AT391141B - DNA which codes for the enzyme penicillin acyltransferase (PAT) - Google Patents

DNA which codes for the enzyme penicillin acyltransferase (PAT)

Info

Publication number
AT391141B
AT391141B AT180688A AT180688A AT391141B AT 391141 B AT391141 B AT 391141B AT 180688 A AT180688 A AT 180688A AT 180688 A AT180688 A AT 180688A AT 391141 B AT391141 B AT 391141B
Authority
AT
Austria
Prior art keywords
dna
codes
pat
enzyme penicillin
penicillin acyltransferase
Prior art date
Application number
AT180688A
Other languages
German (de)
Other versions
ATA180688A (en
Inventor
Norbert Dr Palma
Gerhard Dr Weber
Franz Dr Knauseder
Ernst Dr Leitner
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT180688A priority Critical patent/AT391141B/en
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Priority to EP89106214A priority patent/EP0336446B1/en
Priority to AU33626/89A priority patent/AU637317B2/en
Priority to KR1019890702284A priority patent/KR900700610A/en
Priority to HU892092A priority patent/HU208845B/en
Priority to ES89106214T priority patent/ES2054916T3/en
Priority to AT89106214T priority patent/ATE105860T1/en
Priority to DE58907667T priority patent/DE58907667D1/en
Priority to PCT/EP1989/000374 priority patent/WO1989009821A1/en
Priority to JP1503743A priority patent/JPH0767387B2/en
Priority to FI895846A priority patent/FI103053B/en
Priority to DK198906221A priority patent/DK175769B1/en
Publication of ATA180688A publication Critical patent/ATA180688A/en
Application granted granted Critical
Publication of AT391141B publication Critical patent/AT391141B/en
Priority to HK99996A priority patent/HK99996A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention relates to gene and gene product of a key enzyme which is novel in its structure and multivalent functionality and which catalyzes the last stage in the biosynthesis of penicillin G and penicillin V.
AT180688A 1988-04-08 1988-07-13 DNA which codes for the enzyme penicillin acyltransferase (PAT) AT391141B (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
AT180688A AT391141B (en) 1988-07-13 1988-07-13 DNA which codes for the enzyme penicillin acyltransferase (PAT)
PCT/EP1989/000374 WO1989009821A1 (en) 1988-04-08 1989-04-07 GENE AND GENE PRODUCT FOR PREPARING beta-LACTAM COMPOUNDS
KR1019890702284A KR900700610A (en) 1988-04-08 1989-04-07 Genes and Gene Products for the Production of β-lactam Compounds
HU892092A HU208845B (en) 1988-04-08 1989-04-07 Process for producing penicillin acyle-transferase its coding dna sequence vector containing it and host cell transformated thereby
ES89106214T ES2054916T3 (en) 1988-04-08 1989-04-07 GEN AND GEN PRODUCT FOR THE OBTAINING OF BETA-LACTAMA COMPOUNDS.
AT89106214T ATE105860T1 (en) 1988-04-08 1989-04-07 GENE AND GENE PRODUCT FOR THE PRODUCTION OF BETA- LACTAM COMPOUNDS.
EP89106214A EP0336446B1 (en) 1988-04-08 1989-04-07 Gene and gene product for the production of beta-lactam-compounds
AU33626/89A AU637317B2 (en) 1988-04-08 1989-04-07 Gene and gene product for preparing beta-lactam compounds
JP1503743A JPH0767387B2 (en) 1988-04-08 1989-04-07 Genes and gene products for the production of .BETA.-lactam compounds
DE58907667T DE58907667D1 (en) 1988-04-08 1989-04-07 Gene and gene product for the production of beta-lactam compounds.
FI895846A FI103053B (en) 1988-04-08 1989-12-07 For the production of gene and gene product lactam compounds
DK198906221A DK175769B1 (en) 1988-04-08 1989-12-08 DNA sequence in purified and isolated form encoding the enzyme penicillin acetyltransferase, protein encoding the DNA sequence, vector, ...........
HK99996A HK99996A (en) 1988-04-08 1996-06-06 Gene and gene product for the production of beta-lactam-compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT180688A AT391141B (en) 1988-07-13 1988-07-13 DNA which codes for the enzyme penicillin acyltransferase (PAT)

Publications (2)

Publication Number Publication Date
ATA180688A ATA180688A (en) 1990-02-15
AT391141B true AT391141B (en) 1990-08-27

Family

ID=3521375

Family Applications (1)

Application Number Title Priority Date Filing Date
AT180688A AT391141B (en) 1988-04-08 1988-07-13 DNA which codes for the enzyme penicillin acyltransferase (PAT)

Country Status (1)

Country Link
AT (1) AT391141B (en)

Also Published As

Publication number Publication date
ATA180688A (en) 1990-02-15

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee