ES8802513A1 - Un procedimiento para la preparacion de aminoalquil secocantinas - Google Patents

Un procedimiento para la preparacion de aminoalquil secocantinas

Info

Publication number
ES8802513A1
ES8802513A1 ES557724A ES557724A ES8802513A1 ES 8802513 A1 ES8802513 A1 ES 8802513A1 ES 557724 A ES557724 A ES 557724A ES 557724 A ES557724 A ES 557724A ES 8802513 A1 ES8802513 A1 ES 8802513A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
benzyl
tetrahydropyrido
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557724A
Other languages
English (en)
Other versions
ES557724A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Wuelfing GmbH and Co KG
Original Assignee
Beecham Wuelfing GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858516390A external-priority patent/GB8516390D0/en
Priority claimed from GB858531634A external-priority patent/GB8531634D0/en
Application filed by Beecham Wuelfing GmbH and Co KG filed Critical Beecham Wuelfing GmbH and Co KG
Publication of ES8802513A1 publication Critical patent/ES8802513A1/es
Publication of ES557724A0 publication Critical patent/ES557724A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LAS AMINOALQUIL SECOCANTINAS (I), DONDE NO EXCLUSIVAMENTE R1 ES HIDROGENO O ALQUILO C1-6, R2 Y R3 HIDROGENO O JUNTOS REPRESENTAN UN ENLACE, R4 Y R5 SON HIDROGENO O JUNTOS UN GRUPO OXO, R6 ES ALQUILO C1-7 SUSTITUIDO Y R7 HIDROGENO O ALQUILO C1-4; SE OBTIENEN SOMETIENDO UN COMPUESTO (II) A AMINACION REDUCTIVA CON UNA AMINA PRIMARIA O SECUNDARIA, UTILIZANDO UN AGENTE REDUCTOR COMO EL NABH3CN, EN UN DISOLVENTE POLAR, COMO EL CLORURO DE METILENO/METANOL, A 30GC Y OPCIONALMENTE TRANSFORMAR CON POSTERIORIDAD, LOS RADICALES A OTROS TAMBIEN DEFINIDOS. EJERCEN ACTIVIDAD ANTI-ISQUEMICA, ESPECIALMENTE ACTIVIDAD ANHIHIPOXICA O CONTRA LA DEFICIENCIA DE OXIGENO CEREBRAL POR LO QUE SON UTILES EN EL TRATAMIENTO DE TRASTORNOS CEREBROVASCULARES ASOCIADOS A LA SENILIDAD CEREBRAL. *FORMULA*
ES557724A 1985-06-28 1987-09-15 Un procedimiento para la preparacion de aminoalquil secocantinas Expired ES8802513A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858516390A GB8516390D0 (en) 1985-06-28 1985-06-28 Active compounds
GB858531634A GB8531634D0 (en) 1985-12-23 1985-12-23 Active compounds

Publications (2)

Publication Number Publication Date
ES8802513A1 true ES8802513A1 (es) 1988-07-01
ES557724A0 ES557724A0 (es) 1988-07-01

Family

ID=26289428

Family Applications (7)

Application Number Title Priority Date Filing Date
ES556768A Expired ES8801265A1 (es) 1985-06-28 1986-06-25 Un procedimiento para la preparacion de aminoalquil secocantinas.
ES557725A Expired ES8802312A1 (es) 1985-06-28 1987-09-15 Un procedimiento para la preparacion de aminoalquil secocantinas
ES557726A Expired ES8802385A1 (es) 1985-06-28 1987-09-15 Un procedimiento para la preparacion de aminoalquil secocantinas
ES557724A Expired ES8802513A1 (es) 1985-06-28 1987-09-15 Un procedimiento para la preparacion de aminoalquil secocantinas
ES557817A Expired ES8802226A1 (es) 1985-06-28 1988-02-01 Un procedimiento para la preparacion de aminoalquil secocantinas
ES557823A Expired ES8802314A1 (es) 1985-06-28 1988-02-16 Un procedimiento para la preparacion de aminoalquil secocantinas
ES557822A Expired ES8802313A1 (es) 1985-06-28 1988-02-16 Un procedimiento para la preparacion de aminoalquil secocantinas.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES556768A Expired ES8801265A1 (es) 1985-06-28 1986-06-25 Un procedimiento para la preparacion de aminoalquil secocantinas.
ES557725A Expired ES8802312A1 (es) 1985-06-28 1987-09-15 Un procedimiento para la preparacion de aminoalquil secocantinas
ES557726A Expired ES8802385A1 (es) 1985-06-28 1987-09-15 Un procedimiento para la preparacion de aminoalquil secocantinas

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES557817A Expired ES8802226A1 (es) 1985-06-28 1988-02-01 Un procedimiento para la preparacion de aminoalquil secocantinas
ES557823A Expired ES8802314A1 (es) 1985-06-28 1988-02-16 Un procedimiento para la preparacion de aminoalquil secocantinas
ES557822A Expired ES8802313A1 (es) 1985-06-28 1988-02-16 Un procedimiento para la preparacion de aminoalquil secocantinas.

Country Status (10)

Country Link
US (2) US4835271A (es)
EP (1) EP0213696B1 (es)
JP (1) JPH0764843B2 (es)
AU (1) AU5931486A (es)
DE (1) DE3677101D1 (es)
DK (1) DK303886A (es)
ES (7) ES8801265A1 (es)
GR (1) GR861673B (es)
NZ (1) NZ216676A (es)
PT (1) PT82873B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8416724D0 (en) * 1984-06-30 1984-08-01 Sorbio Sa Lab Active compounds
EP0252643A1 (en) * 1986-07-01 1988-01-13 BEECHAM - WUELFING GmbH & Co. KG Pyrido[1,2-a]indole derivatives, process for their preparation and pharmaceutical compounds containing them
CA1329597C (en) * 1986-12-22 1994-05-17 Dagmar Hoeltje Derivatives of tetrahydropyrido[1,2-a]indole
GB8802127D0 (en) * 1988-02-01 1988-03-02 Glaxo Group Ltd Chemical compounds
CA2585967A1 (en) 2004-11-01 2006-05-11 Wyeth Substituted indolizines and derivatives as cns agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1550496A (en) * 1976-12-31 1979-08-15 Logeais Labor Jacques 1,2,3,3a4,5-hexahydro-canthine derivatives a process for their preparation and their therapeutic applications
US4328343A (en) * 1978-03-13 1982-05-04 The United States Of America As Represented By The Department Of Health And Human Services Cobalt-catalyzed one-step synthesis of annulated pyridines
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
GB8416724D0 (en) 1984-06-30 1984-08-01 Sorbio Sa Lab Active compounds
US4624954A (en) * 1985-12-20 1986-11-25 American Home Products Corporation 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments

Also Published As

Publication number Publication date
ES556768A0 (es) 1987-12-16
JPS6230779A (ja) 1987-02-09
ES557725A0 (es) 1988-05-01
EP0213696A3 (en) 1988-03-23
ES557817A0 (es) 1988-04-16
US4987137A (en) 1991-01-22
EP0213696A2 (en) 1987-03-11
ES557823A0 (es) 1988-05-01
ES557822A0 (es) 1988-05-01
ES8802313A1 (es) 1988-05-01
PT82873B (en) 1988-06-17
DK303886D0 (da) 1986-06-26
DE3677101D1 (de) 1991-02-28
NZ216676A (en) 1990-08-28
US4835271A (en) 1989-05-30
PT82873A (en) 1986-07-01
ES8801265A1 (es) 1987-12-16
ES8802226A1 (es) 1988-04-16
JPH0764843B2 (ja) 1995-07-12
ES8802312A1 (es) 1988-05-01
AU5931486A (en) 1987-01-22
ES557726A0 (es) 1988-05-16
DK303886A (da) 1986-12-29
ES8802385A1 (es) 1988-05-16
ES8802314A1 (es) 1988-05-01
ES557724A0 (es) 1988-07-01
GR861673B (en) 1986-10-30
EP0213696B1 (en) 1991-01-23

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