ES8609304A1 - Procedimiento para la obtencion de derivados de indol - Google Patents

Procedimiento para la obtencion de derivados de indol

Info

Publication number
ES8609304A1
ES8609304A1 ES543991A ES543991A ES8609304A1 ES 8609304 A1 ES8609304 A1 ES 8609304A1 ES 543991 A ES543991 A ES 543991A ES 543991 A ES543991 A ES 543991A ES 8609304 A1 ES8609304 A1 ES 8609304A1
Authority
ES
Spain
Prior art keywords
alkyl
denotes
indole derivatives
unsubstituted
mono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543991A
Other languages
English (en)
Other versions
ES543991A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES8609304A1 publication Critical patent/ES8609304A1/es
Publication of ES543991A0 publication Critical patent/ES543991A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE INDOL. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN UN DISOLVENTE ORGANICO COMO BENCENO, TOLUENO, ACETONA, THF, ETANOL Y OTROS, EN PRESENCIA DE UN ACEPTOR DE ACIDOS COMO UN HIDROXIDO ALCALINO O BASE ORGANICA, DURANTE UN TIEMPO DE MINUTOS A 14 DIAS, Y ENTRE 20 Y 130JC, PARA OBTENER DERIVADOS DE INDOL DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: A, -CN H2N- O -CHFCH-CH2-; IND, INDOL-4-ILO, OPCIONALMENTE SUSTITUIDO POR OXI Y/O SULFOALQUILOS DE C 1 A 4; R, FENILO O 2- O 3-TIENILO, OPCIONALMENTE SUSTITUIDO POR ALQUILO Y HALOGENOS; X1, HAL Y OTROS; X2 Y X3, NH2 O NH; Y N, 2, 3 O 4. SE UTILIZAN COMO SENDANTES, TRANQUILIZANTES, NEUROLEPTICOS Y/O ANTIDEPRESIVOS, Y COMO PRODUCTOS DE PARTIDA PARA PRODUCIR OTROS MEDICAMENTOS.
ES543991A 1984-06-09 1985-06-07 Procedimiento para la obtencion de derivados de indol Expired ES8609304A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843421641 DE3421641A1 (de) 1984-06-09 1984-06-09 Indolderivate

Publications (2)

Publication Number Publication Date
ES8609304A1 true ES8609304A1 (es) 1986-07-16
ES543991A0 ES543991A0 (es) 1986-07-16

Family

ID=6238086

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543991A Expired ES8609304A1 (es) 1984-06-09 1985-06-07 Procedimiento para la obtencion de derivados de indol

Country Status (7)

Country Link
EP (1) EP0164633A3 (es)
JP (1) JPS617275A (es)
AU (1) AU4343885A (es)
DE (1) DE3421641A1 (es)
ES (1) ES8609304A1 (es)
HU (1) HUT41021A (es)
ZA (1) ZA854355B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531658A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
DE3614758A1 (de) * 1986-04-30 1987-11-05 Merck Patent Gmbh Indolderivat
FR2639226B1 (fr) * 1988-11-18 1993-11-05 Sanofi Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610741B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
FR2792313A1 (fr) * 1999-04-13 2000-10-20 Synthelabo Derives de 2-aminoethyl-indole, leur preparation et leur application en therapeutique
AR030357A1 (es) 2000-08-18 2003-08-20 Lundbeck & Co As H Derivados 4 -, 5 -, 6 - y 7-indol
WO2002085888A1 (fr) * 2001-04-20 2002-10-31 Sanofi-Synthelabo Tetrahydropyridyl-alkyl-heterocycles, procede pour leur preparation et compositions pharmaceutiques les contenants
FR2823750B1 (fr) * 2001-04-20 2005-11-04 Sanofi Synthelabo Tetrahydropyridyl-alkyl-heterocycles, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
DE202008018087U1 (de) 2008-04-02 2012-04-30 Andreas Trautmann Strahlenschutzelement, Strahlenschutzanordnung und Rechneranlage, Datenträger sowie Signalfolge

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3183235A (en) * 1961-06-27 1965-05-11 Sterling Drug Inc 1-[3-, 2-, and 1-indolyl-lower-alkanoyl] piperidines
GB1189064A (en) * 1967-05-01 1970-04-22 Sterling Drug Inc Indole Derivatives

Also Published As

Publication number Publication date
AU4343885A (en) 1985-12-12
ZA854355B (en) 1986-02-26
EP0164633A3 (de) 1987-06-03
JPS617275A (ja) 1986-01-13
HUT41021A (en) 1987-03-30
DE3421641A1 (de) 1985-12-12
EP0164633A2 (de) 1985-12-18
ES543991A0 (es) 1986-07-16

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