ES8707296A1 - Un metodo para producir anticuerpos monoclonales humanos - Google Patents
Un metodo para producir anticuerpos monoclonales humanosInfo
- Publication number
- ES8707296A1 ES8707296A1 ES555741A ES555741A ES8707296A1 ES 8707296 A1 ES8707296 A1 ES 8707296A1 ES 555741 A ES555741 A ES 555741A ES 555741 A ES555741 A ES 555741A ES 8707296 A1 ES8707296 A1 ES 8707296A1
- Authority
- ES
- Spain
- Prior art keywords
- exotoxin
- monoclonal antibodies
- human monoclonal
- pseudomonas aeruginosa
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ANTICUERPOS MONOCLONALES HUMANOS ESPECIFICOS PARA LA EPOTOXINA A DE PSEUDOMONAS AERUGINOSA. CONSISTE EN INMORTALIZAR CON VIRUS DE EPSTEIN-BARR CELULAS B HUMANAS DE UN PACIENTE EXPUESTAS A ANTIGENOS DE LA OXOTOXINA A DE PSEUDOMONAS AERUGIONSA; SEPARAR DE ESTAS CELULAS LAS LINEAS CELULARES QUE SEGREGAN ANTICUERPOS MONOCLONALES REACTIVOS CON LA EXOTOXINA A; COMPROBAR ESTOS ANTICUERPOS; CULTIVAR UNA LINEA CELULAR PRODUCTORA DEL ANTICUERPO NEUTRALIZANTE; Y RECUPERAR LOS ANTICUERPOS SEGREGADOS POR LA MISMA. ESTOS ANTICUERPOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74217085A | 1985-06-06 | 1985-06-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8707296A1 true ES8707296A1 (es) | 1987-07-16 |
ES555741A0 ES555741A0 (es) | 1987-07-16 |
Family
ID=24983768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES555741A Expired ES8707296A1 (es) | 1985-06-06 | 1986-06-05 | Un metodo para producir anticuerpos monoclonales humanos |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0229107A4 (es) |
JP (1) | JPS63500035A (es) |
AU (2) | AU5991786A (es) |
DK (1) | DK59387D0 (es) |
ES (1) | ES8707296A1 (es) |
FI (1) | FI870482A (es) |
HU (1) | HU205630B (es) |
IE (1) | IE861494L (es) |
IL (1) | IL79010A0 (es) |
NO (1) | NO174003C (es) |
WO (1) | WO1986007382A1 (es) |
ZA (1) | ZA864196B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK172840B1 (da) * | 1986-07-03 | 1999-08-09 | Genetic Systems Corp | Monoklonale antistoffer mod Pseudomonas aeruginosa flagella, farmaceutiske præparater indeholdende sådanne antistoffer og c |
JPS6463374A (en) * | 1987-09-03 | 1989-03-09 | Agency Ind Science Techn | Human monoclonal antibody, antibody-forming cell, antibody-forming hybridoma and production of antibody |
US5126259A (en) * | 1987-12-24 | 1992-06-30 | Takeda Chemical Industries, Ltd. | Human b. lymphoblastoid cell, hybridoma, antibody and production of antibody |
CA1341375C (en) * | 1988-10-12 | 2002-07-09 | Baxter International Inc. | Compositions and methods for the treatment and prevention of gram-negative bacterial infections |
EP0382031A3 (en) * | 1989-02-10 | 1991-06-26 | Miles Inc. | Monoclonal antibodies in immune serum globulin |
EP2393515A1 (en) * | 2009-02-04 | 2011-12-14 | Kalobios Pharmaceuticals, Inc. | Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4464465A (en) * | 1982-04-05 | 1984-08-07 | Genetic Systems Corporation | Cell-driven viral transfer in eukaryotes |
AU567693B2 (en) * | 1982-09-30 | 1987-12-03 | University Of Rochester | Human monoclonal antibodies against bacterial toxins |
US5179018A (en) * | 1983-10-14 | 1993-01-12 | Centocor, Inc. | Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria |
GB8422649D0 (en) * | 1984-09-07 | 1984-10-10 | Technology Licence Co Ltd | Monoclonal antibodies |
JP2691708B2 (ja) * | 1984-09-26 | 1997-12-17 | 住友製薬株式会社 | ヒトモノクローナル抗体およびその製法 |
-
1986
- 1986-06-02 WO PCT/US1986/001204 patent/WO1986007382A1/en not_active Application Discontinuation
- 1986-06-02 AU AU59917/86A patent/AU5991786A/en not_active Abandoned
- 1986-06-02 JP JP61503371A patent/JPS63500035A/ja active Pending
- 1986-06-02 EP EP19860903954 patent/EP0229107A4/en not_active Withdrawn
- 1986-06-02 HU HU863265A patent/HU205630B/hu not_active IP Right Cessation
- 1986-06-03 IL IL79010A patent/IL79010A0/xx not_active IP Right Cessation
- 1986-06-05 ZA ZA864196A patent/ZA864196B/xx unknown
- 1986-06-05 ES ES555741A patent/ES8707296A1/es not_active Expired
- 1986-06-05 IE IE861494A patent/IE861494L/xx unknown
-
1987
- 1987-02-05 DK DK059387A patent/DK59387D0/da not_active Application Discontinuation
- 1987-02-05 FI FI870482A patent/FI870482A/fi not_active IP Right Cessation
- 1987-02-05 NO NO870457A patent/NO174003C/no unknown
-
1990
- 1990-11-13 AU AU66583/90A patent/AU6658390A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO870457L (no) | 1987-02-05 |
EP0229107A1 (en) | 1987-07-22 |
IE861494L (en) | 1986-12-06 |
WO1986007382A1 (en) | 1986-12-18 |
NO174003B (no) | 1993-11-22 |
FI870482A0 (fi) | 1987-02-05 |
JPS63500035A (ja) | 1988-01-07 |
DK59387A (da) | 1987-02-05 |
FI870482A (fi) | 1987-02-05 |
IL79010A0 (en) | 1986-09-30 |
AU5991786A (en) | 1987-01-07 |
ZA864196B (en) | 1987-02-25 |
HUT42135A (en) | 1987-06-29 |
ES555741A0 (es) | 1987-07-16 |
AU6658390A (en) | 1991-03-14 |
EP0229107A4 (en) | 1987-11-09 |
NO174003C (no) | 1994-03-02 |
DK59387D0 (da) | 1987-02-05 |
HU205630B (en) | 1992-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970505 |