ES8708127A1 - Procedimiento de preparar hidroxamatos farmaceuticamente activos. - Google Patents
Procedimiento de preparar hidroxamatos farmaceuticamente activos.Info
- Publication number
- ES8708127A1 ES8708127A1 ES554125A ES554125A ES8708127A1 ES 8708127 A1 ES8708127 A1 ES 8708127A1 ES 554125 A ES554125 A ES 554125A ES 554125 A ES554125 A ES 554125A ES 8708127 A1 ES8708127 A1 ES 8708127A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxamates
- modulators
- arachidonic acid
- metabolic pathways
- acid metabolic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 title 2
- 229940114079 arachidonic acid Drugs 0.000 title 1
- 235000021342 arachidonic acid Nutrition 0.000 title 1
- 230000037353 metabolic pathway Effects 0.000 title 1
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR HIDROXAMATOS FARMACEUTICAMENTE ACTIVOS. CONSISTE EN HACER REACCIONAR UN ACIDO CARBOXILICO DE FORMULA (II) CON UNA HIDROXILAMINA DE FORMULA (III), EN TETRAHIDROFURANO Y ENTRE 0JC Y LA TEMPERATURA DE REFLUJO, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: AR, FENILO O NAFTILO; R Y R1, H, CICLOALQUILO INFERIOR Y OTROS; R2, H, ALQUILO INFERIOR Y OTROS; R3 Y R4, H, O ALQUILO INFERIOR; R5, H, ARILO Y OTROS; X E Y, O, S O CR3R4; Z, Z1 Y Z2, CADENA DE ALQUILENO SUSTITUIDA POR H, ALQUILO INFERIOR Y OTROS; N, 0, 1 O 2; Y N1, 1 O 2. SE UTILIZAN COMO ANRTIINFLAMATORIOS Y ANTIALERGICOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71919985A | 1985-04-03 | 1985-04-03 | |
US06/830,798 US4792560A (en) | 1985-04-03 | 1986-02-19 | Quinoline hydroxamates and their use as modulators of arachidonic acid metabolic pathways |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8708127A1 true ES8708127A1 (es) | 1987-10-16 |
ES554125A0 ES554125A0 (es) | 1987-10-16 |
Family
ID=27110043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES554125A Expired ES8708127A1 (es) | 1985-04-03 | 1986-04-03 | Procedimiento de preparar hidroxamatos farmaceuticamente activos. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4792560A (es) |
EP (1) | EP0196674A3 (es) |
AU (1) | AU5568186A (es) |
DK (1) | DK150986A (es) |
ES (1) | ES8708127A1 (es) |
FI (1) | FI861444A (es) |
NO (1) | NO861306L (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4607053A (en) * | 1984-05-17 | 1986-08-19 | E. R. Squibb & Sons, Inc. | Arylhydroxamates useful as antiallergy agents |
IE59397B1 (en) * | 1985-03-16 | 1994-02-23 | Wellcome Found | New aryl derivatives |
GB8531839D0 (en) * | 1985-12-30 | 1986-02-05 | Wellcome Found | Aryl derivatives |
US4861798A (en) * | 1986-12-29 | 1989-08-29 | Bristol-Myers Company | Lipoxygenase inhibitory compounds |
US4731382A (en) * | 1986-12-29 | 1988-03-15 | Bristol-Myers Company | Lipoxygenase inhibitory phenylalkanohydroxamic acids |
US5155110A (en) * | 1987-10-27 | 1992-10-13 | Warner-Lambert Company | Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
US4943587A (en) * | 1988-05-19 | 1990-07-24 | Warner-Lambert Company | Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues and their use for cyclooxygenase and 5-lipoxygenase inhibition |
US5112868A (en) * | 1988-05-19 | 1992-05-12 | Warner-Lambert Company | Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition |
US5096919A (en) * | 1989-01-05 | 1992-03-17 | Ciba-Geigy Corporation | Pyrrolylphenyl-substituted hydroxamic acid derivatives |
IL92915A0 (en) * | 1989-01-05 | 1990-09-17 | Ciba Geigy Ag | Certain pyrrolylphenyl-substituted hydroxamic acid derivatives |
US4960787A (en) * | 1989-02-06 | 1990-10-02 | Ciba-Geigy Corporation | Certain pyrrolyl-substituted hydroxamic acid derivatives |
US4981865A (en) * | 1989-05-26 | 1991-01-01 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
US5112846A (en) * | 1989-05-26 | 1992-05-12 | Warner-Lambert Company | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
US5075330A (en) * | 1989-05-26 | 1991-12-24 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, N-hydroxyurea, and N-hydroxythiourea derivatives of selected NSAIDS as antiinflammatory agents |
US5155130A (en) * | 1989-08-11 | 1992-10-13 | Ciba-Geigy Corporation | Certain benzopyran and benzothiopyran derivatives |
US5229516A (en) * | 1989-10-27 | 1993-07-20 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
US5017604A (en) * | 1990-04-11 | 1991-05-21 | Warner-Lambert Company | Novel fenamic acid methyl hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
US5120758A (en) * | 1991-02-08 | 1992-06-09 | Ciba-Geigy Corporation | Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors |
US5140047A (en) * | 1991-05-03 | 1992-08-18 | Smithkline Beecham Corporation | Lipoxygenase inhibitors |
US5334600A (en) * | 1991-07-30 | 1994-08-02 | Ciba-Geigy Corporation | Isoquinolyl substituted hydroxylamine derivatives |
US5260316A (en) * | 1991-07-30 | 1993-11-09 | Ciba-Geigy Corporation | Isoquinolyl substituted hydroxylamine derivatives |
US5350761A (en) * | 1991-07-30 | 1994-09-27 | Ciba-Geigy Corporation | Indolyl substituted hydroxylamine derivatives |
US5358955A (en) * | 1992-10-30 | 1994-10-25 | Abbott Laboratories | Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis |
IT1283637B1 (it) * | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
US6541661B1 (en) | 1999-11-23 | 2003-04-01 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US20040267015A1 (en) * | 2001-04-05 | 2004-12-30 | Ajita Bhat | Peptide deformylase inhibitors |
US8796330B2 (en) * | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
GB0821010D0 (en) | 2008-11-17 | 2008-12-24 | Univ Warwick | Plant development control composition |
US9593136B2 (en) * | 2011-07-01 | 2017-03-14 | The George Washington University | Compounds for inhibiting 1-deoxy-D-xylulose-5-phosphate reductoisomerase |
US9636298B2 (en) | 2014-01-17 | 2017-05-02 | Methylgene Inc. | Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6406688A (es) * | 1964-06-05 | 1965-12-06 | ||
BE689347A (es) * | 1965-12-09 | 1967-04-14 | Madan Ag | |
US3481970A (en) * | 1967-05-08 | 1969-12-02 | Standard Oil Co | Process for preparation of beta-chloromethacrylonitrile |
SE363818B (es) * | 1968-08-15 | 1974-02-04 | Lilly Co Eli | |
GB1396726A (en) * | 1972-06-15 | 1975-06-04 | Boots Co Ltd | Phenylalkanoic acids |
IT1046338B (it) * | 1974-12-06 | 1980-06-30 | Manetti & Roberts Italo Brit | Procedimento per preparare aoido 2,4 isoputil fenil propioidros sanico e combusto intermerio beriesso |
NL7614113A (nl) * | 1976-12-18 | 1978-06-20 | Akzo Nv | Hydroxamzuren. |
-
1986
- 1986-02-19 US US06/830,798 patent/US4792560A/en not_active Expired - Fee Related
- 1986-04-03 AU AU55681/86A patent/AU5568186A/en not_active Abandoned
- 1986-04-03 FI FI861444A patent/FI861444A/fi not_active IP Right Cessation
- 1986-04-03 ES ES554125A patent/ES8708127A1/es not_active Expired
- 1986-04-03 EP EP86104556A patent/EP0196674A3/en not_active Withdrawn
- 1986-04-03 DK DK150986A patent/DK150986A/da not_active IP Right Cessation
- 1986-04-03 NO NO861306A patent/NO861306L/no unknown
Also Published As
Publication number | Publication date |
---|---|
DK150986A (da) | 1986-10-04 |
FI861444A (fi) | 1986-10-04 |
US4792560A (en) | 1988-12-20 |
EP0196674A2 (en) | 1986-10-08 |
FI861444A0 (fi) | 1986-04-03 |
EP0196674A3 (en) | 1988-06-15 |
ES554125A0 (es) | 1987-10-16 |
NO861306L (no) | 1986-10-06 |
DK150986D0 (da) | 1986-04-03 |
AU5568186A (en) | 1986-10-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8708127A1 (es) | Procedimiento de preparar hidroxamatos farmaceuticamente activos. | |
ES2005073A6 (es) | Procedimiento para preparar benzamidas y bencenoacetamidas | |
MY133647A (en) | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | |
PL314300A1 (en) | Peptide-type compounds and their therapeutic application as inhibitors of metalloproteinases | |
PL319503A1 (en) | Peptide compounds and their therapeutic application as inhibitors | |
ES2040208T3 (es) | Pirazolinas insecticidas. | |
AU6328586A (en) | Novel enolamides, pharmaceutical compositions and methods of use thereof for activity as modulators of the arachidonic acid cascade | |
ZA851552B (en) | Benzisoselenazolethiones,processes for their preparation and pharmaceutical products containing these compounds | |
AU6627286A (en) | Electrochemical treatment of lignins | |
BR0315820A (pt) | Inibidores de integrase de hiv, composições farmacêuticas e métodos para a sua utilização | |
ES478967A1 (es) | Un procedimiento para preparar compuestos de acido 3-cefem-4-carboxilico disustituido en las posiciones 3 y 7. | |
ATE41146T1 (de) | Irreversible dopamin-b-hydroxylase-inhibitoren. | |
ES2056983T3 (es) | Compuestos para inhibir la biosintesis de metabolitos de acido araquidonico derivados de lipoxigenasa. | |
AU578295B2 (en) | Phenyl-substituted naphthyridines and their use as anti-ulcer drugs | |
ES8802612A1 (es) | Procedimiento para preparar derivados de benzisoselenazolilo | |
ES8403487A1 (es) | "procedimiento para la preparacion de n-(2-metoxietil)-noroximorfona". | |
ES553207A0 (es) | Un procedimiento para la preparacion de una octahidroindolizina | |
ATE86611T1 (de) | Topische vorstufen von arzneimitteln zur behandlung von akne und hautkrankheiten. | |
WO1986007357A2 (en) | Cyclopentapyrazole and tetrahydroindazole compounds | |
ES2000960A6 (es) | Un procedimiento para preparar n(1-ciclohexenilmetil-2-pirrolidinilmetil)-8-etilsulfonil-1,5-benzodioxepan-6-carboxamida | |
UA12244A1 (uk) | Засіб для передпосівhої обробки hасіhhя кукурудзи | |
ES8605584A1 (es) | Un procedimiento para preparar foroximitina | |
ES2000665A6 (es) | Un procedimiento para la preparacion de acido 1-etil-6-flouro-1,4-dihidro-4-ceto-7-(trimetilolmetilamino)-quinolin-3-carboxilico | |
MX9709982A (es) | Retinoides de chalcona y uso de los mismos. | |
ATE39843T1 (de) | Verwendung von sekundaeren amidverbindungen zur herstellung von arzneimitteln zur behandlung von dermatologischen entzuendungen. |