FI101537B1 - Uppfinningen avser förfarande för framställning av terapeutiskt användbara 2-((2-((1-substituerad piperazin-4-yl)karbonyl)pyrrolidin-4-yl)tio-6-(1-hydroxietyl)-1-metylkarbapenem-3-karboxylsyror och salter av dessa - Google Patents
Uppfinningen avser förfarande för framställning av terapeutiskt användbara 2-((2-((1-substituerad piperazin-4-yl)karbonyl)pyrrolidin-4-yl)tio-6-(1-hydroxietyl)-1-metylkarbapenem-3-karboxylsyror och salter av dessaInfo
- Publication number
- FI101537B1 FI101537B1 FI935698A FI935698A FI101537B1 FI 101537 B1 FI101537 B1 FI 101537B1 FI 935698 A FI935698 A FI 935698A FI 935698 A FI935698 A FI 935698A FI 101537 B1 FI101537 B1 FI 101537B1
- Authority
- FI
- Finland
- Prior art keywords
- lower alkyl
- hydrogen
- represent
- dhp
- methylcarbapenem
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- -1 2 - ((1-substituted piperazin-4-yl) carbonyl) pyrrolidin-4-yl Chemical group 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 230000003389 potentiating effect Effects 0.000 abstract 2
- YKMONJZIUAOVEM-WDSKDSINSA-N 1beta-methylcarbapenem Chemical class C[C@H]1C=CN2C(=O)C[C@@H]12 YKMONJZIUAOVEM-WDSKDSINSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004157 Hydrolases Human genes 0.000 abstract 1
- 108090000604 Hydrolases Proteins 0.000 abstract 1
- 206010029155 Nephropathy toxic Diseases 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- WKDDRNSBRWANNC-ATRFCDNQSA-N Thienamycin Chemical compound C1C(SCCN)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 WKDDRNSBRWANNC-ATRFCDNQSA-N 0.000 abstract 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 230000007694 nephrotoxicity Effects 0.000 abstract 1
- 231100000417 nephrotoxicity Toxicity 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14846991 | 1991-06-20 | ||
| JP3105492 | 1992-02-18 | ||
| PCT/JP1992/000790 WO1993000344A1 (en) | 1991-06-20 | 1992-06-19 | Carbapenem derivative |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI935698A0 FI935698A0 (fi) | 1993-12-17 |
| FI935698A FI935698A (fi) | 1994-02-04 |
| FI101537B1 true FI101537B1 (sv) | 1998-07-15 |
| FI101537B FI101537B (sv) | 1998-07-15 |
Family
ID=26369502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI935698A FI101537B (sv) | 1991-06-20 | 1993-12-17 | Uppfinningen avser förfarande för framställning av terapeutiskt använd bara 2-((2-((1-substituerad piperazin-4-yl)karbonyl)pyrrolidin-4-yl)ti o-6-(1-hydroxietyl)-1-metylkarbapenem-3-karboxylsyror ochsalter av de ssa |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5559224A (sv) |
| EP (1) | EP0641795B9 (sv) |
| JP (1) | JP3048196B2 (sv) |
| KR (1) | KR100189667B1 (sv) |
| AT (1) | ATE224897T1 (sv) |
| AU (1) | AU659172B2 (sv) |
| CA (1) | CA2111974C (sv) |
| DE (1) | DE69232791T2 (sv) |
| DK (1) | DK0641795T3 (sv) |
| ES (1) | ES2184731T3 (sv) |
| FI (1) | FI101537B (sv) |
| NO (1) | NO303636B1 (sv) |
| RU (1) | RU2091381C1 (sv) |
| TW (1) | TW201747B (sv) |
| WO (1) | WO1993000344A1 (sv) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2026424A6 (es) * | 1991-02-26 | 1992-04-16 | Play Sa | Cuna infantil plegable. |
| CZ298246B6 (cs) * | 1995-12-21 | 2007-08-01 | Sankyo Company Limited | Deriváty 1-methylkarbapenu, zpusob jejich prípravy a farmaceutické prostredky, které je obsahují |
| WO2001057041A1 (fr) * | 2000-01-31 | 2001-08-09 | Sankyo Company, Limited | Composes 1-methylcarbapedem |
| IN191798B (sv) | 2000-11-03 | 2004-01-03 | Ranbaxy Lab Ltd | |
| ES2368997T3 (es) * | 2001-09-26 | 2011-11-24 | Merck Sharp & Dohme Corp. | Procedimiento de fabricación de compuestos de carbapenem. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| JPS6019787A (ja) * | 1983-07-12 | 1985-01-31 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物及びその製造法 |
| JPS60233076A (ja) * | 1984-05-03 | 1985-11-19 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| KR880006244A (ko) * | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
| AU631671B2 (en) * | 1989-08-04 | 1992-12-03 | Banyu Pharmaceutical Co., Ltd. | 2-(2-vinylpyrrolidinylthio)carbapenem derivatives |
-
1992
- 1992-06-18 JP JP04159017A patent/JP3048196B2/ja not_active Expired - Fee Related
- 1992-06-19 DE DE69232791T patent/DE69232791T2/de not_active Expired - Fee Related
- 1992-06-19 TW TW081104823A patent/TW201747B/zh active
- 1992-06-19 DK DK92913257T patent/DK0641795T3/da active
- 1992-06-19 CA CA002111974A patent/CA2111974C/en not_active Expired - Fee Related
- 1992-06-19 AT AT92913257T patent/ATE224897T1/de not_active IP Right Cessation
- 1992-06-19 AU AU20002/92A patent/AU659172B2/en not_active Ceased
- 1992-06-19 EP EP92913257A patent/EP0641795B9/en not_active Expired - Lifetime
- 1992-06-19 WO PCT/JP1992/000790 patent/WO1993000344A1/ja active IP Right Grant
- 1992-06-19 ES ES92913257T patent/ES2184731T3/es not_active Expired - Lifetime
- 1992-06-19 RU RU93058465/04A patent/RU2091381C1/ru not_active IP Right Cessation
- 1992-06-19 KR KR1019930703980A patent/KR100189667B1/ko not_active IP Right Cessation
-
1993
- 1993-12-17 FI FI935698A patent/FI101537B/sv active
- 1993-12-17 NO NO934670A patent/NO303636B1/no unknown
-
1995
- 1995-05-05 US US08/435,271 patent/US5559224A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK0641795T3 (da) | 2003-01-20 |
| JPH05294969A (ja) | 1993-11-09 |
| EP0641795A1 (en) | 1995-03-08 |
| NO303636B1 (no) | 1998-08-10 |
| WO1993000344A1 (en) | 1993-01-07 |
| FI935698A (fi) | 1994-02-04 |
| RU2091381C1 (ru) | 1997-09-27 |
| DE69232791D1 (en) | 2002-10-31 |
| CA2111974C (en) | 2001-07-24 |
| AU659172B2 (en) | 1995-05-11 |
| KR100189667B1 (ko) | 1999-06-01 |
| NO934670D0 (no) | 1993-12-17 |
| EP0641795B9 (en) | 2003-01-29 |
| CA2111974A1 (en) | 1993-01-07 |
| FI101537B (sv) | 1998-07-15 |
| AU2000292A (en) | 1993-01-25 |
| JP3048196B2 (ja) | 2000-06-05 |
| DE69232791T2 (de) | 2003-05-15 |
| ES2184731T3 (es) | 2003-04-16 |
| EP0641795A4 (en) | 1994-06-09 |
| EP0641795B1 (en) | 2002-09-25 |
| FI935698A0 (fi) | 1993-12-17 |
| NO934670L (no) | 1994-02-18 |
| TW201747B (sv) | 1993-03-11 |
| KR940701395A (ko) | 1994-05-28 |
| ATE224897T1 (de) | 2002-10-15 |
| US5559224A (en) | 1996-09-24 |
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