FI104618B - Förfarande för framställning av ett adhesivt tillförseldon för transdermalt läkemedel - Google Patents

Förfarande för framställning av ett adhesivt tillförseldon för transdermalt läkemedel Download PDF

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Publication number
FI104618B
FI104618B FI904358A FI904358A FI104618B FI 104618 B FI104618 B FI 104618B FI 904358 A FI904358 A FI 904358A FI 904358 A FI904358 A FI 904358A FI 104618 B FI104618 B FI 104618B
Authority
FI
Finland
Prior art keywords
drug
weight
multipolymer
vinyl acetate
rubber
Prior art date
Application number
FI904358A
Other languages
English (en)
Finnish (fi)
Other versions
FI904358A0 (fi
Inventor
Steven Sablotsky
John M Questel
Original Assignee
Noven Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noven Pharma filed Critical Noven Pharma
Publication of FI904358A0 publication Critical patent/FI904358A0/fi
Application granted granted Critical
Publication of FI104618B publication Critical patent/FI104618B/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
    • B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
    • B26F1/38—Cutting-out; Stamping-out
    • B26F1/384—Cutting-out; Stamping-out using rotating drums

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Botany (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (13)

1. Förfarande för framställning av ett adhesivt tillförseldon för transdermalt läkemedel, kanne - 5 tecknat av att ett tryckkänsligt adhesivt skikt hos detta tillförseldon framställs genom att sammanblanda en multipolymer, som innehäller viny-lacetat och etenmonomerer, och gummi och ett klibbande medel, varvid viktförhällandet mellan multipolymeren och 10 gummi är cirka 1:1 - 10:1, och genom att upplösa eller dispergera läkemedlet i den blandning som erhällits, vilket läkemedel är ett fast ämne eller en vätska vid rumstemperatur och absorberas genom huden.
2. Förfarande enligt patentkrav 1, k ä n n e -15 tecknat av att som multipolymer används karboxylerad vinylacetat/etenterpolymer och som gummi polyisopren.
3. Förfarande enligt patentkrav 1, k ä n n e -tecknat av att läkemedel används cirka 1-50 viktprocent frän vikten av det adhesiva skiktet hos till- 20 förseldonet för transdermalt läkemedel.
4. Förfarande enligt patentkrav 1, kanne-tecknat av att multipolymeren tvärbinds tili en multipolymer, som innehäller en tvärbunden multipolymer av < I ; karboxylerad vinylacetat/eten. 25
5. Förfarande enligt patentkrav 4, k ä n n e - » · * I tecknat av att för tvärbindning används ett medel * » · **;! som väljs bland en grupp av medel som är kända för tvär- • * *'!* bindning av fria karboxylgrupper hos polymera substanser.
*.· ° 6. Förfarande enligt patentkrav 4, k ä n n e - 30 tecknat av att för tvärbindning används ett medel • · f ϊ.ί i som väljs bland en grupp som bestär av melaminformaldehyd- harts, ureaformaldehydharts, fenolhartser, epoxihartser, glyoxaler, zinkoxid, magnesiumoxid och ammoniumdikromat.
7. Förfarande enligt patentkrav 4, k ä n n e -35 tecknat av att som multipolymer används en terpoly-mer av eten, vinylacetat och akrylsyra. « I «tl I II « · 104618
8. Förfarande enligt patentkrav 7, k ä n n e -tecknat av att som multipolymer används en terpoly-mer, där viktprocenttalen för eten-, vinylacetat- och ak-rylsyraenheter är cirka 15 - 90, 4-80 respektive 0-5. 5
9. Förfarande enligt patentkrav 7, kanne- tecknat av att som multipolymer används en terpoly-mer, där mängderna eten, vinylacetat och akrylsyra är cirka 77 %, 20 % respektive 3 %.
10. Förfarande enligt patentkrav 1 eller 4, k ä n-10 netecknat av att som gummi används naturgummi och karboxylerad vinylacetat/etensampolymer och gummi används i ett förhällande av cirka 3:1.
11. Förfarande enligt patentkrav 1 eller 4, k ä n-netecknatav att man använder en multipolymer med 15 cirka 20 - 39 viktprocent karboxylerad vinylace tat/etensampolymer, och att ytterligare, för tillverkning av det adhesiva skiktet, används cirka 5-20 viktprocent naturgummi, cirka 10 - 30 viktprocent klibbande medel, cirka 1-50 viktprocent läkemedel och cirka 0-2 viktp-20 rocent tvärbindningsmedel.
12. Förfarande enligt patentkrav 11, k ä n n e -tecknat av att för tillverkning av det adhesiva skiktet används en multipolymer med cirka 30 viktprocent • I : karboxylerad vinylacetat/etensampolymer, cirka 11 viktpro- 25 cent naturgummi, cirka 12 viktprocent klibbande medel och cirka 41 viktprocent läkemedel. t
*.*“ 13. Förfarande enligt patentkrav 12, k ä n n e - • · “f tecknat av att som läkemedel används nitroglycerin *·' ’ eller estradiol. 30 « · » · * < • • M » I » • · · < « I I I » » I I I
FI904358A 1988-03-04 1990-09-04 Förfarande för framställning av ett adhesivt tillförseldon för transdermalt läkemedel FI104618B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/164,482 US4814168A (en) 1988-03-04 1988-03-04 Transdermal multipolymer drug delivery system
US16448288 1988-03-04
PCT/US1989/000678 WO1989007950A1 (en) 1988-03-04 1989-02-21 Transdermal multipolymer drug delivery system
US8900678 1989-02-21

Publications (2)

Publication Number Publication Date
FI904358A0 FI904358A0 (fi) 1990-09-04
FI104618B true FI104618B (sv) 2000-03-15

Family

ID=22594693

Family Applications (1)

Application Number Title Priority Date Filing Date
FI904358A FI104618B (sv) 1988-03-04 1990-09-04 Förfarande för framställning av ett adhesivt tillförseldon för transdermalt läkemedel

Country Status (12)

Country Link
US (1) US4814168A (sv)
EP (1) EP0418248B1 (sv)
JP (1) JP2659837B2 (sv)
KR (1) KR950013461B1 (sv)
AT (1) ATE99176T1 (sv)
AU (1) AU606840B2 (sv)
CA (1) CA1338660C (sv)
DE (1) DE68911920T2 (sv)
DK (1) DK174994B1 (sv)
FI (1) FI104618B (sv)
HK (1) HK1006285A1 (sv)
WO (1) WO1989007950A1 (sv)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970009886B1 (ko) * 1981-08-30 1997-06-19 히사미쯔세이야꾸 가부시기가이샤 소염진통 첩부제
US5560922A (en) * 1986-05-30 1996-10-01 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process
JPH0696529B2 (ja) * 1987-03-31 1994-11-30 積水化学工業株式会社 ニトログリセリン貼付剤およびその製造方法
US5656286A (en) 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5719197A (en) * 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
WO1991014463A1 (en) * 1990-03-28 1991-10-03 Noven Pharmaceuticals, Inc. Method and device for the release of drugs to the skin
US5300291A (en) * 1988-03-04 1994-04-05 Noven Pharmaceuticals, Inc. Method and device for the release of drugs to the skin
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
JPH0725669B2 (ja) * 1988-12-23 1995-03-22 日東電工株式会社 経皮投与用医薬製剤
US5147916A (en) * 1990-02-21 1992-09-15 Dow Corning Corporation Hot-melt silicone pressure sensitive adhesive composition and related methods and articles
ES2082973T3 (es) * 1990-03-30 1996-04-01 Alza Corp Dispositivo para administracion iontoforetica de farmacos.
US5383848A (en) * 1990-04-12 1995-01-24 Gensia, Inc. Iontophoretic administration of drugs
US5162410A (en) * 1990-04-13 1992-11-10 Dow Corning Corporation Hot-melt silicon pressure sensitive adhesives with phenyl-containing siloxane fluid additive and related methods and articles
US5202125A (en) * 1990-12-10 1993-04-13 Theratech, Inc. Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
EP0588839B1 (de) * 1991-06-10 1995-08-16 Schwarz Pharma Ag Nitroglycerin-pflaster und verfahren zu seiner herstellung
US5705185A (en) * 1991-09-25 1998-01-06 Beta Pharmaceuticals Co. Transdermal delivery of estradiol and process for manufacturing said device
US5352456A (en) * 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
EP0612526A4 (en) * 1991-11-15 1995-08-02 Ss Pharmaceutical Co ANTI-INFLAMMATORY AND ANALGESIC PLATTER.
DE4226753A1 (de) * 1992-08-13 1994-02-17 Basf Ag Wirkstoffe enthaltende Zubereitungen in Form fester Teilchen
DE4230588C1 (de) * 1992-09-12 1993-10-07 Lohmann Therapie Syst Lts Dexpanthenol-haltiges Pflaster zur transdermalen Applikation von Steroidhormonen und Verfahren zu seiner Herstellung
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
US5427585A (en) * 1993-03-29 1995-06-27 Bettinger; David S. On-demand iontophoretic system
US5762952A (en) * 1993-04-27 1998-06-09 Hercon Laboratories Corporation Transdermal delivery of active drugs
BR9401951A (pt) * 1994-05-11 1995-12-05 Alba Quimica Ind E Com Ltda Adesivo de contato à base de água
US5498417A (en) * 1994-05-12 1996-03-12 Coating Sciences, Inc. Transdermal delivery of appetite suppressant drug
US6316022B1 (en) * 1995-06-07 2001-11-13 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
US6572879B1 (en) * 1995-06-07 2003-06-03 Alza Corporation Formulations for transdermal delivery of pergolide
EP0833671A2 (en) 1995-06-07 1998-04-08 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
DE19650471A1 (de) * 1996-12-05 1998-06-10 Beiersdorf Ag Wirkstoffhaltige Pflaster
US5948433A (en) * 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
GB9720470D0 (en) 1997-09-25 1997-11-26 Ethical Pharmaceuticals South Inhibition of crystallization in transdermal devices
AU768283B2 (en) * 1998-08-20 2003-12-04 3M Innovative Properties Company Spray on bandage and drug delivery system
US7026290B1 (en) 1998-12-30 2006-04-11 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosprin
US6337086B1 (en) 1999-02-06 2002-01-08 Dow Corning Corporation Pressure sensitive adhesive compositions for transdermal drug delivery devices
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6905016B2 (en) 2000-03-14 2005-06-14 Noven Pharmaceuticals, Inc. Packaging system for transdermal drug delivery systems
ES2410532T3 (es) * 2000-09-19 2013-07-02 Henkel Ag & Co. Kgaa Adhesivo de acrilo útil en sistemas de administración transdérmica de fármacos
WO2002069942A1 (fr) * 2001-03-07 2002-09-12 Hisamitsu Pharmaceutical Co., Inc. Timbre adhesif
DE10118282A1 (de) * 2001-04-12 2002-12-05 Lohmann Therapie Syst Lts Haftkleber auf Basis von Ethylen-Vinylacetat-Copolymeren und Klebharzen, für medizinische Verwendungszwecke
US20040131873A1 (en) * 2003-01-08 2004-07-08 Jiangbo Ouyang Pressure sensitive adhesive composition containing ethylene/vinyl ester functional copolymers having high ethylene content
JP2005325165A (ja) * 2004-05-12 2005-11-24 Three M Innovative Properties Co １００℃以下の温度で溶融塗布可能なヨウ素含有ホットメルト粘着剤および該粘着剤を用いた医療用粘着シート製品
US20060127463A1 (en) * 2004-12-15 2006-06-15 Nugara Peter N Composite structure including a low vinyl acetate layer
US20090214643A1 (en) * 2005-07-19 2009-08-27 Franklin Amie E Improved pharmacokinetic profile of beta-adrenergic inverse agonists for the treatment of pulmonary airway diseases
CN101431988A (zh) * 2006-02-27 2009-05-13 诺芬药品公司 包含东莨菪碱的透皮治疗系统
US20070287727A1 (en) * 2006-06-08 2007-12-13 Jacob Hiller Anti-Nicotine Treatment
US20080226698A1 (en) * 2007-03-16 2008-09-18 Mylan Technologies, Inc. Amorphous drug transdermal systems, manufacturing methods, and stabilization
EP2187969A2 (en) * 2007-08-17 2010-05-26 Arcion Therapeutics, Inc. High concentration local anesthetic formulations
US8231906B2 (en) 2008-07-10 2012-07-31 Noven Pharmaceuticals, Inc. Transdermal estrogen device and delivery
WO2010019953A1 (en) * 2008-08-15 2010-02-18 Arcion Therapeutics, Inc. High concentration local anesthetic formulations for treating non-neuropathic pain
CA2739380C (en) * 2008-10-06 2014-12-09 Mylan Technologies, Inc. Amorphous rotigotine transdermal system
DE102011114411A1 (de) * 2011-09-26 2013-03-28 Lts Lohmann Therapie-Systeme Ag Pflaster mit einstellbarer Okklusion
FR2984906B1 (fr) * 2011-12-26 2014-02-28 Bostik Sa Composition de colle pelable
TW201431570A (zh) 2012-11-22 2014-08-16 Ucb Pharma Gmbh 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片
WO2014144109A1 (en) * 2013-03-15 2014-09-18 Naimco, Inc. Transdermal patch with non-water soluble adhesive and anesthetic
WO2015001012A1 (de) 2013-07-03 2015-01-08 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches system mit elektronischem bauteil
US11752110B2 (en) 2014-05-20 2023-09-12 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system including an interface mediator
JP6573913B2 (ja) 2014-05-20 2019-09-11 エルテーエス ローマン テラピー−ジステーメ アーゲー ロチゴチンを含む経皮送達システム
JP6895755B2 (ja) 2014-05-20 2021-06-30 エルテーエス ローマン テラピー−ジステーメ アーゲー 経皮送達システムにおける活性薬剤の放出を調節するための方法
FR3021973B1 (fr) * 2014-06-05 2016-07-01 Bostik Sa Composition de colle pelable
US10406116B2 (en) 2015-02-06 2019-09-10 Noven Pharmaceuticals, Inc. Pressure-sensitive adhesives for transdermal drug delivery
WO2016127020A1 (en) 2015-02-06 2016-08-11 Noven Pharmaceuticals, Inc. Pressure-sensitive adhesives for transdermal drug delivery
KR102033243B1 (ko) * 2017-07-31 2019-10-17 이민희 아로마테라피 기능성 발열팩 및 그 제조방법
KR20220004088A (ko) * 2019-04-24 2022-01-11 가부시키가이샤 메드렉스 리도카인 함유 첩부제

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
JPS56133381A (en) * 1980-03-25 1981-10-19 Nippon Kayaku Co Ltd Pressure-sensitive adhesive tape or sheet containing nitroglycerin
JPS6059207B2 (ja) * 1981-03-13 1985-12-24 日東電工株式会社 複合製剤の製法
JPS57181020A (en) * 1981-04-30 1982-11-08 Kao Corp Poultice base composition
JPS57209217A (en) * 1981-06-17 1982-12-22 Nitto Electric Ind Co Ltd Medicament preparation
GB2105990B (en) * 1981-08-27 1985-06-19 Nitto Electric Ind Co Adhesive skin patches
JPS615012A (ja) * 1984-06-11 1986-01-10 Dai Ichi Seiyaku Co Ltd 貼付剤
US4725439A (en) * 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4704282A (en) * 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
DE3587616D1 (de) * 1984-12-22 1993-11-11 Sanol Arznei Schwarz Gmbh Wirkstoffpflaster.
DE3682165D1 (de) * 1985-11-08 1991-11-28 Nitto Denko Corp Verwendung von heftpflastern fuer die haut und perkutanen praeparaten.
US4743249A (en) * 1986-02-14 1988-05-10 Ciba-Geigy Corp. Dermal and transdermal patches having a discontinuous pattern adhesive layer
FR2612785A1 (fr) * 1987-03-25 1988-09-30 Lhd Lab Hygiene Dietetique Dispositif auto-adhesif d'administration d'un principe actif par voie percutanee

Also Published As

Publication number Publication date
HK1006285A1 (en) 1999-02-19
CA1338660C (en) 1996-10-22
AU3284789A (en) 1989-09-22
US4814168A (en) 1989-03-21
AU606840B2 (en) 1991-02-14
ATE99176T1 (de) 1994-01-15
WO1989007950A1 (en) 1989-09-08
EP0418248A1 (en) 1991-03-27
JP2659837B2 (ja) 1997-09-30
FI904358A0 (fi) 1990-09-04
DK549489A (da) 1989-11-29
JPH03503283A (ja) 1991-07-25
DE68911920T2 (de) 1994-07-07
DE68911920D1 (de) 1994-02-10
KR950013461B1 (ko) 1995-11-08
EP0418248B1 (en) 1993-12-29
DK174994B1 (da) 2004-04-13
KR900700141A (ko) 1990-08-11
DK549489D0 (da) 1989-11-03

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