FI106034B - Menetelmä sulfatoitujen polysakkaridien terapeuttisesti käyttökelpoisen seoksen valmistamiseksi - Google Patents

Menetelmä sulfatoitujen polysakkaridien terapeuttisesti käyttökelpoisen seoksen valmistamiseksi Download PDF

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Publication number
FI106034B
FI106034B FI943642A FI943642A FI106034B FI 106034 B FI106034 B FI 106034B FI 943642 A FI943642 A FI 943642A FI 943642 A FI943642 A FI 943642A FI 106034 B FI106034 B FI 106034B
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FI
Finland
Prior art keywords
heparin
mixture
process according
oligosaccharides
molecular weight
Prior art date
Application number
FI943642A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943642A (fi
FI943642A0 (fi
Inventor
Andre Uzan
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of FI943642A publication Critical patent/FI943642A/fi
Publication of FI943642A0 publication Critical patent/FI943642A0/fi
Application granted granted Critical
Publication of FI106034B publication Critical patent/FI106034B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
FI943642A 1992-02-07 1994-08-05 Menetelmä sulfatoitujen polysakkaridien terapeuttisesti käyttökelpoisen seoksen valmistamiseksi FI106034B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9201383 1992-02-07
FR9201383A FR2687158B1 (fr) 1992-02-07 1992-02-07 Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.
FR9300114 1993-02-04
PCT/FR1993/000114 WO1993016112A1 (fr) 1992-02-07 1993-02-04 Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation

Publications (3)

Publication Number Publication Date
FI943642A FI943642A (fi) 1994-08-05
FI943642A0 FI943642A0 (fi) 1994-08-05
FI106034B true FI106034B (fi) 2000-11-15

Family

ID=9426428

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943642A FI106034B (fi) 1992-02-07 1994-08-05 Menetelmä sulfatoitujen polysakkaridien terapeuttisesti käyttökelpoisen seoksen valmistamiseksi

Country Status (17)

Country Link
EP (1) EP0625166B1 (es)
JP (1) JP3218039B2 (es)
KR (1) KR950700334A (es)
AT (1) ATE157991T1 (es)
AU (1) AU671817B2 (es)
CA (1) CA2126241C (es)
DE (1) DE69313826T2 (es)
DK (1) DK0625166T3 (es)
ES (1) ES2109478T3 (es)
FI (1) FI106034B (es)
FR (1) FR2687158B1 (es)
GR (1) GR3024695T3 (es)
HU (1) HU214327B (es)
MX (1) MX9300584A (es)
NO (1) NO307466B1 (es)
NZ (1) NZ249165A (es)
WO (1) WO1993016112A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0735050B1 (en) * 1995-03-31 2002-09-25 Hamilton Civic Hospitals Research Development, Inc. Compositions for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
WO1998055515A1 (en) * 1997-06-06 1998-12-10 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
EP2284535A1 (en) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
JP2009538386A (ja) * 2006-05-25 2009-11-05 モメンタ ファーマシューティカルズ インコーポレイテッド 低分子量ヘパリン組成物およびその使用
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP3144325B1 (en) * 2010-09-14 2020-11-04 University Of Miyazaki High purity heparin and production method therefor
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2945595A1 (de) * 1979-11-12 1981-05-21 Sandoz-Patent-GmbH, 7850 Lörrach Verfahren zur herstellung von niedermolekularem heparin bzw. seinen salzen
FR2622450B1 (fr) * 1987-11-03 1991-02-22 Sanofi Sa Association heparine/dermatane sulfate
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
FR2675806B1 (fr) * 1991-04-23 1994-06-10 Rhone Poulenc Rorer Sa Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.

Also Published As

Publication number Publication date
NO942897D0 (es) 1994-08-04
JP3218039B2 (ja) 2001-10-15
AU671817B2 (en) 1996-09-12
WO1993016112A1 (fr) 1993-08-19
AU3505193A (en) 1993-09-03
ATE157991T1 (de) 1997-09-15
JPH07503496A (ja) 1995-04-13
HUT67878A (en) 1995-05-29
FR2687158B1 (fr) 1995-06-30
NO307466B1 (no) 2000-04-10
MX9300584A (es) 1993-08-01
FI943642A (fi) 1994-08-05
KR950700334A (ko) 1995-01-16
FR2687158A1 (fr) 1993-08-13
CA2126241A1 (fr) 1993-08-19
HU214327B (hu) 1998-03-02
NO942897L (no) 1994-08-04
CA2126241C (fr) 2004-06-22
DE69313826D1 (de) 1997-10-16
GR3024695T3 (en) 1997-12-31
FI943642A0 (fi) 1994-08-05
DE69313826T2 (de) 1998-02-12
NZ249165A (en) 1996-01-26
EP0625166A1 (fr) 1994-11-23
EP0625166B1 (fr) 1997-09-10
DK0625166T3 (da) 1998-02-02
HU9401994D0 (en) 1994-09-28
ES2109478T3 (es) 1998-01-16

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