ES8800670A1 - Un metodo para preparar estano mesoporfirina. - Google Patents

Un metodo para preparar estano mesoporfirina.

Info

Publication number
ES8800670A1
ES8800670A1 ES553306A ES553306A ES8800670A1 ES 8800670 A1 ES8800670 A1 ES 8800670A1 ES 553306 A ES553306 A ES 553306A ES 553306 A ES553306 A ES 553306A ES 8800670 A1 ES8800670 A1 ES 8800670A1
Authority
ES
Spain
Prior art keywords
therapeutic use
tin mesoporphyrin
mammals
rate
heme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553306A
Other languages
English (en)
Other versions
ES553306A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Publication of ES553306A0 publication Critical patent/ES553306A0/es
Publication of ES8800670A1 publication Critical patent/ES8800670A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE ESTAÑO-MESOPORFIRINA. COMPRENDE: A) TRATAR MESOPORFIRINA CON UN EXCESO DE CLORURO ESTANOSO, EN ACIDO ACETICO EN PRESENCIA DE NITROGENO, A 50JC Y DURANTE 24 A 48 HORAS, PARA FORMAR UNA MEZCLA; B) DEJAR REPOSAR LA MEZCLA DURANTE 10 HORAS, PARA CRISTALIZAR EL COMPUESTO DE ESTAÑO-MESOPORFIRINA; C) FILTRAR LA SOLUCION CON CRISTALES A TRAVES DE UN PAPEL DE FILTRO WHATMAN N.O 1; D) LAVAR EL FILTRADO CON ACIDO ACETICO GLACIAL; E) SECAR EL FILTRADO CON AIRE; F) TRATAR A LOS CRISTALES SECOS CON CLH 6N, PARA PURIFICARLOS; G) LAVAR A LOS CRISTALES PURIFICADOS CON CLH 0,1 N; Y H) SECAR A VACIO DICHOS CRISTALES LAVADOS Y PURIFICADOS. SE UTILIZA PARA INHIBIR EL METABOLISMO DE HEMO EN MAMIFEROS Y CONTROLAR LA VELOCIDAD DEL METABOLISMO DEL TRIPTOFANO EN MAMIFEROS.
ES553306A 1985-03-25 1986-03-24 Un metodo para preparar estano mesoporfirina. Expired ES8800670A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/715,515 US4657902A (en) 1985-03-25 1985-03-25 Therapeutic use of tin mesoporphyrin

Publications (2)

Publication Number Publication Date
ES553306A0 ES553306A0 (es) 1987-11-16
ES8800670A1 true ES8800670A1 (es) 1987-11-16

Family

ID=24874343

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553306A Expired ES8800670A1 (es) 1985-03-25 1986-03-24 Un metodo para preparar estano mesoporfirina.

Country Status (15)

Country Link
US (1) US4657902A (es)
EP (1) EP0196079B1 (es)
JP (1) JPS62500787A (es)
KR (1) KR870700341A (es)
AT (1) ATE61221T1 (es)
AU (1) AU567041B2 (es)
CA (1) CA1293504C (es)
DE (1) DE3677804D1 (es)
DK (1) DK162716C (es)
ES (1) ES8800670A1 (es)
GR (1) GR860768B (es)
IE (1) IE58532B1 (es)
PH (2) PH23102A (es)
WO (1) WO1986005685A1 (es)
ZA (1) ZA861793B (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0976652A1 (en) 1998-07-29 2000-02-02 Construcciones Aeronauticas, S.A. Lightning protection system for composite aircraft structures
EP0976653A1 (en) 1998-07-29 2000-02-02 Construcciones Aeronauticas, S.A. Lightning protection system for composite aircraft structures

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657902A (en) * 1985-03-25 1987-04-14 The Rockefeller University Therapeutic use of tin mesoporphyrin
KR910009202B1 (ko) * 1985-10-23 1991-11-04 니혼메디피직스 가부시끼가이샤 포르피린 유도체의 제조방법
EP0249966A1 (en) * 1986-06-20 1987-12-23 The Rockefeller University Tin diiododeuteroporphyrin, its preparation and use, and pharmaceutical compositions thereof
US4782049A (en) * 1986-12-08 1988-11-01 The Rockefeller University Tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis
US4831024A (en) * 1987-10-15 1989-05-16 The Board Of Trustees Of The Leland Stanford Junior University Method to prevent neonatal jaundice
US4997828A (en) * 1989-02-14 1991-03-05 The Rockefeller University Method of weight control by low level administration of cobalt protoporphyrin or cobalt mesoporphyrin
AU634307B2 (en) * 1989-09-25 1993-02-18 Rockefeller University, The Orally administered porphyrins to control intestinal iron absorption
US5010073A (en) * 1989-10-05 1991-04-23 The Rockefeller University Use of liposomes as carriers for metalloporphyrins
US5192757A (en) * 1990-12-20 1993-03-09 Glaxo Inc. Cobalt porphyrins
US5149697A (en) * 1991-04-18 1992-09-22 Glaxo Inc. Cobalt porphyrin pharmaceutical compositions
FR2676738B1 (fr) * 1991-05-22 1995-05-05 Ir2M Nouveau derive organique de metal de transition a structure porphyrinique, composition therapeutique le contenant, en particulier a activite hypoglycemiante.
US5599924A (en) * 1992-08-14 1997-02-04 Trustees Of The University Of Pennsylvania Electron-deficient porphyrins and processes and intermediates for preparing same
US5817830A (en) * 1992-08-14 1998-10-06 Trustees Of The University Of Pennsylvania Pyrrolic compounds
US5371199B1 (en) * 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5493017A (en) * 1992-08-14 1996-02-20 The Trustees Of The University Of Pennsylvania Ring-metalated porphyrins
AU7103594A (en) * 1993-06-14 1995-01-03 Rockefeller University, The Treatment of neonatal hyperbilirubin with metalloporphyrin
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
FI100454B (fi) * 1995-01-30 1997-12-15 Leiras Oy Hemi-tuotteiden uusi lääkinnällinen käyttö
AU6497996A (en) * 1995-08-02 1997-02-26 Warner-Lambert Company Amino acid complexes of cobalt (iii) mesoporphyrin ix and cobalt (iii) protoporphyrin ix
CA2309154C (en) 1997-11-03 2010-02-16 Duke University Substituted porphyrins
CN1093541C (zh) * 1998-01-19 2002-10-30 徐濂 金属卟啉及其生产工艺
EP1117384A1 (en) * 1998-10-01 2001-07-25 Elan Pharma International Limited Controlled release nanoparticulate compositions
DK1155019T3 (da) * 1999-01-25 2006-04-18 Nat Jewish Med & Res Center Substituerede porphyriner og deres terapeutiske anvendelse
EP1392328B1 (en) * 2001-01-19 2009-08-12 National Jewish Medical and Research Center Medicament for protection in radiotherapy
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
WO2002098431A1 (en) * 2001-06-01 2002-12-12 National Jewish Medical And Research Center Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
US7011854B2 (en) * 2002-02-04 2006-03-14 Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7375216B2 (en) * 2002-06-04 2008-05-20 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin compounds
NZ536666A (en) 2002-06-04 2007-10-26 Infacare Pharmaceutical Corp Preparation of metal mesoporphyrin halide compounds
AU2003237500A1 (en) * 2002-06-07 2003-12-22 Duke University Substituted porphyrins
US20040097481A1 (en) * 2002-11-20 2004-05-20 Benjamin Levinson Water-soluble mesoporphyrin compounds and methods of preparation
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US7008937B2 (en) * 2003-06-10 2006-03-07 Frontier Scientific, Inc. Porphyrins and metalloporphyrins for inhibiting heme iron uptake
US20060222668A1 (en) * 2005-04-01 2006-10-05 Wellspring Pharmaceutical Corporation Stannsoporfin compositions, drug products and methods of manufacture
AU2006232330A1 (en) * 2005-04-01 2006-10-12 Infacare Pharmaceutical Corporation Stannsoporfin compositions and administration
WO2007073226A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda Method for treating a mammal by administration of a compound having the ability to release co
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
RS52185B (en) 2006-10-04 2012-10-31 Infacare Pharmaceutical Corporation STANSOPORPHINE PREPARATION WITH HIGH PURITY
ES2600469T3 (es) 2008-05-23 2017-02-09 National Jewish Health Un compuesto para su uso en el tratamiento de lesiones asociadas con la exposición al gas fosgeno o al gas de cloro
PT2691398T (pt) 2011-03-30 2017-01-02 Infacare Pharmaceutical Corp Métodos para sintetizar mesoporfirinas de metal
WO2012145520A2 (en) 2011-04-19 2012-10-26 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
WO2013013179A1 (en) 2011-07-21 2013-01-24 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof
GB201120860D0 (en) 2011-12-05 2012-01-18 Cambridge Entpr Ltd Cancer immunotherapy
DK3200582T3 (da) 2014-09-29 2024-02-19 Fred Hutchinson Cancer Center Sammensætninger, kits og fremgangsmåder til induktion af erhvervet cytoresistens under anvendelse af stressproteininducere
US10676490B2 (en) 2015-07-07 2020-06-09 Florida Southwestern State College Use of amine carboxyboranes as therapeutic delivery of carbon monoxide and as general drug delivery system in the presence of reactive oxygen species
CN111603472A (zh) * 2020-06-09 2020-09-01 上海市闵行区中心医院 一种锡-中卟啉与青蒿素联合应用在制备抗肿瘤药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579533A (en) * 1968-03-18 1971-05-18 Antioch College Preparation of porphin,substituted porphin and metal chelates thereof
US3687863A (en) * 1970-05-25 1972-08-29 Gen Telephone & Elect Optical filters containing tetraphenyl-porphins and method of making same
US4393071A (en) * 1975-03-17 1983-07-12 Naoharu Fujii Method of treating gastric, mammary, lung and uterus tumors
JPS53109929A (en) * 1977-03-04 1978-09-26 Nippon Oil Co Ltd Medicin for malignant tumor
CA1176978A (en) * 1981-07-15 1984-10-30 Attallah Kappas Method of controlling of heme metabolism
EP0127797B1 (de) * 1983-06-03 1987-06-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung
US4657902A (en) * 1985-03-25 1987-04-14 The Rockefeller University Therapeutic use of tin mesoporphyrin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0976652A1 (en) 1998-07-29 2000-02-02 Construcciones Aeronauticas, S.A. Lightning protection system for composite aircraft structures
EP0976653A1 (en) 1998-07-29 2000-02-02 Construcciones Aeronauticas, S.A. Lightning protection system for composite aircraft structures

Also Published As

Publication number Publication date
KR870700341A (ko) 1987-12-28
US4657902A (en) 1987-04-14
AU567041B2 (en) 1987-11-05
EP0196079B1 (en) 1991-03-06
ZA861793B (en) 1986-10-29
AU5549586A (en) 1986-10-23
EP0196079A1 (en) 1986-10-01
DK162716B (da) 1991-12-02
IE860751L (en) 1986-09-25
GR860768B (en) 1986-07-22
DK565786D0 (da) 1986-11-25
ES553306A0 (es) 1987-11-16
ATE61221T1 (de) 1991-03-15
PH24689A (en) 1990-09-07
DK565786A (da) 1986-11-25
WO1986005685A1 (en) 1986-10-09
PH23102A (en) 1989-04-10
JPS62500787A (ja) 1987-04-02
DK162716C (da) 1992-05-11
JPH0317806B2 (es) 1991-03-11
CA1293504C (en) 1991-12-24
IE58532B1 (en) 1993-10-06
DE3677804D1 (de) 1991-04-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060909