FI103053B1 - Gene and gene product for the production of -lactam products - Google Patents

Gene and gene product for the production of -lactam products

Info

Publication number
FI103053B1
FI103053B1 FI895846A FI895846A FI103053B1 FI 103053 B1 FI103053 B1 FI 103053B1 FI 895846 A FI895846 A FI 895846A FI 895846 A FI895846 A FI 895846A FI 103053 B1 FI103053 B1 FI 103053B1
Authority
FI
Finland
Prior art keywords
gene
production
gene product
lactam products
product
Prior art date
Application number
FI895846A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI895846A0 (en
FI103053B (en
Inventor
Franz Knauseder
Ernst Leitner
Norbert Palma
Gerhard Weber
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT92288A external-priority patent/AT390268B/en
Priority claimed from AT180688A external-priority patent/AT391141B/en
Priority claimed from AT220188A external-priority patent/AT391142B/en
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of FI895846A0 publication Critical patent/FI895846A0/en
Application granted granted Critical
Publication of FI103053B1 publication Critical patent/FI103053B1/en
Publication of FI103053B publication Critical patent/FI103053B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)

Abstract

Gene and gene product of a key enzyme which is novel because of its structure and multivalent functionality, and catalyses the last stage of the biosynthesis of penicillin G and penicillin V.
FI895846A 1988-04-08 1989-12-07 For the production of gene and gene product lactam compounds FI103053B (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
AT92288 1988-04-08
AT92288A AT390268B (en) 1988-04-08 1988-04-08 DNA from Penicillium chrysogenum and protein for which this DNA codes
AT180688 1988-07-13
AT180688A AT391141B (en) 1988-07-13 1988-07-13 DNA which codes for the enzyme penicillin acyltransferase (PAT)
AT220188A AT391142B (en) 1988-09-08 1988-09-08 DNA from Penicillium chrysogenum
AT220188 1988-09-08
EP8900374 1989-04-07
PCT/EP1989/000374 WO1989009821A1 (en) 1988-04-08 1989-04-07 GENE AND GENE PRODUCT FOR PREPARING beta-LACTAM COMPOUNDS

Publications (3)

Publication Number Publication Date
FI895846A0 FI895846A0 (en) 1989-12-07
FI103053B1 true FI103053B1 (en) 1999-04-15
FI103053B FI103053B (en) 1999-04-15

Family

ID=27146880

Family Applications (1)

Application Number Title Priority Date Filing Date
FI895846A FI103053B (en) 1988-04-08 1989-12-07 For the production of gene and gene product lactam compounds

Country Status (12)

Country Link
EP (1) EP0336446B1 (en)
JP (1) JPH0767387B2 (en)
KR (1) KR900700610A (en)
AT (1) ATE105860T1 (en)
AU (1) AU637317B2 (en)
DE (1) DE58907667D1 (en)
DK (1) DK175769B1 (en)
ES (1) ES2054916T3 (en)
FI (1) FI103053B (en)
HK (1) HK99996A (en)
HU (1) HU208845B (en)
WO (1) WO1989009821A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747285A (en) * 1989-02-01 1998-05-05 Gist-Brocades, Nv. DNA comprising regulatory regions from gene y of penicillium chrysogenum
IL95766A (en) * 1989-09-27 1996-12-05 Lilly Co Eli Recombinant DNA expression vectors and DNA compounds that encode acyltransferase activity of aspergillus
US5882879A (en) * 1990-02-28 1999-03-16 Gist-Brocades, N.V. Method for influencing β-lactam antibiotic production and for isolation of large quantities of ACV synthetase
US5168048A (en) * 1990-04-18 1992-12-01 Gist-Brocades Nv Penicillin G acylase, a gene encoding the same and a method for the production of this enzyme
AU4201897A (en) * 1996-07-16 1998-02-09 Gist-Brocades B.V. Novel process for the preparation of cephalosporins using (acremonium chrysogenum)
EP1851309A2 (en) * 2005-02-24 2007-11-07 DSMIP Assets B.V. Altered isopenicillin-n acyltransferase polypeptides and related polynucleotides

Also Published As

Publication number Publication date
DK175769B1 (en) 2005-02-14
KR900700610A (en) 1990-08-16
JPH02503750A (en) 1990-11-08
EP0336446B1 (en) 1994-05-18
DK622189D0 (en) 1989-12-08
HK99996A (en) 1996-06-14
ES2054916T3 (en) 1994-08-16
AU3362689A (en) 1989-11-03
ATE105860T1 (en) 1994-06-15
HU892092D0 (en) 1990-02-28
AU637317B2 (en) 1993-05-27
EP0336446A1 (en) 1989-10-11
JPH0767387B2 (en) 1995-07-26
HU208845B (en) 1994-01-28
DK622189A (en) 1990-02-02
FI895846A0 (en) 1989-12-07
DE58907667D1 (en) 1994-06-23
FI103053B (en) 1999-04-15
HUT52156A (en) 1990-06-28
WO1989009821A1 (en) 1989-10-19

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: BIOCHEMIE GESELLSCHAFT M.B.H

PC Transfer of assignment of patent

Owner name: SANDOZ AG

MA Patent expired