ES8802457A1 - Un procedimiento para la preparacion de polipeptidos inmunogenicos - Google Patents

Un procedimiento para la preparacion de polipeptidos inmunogenicos

Info

Publication number
ES8802457A1
ES8802457A1 ES557387A ES557387A ES8802457A1 ES 8802457 A1 ES8802457 A1 ES 8802457A1 ES 557387 A ES557387 A ES 557387A ES 557387 A ES557387 A ES 557387A ES 8802457 A1 ES8802457 A1 ES 8802457A1
Authority
ES
Spain
Prior art keywords
antibodies
ras oncogene
p21ras
protein family
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557387A
Other languages
English (en)
Other versions
ES557387A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8802457A1 publication Critical patent/ES8802457A1/es
Publication of ES557387A0 publication Critical patent/ES557387A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

UNA COMPOSICION INMUNOGENICA A BASE DE UN POLIPEPTIDO (I, II O III), ENTRE OTRAS, SE OBTIENE ACOPLANDO DICHO POLIPEPTIDO, BIEN DIRECTAMENTE O BIEN VIA UN GRUPO DE ENLACE BIFUNCIONAL CONVENCIONAL, A UN MATERIAL DE VEHICULO INMUNOGENICO, COMO UNA RESINA DE POLIESTIRENO RETICULADA, A TEMPERATURA AMBIENTE Y DISOLVIENDO EL MATERIAL DE VEHICULO INMUNOGENICO EN UNA SOLUCION TAMPON A PH 7,2. SON APLICABLES EN LA PREPARACION DE ANTICUERPOS, EDUCIDOS DE ESTOS POLIPEPTIDOS CON SECUENCIA DE PROTEINA P21RAS HUMANAS Y ESPECIFICAS PARA EL ONCONGEN RAS Y A METODOS DE INMUNOENSAYOS QUE UTILIZAN ESTOS ANTICUERPORS. *FORMULA*
ES557387A 1985-05-30 1987-02-13 Un procedimiento para la preparacion de polipeptidos inmunogenicos Expired ES8802457A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73941685A 1985-05-30 1985-05-30

Publications (2)

Publication Number Publication Date
ES8802457A1 true ES8802457A1 (es) 1988-07-01
ES557387A0 ES557387A0 (es) 1988-07-01

Family

ID=24972206

Family Applications (4)

Application Number Title Priority Date Filing Date
ES555435A Expired ES8800274A1 (es) 1985-05-30 1986-05-29 Un procedimiento para la preparacion de un polipeptido-c-terminal p21ras
ES557387A Expired ES8802457A1 (es) 1985-05-30 1987-02-13 Un procedimiento para la preparacion de polipeptidos inmunogenicos
ES557385A Expired ES8900246A1 (es) 1985-05-30 1987-02-13 Un procedimiento para la preparacion de anticuerpos especificos para uno de los miembros de la familia p 2 de proteinas
ES557386A Expired ES8801729A1 (es) 1985-05-30 1987-02-13 Un ensayo inmunometrio para proteina p21ras humana

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES555435A Expired ES8800274A1 (es) 1985-05-30 1986-05-29 Un procedimiento para la preparacion de un polipeptido-c-terminal p21ras

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557385A Expired ES8900246A1 (es) 1985-05-30 1987-02-13 Un procedimiento para la preparacion de anticuerpos especificos para uno de los miembros de la familia p 2 de proteinas
ES557386A Expired ES8801729A1 (es) 1985-05-30 1987-02-13 Un ensayo inmunometrio para proteina p21ras humana

Country Status (6)

Country Link
EP (1) EP0203587A3 (es)
JP (1) JPS61289099A (es)
AU (1) AU600439B2 (es)
DK (1) DK253386A (es)
ES (4) ES8800274A1 (es)
NO (1) NO862144L (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733738A (en) * 1983-08-17 1998-03-31 Ligand Pharmaceuticals Polypeptide-induced monoclonal receptors to protein ligands
US5084380A (en) * 1985-01-29 1992-01-28 Applied Biotechnology Monoclonal antibodies reactive with activated and oncogenic ras p21 proteins
US6200764B1 (en) 1985-01-29 2001-03-13 Bayer Corporation Detection, quantitation and classification of ras proteins in body fluids and tissues
IL79755A0 (en) * 1985-08-21 1986-11-30 Oncogene Science Inc Immunoassay for detection of ras encoded protein
DK354487A (da) * 1986-07-11 1988-01-12 Noboru Yanaihara Oncogen-relaterede peptider
JPS6374492A (ja) * 1986-09-18 1988-04-04 Hiroshi Shiyuku モノクロ−ナル抗体
US5112737A (en) * 1988-02-22 1992-05-12 Applied Biotechnology, Inc. Monoclonal antibodies against activated ras proteins with amino acid mutations at position 13 of the protein
AU3533089A (en) * 1988-04-22 1989-11-24 E.I. Du Pont De Nemours And Company Monoclonal antibodies specific for the harvey, kirsten, and n ras proteins and their use as diagnostic reagents
JPH04500122A (ja) * 1988-08-12 1992-01-09 プロジェンクス・インコーポレイテッド 蛋白リガンドに対するポリペプチド誘発モノクローナル受容体
CA2044333A1 (en) * 1990-06-12 1991-12-13 Jackson B. Gibbs Chemotherapeutic agents
US5965539A (en) * 1993-05-18 1999-10-12 Univeristy Of Pittsburgh Inhibitors of prenyl transferases
US5834434A (en) * 1993-05-18 1998-11-10 University Of Pittsburgh Inhibitors of farnesyltransferase
US5705686A (en) * 1993-05-18 1998-01-06 University Of Pittsburgh Inhibition of farnesyl transferase
US5602098A (en) * 1993-05-18 1997-02-11 University Of Pittsburgh Inhibition of farnesyltransferase
US6011175A (en) * 1993-05-18 2000-01-04 University Of Pittsburgh Inhibition of farnesyltransferase
US5840683A (en) * 1995-09-21 1998-11-24 Innapharma, Inc. Peptides inhibiting the oncogenic action of p21 ras
US5910478A (en) * 1995-09-21 1999-06-08 Innapharma, Inc. Peptidomimetics inhibiting the oncogenic action of p21 ras
US6204293B1 (en) 1995-11-06 2001-03-20 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6221865B1 (en) 1995-11-06 2001-04-24 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6693123B2 (en) 1995-11-06 2004-02-17 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6310095B1 (en) 1995-11-06 2001-10-30 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US20020156257A1 (en) * 2001-03-29 2002-10-24 Chunhua Yan Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1252046A (en) * 1982-11-04 1989-04-04 Martin J. Cline Methods for oncogenic detection
ZA84617B (en) * 1983-02-14 1984-09-26 Arup Sen Synthetic polypeptides from viryl oncogenes
AU2650984A (en) * 1983-02-14 1984-08-30 Arup Sen Synthetic polypeptides from viral oncogenes
CA1219232A (en) * 1983-08-17 1987-03-17 Richard A. Lerner Polypeptide-induced monoclonal receptors to protein ligands
US4798787A (en) * 1984-09-19 1989-01-17 Cetus Corporation Peptide antibodies and their use in detecting oncogene products

Also Published As

Publication number Publication date
DK253386D0 (da) 1986-05-29
AU600439B2 (en) 1990-08-16
DK253386A (da) 1986-12-01
ES8801729A1 (es) 1988-02-16
ES8800274A1 (es) 1987-10-16
ES555435A0 (es) 1987-10-16
ES557385A0 (es) 1989-05-16
ES557386A0 (es) 1988-02-16
ES557387A0 (es) 1988-07-01
EP0203587A2 (en) 1986-12-03
ES8900246A1 (es) 1989-05-16
EP0203587A3 (en) 1989-08-09
JPS61289099A (ja) 1986-12-19
AU5805886A (en) 1986-12-04
NO862144L (no) 1986-12-01

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