ES8900017A1 - Procedimiento para la preparacion de dipeptidos de n,n-dialquil-guanidino. - Google Patents

Procedimiento para la preparacion de dipeptidos de n,n-dialquil-guanidino.

Info

Publication number
ES8900017A1
ES8900017A1 ES557827A ES557827A ES8900017A1 ES 8900017 A1 ES8900017 A1 ES 8900017A1 ES 557827 A ES557827 A ES 557827A ES 557827 A ES557827 A ES 557827A ES 8900017 A1 ES8900017 A1 ES 8900017A1
Authority
ES
Spain
Prior art keywords
dipeptides
dialkylguanidino
proline
antihypertensives
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557827A
Other languages
English (en)
Other versions
ES557827A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES557827A0 publication Critical patent/ES557827A0/es
Publication of ES8900017A1 publication Critical patent/ES8900017A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

LA PREPARACION DE DIPEPTIDOS DE FORMULA GENERAL (I) SE REALIZA MEDIANTE LA HIDROLISIS CON UN ACIDO ORGANICO O INORGANICO O UNA BASE INORGANICA, A UNA TEMPERATURA ENTRE -20GC Y 100GC, DE UN COMPUESTO DE FORMULA (II). OPCIONALMENTE TAMBIEN SE PUEDE CONVERTIR UNA SAL DE ADICION DE ACIDO DEL DIPEPTIDO DE FORMULA (I) CON UNA BASE, O UNA SAL DEL DIPEPTIDO DE FORMULA (I) (PROCEDENTE DE UNA BASE) CON UN ACIDO, EN EL DIPEPTIDO DE FORMULA (I). ESTOS COMPUESTOS POSEEN PROPIEDADES INHIBITORIAS FRENTE A LA ENZIMA DE CONVERSION DE ANGIOTENSINA Y SE UTILIZAN PARA EL TRATAMIENTO DE LA HIPERTENSION EN MAMIFEROS. *FORMULA*
ES557827A 1985-03-22 1988-03-30 Procedimiento para la preparacion de dipeptidos de n,n-dialquil-guanidino. Expired ES8900017A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71476785A 1985-03-22 1985-03-22

Publications (2)

Publication Number Publication Date
ES557827A0 ES557827A0 (es) 1988-11-16
ES8900017A1 true ES8900017A1 (es) 1988-11-16

Family

ID=24871369

Family Applications (2)

Application Number Title Priority Date Filing Date
ES553266A Expired ES8801930A1 (es) 1985-03-22 1986-03-21 Procedimiento para la preparacion de dipeptidos de n,n'-dialquilguanidino
ES557827A Expired ES8900017A1 (es) 1985-03-22 1988-03-30 Procedimiento para la preparacion de dipeptidos de n,n-dialquil-guanidino.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES553266A Expired ES8801930A1 (es) 1985-03-22 1986-03-21 Procedimiento para la preparacion de dipeptidos de n,n'-dialquilguanidino

Country Status (15)

Country Link
EP (1) EP0196841A1 (es)
JP (1) JPS61227594A (es)
KR (1) KR860007287A (es)
CN (1) CN86101850A (es)
AU (1) AU5502386A (es)
DD (1) DD243932A5 (es)
DK (1) DK133686A (es)
ES (2) ES8801930A1 (es)
FI (1) FI861210A (es)
GR (1) GR860755B (es)
HU (1) HUT40143A (es)
IL (1) IL78219A0 (es)
NO (1) NO861141L (es)
PT (1) PT82250B (es)
ZA (1) ZA862139B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
JP2579323B2 (ja) * 1986-09-10 1997-02-05 シンテックス（ユー・エス・エイ）インコーポレイテッド ジアミン類の選択的アミジン化
US5948939A (en) * 1986-09-10 1999-09-07 Syntex (U.S.A.) Inc. Selective amidination of diamines
US4876359A (en) * 1986-10-07 1989-10-24 Ss Pharmaceutical Co., Ltd. Novel gamma-butyrolactone derivatives
DE3803225A1 (de) * 1988-02-04 1989-08-17 Hoechst Ag Aminosaeureamide mit psychotroper wirkung, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung
US5710324A (en) * 1990-02-26 1998-01-20 Merrell Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
US5318992A (en) * 1990-02-26 1994-06-07 Merrell Dow Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
AU636713B2 (en) * 1990-02-26 1993-05-06 Merrell Dow Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
US5543423A (en) * 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5801187A (en) * 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US6218424B1 (en) 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US5846979A (en) 1997-02-28 1998-12-08 Gpi Nil Holdings, Inc. N-oxides of heterocyclic esters, amides, thioesters, and ketones
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6274617B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
DE3271043D1 (en) * 1981-11-09 1986-06-12 Merck & Co Inc N-carboxymethyl(amidino)lysyl-proline antihypertensive agents

Also Published As

Publication number Publication date
FI861210A (fi) 1986-09-23
ES557827A0 (es) 1988-11-16
FI861210A0 (fi) 1986-03-21
KR860007287A (ko) 1986-10-10
AU5502386A (en) 1986-09-25
ES8801930A1 (es) 1988-03-16
DD243932A5 (de) 1987-03-18
DK133686A (da) 1986-09-23
GR860755B (en) 1986-05-27
IL78219A0 (en) 1986-07-31
HUT40143A (en) 1986-11-28
ZA862139B (en) 1987-11-25
PT82250B (en) 1988-01-07
EP0196841A1 (en) 1986-10-08
JPS61227594A (ja) 1986-10-09
ES553266A0 (es) 1988-03-16
DK133686D0 (da) 1986-03-21
NO861141L (no) 1986-09-23
PT82250A (en) 1986-04-01
CN86101850A (zh) 1987-02-04

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