FI109273B - Bioactive product derived from peat - Google Patents

Description

109273

Bioactive product derived from peat - Bioaktiv produk deriverad frän Torv This application is subdivided by application 925199.

The present invention is primarily directed to novel peat-derived bioactive products and processes for the preparation of such products. The invention also relates to cosmetic compositions containing these products and to methods of making cosmetic formulations containing said peat-derived bioactive products.

Extraction of peat by various methods using various extraction media 10 and the use of such extracts containing peat-derived bioactive ingredients for cosmetic and pharmaceutical purposes is known.

These known methods are described in Polish Patent Publication No. 124,110 (Chemical Abstracts 101 (10), 78854e). Bioactive products derived from peat by this prior art are obtained by primary and secondary alkaline hydrolysis of air-dried crude lime, followed by acidification of the hydrolyzate thus obtained and subsequent separation of the insoluble solids by subsequent alkalization, clarification of the liquid phase and acidification of the liquid phase. In said process, the aqueous phase derived from the organic extraction is liquid v; 20 bioactive product derived from peat.

: v. Well-known liquid product which is a solution of the active ingredients derived from peat [. ·. in a highly concentrated, almost saturated aqueous solution of sodium chloride and obtained in accordance with the above-mentioned Polish Patent Publication, is unstable when stored for a long time and contains, in terms of biological activity of the composition, a large excess of neutral inorganic substances.

'' As a bulk product, it is difficult to handle, store and process.

. '. The main object of the present invention is to provide a product without these disadvantages; and, that is. a product that is stable and that can be readily formulated into products and that can be incorporated either in solid form or in any suitable solution in cosmetic products.

Since previous attempts to concentrate and desalinate known aqueous solutions of peat-derived bioactive substances have failed to produce 2,109,273 positive results due to the occlusion of the active ingredients in the crystallization solid phase, which causes a reduction in the biological activity of the composition, it is difficult to find a suitable method

Unexpectedly, it was found that a positive result can be achieved if the liquid composition is first diluted several times prior to concentration, i. volumes of water many times the volume of the composition.

Accordingly, the invention provides a process whereby a peat-derived bioactive product having the above advantageous characteristics is obtainable from a highly concentrated aqueous solution of an inorganic salt, in particular sodium chloride, containing the peat-derived bioactive ingredients by diluting said solution with water. desalted, e.g., with distilled water, followed by reverse osmosis, concentration and clarification.

The solution thus obtained can be easily converted by sterilization and spray drying into a sterile and solid product which is well suited for the intended purposes. The dilution is preferably carried out in quantities of water several times, preferably 5-8 times, the amount of concentrated solution to be diluted.

This process, which is used to treat the product obtained according to Polish Patent Publication No. 124 110, consists of separating the remaining organic solvents from the aqueous phase after extraction, separating the insoluble parts by filtration under reduced pressure through a sintered ceramic material. dilution of permeate several times with distilled water and its volume:; ' from desalting by reverse osmosis to additional mineral salts, mainly- * ·. ' sodium chloride as a permeate. The desalted solution is then concentrated, clarified by centrifugation, and sterilized by filtration through a membrane filter, eg a Millipore (R) filter. Optionally, the resulting microbiologically pure solution may be spray-dried. The sterilized product (liquid or solid) may be formulated into a cosmetic composition. Concentrated and streamlined. '. the solution may be used optionally without sterilization and without spray drying; 30 gloves as a suitable dilution component in numerous cosmetic compositions.

'. In the spray drying step, the inlet temperature is preferably set at about 180 ° C, while the outlet temperature is set at about 90 ° C.

3, 109273

Although the process of the present invention is described above in conjunction with the process of Polish Patent No. 124,110, its use is not limited to such a combination, but is generally available in the process of obtaining a bioactive product from peat from a highly concentrated aqueous solution of inorganic salts, especially sodium chloride. , which contains bioactive ingredients derived from peat.

The peat-derived bioactive products provided by the present invention do not contain more than 70% by weight, preferably more than 60% by weight, of inorganic salts, especially sodium chloride. Because low sodium chloride concentrations as low as $ 10 or more are desired for optimal product and cosmetic uses that require higher concentrations, i. for facial care, lower concentrations of sodium chloride, such as 55% or less, are most preferred, especially when obtained by the dilution and reverse osmosis steps.

If the process is terminated by the concentration and clarification steps, the product is a concentrated (or thickened) solution. "Concentrated peat extract" as used in this specification is a dark brown liquid having a density of 1.02 to 10.9 g / ml and a dry matter content of not less than 5% by weight. The chloride ion content in dry solids, calculated as NaCl, does not exceed 70%, preferably 60%, and the pH of a 1% aqueous solution is 5.0 to 6.5, usually about 6.0. The absence of an additional sterilization step is not detrimental in certain cases, e.g., in certain cosmetic uses of the concentrated peat extract in question.

:: ': Particularly when a sterilization step is used, an additional spray-drying step is preferred, t' 1 ': although not mandatory. The product obtained after such a spray-drying step is in powder form and is thus particularly suitable for the preparation of certain compositions. Preferably, this type of product is a product commercialized under the name "TOLPA (R) !!! 25 Torf Preparation" with TOLPA (R) being Torf Corporation, ui. Mydlana 2, Wroclaw,

'Poland, a registered trademark. The abbreviation TTP is used throughout this specification

to describe said product.

The present invention also relates to compositions containing as active ingredient ai. . as part of the bioactive product derived from peat as described above, in particular • 30 products containing not more than 70% by weight, preferably more than 60% by weight, of inorganic salts, in particular sodium chloride, calculated on the dry solids, together with: : '; with a carrier. A bioactive product derived from peat that is included; * ·; Such compositions preferably have TTP as defined above. The preparation contains a bioactive product derived from peat and an acceptable carrier material-35, preferably in a weight ratio of about 1: 5 to 1.25 and most preferably 1: 9 to 1:19.

4,109,273

The present invention further relates to a process for the preparation of a gel formulation containing a bioactive product derived from peat. This process is characterized in that sterile alcoholic herbal extract is combined with sterile glycerol, a sterile, preferably concentrated aqueous, : 10-94: 6. TTP is preferably used as a powdered or concentrated bioactive product derived from peat.

The present invention also relates to a process for preparing a formulation in the form of an ointment containing a bioactive product derived from peat. This process is characterized in that the sterile herb extract is gradually combined with a sterile solution of the turf powdered bioactive product, the resulting mixture is gelled by addition of colloidal silica and the gel thus obtained is triturated with previously sterilized fat components such as e about 30:20 and the gel fat composition 32: 68-34: 66. Here again, TTP is used as a bioactive product derived from peat or concentrated peat.

Cosmetic preparations which may contain herbal extracts and other auxiliary and rich,. Formulations, fragrance compositions and carrier materials permitted for cosmetic use contain from 0.01 to 10% by weight, preferably 0.05 to 1.00% by weight, of a peat-derived bioactive product of the present invention and most preferably 0.05-0.10% by weight.

. The carrier materials may be aqueous alcohols, emulsions of all types, gels, foaming compositions, and fat carriers. The use of one specific carrier selected from the group of substances mentioned above allows the formulation of various types of cosmetic products of the invention, such as daily lotions, foams, balms, cleansing milks, etc. for the treatment of the body, and Y .: shampoos, hair balsams, bath foam compositions. tur-; ' · T: 30 pe from bioactive products.

Peat-derived bioactive products (peat extracts in abbreviated form) which: Y originates from raw peat material such as (including) medicinal sludge, contains: • i well-balanced amounts of mineral and organic compounds such as the mineral salts of the following: B, Si, Ab, Fe, Mg, Mn, Cu, Sn, Ni, Ca, 35 Ag and Na; organic compounds such as amino acids in free form and in salts; polysaccharides, partially degraded / reacted during hydrolysis to deoxy saccharides and / or amino saccharides. Peat, especially medicinal mud, is known and identified as a material of biological plant and microorganism origin; due to the concentration of its nutritional and stimulatory components, it has beneficial effects on humans and mammals; thus, the bioactive compositions derived from peat contain the above-mentioned substances in proportions which are characteristic of living organisms; this is considered to be an explanation of the beneficial effects of cosmetic products containing peat-derived active products and compositions.

Particularly good effects of the new cosmetic compositions are observed when herbal extract is also present in the foam for-10. The selection of a suitable herbal extract is based on the known conventional use of such extracts in cosmetics, which modifies the activity of the formulations and thus allows the contents of the cosmetic formulations to be consistent with the requirements and needs of the persons being treated.

The present invention will be further characterized and explained in the following Examples.

The examples are directed to a plurality of cosmetic formulations according to the invention of various compositions and for various purposes containing advantageous additions of peat-derived bioactive agents. Various facial lotions, balms, creams, milks, shampoos, wax-20 toothpick compositions, etc. are described.

; Example 1 .: . Starting with 1000 kg of air-dried raw peat material, followed by eg · · *; * the process according to U.S. Patent No. 124110 provided a solution V of peat-derived bio-'··' · * active ingredients in saturated aqueous sodium chloride solution; 25 about 10 liters. The solution was filtered through a sintered ceramic filter under reduced pressure to clarify the solution before desalting. The clear Liu-1: '' thus obtained contains about 95% NaCl in the dry mass. The dry mass consists of about 32% by weight of the solution. The volume of this clear solution is about 7 liters.

. The clear solution is diluted 5-8 times with distilled water and diluted with dilute solution. 30 in a lost form to a desalting step which is performed using a reverse *! ·, Using the DDS device in the theosmosis technique. Desalting is carried out for 3-4 hours, whereupon the excess of mineral salts, mainly NaCl, is removed in the form of permeate. The desalted composition contained approximately 65-70% sodium chloride in solids. The solution thus obtained, 6-7 volumes per liter, was concentrated 4-5] 6 109273 times in a Buechi rotary evaporator to give a concentrated solution containing approximately 20% dry weight. The resulting concentrated solution was clarified using a Biofuga-Heraeus centrifuge (flow separator) and then sterilized by filtration through a Millipore (R) filter.

The resulting microbiologically pure solution was spray dried in an Anhydro dryer with an outlet notch set to 90 ° C and an inlet temperature set to 180 ° C.

The yield of the dried powder was about 200 g.

Example 2

The product of Example 1 was used to prepare gel and cream compositions which also contain herbal extracts synergistically. The gel and ointment were prepared as follows: 20 g horse chestnut extract, 10 g marigold extract, 60 g glycerol, 0.1 TTP obtained as described in Example 1 in powder form, 0.1 g salicylic acid, 1.0 g distilled water and 8.8 g g Aerosil (R) (colloidal silica) was used to obtain the gel form of the preparation.

The liquid (non-volatile) ingredients were sterilized by heating under reflux for two hours before use. The herbal extracts were combined with glycerol and an aqueous solution of TTP and menthol and silica were gradually added with continuous mixing.

,. Similarly, the following ingredients were used to obtain the ointment composition: 22 g; '; 'Horse chestnut extract, 10 g of marigold extract, 0.1 g of salicylic acid, 0.1 g of TTP' 'in powder form obtained as described in Example 1 and 2.0 Aerosil (R).

; * ·. The fat components used were a mixture of the following substances: 22 g of euserine and. . ·. 45.8 g petrolatum. The herb extracts were sterilized by heating for about 2 hours under reflux. Euserine and petroleum jelly were sterilized in the same manner. The liquid ingredients were carefully blended with silica to obtain a gel, which in turn was triturated with sterilized gas and fat components cooled to room temperature. A stable ointment was obtained which did not stand out on storage.

•. Example 3

A reaction vessel equipped with a stirrer was charged with 150 mg of chamomile extract obtained by extraction of chamomile flower with 1: 1 ethanol: aqueous solution, as well as 1 g above; 30 TTPs described. To the resulting mixture was added 50 g of glycerol. The three substances were mixed to obtain a uniform mixture. Next, another mixture was introduced into the same reaction vessel, which was formulated as before. It consisted of 340 g of 95: 5 ethanol-7 109 273 l: aqueous solution, 1 g of salicylic acid and 0.5 g of menthol. The two mixtures were combined by stirring to obtain a uniform solution. Next, 3 g of fragrance composition TILIANA H4308 was added. TILIANA H4308 is a product of Fabryka Syntetykow Za-pachowych Pollena-Aroman (Syntetic Fragrance Works Pollena-Aroma), Warsaw, Poland. The husk was then brought to a total volume of 1000 ml by the addition of 454.5 g of distilled water; stirring was continued until a homogeneous mixture was obtained.

In the above procedure, 86% mentoha and water were used according to Polish Pharma-Copea according to FP IV and ethanol at a concentration of 95% according to Polish industrial standard BN-75 / 6193-01.

10 Concentrated peat extract used is a light brown liquid having a density of 1.020-1.090 g / ml and a solids content of up to 5%; The pH of a 1% aqueous solution was 5.0-6.5. Chamomile extract oh reddish-brown liquid with density o 0.9160-0.9503 g / ml and ethanol content 52-56% by volume.

The face water preparation obtained above is suitable for all skin types. It is a clear liquid with no solids. Its color is yellow. The pH is 4.28 and the ethanol content is 45.92% by volume. The total acidity, calculated as the sacchylic acid content, is 0.1 wt%, namely 0.23 wt%. The product did not lose any of the above characteristics during storage for 12 months.

I Example 4 '·' 20 The method described in Example 4 was repeated with the only difference that the chamomile •. ·: Peripheral flower was used in place of the extract and TILIANA H4308 fragrance composition. · * Ration and composition FINUS H4625 (which is also a product of Fabryka Syntetykow Za-: pachowych Pollena-Aroma) in the same manner and in the same mooh: weight ratio: *: *. The resulting lotion is suitable for dry and sensitive skin. It is also a clear liquid which does not contain any solid particles. pH-oh 4.30, total-oh: oan content 45.82% by volume and total acidity 0.27% by weight. Va, ···, the dashed preparation remained unchanged for 12 months, such as that obtained according to Example 4.

. . ·: Example 5 ':': The procedure described in Example 4 was repeated except that instead of the camomile extract, sage leaf extract was observed and LELIA 90368 (Pohena-Aroma, Warsaw) was observed instead of TILIANA H4308. The sage leaf extract was obtained by extraction of the dried sage leaves with ethanol at 50 ° C and its color brown, having a characteristic salvia 8,109,273 odor density of 0.9503; it contained 52-56% ethanol. The resulting facial conditioner is particularly suitable for oily skin. It is a clear and homogeneous liquid with a dark yellow color; pH, ethanol content and acidity are comparable to the conditioner of Example 4.

Example 6

The following composition was shown to be particularly effective in preventing or treating rapid tooth fixation: 24.0 g of chamomile extract 3.0 g of sage leaf extract 10 0.3 g of salicylic acid

0.2 g menthol 0, IgTTP

Up to 100.0 g commercial gel base.

Example 7 The following carefully weighed components were introduced into a 200 mL reaction vessel equipped with a mechanical stirrer: 270 g of chamomile extract obtained by extraction of chamomile flower with 50% ethanol; extract oh reddish-brown liquid having a density of 0.9160-0.9503 g / ml and a content of about 55% by volume of ethane: ':'; . 20 g of glycerol, 86% according to Polish Pharmacopean FPIV:: 30 g of Saponaria officinalis extract obtained by extraction of Saponaria officinalis: '·'; roots in 70% ethanol; extract oh reddish liquid, density oh 0.9630-0.9810 g / ml and ethanol content approximately 75% by volume, 1.0 g of the inventive concentrated peat extract, which is a thinner brown liquid having a density of 1.02- 1.09 g / ml, not more than 2% chloride ions, calculated as sodium chloride; if- '. : solids content up to 5%; the pH of the 1% aqueous extract of the extract was oh 6.0.

The ingredients listed above were thoroughly mixed. A previously prepared solution of: v: 1 g of salicylic acid in 260 g of 95% ethanol was added thereto. A combined slurry of 383 g of distilled water and 5 fragrance compositions TILIANA H4308 was added and stirred until a uniform slurry was obtained. The preparation was analyzed and stored in 200 ml retail bottles. The preparation obtained was suitable as a hair care product. It was a clear, slightly opalescent liquid containing approximately 45% v / v ethanol: pH 4.5; total acidity, calculated as salicylic acid oh greater than 0,1%. The product is suitable for blonde hair. During the 12 months of storage, the product remained unchanged.

Example 8

The procedure described in Example 8 was repeated except that instead of the chamomile extract and the TELLANA H4308 composition were used in the same sequence and ratio: the herbal extract and the fragrance composition FINUS H4625. The horsetail extract was a green-brown liquid having a density of 0.9160-0.9503 g / ml and an ethanol content of 55% vol / vol.

The resulting preparation is particularly suitable for all types of hair. It is a clear and translucent liquid which does not contain any solid components and is yellow-brown in color; The pH, ethanol content and total acidity, as well as the stability after 12 months storage are the same as in the preparation of Example 6.

15 Example 9

The method described in Example 8 was repeated with comparable results. The only difference was that chamomile extract and TILIANA H4308 were used in the same sequence and in proportion to the nettle extract and fragrance composition: 'LELIA 90368 (product of the same Fabryka Syntetykow Zapachowych Pohena-Aroma).

• · I

'·' 20 The herb extract used was oh olive green in color, its density oh 0.9160-0.9503 g / ml and · '* ethanol content 55% by volume. This product is suitable for all types of hair.

• * *; . Example 10 '·' 'In general, cosmetic milks are dispersions of fat substances that act both chemically and mechanically on the skin. In fact, due to the convenient 25 ways of administration and the better fluid-skin interaction, it is very convenient to use liquid creams, more particularly lotions. They can penetrate, · '; easily penetrates deeper layers of the skin, thus preventing age-related skin changes.

'! Cosmetic milks are mainly used to cleanse dry and sensitive skin.

Thus, they must not contain any aggressive essential oils, while they often contain suitable herbal extracts such as chamomile extract or wheat germ extract.

•: · ·: Addition of peat-derived bioactive substances to such compositions further enhances their positive effects. The new recipe is as follows: 10 109273 TTP 0.05 g aloe extract 20.00 g glycerol 3.00 g euserine 2.00 g 5 white paraffin oil 1.00 g triethylamine 1.00 g

Aerosil (R) (colloidal silica) 4.00 g

Example 11 10 Improved refreshing results were obtained when TTP and carefully selected fat carriers were used in the classic nourishing and refreshing cream formula. TTP is used in an amount of 0.01% to 1.00% by weight combined with herbal extract (the choice depends on the type of skin for which the cream is intended) in an amount of at least 0.05% to 1.00% by weight with an antimicrobial agent in an amount of 0.05 to 1.00% by weight, to a synthetic fragrance compound in an amount of 0.01 to 0.05% by weight and to a fatty acid carrier in the form of an aqueous emulsion of 97.00 to 99.50% by weight of the whole composition. The fatty acid composition must be a good carrier for the active ingredients and be well suited for the skin. It is preferably an emulsion (all amounts by weight) of 35-45 euserines, 8-14 petroleum jelly, 2.5-4 olive oils, 6-10 glycerol-20 ha and 35-40 water. Preferred herbal extracts are marigold flower extract, chamomile extract; ·. cerebrospinal fluid and the like. The preferred recipes are as follows: '·' Euserine 39.00 parts by weight: Vaseline 11.50 parts by weight: Olive oil 3.13 parts by weight: 25 Glycerol 7.80 parts by weight: Water 38.00 parts by weight N1PAGINA A (antibacterial preparation) 0.40 parts by weight ....: TTP 0.05 parts by weight I, ···, Marigold extract 0.10 parts by weight • '30 Synthetic fragrance 0.02 parts by weight

100,000 parts by weight in total »» 11 109273

Euserine 42.00 parts by weight

Vaseline 8.50 parts by weight

Olive oil 3.08 parts by weight

Glycerol 7.90 parts by weight 5 Water 38.00 parts by weight NIPAGINA A (antimicrobial preparation) 0.40 parts by weight TTP 0.05 parts by weight

Chamomile extract 0.02 parts by weight

Synthetic fragrance 0.05 parts by weight 10 Total 100,000 parts by weight

Example 12

The lotion preparation contains TTP as a peat extract in an amount of 0.01-1% by weight, herbal extracts in an amount of 1-30% by weight, glycerol in an amount of 1-8% by weight, salicylic acid and menthol in an aqueous alcoholic solution. Preferred herbal extracts are: chamomile, marigold, yarrow, aloe extract and the like. Glycerol addition is also advantageous due to its effect on skin elasticity. It accelerates the application of the preparation to the face and its penetration into the deeper layers of the skin, thus enhancing the beneficial effects of the active peat composition and herbal extracts. Preferred recipes are: ·, · '20 TTP 0.10 parts by weight::': Chamomile extract 15.00 parts by weight

Glycerol 5.00 parts by weight; '. *. Menthol 0.10 parts by weight. Salicylic acid 0.10 parts by weight, 25% ethanol (conc. 95%) 10.00 parts by weight

Fragrance composition 0.30 parts by weight

Distilled water ad 100.00 parts by weight *: Example 13 :: A shampoo composition was prepared according to the following recipe: 30 Fuller Herbal Extract 15.00 g 7.50% w / w

Nettle Leaf Extract 20.00 g 10.00% by weight ':: GAMAL SBS-11 (detergent) 3.00 g 15.00% by weight GAMAL NO-3 (detergent) 20.00 g 10.00% by weight

Aseptin 0.40 g 0.20 wt% 12109273

Ethanol 1.60 g 3.80% by weight BRONOPOL (preservative) 0.04g 0.02% by weight

Sodium chloride 6.00 g 3.00% by weight

Water 106.96 g 5348% by weight A total of 200.00 g 100.00% by weight of 92 parts by weight of the above shampoo composition was added with 8 parts by weight of TTP to obtain 100 parts by weight of the shampoo of the invention. Other herbal extracts can be used instead of nettle leaf extract.

Example 14 The following shampoo composition was prepared:

Horse chestnut extract 13.00 g

Marigold Flower Extract 22.00 g GAMAL SBS-11 30.00 g GAMALNO-3 20.00 g 15 Aseptin 0.40 g

Ethanol 1.60 g BRONOPOL 0.04 g

Sodium chloride 6.00 g

Water 10696 g. ·: ·. A total of 200.00 g: 95 parts by weight of the above shampoo composition was added with 5 parts by weight of TTP: 100 parts by weight of the shampoo of the invention.

* 'I

,: '. Example 15

Toothpaste contains TTP as a concentrated peat extract in an amount of 0.01-0.10% by weight: '25% by weight, essential oils or their compositions or other fruit essences in an amount of' ': 1-10% by weight, herbal extracts in an amount of 0 , 10 to 10% by weight and cleansing agents . in an amount of 20-35% by weight dispersed in water in an amount of 45-60% by weight; and in the amount of dyes and bleaching components in an amount of 1-2% by weight.

. ·, ·. Titanium dioxide may be used as a bleaching component; TTP itself can be used as an antibacterial additive; sage leaf, chamomile or marigold flower extracts can be used as beneficial inexpensive herbal extracts. The preferred recipe is as follows: 13 109273

Alloyed calcium carbonate 150.00 g

Magnesium carbonate 0.00 g

Glycerol 0.00 g

Herbal Extract 5.00 g 5 TTP 0.50 g

Titanium dioxide 10.00 g

Essential oils (mint, lemon, etc. essences) 5.00 g

Water 400.00 g Color slightly 10 Example 16

Bath Salt Preparation: The process for obtaining a bioactive product derived from peat according to the invention, in particular when converted from a liquid form to a powder form, is a desalting step in which sodium chloride is separated as a by-product. In said by-product, 95% consists of sodium chloride, the other separated mineral salts being calcium salts, magnesium salts, mainly chlorides and sulphates; saline products also contain some organic peat-derived low-molecule compounds embedded in the crystalline structure of these inorganic salts. These organic compounds are components of TTP and include polysaccharides, amino acids, fulvic acids and the like. The presence of these components. The presence of the salt in the by-products is useful if the salt is used as a bath salt, * t: '' because they can add other beneficial effects to the standard activity of the bath salt. Therefore, this by-product was tested for chemical and physical properties at the Poznan Balneological Institute in Poland to see if: V can be used in cosmetic baths. Because the institute couldn't find anything:; : 25 unwanted whole salt, it was approved for cosmetic use. Preferred:: *; Here's the recipe:

Salt (NaCl) containing 97.00 g of entrapped TTP

Essential tall oil or composition of essential oils 3.00 g • »30 Example 17 'New hair balm contains 0.01 to 1% by weight of herbal extracts, 0.01 to 10% by weight of herbal extracts, 3 -4% by weight of components: · · which prevent excessive drying of hair and skin up to 2% by weight, glycerol in amounts of 1-5% by weight, preservatives and stabilizers in amounts of 0.05-35 0.50% by weight % and water up to 100% by weight.

14 109273

The present balm contains, as an anticancer agent, an alcoholic flesh of trimethylamine and an ammonium chloride salt obtained from fatty animal, a thickening agent of a cosmetic alcohol which also acts as a stabilizer; vegetable oils, which act simultaneously as co-emulsifiers as an agent to prevent excessive drying of hair and skin; and glycerol to facilitate the spread and penetration of the balsam, especially its active substances, TTP and herbal extracts. Because the acidic medium stops bacterial growth, the balm of the invention contains citric acid or fumaric acid in an amount of 0.1%, as well as a preservative known as BRONOPOL, and fragrance compositions. The preferred 10 recipe is:

Trimethylamine and ammonium chloride alcoholic solution 3 to 4% by weight

Cosmetic Alcohols 3-4% by weight TTP 0.01-10% by weight

Thickened Herbal Extracts 0.01-10% by weight 15 Glycerol 1.5% by weight

Vegetable oils up to 2% by weight

Citric acid or fumaric acid 0,1% by weight BRONOPOL 0,1% by weight

Fragrance composition 0.3 wt% 20 Distilled water up to 100.00 wt%

Example 18, '·': Beauty masks are well-known cosmetic preparations which serve many purposes. Medicinal mud has a known beneficial effect on skin and skin. . · Hoon, it was believed that the post-extraction peat obtained by the method of bioactive

1 * I

: · For separating 25 peat-derived compositions from peat, they can be used for cosmetic applications. The post-extraction peat contains a solution of the active bodies liberated in the alkaline hydrolysis process due to the extremely high sorption properties of the peat after neutralization. Thus, it was found to be a valuable component of distant ... masks. To enrich post-extraction peat with several valuable constituents, natural medicinal sludge and humic acid fraction present in natural peat were added and separated in the process for obtaining the bioactive compositions derived from peat from the alkaline hydrolyzate. Such a composition was tested at the aforementioned balneological institute and was found to be suitable for cosmetic use. The preferred recipe is as follows: Post-extraction peat 100.0 g

Natural medicinal mud or peat 20.0 g

Humic acid fraction 10.0 g

Magnesium carbonate 10.0 g 5 Zinc oxide 5.0 g

Citric acid or the like 0,1 g

Herb extract or powdered plant material 5.0 g

Distilled water q.s.

No mutagenic, genotoxic, embryotoxic teratogenic or carcinogenic activity was observed in TTP. TTP has no allergenic properties and no locally irritating activity.

Some compositions, such as shampoo, which is washed off almost immediately, have short contact times with the body or skin and may contain a relatively more useful component; others are used several times a day and thus become | 15 be a lower concentration of active substance.

j!

In addition, in the case of toothpaste in contact with the oral mucosa, penetration of the active agent is easier than transdermal delivery and the concentration of the active agent may be low.

»· I ·» * »• * t t * i! · '»; - * * • f 1 * t t * * I i »I * * '» »

Claims (10)

109273 1 I Peat-derived bioactive product for use as a cosmetic product, characterized in that it contains less than 70% by weight, preferably less than 60% by weight, of inorganic salts, in particular sodium chloride, based on dry weight. 2. The product enligt patentkrav 1, kännetecknad av att den kanvinnas enligt * · · · · et förfarande, vid vilket en synnerligen concentrerad, av oorganiska salter, i ...: synnerhet av sodium chloride, bestäende vattenlösning, som innehäller ur Torv här- ledda bioactiv beständsdelar, utspäds med vatien som är avsaltat, och utsätts.,.,: för omvänd Osmos för att avlägsna salter ur lösningen och vid livningen concentreras och Klaras och optionellt steriliseras' / eller 'slammed into iminin ett steg. 109273 Product according to Claim 1, characterized in that it is obtainable by a process in which a highly concentrated aqueous solution of inorganic salts, in particular sodium chloride, containing bioactive ingredients derived from peat, is diluted with desalted water and subjected to reverse osmosis to remove salts. and wherein the resulting solution is concentrated and clarified and optionally sterilized and / or spray dried in at least one step. 3. The product is patented 1 eller 2, the transducers are avant den can use, the concentration is sodium chloride wadding, som innehäller ur Torvled bioactive beständsdelar, this kind of lymphatic hydrolysis secondary av lufttorrt horn material, colors hydrolysis efterf oils av en acidifikation av hydrolysatet, avskiljning av oligliga beständsdelar samt elimination av grussub-stanser genome extraction med organic litterfilter , colors det lunda 10 erhällna Klara filtratet utspäds med avsaltat vatien och utsätts för omvänd Osmos för avlägsnande av salter frän lösningen, da de ororganiska saltema och dör den erhällen larsning och klaras aytorkas. Product according to claim 1 or 2, characterized in that it is obtainable by a process wherein a highly concentrated aqueous solution of sodium chloride containing bioactive ingredients derived from peat, said solution being obtained by primary and secondary alkaline hydrolysis of air-dried crude peat material. followed by acidification of the hydrolyzate, separation of insoluble moieties and stabilization of the gravel substances by extraction with organic solvents and removal of residual organic solvents from the after-leach water phase, * ·: 1 .: filtered through a sintered ceramic filter with desalted and plated. : ': Reverse osmosis to remove salts from solution with inorganic salts removed and wherein the resulting solution is concentrated and clarified and optionally sterile; sputtered and / or spray dried. Peat-derived bioactive product according to one or more of the preceding claims, characterized in that said product is in the form of a concentrated bulk solution or in the form of a powder. 4. Ur Torv calf bioactive product enligt et eller flera ovanstäende patent-15 krav, tongue-in-mouth such product föreligger i form av concentrerad lösning eller Powder. 5. Cosmetic preparations, kangetecknat av att det innehäller som Aktiv Ingre-diens ur Torv härdd bioactive product enligt vilket som Heist av patentkraven 1-4 i en play 0.01-10 wt.%, Fördelaktigt 0.05-1 wt. % och ännu fördelakti- 20 Gare 0.05-0.1 vikt-%. •:: 6. Cosmetic Preparat enligt patentkrav 5, kännetecknat av att det dessut-: ': om innehäller ätminstone et eltextrakt och / eller ätminstone et doftämne. !! 7. A cosmetic preparation of patent application 5 eller 6, a calligraphy of an att det som ur bioactive product innehäller male description "concentrate 25 torve extract" eller en del davav. » Cosmetic product, characterized in that it contains as an active ingredient '·' · a peat-derived bioactive product according to any one of claims 1 to 4 in an amount of 0.01-10% by weight, preferably 0.05-1% by weight and further more preferably:. 30 0.05-0.1% by weight. Cosmetic preparation according to Claim 5, characterized in that it further contains at least one herbal extract and / or at least one fragrance. 109273 Cosmetic product according to Claim 5 or 6, characterized in that it contains, as a bioactive product derived from peat, a "concentrated peat extract" or a part thereof as described herein. 8. A cosmetic preparation according to claim 5, 7-8. '. tecknat av att det innehäller dessutom en warmplig bärare och / eller et warming • '; vodka, fatty acids, alcoholic, organic, antibiotic, preservative, stabilizing, emulsifying, preservative: V; 30 tjockningsmedel that oorganiskt site, en naturlig eller synthetisk ol, en etherisk •; : olta that ringer ring eller et farkämne. 109273 Cosmetic preparation according to one or more of Claims 5 to 7, characterized in that it further comprises at least one suitable carrier and / or additive which is preferably an alcohol, an organic acid, an antibiotic, a preservative, a stabilizer, an emulsifier, a thickener. , inorganic salt, natural or synthetic oil, essential oil, cleanser or dye. 9. Förfarande för ffamställning av kosmetiskt preparat, kännetecknat av att man förenar en bioactive product enligt face av patentkraven 1-4 i en av 0.01-10 vikt-%, fördelaktigt 0.05-1 vikt-% och ännu fördelaktigare 0 , 05-0.1 vikt-% med en kosmetiskt godtagbar bar och optionellt med atminstone 5 et suffigigt tilsatsämne som fördelaktigt en alcohol, en organic syra, anti-antibiotic, preservative, stabilizer, emulgerings, förtjock , that oorganic site, en naturlig eller synthetic oil, en etheric oil olive oil, yellow color, yellow color, ingredient coloring blandas och processeras vidare ä, att man erhäller suskade för kosmetisk 10 behandling with smother former, mica fördelaktigt är Pulver, , scham-pon, geler, Krämer och lösningssammansättningar. A process for the preparation of a cosmetic product, characterized in that 0.01 to 10% by weight, preferably 0.05 to 1% by weight, and more preferably 0.05 to 0.1% by weight of any one of claims 1-4 The bioactive product of the invention is combined with a cosmetically acceptable carrier and optionally at least one additive which is preferably an alcohol, an organic acid, an antibiotic, a preservative, a stabilizer, an emulsifier, a thickening agent, an inorganic salt, a natural or synthetic oil, an essential oil, wherein the blend ingredients are further blended and further processed to obtain the desired forms for cosmetic treatment, which are preferably powders, salts, mud, shampoos, gels, creams and solution compositions. Method according to Claim 9, characterized in that at least one herb extract and / or at least one fragrance are further mixed according to '': 20. ! .. Patent krav j '·' 1. Ur Torv härledd, som cosmetic ämne användbar bioactive product, kän-:: ': netecknad av att den innehäller under 70 vikt-%, fördelaktigt under 60 vikt-%,: I'; oorganiska salter, i synnerhet sodium chloride, racknings torrvikten. 10. Förfarande enligt patentkrav 9, kännetecknat av att man dessutom blan-Dar in ytterligare atminstone et eltextrakt och / eller atminstone et doftämne. 1 I »