1996008494A1 (sv)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
DE69922936T2 (de) * 1998-03-31 2005-12-08 Neurosearch A/S Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten
AU4910500A (en) * 1999-05-19 2000-12-12 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
PT1255734E (pt) * 2000-01-24 2006-09-29 Neurosearch As Derivados de isatina com actividade neurotrofica
US20040063742A1 (en) * 2001-02-15 2004-04-01 Dan Peters Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
CA2452610A1 (en) 2001-07-13 2003-01-23 Pharmacia & Upjohn Company Hexahydroazepino (4, 5-g) indoles and indolines as 5-ht receptor ligands
CN101346375B (zh) 2005-11-23 2013-04-10 阿罗斯药物有限责任公司 调节门离子通道用组合物和方法
US20100041691A1 (en) * 2006-09-12 2010-02-18 Neurosearch A/S Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use
MX9204914A (es) * 1991-08-28 1993-07-01 Frank Watjen Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
ATE157977T1 (de) * 1992-10-13 1997-09-15 Warner Lambert Co Chinoxalinderivate als eaa antagonisten

Also Published As

Publication number Publication date
JPH09511524A (ja) 1997-11-18
EE03355B1 (et) 2001-02-15
DE69514532T2 (de) 2000-07-06
AU687255B2 (en) 1998-02-19
AU3566495A (en) 1996-03-29
NZ293265A (en) 1998-01-26
CA2199613C (en) 2000-02-29
EP0781284B1 (en) 2000-01-12
DE69514532D1 (de) 2000-02-17
FI970750A0 (sv) 1997-02-21
JP3164371B2 (ja) 2001-05-08
NO970904D0 (no) 1997-02-27
US5917053A (en) 1999-06-29
NO970904L (no) 1997-04-24
ATE188700T1 (de) 2000-01-15
FI970750A (sv) 1997-03-13
WO1996008494A1 (en) 1996-03-21
EP0781284A1 (en) 1997-07-02
CA2199613A1 (en) 1996-03-21
NO308852B1 (no) 2000-11-06

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